UniProtKB - N0E4C7 (N0E4C7_HUMAN)
Protein
Casein kinase II subunit beta
Gene
CSNK2B
Organism
Homo sapiens (Human)
Status
Functioni
Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.UniRule annotation
GO - Molecular functioni
- kinase activity Source: UniProtKB-KW
- protein kinase regulator activity Source: InterPro
GO - Biological processi
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | KinaseImported, Transferase |
Biological process | Wnt signaling pathwayARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Casein kinase II subunit betaUniRule annotationARBA annotationShort name: CK II betaUniRule annotation |
Gene namesi | Name:CSNK2BImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000204435.13 |
Subcellular locationi
Other locations
- protein kinase CK2 complex Source: UniProtKB-UniRule
Expressioni
Gene expression databases
Bgeei | ENSG00000204435, Expressed in right testis and 112 other tissues |
ExpressionAtlasi | N0E4C7, baseline and differential |
Interactioni
Subunit structurei
Tetramer of two alpha and two beta subunits.
UniRule annotationChemistry databases
BindingDBi | N0E4C7 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_034027_3_3_1 |
OrthoDBi | 1335521at2759 |
PhylomeDBi | N0E4C7 |
Family and domain databases
Gene3Di | 1.10.1820.10, 1 hit |
InterProi | View protein in InterPro IPR016149, Casein_kin_II_reg-sub_N IPR035991, Casein_kinase_II_beta-like IPR000704, Casein_kinase_II_reg-sub |
PANTHERi | PTHR11740, PTHR11740, 1 hit |
Pfami | View protein in Pfam PF01214, CK_II_beta, 1 hit |
PRINTSi | PR00472, CASNKINASEII |
SMARTi | View protein in SMART SM01085, CK_II_beta, 1 hit |
SUPFAMi | SSF57798, SSF57798, 1 hit |
PROSITEi | View protein in PROSITE PS01101, CK2_BETA, 1 hit |
i Sequence
Sequence statusi: Complete.
N0E4C7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL
60 70 80 90 100
DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK
110 120 130 140 150
YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR
160 170 180 190 200
HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ
210
LQAASNFKSP VKTIR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HE864446 mRNA Translation: CCI79683.1 |
RefSeqi | NP_001311.3, NM_001320.6 |
Genome annotation databases
GeneIDi | 1460 |
KEGGi | hsa:1460 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HE864446 mRNA Translation: CCI79683.1 |
RefSeqi | NP_001311.3, NM_001320.6 |
3D structure databases
SMRi | N0E4C7 |
ModBasei | Search... |
Chemistry databases
BindingDBi | N0E4C7 |
Protocols and materials databases
Antibodypediai | 1045, 586 antibodies |
Genome annotation databases
GeneIDi | 1460 |
KEGGi | hsa:1460 |
Organism-specific databases
CTDi | 1460 |
VEuPathDBi | HostDB:ENSG00000204435.13 |
Phylogenomic databases
HOGENOMi | CLU_034027_3_3_1 |
OrthoDBi | 1335521at2759 |
PhylomeDBi | N0E4C7 |
Miscellaneous databases
BioGRID-ORCSi | 1460, 666 hits in 891 CRISPR screens |
ChiTaRSi | CSNK2B, human |
GenomeRNAii | 1460 |
Gene expression databases
Bgeei | ENSG00000204435, Expressed in right testis and 112 other tissues |
ExpressionAtlasi | N0E4C7, baseline and differential |
Family and domain databases
Gene3Di | 1.10.1820.10, 1 hit |
InterProi | View protein in InterPro IPR016149, Casein_kin_II_reg-sub_N IPR035991, Casein_kinase_II_beta-like IPR000704, Casein_kinase_II_reg-sub |
PANTHERi | PTHR11740, PTHR11740, 1 hit |
Pfami | View protein in Pfam PF01214, CK_II_beta, 1 hit |
PRINTSi | PR00472, CASNKINASEII |
SMARTi | View protein in SMART SM01085, CK_II_beta, 1 hit |
SUPFAMi | SSF57798, SSF57798, 1 hit |
PROSITEi | View protein in PROSITE PS01101, CK2_BETA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | N0E4C7_HUMAN | |
Accessioni | N0E4C7Primary (citable) accession number: N0E4C7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 26, 2013 |
Last sequence update: | June 26, 2013 | |
Last modified: | February 10, 2021 | |
This is version 43 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |