UniProtKB - M9PF24 (M9PF24_DROME)
Protein
Kinesin light chain
Gene
Klc
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.UniRule annotation
Keywordsi
Molecular function | Motor proteinUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Kinesin light chainUniRule annotation |
Gene namesi | Name:KlcImported Synonyms:DKLCImported, Dmel\CG5433Imported, kinesinImported, KLCImported, klcImported ORF Names:CG5433Imported, Dmel_CG5433Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0010235, Klc |
Subcellular locationi
Cytoskeleton
- cytoskeleton UniRule annotationARBA annotation
Cytoskeleton
- kinesin complex Source: UniProtKB-UniRule
- microtubule Source: UniProtKB-UniRule
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, CytoskeletonUniRule annotationARBA annotation, MicrotubuleUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | FBgn0010235, Expressed in embryonic/larval hemocyte (Drosophila) and 56 other tissues |
ExpressionAtlasi | M9PF24, baseline and differential |
Interactioni
Subunit structurei
Oligomeric complex composed of two heavy chains and two light chains.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 186 – 387 | TPR_REGIONInterPro annotationAdd BLAST | 202 | |
Repeati | 186 – 219 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 228 – 261 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 270 – 303 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 312 – 345 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 354 – 387 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 437 – 470 | TPRPROSITE-ProRule annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 156 – 175 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 484 – 508 | DisorderedSequence analysisAdd BLAST | 25 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 64 – 126 | Sequence analysisAdd BLAST | 63 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 488 – 508 | PolyampholyteSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisARBA annotation, RepeatARBA annotation, TPR repeatPROSITE-ProRule annotationPhylogenomic databases
PhylomeDBi | M9PF24 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR002151, Kinesin_light IPR015792, Kinesin_light_repeat IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
PRINTSi | PR00381, KINESINLIGHT |
SMARTi | View protein in SMART SM00028, TPR, 5 hits |
SUPFAMi | SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS01160, KINESIN_LIGHT, 1 hit PS50005, TPR, 6 hits PS50293, TPR_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
M9PF24-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTQMSQDEII TNTKTVLQGL EALRVEHVSI MNGIAEVQKD NEKSDMLRKN
60 70 80 90 100
IENIELGLSE AQVMMALTSH LQNIEAEKHK LKTQVRRLHQ ENAWLRDELA
110 120 130 140 150
NTQQKFQASE QLVAQLEEEK KHLEFMASVK KYDENQEQDD ACDKSRTDPV
160 170 180 190 200
VELFPDEENE DRHNMSPTPP SQFANQTSGY EIPARLRTLH NLVIQYASQG
210 220 230 240 250
RYEVAVPLCK QALEDLERTS GHDHPDVATM LNILALVYRD QNKYKEAANL
260 270 280 290 300
LNDALSIRGK TLGENHPAVA ATLNNLAVLY GKRGKYKDAE PLCKRALEIR
310 320 330 340 350
EKVLGKDHPD VAKQLNNLAL LCQNQGKYDE VEKYYQRALD IYESKLGPDD
360 370 380 390 400
PNVAKTKNNL AGCYLKQGRY TEAEILYKQV LTRAHEREFG AIDSKNKPIW
410 420 430 440 450
QVAEEREEHK FDNRENTPYG EYGGWHKAAK VDSPTVTTTL KNLGALYRRQ
460 470 480 490 500
GMFEAAETLE DCAMRSKKEA YDLAKQTKLS QLLTSNEKRR SKAIKEDLDF
SEEKNAKP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP46824 | KLC_DROME | Kinesin light chain | Klc CG5433 | 508 | Annotation score: | ||
M9PFG7 | M9PFG7_DROME | Kinesin light chain | Klc DKLC, Dmel\CG5433, kinesin, KLC, klc | 507 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AGB94473.1 |
RefSeqi | NP_001261780.1, NM_001274851.1 NP_524049.1, NM_079325.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0075951; FBpp0075683; FBgn0010235 FBtr0331555; FBpp0303945; FBgn0010235 |
GeneIDi | 39445 |
KEGGi | dme:Dmel_CG5433 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AGB94473.1 |
RefSeqi | NP_001261780.1, NM_001274851.1 NP_524049.1, NM_079325.3 |
3D structure databases
SMRi | M9PF24 |
ModBasei | Search... |
Proteomic databases
PRIDEi | M9PF24 |
Genome annotation databases
EnsemblMetazoai | FBtr0075951; FBpp0075683; FBgn0010235 FBtr0331555; FBpp0303945; FBgn0010235 |
GeneIDi | 39445 |
KEGGi | dme:Dmel_CG5433 |
Organism-specific databases
CTDi | 39445 |
FlyBasei | FBgn0010235, Klc |
Phylogenomic databases
PhylomeDBi | M9PF24 |
Miscellaneous databases
BioGRID-ORCSi | 39445, 0 hits in 3 CRISPR screens |
GenomeRNAii | 39445 |
Gene expression databases
Bgeei | FBgn0010235, Expressed in embryonic/larval hemocyte (Drosophila) and 56 other tissues |
ExpressionAtlasi | M9PF24, baseline and differential |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR002151, Kinesin_light IPR015792, Kinesin_light_repeat IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
PRINTSi | PR00381, KINESINLIGHT |
SMARTi | View protein in SMART SM00028, TPR, 5 hits |
SUPFAMi | SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS01160, KINESIN_LIGHT, 1 hit PS50005, TPR, 6 hits PS50293, TPR_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | M9PF24_DROME | |
Accessioni | M9PF24Primary (citable) accession number: M9PF24 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 26, 2013 |
Last sequence update: | June 26, 2013 | |
Last modified: | April 7, 2021 | |
This is version 57 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |