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Protein
Submitted name:

CENP-meta, isoform F

Gene

cmet

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi83 – 90ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • microtubule-based movement Source: FlyBase
  • mitotic metaphase plate congression Source: FlyBase
  • regulation of cell cycle Source: FlyBase

Keywordsi

Molecular functionHydrolaseImported, Motor proteinPROSITE-ProRule annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-DME-983189 Kinesins

Names & Taxonomyi

Protein namesi
Submitted name:
CENP-meta, isoform FImported (EC:3.6.1.3Imported, EC:3.6.4.4Imported)
Gene namesi
Name:cmetImported
Synonyms:CENP-EImported, Cenp-EImported, CENP-E metaImported, Cenp-MImported, CENP-METAImported, CENP-MetaImported, Cenp-metaImported, Cenp_EImported, CENPEImported, CENPmetaImported, CG6392Imported, CmetImported, DmCmetImported, DmCmetaImported, Dmel\CG6392Imported, KIF 10Imported, KIF10Imported, l(2)04431Imported
ORF Names:CG6392Imported, Dmel_CG6392Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0040232 cmet

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiFBgn0040232 Expressed in 5 organ(s), highest expression level in embryo
ExpressionAtlasiM9PFL9 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiM9PFL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 321Kinesin motorInterPro annotationAdd BLAST314

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili337 – 370Sequence analysisAdd BLAST34
Coiled coili505 – 546Sequence analysisAdd BLAST42
Coiled coili575 – 602Sequence analysisAdd BLAST28
Coiled coili617 – 663Sequence analysisAdd BLAST47
Coiled coili678 – 698Sequence analysisAdd BLAST21
Coiled coili713 – 747Sequence analysisAdd BLAST35
Coiled coili749 – 835Sequence analysisAdd BLAST87
Coiled coili955 – 996Sequence analysisAdd BLAST42
Coiled coili1000 – 1034Sequence analysisAdd BLAST35
Coiled coili1069 – 1096Sequence analysisAdd BLAST28
Coiled coili1111 – 1145Sequence analysisAdd BLAST35
Coiled coili1153 – 1173Sequence analysisAdd BLAST21
Coiled coili1187 – 1214Sequence analysisAdd BLAST28
Coiled coili1242 – 1276Sequence analysisAdd BLAST35
Coiled coili1278 – 1298Sequence analysisAdd BLAST21
Coiled coili1303 – 1334Sequence analysisAdd BLAST32
Coiled coili1336 – 1356Sequence analysisAdd BLAST21
Coiled coili1385 – 1419Sequence analysisAdd BLAST35
Coiled coili1438 – 1514Sequence analysisAdd BLAST77
Coiled coili1519 – 1539Sequence analysisAdd BLAST21
Coiled coili1557 – 1577Sequence analysisAdd BLAST21
Coiled coili1592 – 1612Sequence analysisAdd BLAST21
Coiled coili1631 – 1717Sequence analysisAdd BLAST87
Coiled coili1750 – 1801Sequence analysisAdd BLAST52
Coiled coili1806 – 1826Sequence analysisAdd BLAST21
Coiled coili1831 – 1851Sequence analysisAdd BLAST21
Coiled coili1975 – 2002Sequence analysisAdd BLAST28
Coiled coili2108 – 2128Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0242 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00910000143992
OrthoDBiEOG091G0CFT

