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Entry version 42 (10 Feb 2021)
Sequence version 1 (26 Jun 2013)
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Protein

Non-specific serine/threonine protein kinase

Gene
N/A
Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinasePROSITE-ProRule annotationImportedARBA annotation, Transferase
Biological processDNA damage, DNA repairARBA annotation
LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10029 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeCricetulus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati806 – 840HEATPROSITE-ProRule annotationAdd BLAST35
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1635 – 2180FATInterPro annotationAdd BLAST546
Domaini2314 – 2636PI3K/PI4KInterPro annotationAdd BLAST323
Domaini2604 – 2636FATCInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni424 – 453DisorderedSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.ARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
80538at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit
1.25.10.10, 1 hit
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR003152, FATC_dom
IPR021133, HEAT_type_2
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR011990, TPR-like_helical_dom_sf
IPR012993, UME

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF08064, UME, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SM00802, UME, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF48452, SSF48452, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS50077, HEAT_REPEAT, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

N0DNU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDHGLELAS MIPALRELGS ATPEEYNTVV QKPRQILCQF IDRILTDVNV
60 70 80 90 100
VALELVKKTD AQPTSVMLLD FIQHIMKSSP LMFVNVNGSQ GQNEAKDSCI
110 120 130 140 150
EFSHWIITRL LRIAATPSCH MLHKKICEVI CSLLFLFKSK NPTIFGILTR
160 170 180 190 200
ELLYLFEDLI YLHKRNAVDN VIEWPVVASR FLSRLDEYMG CLQPAPLQFM
210 220 230 240 250
NMQNVEFIEV TLLMVLIHIV PTVFFRRQEL LLWQIGCALL EHGSPKIRSL
260 270 280 290 300
AISLLTELFE LGGLPAQPAS TFFSLFLELL QHLVGMDADQ LKLYEEPLSK
310 320 330 340 350
LVKTLFPFEA EAYRNIEPVY LNVLLEKLCV MFEDRVLMRL KSDLLKASLC
360 370 380 390 400
HLLQYFLKFV PAGYESALQV RKIYVTNICR ALVDVLGVQK HIGYLLGPFY
410 420 430 440 450
AALRMESIEI IEGIQCQTQQ ENLSDLNDEV SPKRRRLSSS LNSSKRPSRQ
460 470 480 490 500
SEEITRVDMD KKSILWNVLK QKAESLQISL ECGTLRNSVA EKLEGITIVL
510 520 530 540 550
QLTALCTVHC SHQDIDSQNF KDCQQKYKKK SPVMITWMSL DFYTKVLKSC
560 570 580 590 600
RSLLGSVQKL ELELVIDNMV RIYDALMYMQ VKSSFEDHIL EELCGMLSLP
610 620 630 640 650
WIYSHSDDNS LKLTTFATNL LPLSQRICDS YSPQAQSQCV FLLTLFPRRI
660 670 680 690 700
FLEWRTAVYN WALMSSHEVI RASCVKGFFI LLQQQNSCNQ IPKMLIDRVK
710 720 730 740 750
DDSDIVKKEF ASILGQLVCT LHGMFYLTSS SVEPLFEHVD LFCKNLKATP
760 770 780 790 800
QLECSSSQVR ASVCKPFLFL LAEKTPSPVK LAFIDNLHHL CKHLDFQEDE
810 820 830 840 850
TEVKAVLGTL LNLMEDPDKD VRVAFSGNIK YILESLDSED GFIKELFVLR
860 870 880 890 900
MKEAYTHAQI SRNNELKDTL ILTTGDIGRA AKGDLIPFAL LHLLHCLLSK
910 920 930 940 950
SASVSGAAYT EIRALVAAKS VKLQNFFSQY KKPICQFLVE SLHSSQMTAL
960 970 980 990 1000
PGTPCQTAEM RKQDVAHHRE MALNTLSEIA NVFDFPDLNR FLTRTLQVLL
1010 1020 1030 1040 1050
PDLAAKASPA ASALIRTLGK QLNVNRREIL INNFKYIFSH LVCSCTKDEL
1060 1070 1080 1090 1100
ERALHYLKNE TEIELGSLLR QDFQGLHNEL LLRIGEHYQQ VFNGLSILAS
1110 1120 1130 1140 1150
FASSDDPYQG PRDITSPELM ADYLQPKLLG ILAFFNMQLL SSSVGIEDKK
1160 1170 1180 1190 1200
MALNSLMSLM KLMGPKHVSS VRVKMMTTLR TGLRFKDDFP ELCCRAWDCF
1210 1220 1230 1240 1250
VRCLDHAYLG PLLSHVIVAL LPLIHMQPKE TAAIFHYLII ENRDAVQDFL
1260 1270 1280 1290 1300
HEIYFLPDHP ELEKIKAILQ EYRKETSEST DLQTTLQLSM KAIQHENVDV
1310 1320 1330 1340 1350
RIHALTSLKE TLHKNQEKLI KYATDSETVE PVISQLVTVI LKGCQDANSQ
1360 1370 1380 1390 1400
ARLLCGECLG ELGAIDPGRL DFSTTETQGK DFTFVSGVED LSFAYGLLME
