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UniProtKB - M9PES2 (M9PES2_DROME)
Protein
Submitted name:
Grunge, isoform I
Gene
Gug
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor binding Source: FlyBase
- NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
- transcription corepressor activity Source: FlyBase
GO - Biological processi
- embryonic pattern specification Source: FlyBase
- imaginal disc-derived leg morphogenesis Source: FlyBase
- imaginal disc-derived wing vein morphogenesis Source: FlyBase
- inter-male aggressive behavior Source: FlyBase
- larval somatic muscle development Source: FlyBase
- negative regulation of smoothened signaling pathway Source: FlyBase
- negative regulation of transcription, DNA-templated Source: FlyBase
- regulation of histone acetylation Source: FlyBase
- segmentation Source: FlyBase
- segment specification Source: FlyBase
Keywordsi
Molecular function | HydrolaseImported |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:GugImported Synonyms:AtroImported, atroImported, Dmel\CG6964Imported, GUGImported, gugImported, l(3)01323Imported, l(3)03928Imported, l(3)j5A3Imported, l(3)rO116Imported, l(3)S146907Imported ORF Names:CG6964Imported, Dmel_CG6964Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0010825, Gug |
VEuPathDBi | VectorBase:FBgn0010825 |
Subcellular locationi
Nucleus
- nucleus Source: FlyBase
Other locations
- polytene chromosome interband Source: FlyBase
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | FBgn0010825, Expressed in wing disc (Drosophila) and 42 other tissues |
ExpressionAtlasi | M9PES2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 113 | ELM2InterPro annotationAdd BLAST | 107 | |
Domaini | 117 – 169 | SANTInterPro annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 43 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 168 – 503 | DisorderedSequence analysisAdd BLAST | 336 | |
Regioni | 553 – 592 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 630 – 676 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 688 – 727 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 786 – 1225 | DisorderedSequence analysisAdd BLAST | 440 | |
Regioni | 1262 – 1289 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 1306 – 1344 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 1357 – 1396 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 1426 – 1452 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 1539 – 1659 | DisorderedSequence analysisAdd BLAST | 121 | |
Regioni | 1671 – 1722 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 1755 – 1805 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 1912 – 1931 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 171 – 186 | Basic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 187 – 237 | Polar residuesSequence analysisAdd BLAST | 51 | |
Compositional biasi | 250 – 267 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 268 – 319 | Polar residuesSequence analysisAdd BLAST | 52 | |
Compositional biasi | 336 – 353 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 356 – 400 | Basic and acidic residuesSequence analysisAdd BLAST | 45 | |
Compositional biasi | 415 – 432 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 433 – 476 | Basic and acidic residuesSequence analysisAdd BLAST | 44 | |