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

M9PFL9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAKNASSIQ VCIKVRPCEP GLTSLWQVKE RRSIHLADSH AEPYVFDYVF
60 70 80 90 100
DEGASNQEVF DRMAKHIVHA CMQGFNGTIF AYGQTSSGKT YTMMGDEQNP
110 120 130 140 150
GVMVLAAKEI FQQISSETER DFLLRVGYIE IYNEKIYDLL NKKNQDLKIH
160 170 180 190 200
ESGNGIVNVN CEECIITSEV DLLRLLCLGN KERTVGETNM NERSSRSHAI
210 220 230 240 250
FKIIIESRKS DHSDDDAVIQ SVLNLVDLAG SERADQTGAR GARLKEGGHI
260 270 280 290 300
NKSLLFLSNV IKSLSENADN RFTNYRDSKL TRILQASLGG NAFTSIICTI
310 320 330 340 350
KPSIMEESQS TLSFATRAKK IRIKPQVNEM VSDATMMKRL EREIKVLKDK
360 370 380 390 400
LAEEERKNEN QQKVEHLERQ IKHDMHKIIC GHSLSDKGQQ KRRRTWCPTA
410 420 430 440 450
SGSHLELAET GTTEDRIDQF PKVSHLPKPV FFHTSNAGKR WDNIPKTINI
460 470 480 490 500
LGSLDIGTES NSISEEFLPA ECIDFGSPRP DVLKPMLTIR QLPDLPLTPK
510 520 530 540 550
GPLTYDALEK EVTSLRADNE AANSKISELE EKLSTLKQTM RIMEVENQVA
560 570 580 590 600
VGLEFEFEAH KKSSKLRVDD LLSALLEKES TIESLQKSLD NLTRDVLRNS
610 620 630 640 650
KEGHMLSIAP EQEDIAGDSI CNKCEELEKL IADLESKKNS CECDQLRLEI
660 670 680 690 700
VSVRDKLESV ESAFNLASSE IIQKATDCER LSKELSTSQN AFGQLQERYD
710 720 730 740 750
ALDQQWQAQQ AGITTLHEKH EHVQEKYQKL QEEYEQLESR ARSASSAEFQ
760 770 780 790 800
RLQNDNTKFQ ADIASLNERL EEAQNMLTEV QNSESTVEKL RIQNHELTAK
810 820 830 840 850
IKELETNFEE MQREYDCLSN QLMESVQEND ALREEIKQRP TSHVEESMRS
860 870 880 890 900
SGISSDFDEQ KQDINLLHQF VQLSESVQQI ELQHHSGISR LFRANQMKLD
910 920 930 940 950
QSEPGLKLCL ESAEYIEEDN RQSDATEPIC LKGFLKRHRF QIKRLSQEHV
960 970 980 990 1000
DMGEEKRLLD IISQLEQEIE EKSALMEATE ATINEMREQM TNLESALLEK
1010 1020 1030 1040 1050
SVIINKVEDY QRQIESLEKQ NAEMTMVYEE LQDRVTRESS MSESLLRVPP
1060 1070 1080 1090 1100
DEDTLPGCPT SPSRREQEVA TLKTSITELQ SQVSDLKAEL ENHLRQIQLK
1110 1120 1130 1140 1150
DGNIARLQTD FEEMSERCLS MEVRLAELDE DTKQKQELLD RQAQKLSDDL
1160 1170 1180 1190 1200
CLIDQLQKKN AQLVEQYHKA TESLSLADAK PDQILLSSQY DSQIEKLNQL
1210 1220 1230 1240 1250
LNAAKDELHD VRRIKDDEIS ALRMEFLLQI ETNEKENQAK FYAELQETKD
1260 1270 1280 1290 1300
RYESNVAELK EKLLQVEETL SSVTVRCQAE LEALKSAHKE NISQAVEERN
1310 1320 1330 1340 1350
NLIVQHQAEM ETIRETLKNK LAEASTQQSK MEDAFRAEIN EVRATLMEQL
1360 1370 1380 1390 1400
NQTKEDRDKG ASKLEEVKKT LEQMINGGRV MSDTIAELEK TKAEQDLAVN
1410 1420 1430 1440 1450
KLTKDNIELE KQCSKTQEQL QMESLTRDQI SFEIEAHIKK LELIVASSKK
1460 1470 1480 1490 1500
RIIELEEKCD QQVLELDKCR LEKLSLESEI QKANSEHSCT MEKLQELQAE
1510 1520 1530 1540 1550
MKVLSNRNEK EKCDFETKLE TFTFKITDLE EVLKEAQHKV ILYDDLVSQH
1560 1570 1580 1590 1600
ERLKICLAEA NELSSNLQKK VMSLHTELID SQKGISSRDV EINELREELK
1610 1620 1630 1640 1650
AAMDAKATAS AEQMTLVTQL KDVEERMANQ AEKFTREAAN LKGSINELLL
1660 1670 1680 1690 1700
KLNSMQETKD MLESGNEELK EQLRNSQNLR NMLDEESKMC ISLKEKLVKL
1710 1720 1730 1740 1750
EDAKTSLEQQ LRDNKSEIYQ RHTELTKEVE LGRNRIGELT KKCEELCSDL
1760 1770 1780 1790 1800
ENSDQIRLDL QETKEQLKKT LENNLGWQQK VDEVTRECEK LRFDMQSKEV
1810 1820 1830 1840 1850
QNESKVQELI SECEELRSTL KSKEASFQSE KESMDRTISS LLEDKRNLEE
1860 1870 1880 1890 1900
KLCSANDIVA KLETEIAALR PRKSLDRNPV PRKSITFESE IRKNRRISVH
1910 1920 1930 1940 1950
DERRQSYWND VREFGIMTDP VDNNCNCAEL NSKLQDCQRE LFIRESQVTA
1960 1970 1980 1990 2000
LKMELDHHPL KDENAQLTKR VIEEQDKAKV EQKRLKMKLQ DLNARINDLT
2010 2020 2030 2040 2050
TASAKEPESN QMAQAAKPAT VAAQTQTESD LETILEKTNV KYQEAVRMLR
2060 2070 2080 2090 2100
YRYHLIQELK EKLRQNENSD TSNITSLSAG QTSALKCESQ KKEILAIKYK
2110 2120 2130
YEAAKRILAI RNDDLDALRE KLAKYETTTS DK
Length:2,132
Mass (Da):244,829
Last modified:June 26, 2013 - v1
Checksum:iFBA680F17B55BB0E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9VKI0Q9VKI0_DROME
CENP-meta, isoform C
cmet CENP-E, Cenp-E, CENP-E meta, Cenp-M, CENP-META cmet CENP-E, Cenp-E, CENP-E meta, Cenp-M, CENP-META, CENP-Meta, Cenp-meta, Cenp_E, CENPE, CENPmeta, CG6392, Cmet, DmCmet, DmCmeta, Dmel\CG6392, KIF 10, KIF10, l(2)04431, CG6392, Dmel_CG6392
2,189Annotation score:
M9PD87M9PD87_DROME
CENP-meta, isoform D
cmet CENP-E, Cenp-E, CENP-E meta, Cenp-M, CENP-META cmet CENP-E, Cenp-E, CENP-E meta, Cenp-M, CENP-META, CENP-Meta, Cenp-meta, Cenp_E, CENPE, CENPmeta, CG6392, Cmet, DmCmet, DmCmeta, Dmel\CG6392, KIF 10, KIF10, l(2)04431, CG6392, Dmel_CG6392
2,134Annotation score:
M9PCX3M9PCX3_DROME
CENP-meta, isoform E
cmet CENP-E, Cenp-E, CENP-E meta, Cenp-M, CENP-META cmet CENP-E, Cenp-E, CENP-E meta, Cenp-M, CENP-META, CENP-Meta, Cenp-meta, Cenp_E, CENPE, CENPmeta, CG6392, Cmet, DmCmet, DmCmeta, Dmel\CG6392, KIF 10, KIF10, l(2)04431, CG6392, Dmel_CG6392
2,186Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AGB92917.1
RefSeqiNP_001260382.1, NM_001273453.1
UniGeneiDm.12764

Genome annotation databases

EnsemblMetazoaiFBtr0332205; FBpp0304514; FBgn0040232
GeneIDi53561

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AGB92917.1
RefSeqiNP_001260382.1, NM_001273453.1
UniGeneiDm.12764

3D structure databases

SMRiM9PFL9
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0332205; FBpp0304514; FBgn0040232
GeneIDi53561

Organism-specific databases

CTDi53561
FlyBaseiFBgn0040232 cmet

Phylogenomic databases

eggNOGiKOG0242 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00910000143992
OrthoDBiEOG091G0CFT

Enzyme and pathway databases

ReactomeiR-DME-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-DME-983189 Kinesins

Miscellaneous databases

GenomeRNAii53561

Gene expression databases

BgeeiFBgn0040232 Expressed in 5 organ(s), highest expression level in embryo
ExpressionAtlasiM9PFL9 baseline and differential

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM9PFL9_DROME
AccessioniPrimary (citable) accession number: M9PFL9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: September 12, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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