1410 1420 1430 1440 1450
LTRAYLAYAD NSRAQDSAAY AIQELLSIYD CREIQSNGPG HQLWKRFPEH
1460 1470 1480 1490 1500
VREILEPHLN TRYKSSQKST DWSGVKKPIY LSKLGNNFAE WSSSWAGYLI
1510 1520 1530 1540 1550
TKVRHDLASK IFTCCSIMMK HDFKVTIYLL PHILVYVLLG CNQEDQQEVY
1560 1570 1580 1590 1600
AEIMAVLKHD DQHAISTQDS ASDLCQLSTQ TVFSMLDHLT QWARHKFQAL
1610 1620 1630 1640 1650
NAEKHPQNKL KGVSNVNLED YQSVTRFLDL IPQDTLAVAS FRSKAYTRAV
1660 1670 1680 1690 1700
MHFESFITEK KQNIQKHLGF LQKLYAAMHE PDGVAGVSAI RKAEPSLKEQ
1710 1720 1730 1740 1750
ILEHESIGLL RDATACYDRA IQLEPDQIIH YHGVVKSMLG LGQLSTVITQ
1760 1770 1780 1790 1800
VNGVHANRSE WTDELNTYRV EAAWKLSQWD LVENYLAGDG KSTTWSVRLG
1810 1820 1830 1840 1850
QLLLSAKKRD TTAFYDTLKL VRAEQIVPLS AASFERGSYQ RGYEFIVRLH
1860 1870 1880 1890 1900
MLCELEHSIK PLFHKSPGDT CNEDSLNWAA RLEMTQNSYR AKEPILALRR
1910 1920 1930 1940 1950
ALLSLNKRPD YNEMVGECWL QSARVARKAG HHQTAYNALL NAGESRLAEL
1960 1970 1980 1990 2000
YVERAKWLWS KGDVHQALIV LQKGVELCFP ENKSPTESKH MLIHGRATLL
2010 2020 2030 2040 2050
VGRFMEETAN FESNAIMKKY KDVTLFLPEW EDGHFYLAKY YDKLMPMVTD
2060 2070 2080 2090 2100
NKMEKQGDLI RYIVLHFGRS LQYGNQFIYQ SMPRMLSLWL DFGAKAYEWE
2110 2120 2130 2140 2150
KGGRSDRVQM RSDLAKINSV LTEHTNRLAP YQFLTAFSQL ISRICHSHDE
2160 2170 2180 2190 2200
VFVVLMEIIA KVFLAYPQQA MWMMTAVSKS SYPMRVNRCK EILTKAIHMK
2210 2220 2230 2240 2250
KSLEKFVGDA TRLTDKLLEL CNKSVDGSNS TLSMSTHFKM LKKLVEDPTF
2260 2270 2280 2290 2300
SEILIPLQSV MIPTLPSILG AHANHDPFPG HWAYLAGFDD VVEILSSLQK
2310 2320 2330 2340 2350
PKKISLKGSD GKFYIMMCKP KDDLRKDCRL MEFNSLINKS LRKDAESRRR
2360 2370 2380 2390 2400
ELHIRTYAVI PLNDECGIIE WVNNTAGLRP ILTKIYKEKG VYMTGKELRQ
2410 2420 2430 2440 2450
CMLPKSAALS EKLKVFQELL LPRHPPVFHE WFLRTFPDPT SWYSSRSAYC
2460 2470 2480 2490 2500
RSTAVMSMVG YILGLGDRHG ENILFDSFTG ECVHVDFNCL FNKGETFEVP
2510 2520 2530 2540 2550
EIVPFRLTHN MVNGMGPMGT EGLFRRACEV TLRLMRDQRE PLMSVLKTFL
2560 2570 2580 2590 2600
HDPLVEWSKP VKGHSKAPLN ETGEVVNEKA KTHVLDIEQR LQGVIKTRNR
2610 2620 2630
VTGLPLSIEG HVHYLIQEAT DENLLCQMYL GWTPYM
Length:2,636
Mass (Da):300,701
Last modified:June 26, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7FC92B4AB5988D7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB761036 mRNA Translation: BAN16660.1

NCBI Reference Sequences

More...
RefSeqi
NP_001278986.1, NM_001292057.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCGRT00015008956; ENSCGRP00015007298; ENSCGRG00015005173

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100766256

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cge:100766256

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB761036 mRNA Translation: BAN16660.1
RefSeqiNP_001278986.1, NM_001292057.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSCGRT00015008956; ENSCGRP00015007298; ENSCGRG00015005173
GeneIDi100766256
KEGGicge:100766256

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
545

Phylogenomic databases

OrthoDBi80538at2759

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.25.10.10, 1 hit
1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR003152, FATC_dom
IPR021133, HEAT_type_2
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR011990, TPR-like_helical_dom_sf
IPR012993, UME
PfamiView protein in Pfam
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF08064, UME, 1 hit
SMARTiView protein in SMART
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SM00802, UME, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF48452, SSF48452, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS50077, HEAT_REPEAT, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiN0DNU5_CRIGR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: N0DNU5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: February 10, 2021
This is version 42 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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