Compositional biasi | 477 – 497 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 553 – 579 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 842 – 860 | Pro residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 940 – 957 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 958 – 985 | Pro residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 1003 – 1021 | Pro residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1035 – 1060 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1111 – 1174 | Polar residuesSequence analysisAdd BLAST | 64 | |
Compositional biasi | 1274 – 1289 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1306 – 1327 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1357 – 1385 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 1589 – 1606 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1629 – 1646 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1692 – 1708 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1755 – 1776 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1777 – 1795 | Polar residuesSequence analysisAdd BLAST | 19 |
Phylogenomic databases
GeneTreei | ENSGT00940000153615 |
OrthoDBi | 802091at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR002951, Atrophin-like IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR001005, SANT/Myb IPR017884, SANT_dom |
Pfami | View protein in Pfam PF03154, Atrophin-1, 1 hit PF01448, ELM2, 1 hit |
SMARTi | View protein in SMART SM01189, ELM2, 1 hit SM00717, SANT, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
M9PES2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAASTQGEIR VGPGHQAKLP DYNPISSFPI DKETDERELE ESRWSPGVVA
60 70 80 90 100
DGDLLMFLRA ARSMAAFQGM CDGGLEDGCL AASRDDTTIN ALDVLHDSGY
110 120 130 140 150
DPGKALQALV KCPVSKGIDK KWTEDETKKF IKGLRQFGKN FFRIHKDLLP
160 170 180 190 200
HKDTPELVEF YYLWKKTPGA NNNRPHRRRR QSALRRNRVT RANNSNSNTP
210 220 230 240 250
PKKEDTPEPQ TATTATAAAT AASETASRSS PAVSKEENSS LTEDDASECD
260 270 280 290 300
SDSSLTHKRD ESPSRMRTRN KQQNNNSSTS SGNNTAGNGG GNATSISSGS
310 320 330 340 350
TGGGAAGGNS SSKDQSANAV ANGKRPKRGS ETPDVSGGAS VDSPKTPTKA
360 370 380 390 400
VAESSANKRK GGKQDTPNKK KRTEQESNEP SAHEENAIKE KRKRPDSPVE
410 420 430 440 450
SMNSDSRPDS VLDDGESNTT DTTTAEQQST KDSKETVSCK EEREMVTNDL
460 470 480 490 500
EAKAEEKAIK AEALAEDSKD SAIKNMDEET NIQAPSSADT SLVDGPNPNA
510 520 530 540 550
LPSPVAAPIT MKVPTIATVE ALNASVDRKE AIEKMESCDS DPEMLKKLAT
560 570 580 590 600
IKQEVSPQQQ QHMQQQSQQQ MQQQLAPVGI PQPPSCPPSE SVYIKKEPME
610 620 630 640 650
DSMDATCNQN SNEPQDLKVK IEIKNEDALK HSAGGLPPSG PCAPPSALHP
660 670 680 690 700
LSGAPVESGQ EPLHLQHMPH GQVTTQPPPG YLIDGQLKYG PSGQGVPPQP
710 720 730 740 750
PQLHSDAAGG VSGAPPGAPT TPQKYPPEME MKFAPQDLKY PPPPPLDALK
760 770 780 790 800
YSQEMQAAAA AAAAAGKYDM KYMMEQQGKY NVELSAAHQP PSKPGYQDSL
810 820 830 840 850
KIPDIKPGFG HLPHNVGSPL DAAHKYGPPP TSQESQQQQP QPPAHQVPPG
860 870 880 890 900
ATPPPGIAMP KPHYQHDVQT PPLGRPFEPT GLMLKYGDPL AAKYGPPQDL
910 920 930 940 950
KYPMPPVSQA GPADVKPYGG ENLIKSSPYG PPPESPIDAS ARSTPGQDSQ
960 970 980 990 1000
GSNSNSQPPS MPPQPQQFQS PHPSPHMPSP AGGGLPPGMH PQNLIHGPPP
1010 1020 1030 1040 1050
GAAGGSGPQP PPPPTSLHQP TPTSAGPPSL QHGLHPGHQH SQLSVASSIP
1060 1070 1080 1090 1100
PSSIGIPPTL STMAPSHMHP HLHPHAHLQG LHRPHDLPPS MHPHAPMPLS
1110 1120 1130 1140 1150
LQGHPQHGHG LPPSHTSQQQ QQQQQQQQPG GPAGTVRTPS PAQQPPRSMH
1160 1170 1180 1190 1200
DPQSSREPPT SQPSTTMAGS SGPGGPPPQQ SPHAHRTSPL PGLAGSGPPP
1210 1220 1230 1240 1250
PGLIGHPMAI HPHLAHLPPG HPAHAALAHP GHHLLSHSIA GLGPGGGPIA
1260 1270 1280 1290 1300
LLAGPGGLGG IPESALSRRT PPSHLPHSHA SSAPLTAHSV ASMTSTSMSL
1310 1320 1330 1340 1350
TTSTVPSSAF SRASPSVQIS SSGGGPSGPG SVGPGGMPNS SAAAAAAAAA
1360 1370 1380 1390 1400
HRAASPASSV SSLSRQSPLH PVPQSPLSHH PSSSALSAAA AAVAERDRHA
1410 1420 1430 1440 1450
LMRQQSPHMT PPPVSNASLM ASPLSKMYAP QPGQRGLGTS PPPHLRPGAS
1460 1470 1480 1490 1500
PPVIRHPQMP LPLPLIAPGG GIPQIGVHPG QSPYPHPLLH PSVFYSPHHH
1510 1520 1530 1540 1550
PFNSPYGYAP YGPGFPAYMK PPPQPGQLDP AAVMAAHHAG LQGPPPQQMR
1560 1570 1580 1590 1600
QDEQNAAAAA AQAAAEKQHQ AAAAAAAQQH KAPQQQQPGG MPPNKPPTPK
1610 1620 1630 1640 1650
TPQGPGGGMP PGMGGPGTPT GLPPGAYPGS HMPGYPQGPP HGSPFAPQDG
1660 1670 1680 1690 1700
QPHGLKPTSH MDALRAHAHS ANSAGMGGGH HPTEPLPIDI EPDPEPEIPS
1710 1720 1730 1740 1750
PTHNIPRGPS PEAKPDDTEC HRSQSAIFVR HIDRGDYNSC TRTDLIFKPV
1760 1770 1780 1790 1800
ADSKLARKRE ERDRKLAEKE RERRQQQQQQ QQQQQQQQAA AAQQAAQQAK
1810 1820 1830 1840 1850
MKAELKPPYA DTPALRQLSE YARPHVAFRE LEEIKNAQAA AASQSRLDPH
1860 1870 1880 1890 1900
WMEYYRRGIH PSQFPLYANP AISQMERERL GIPPPHHVGL DPGEHMIRLT
1910 1920 1930 1940 1950
REYHAHSHTH LHLPLHPQPQ PPEAGFQLPP NVGQYPRPNM LIPREPHSDV
1960 1970 1980
LLRMSYADQL QYLQAAEFQR QSLHDQYFRQ RPR
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM9PHT1 | M9PHT1_DROME | Grunge, isoform J | Gug Atro, atro, Dmel\CG6964, GUG, gug | 2,007 | Annotation score: | ||
Q8IQA6 | Q8IQA6_DROME | Grunge, isoform A | Gug Atro, atro, Dmel\CG6964, GUG, gug | 1,966 | Annotation score: | ||
Q86BH2 | Q86BH2_DROME | Grunge, isoform C | Gug Atro, atro, Dmel\CG6964, GUG, gug | 1,988 | Annotation score: | ||
M9NE54 | M9NE54_DROME | Grunge, isoform G | Gug Atro, atro, Dmel\CG6964, GUG, gug | 2,006 | Annotation score: | ||
Q9VSK5 | Q9VSK5_DROME | Grunge, isoform H | Gug Atro, atro, Dmel\CG6964, GUG, gug | 1,985 | Annotation score: | ||
M9NDL9 | M9NDL9_DROME | Grunge, isoform F | Gug Atro, atro, Dmel\CG6964, GUG, gug | 1,988 | Annotation score: | ||
Q7KUA8 | Q7KUA8_DROME | Grunge, isoform D | Gug Atro, atro, Dmel\CG6964, GUG, gug | 1,985 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AGB94275.1 |
RefSeqi | NP_001261580.1, NM_001274651.1 |
Genome annotation databases
EnsemblMetazoai | FBtr0333048; FBpp0305262; FBgn0010825 |
GeneIDi | 46156 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AGB94275.1 |
RefSeqi | NP_001261580.1, NM_001274651.1 |
3D structure databases
SMRi | M9PES2 |
ModBasei | Search... |
Genome annotation databases
EnsemblMetazoai | FBtr0333048; FBpp0305262; FBgn0010825 |
GeneIDi | 46156 |
Organism-specific databases
CTDi | 46156 |
FlyBasei | FBgn0010825, Gug |
VEuPathDBi | VectorBase:FBgn0010825 |
Phylogenomic databases
GeneTreei | ENSGT00940000153615 |
OrthoDBi | 802091at2759 |
Miscellaneous databases
BioGRID-ORCSi | 46156, 0 hits in 3 CRISPR screens |
GenomeRNAii | 46156 |
Gene expression databases
Bgeei | FBgn0010825, Expressed in wing disc (Drosophila) and 42 other tissues |
ExpressionAtlasi | M9PES2, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR002951, Atrophin-like IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR001005, SANT/Myb IPR017884, SANT_dom |
Pfami | View protein in Pfam PF03154, Atrophin-1, 1 hit PF01448, ELM2, 1 hit |
SMARTi | View protein in SMART SM01189, ELM2, 1 hit SM00717, SANT, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | M9PES2_DROME | |
Accessioni | M9PES2Primary (citable) accession number: M9PES2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 26, 2013 |
Last sequence update: | June 26, 2013 | |
Last modified: | January 19, 2022 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |