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Protein

Receptor-type guanylate cyclase gcy-6

Gene

gcy-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward the salt ion Mg2+ and to a lesser extent toward Cl1- in ASE left (ASEL) sensory neuron (PubMed:19523832).By similarity1 Publication

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei589ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi566 – 574ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • cGMP biosynthetic process Source: GO_Central
  • chemosensory behavior Source: UniProtKB
  • chemotaxis Source: UniProtKB
  • intracellular signal transduction Source: InterPro
  • positive regulation of calcium-mediated signaling Source: UniProtKB
  • response to inorganic substance Source: UniProtKB
  • response to magnesium ion Source: UniProtKB
  • response to salt Source: UniProtKB
  • signal transduction Source: GO_Central

Keywordsi

Molecular functionLyase, Receptor
Biological processcGMP biosynthesis, Chemotaxis
LigandATP-binding, GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type guanylate cyclase gcy-6Curated (EC:4.6.1.2By similarity)
Gene namesi
Name:gcy-6Imported
ORF Names:B0024.6Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiB0024.6a ; CE47853 ; WBGene00001533 ; gcy-6
B0024.6b ; CE46160 ; WBGene00001533 ; gcy-6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 487ExtracellularSequence analysisAdd BLAST466
Transmembranei488 – 508HelicalSequence analysisAdd BLAST21
Topological domaini509 – 1086CytoplasmicSequence analysisAdd BLAST578

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000043327522 – 1086Receptor-type guanylate cyclase gcy-6Sequence analysisAdd BLAST1065

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi325N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi343N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi387N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi427N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiN1NVB7
PaxDbiN1NVB7

Expressioni

Tissue specificityi

Expressed in both ASEL and ASER neurons throughout late embryonic and early larval stages. In adults, expressed asymmetrically in ASE left (ASEL) sensory neuron.2 Publications

Gene expression databases

BgeeiWBGene00001533

Interactioni

Protein-protein interaction databases

STRINGi6239.B0024.6

Structurei

3D structure databases

ProteinModelPortaliN1NVB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini560 – 836Protein kinasePROSITE-ProRule annotationAdd BLAST277
Domaini894 – 1024Guanylate cyclasePROSITE-ProRule annotationAdd BLAST131

Domaini

The protein kinase domain is predicted to be catalytically inactive.PROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1023 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00760000118959
HOGENOMiHOG000016255
InParanoidiQ9XVV4
OMAiGFLHCDV
OrthoDBiEOG091G02QS

Family and domain databases

Gene3Di3.30.70.1230, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR001828 ANF_lig-bd_rcpt
IPR011645 HNOB_dom_associated
IPR011009 Kinase-like_dom_sf
IPR029787 Nucleotide_cyclase
IPR028082 Peripla_BP_I
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00211 Guanylate_cyc, 1 hit
PF07701 HNOBA, 1 hit
PF07714 Pkinase_Tyr, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit
SSF55073 SSF55073, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform aImported (identifier: N1NVB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIGVYLRSVI FPLLFVIQTI CQPPGNVFHL GFLHCDVLEN NVEGSTTYIN
60 70 80 90 100
YRTSASAASI AIDKIKREGL LLGYDFKFTI LYDQCDENIA AGNAIKLFAE
110 120 130 140 150
HNVDVLFGPT TNNAAMPVFI LATYYNIPLI TWGITSSATL DDESRFPTAG
160 170 180 190 200
MLSIGSRSLA VTFREVMKEY GWDQFVFAYS LEMNDEKCET LRDDFQNMVA
210 220 230 240 250
YYGDIVLSYA VQIMDHSEEG LLAILKDVST RGRIIVPCFH EGNSRGLHRR
260 270 280 290 300
WMLVAARNGF VNDEYVYIFP SLRSRGYAVP QADGTFRYPW TEATGPQPGD
310 320 330 340 350
QEALLGFQKS IFIVDMQGQG NVGSNYTQFE HEIIQRMKEP PYNCTDACAS
360 370 380 390 400
PEYQTAATYA GQLHDSVYIY GVVMDQIMKT VPNQYKNGTA FPRKMAGVFN
410 420 430 440 450
GVGGTVAIDE GGGLQPTLFV LTLDSNNNSS LIMTVDVDQQ EAVVTKHYTN
460 470 480 490 500
EATALWSHRK GIRPPDQPIC GYTGSLCPAN VFFQYIGWFI AAIIIIFFTI
510 520 530 540 550
MGAILAFIYL CHAKQQEVER QNALWQIPFK SMMTVTKKGK GEHSMRSISS
560 570 580 590 600
VPSTISSTRS STLSEVGETR NYLFFQIQND VEMERVAAKK HSIRMVFDNK
610 620 630 640 650
TCATMRQMRL IDHANLNKFI GMSLDAPQLY SVWRFCSRGS LADVIRKASM
660 670 680 690 700
QMDGFFIYSL MKDIINGLTW IHESSHEFHG MLTSKNCLLN DRWQLKITDF
710 720 730 740 750
GLRIFRTHDQ YNKSDRLWTS PELLRTDDIL GSREGDIYSF GIISAELITR
760 770 780 790 800
SSVFDLENRK EDAEEIIYML KKGGLQSPRP SLEHDESIEI NPALLHLVRD
810 820 830 840 850
CWTERPSERP DIKQVASQLR SMNTNRNDNL MDHVFNVLES YASTLEDEVA
860 870 880 890 900
ERMKELVEEK KKSDVLLYRM LPRQVADKLK LGQTVEPETF DIVTLFFSDV
910 920 930 940 950
VSFTTLAGKC TPLQVVNLLN GLYTIFDGII EQHDVYKVET IGDGYFVASG
960 970 980 990 1000
VPRRNGNEHT RNIASMSINF VKSLADFSIP HLPGEKIKIR VGFHCGSVVA
1010 1020 1030 1040 1050
GVVGLTMPRY CLFGDAVNTA SRMESNSKPG QIHLSEEANQ MLMRLGGFTT
1060 1070 1080
EPRGEVIIKG KGVMATYWLL KMDESAAPKI LKKKQD
Note: No experimental confirmation available.Curated
Length:1,086
Mass (Da):122,390
Last modified:June 26, 2013 - v1
Checksum:iB9C28158733BD1CF
GO
Isoform bImported (identifier: N1NVB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-40: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,082
Mass (Da):121,935
Checksum:i6A3B4D75670BD636
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05769937 – 40Missing in isoform b. Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAA94879.4
BX284605 Genomic DNA Translation: CCW45984.1
RefSeqiNP_001294696.1, NM_001307767.1 [N1NVB7-1]
NP_505650.3, NM_073249.3 [N1NVB7-2]

Genome annotation databases

EnsemblMetazoaiB0024.6b; B0024.6b; WBGene00001533 [N1NVB7-1]
GeneIDi191644
KEGGicel:CELE_B0024.6

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGCY6_CAEEL
AccessioniPrimary (citable) accession number: N1NVB7
Secondary accession number(s): Q9XVV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: June 26, 2013
Last modified: March 28, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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