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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Streptomyces sp. PAMC 26508
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei740ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
ORF Names:F750_2393Imported
OrganismiStreptomyces sp. PAMC 26508Imported
Taxonomic identifieri1265601 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000012995 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 176tRNA-synt_1gInterPro annotationAdd BLAST103
Domaini302 – 507tRNA-synt_1_2InterPro annotationAdd BLAST206
Domaini815 – 927Anticodon_1InterPro annotationAdd BLAST113

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi737 – 741"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

KOiK01869
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 3 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

M9TWR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIDGALRIM SETNSAAEVA APHRYTAAMA ADIEARWQDF WDAEGTYEAP
60 70 80 90 100
NPTGDLADGS GLAAKPKRFI MDMFPYPSGA GLHVGHPLGY IATDVYARHQ
110 120 130 140 150
RMTGHNVLHT LGFDAFGLPA EQYAVQTGTH PRASTEANME NMKVQLRRLG
160 170 180 190 200
LGHDKRRSFA TIDAEYYKWT QWIFLQIFNS WYDTEADKAR PIADLVAQFE
210 220 230 240 250
SGERPVPGGG EWGALSAADR ADILGQYRLA YASDAPVNWA PGLGTVLANE
260 270 280 290 300
EVTADGRSER GNFPVFKAKL RQWNMRITAY ADRLLNDLDG LDWPEAIKLQ
310 320 330 340 350
QRNWIGRSEG ARVDFPVDGA GDITVFTTRQ DTLFGATYMV LAPEHELVER
360 370 380 390 400
IIPAAWPEGT HPVWTGGHAN PAEAVTAYRK QAAAKSDVER QAEAKDKTGV
410 420 430 440 450
FTGAYATNPV SGEKVPVFIA DYVLMGYGTG AIMAVPAHDA RDFAFARAFE
460 470 480 490 500
LPMRCVVEPS DDRGLDTSTW EDAFASYEAK LVNSANDEVS LDGLGVVDAK
510 520 530 540 550
ARITEWLQAH GVGEGTVNFR LRDWLFSRQR YWGEPFPIVY DEEGIAHALP
560 570 580 590 600
ESMLPLELPE VEDYSPRTFD PEDADTQPET PLSRNADWVN VTLDLGDGSG
610 620 630 640 650
PRNYRRETNT MPNWAGSCWY ELRYLDPHND QRLVDPAIEQ YWMGPREGQP
660 670 680 690 700
TGGVDLYVGG AEHAVLHLLY ARFWSKVLHD LGHISSAEPF HKLYNQGMIQ
710 720 730 740 750
AFVYRDSRGI AVPAVEVEER DGAYYHAGEK VSRVLGKMGK SLKNAVTPDE
760 770 780 790 800
ICGEYGADTL RLYEMAMGPL DVSRPWDTRA VVGQYRLLQR LWRNVVDEET
810 820 830 840 850
GEVTVVDTEP GEDTLRALHK AIDGVGQDMA GMRFNTAIAK ITELNNHLTK
860 870 880 890 900
AGGPLSRSVA ERLVLLTAPL APHVAEELWR RLGHTESVVH QDFPVADPAY
910 920 930 940 950
VVDETVTCVV QIKGKVKARL EISPSITSEE LEALALADGN VVAALGGAGI
960
RKVIVRAPKL VNIVPA
Length:966
Mass (Da):106,627
Last modified:June 26, 2013 - v1
Checksum:iE60E882E4F76FF18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003990 Genomic DNA Translation: AGJ54884.1

Genome annotation databases

EnsemblBacteriaiAGJ54884; AGJ54884; F750_2393
KEGGistrp:F750_2393
PATRICifig|1265601.4.peg.2270

Similar proteinsi

Entry informationi

Entry nameiM9TWR0_9ACTN
AccessioniPrimary (citable) accession number: M9TWR0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: March 28, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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