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Entry version 53 (26 Feb 2020)
Sequence version 1 (26 Jun 2013)
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Protein
Submitted name:

Fife, isoform D

Gene

Fife

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-181429 Serotonin Neurotransmitter Release Cycle
R-DME-181430 Norepinephrine Neurotransmitter Release Cycle
R-DME-210500 Glutamate Neurotransmitter Release Cycle
R-DME-212676 Dopamine Neurotransmitter Release Cycle
R-DME-264642 Acetylcholine Neurotransmitter Release Cycle
R-DME-888590 GABA synthesis, release, reuptake and degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Fife, isoform DImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FifeImported
Synonyms:anon-EST:Posey171Imported, CG12187Imported, CG14950Imported, CG16976Imported, CG43375Imported, Dmel\CG43955Imported, fifeImported
ORF Names:CG43955Imported, Dmel_CG43955Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0264606 Fife

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
M9PE32

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0264606 Expressed in head and 6 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
M9PE32 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0305807

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
M9PE32

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini492 – 583PDZInterPro annotationAdd BLAST92
Domaini666 – 761C2InterPro annotationAdd BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni16 – 42DisorderedSequence analysisAdd BLAST27
Regioni56 – 124DisorderedSequence analysisAdd BLAST69
Regioni211 – 321DisorderedSequence analysisAdd BLAST111
Regioni350 – 418DisorderedSequence analysisAdd BLAST69
Regioni596 – 642DisorderedSequence analysisAdd BLAST47
Regioni873 – 912DisorderedSequence analysisAdd BLAST40
Regioni932 – 970DisorderedSequence analysisAdd BLAST39
Regioni997 – 1054DisorderedSequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi25 – 42PolarSequence analysisAdd BLAST18
Compositional biasi68 – 111PolarSequence analysisAdd BLAST44
Compositional biasi212 – 226PolarSequence analysisAdd BLAST15
Compositional biasi236 – 257PolyampholyteSequence analysisAdd BLAST22
Compositional biasi1023 – 1054PolarSequence analysisAdd BLAST32

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2060 Eukaryota
KOG3528 Eukaryota
ENOG410XNTC LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009277_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
TEDISCT

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR039032 Rim-like
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR12157 PTHR12157, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 2 hits
PF17820 PDZ_6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 2 hits
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 1 hit
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

M9PE32-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPTNVMSFM KKMVATDEQT SERQQHAADS GGGASQTGAL NKMKATISSS
60 70 80 90 100
LLTVTDKVNK MSPRPSLVPT DADTSGSYGS PSYQSQQQQQ QDYGSSLNNN
110 120 130 140 150
NNNSSGGGTA TTGGGGGGAA AKQEPGRRAG ACRVCLKSFK PDDYHKTCFE
160 170 180 190 200
CQQRVCEDCA SYSKLDEHED ATMWRCSVCR RKMASRVCIP QDSTDSMLDV
210 220 230 240 250
PVLEALQRRH SDAKLGSSTQ TLAPSNGAAL APPRSPELRR HSDVSPASLK
260 270 280 290 300
ELERQLKGGR SMAPSRSNSP PRGEGPDGQP PFGAPLSRMQ SRRGSRVARQ
310 320 330 340 350
HSYDDDMKTG PVGGSMGGGG PALGLGADGA GLGIPTMPRR KSAYDVFAPG
360 370 380 390 400
LTQGGATPAT QLQRSPGEGG IMPPIQLPGS RRPSFRVPHP SEDIQNDDSP
410 420 430 440 450
GSPDKGSPVL TVDDDRRMRR RGSQLPDIAM LQNRGALPAV PPSSIPPPMA
460 470 480 490 500
SFTGPNLEDL EAPRRQTSMD GEAIRIVIHD VDSGPICASK RRIILRRDPT
510 520 530 540 550
DKAHRTRGFG MRVVGGKTGA DGRLFAYIVW TVPGGAAEKN GLQQGDKILE
560 570 580 590 600
WNGMSLIDRS FEEVCSIMDR TGDVVELLVE HATDFRMCDL FDENLPPGNA
610 620 630 640 650
GGQSGPRRSG DGPVGLGLIA EPETTTDKSP ASPTRRKLPK TPEQIAREKL
660 670 680 690 700
VTGRVQIQVW YHAERSELVV SLMAGDDLAP RDEAYGHGNL PEAYAKVRIL
710 720 730 740 750
PKCGDGSVQQ TEVSRPTQNP IWNATLTFGH VKADTLMVRY IDIQLWDLVP
760 770 780 790 800
HTESIFLGEC SIELQQAFLD DQAIWCRLED TKGLRGISIS KSPSVSPRGS
810 820 830 840 850
IAAGAGAPSG DVTRLLRRDY NMQRSNSDDV DSIGDGTSLL HPDHAWIAGS
860 870 880 890 900
RRGSSQSETM EVEVYQLGKD FSRSLPGSRR SSFQDAEKNR LEEDAMATPP
910 920 930 940 950
TSYLVGRRRS SVARRDPDEI LKSLKAVRGE LGRTMSLGTE QHKRMGSRRA
960 970 980 990 1000
SRVGLPSGPS SRKSSVLDLS QQHQQQLQQL QQLQLQQQQY LQQQLPMGVG
1010 1020 1030 1040 1050
NADTSPPSED EDKRYRPRWK GSVSQLPPQS PKQALSRLKQ AASASNVAQD
1060 1070 1080 1090 1100
TQRQGQLLTT NPLQQRKSSM FQLGESQASP PTTTTTHLQR KGSMYVAKVT
1110 1120 1130 1140 1150
ETPPHGTPTR KGSVYQRSVV GLSVDSPGAD SPQRKQSVVK TLSGSYVNIC
1160 1170 1180 1190 1200
PLTGGESSYG LKLGPSQIHP KGYRLTTARY GELKMGFLKI KGNVEVELIC
1210 1220 1230 1240 1250
ARNIVNEDCE TPPDTYVKCY IKDGDRLRHK KKTRVVRHAA EPLYRQTIKY
1260 1270 1280 1290 1300
QSSDVFGRNI VIMVWQRCVG FEHNQGLGGT EVNLDKLSIG QPISGWYPLF
1310
PMHSYGGSDS DNSP
Length:1,314
Mass (Da):142,802
Last modified:June 26, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB4886C62D7D0BDE2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9VZY3Q9VZY3_DROME
Fife, isoform F
Fife anon-EST:Posey171, CG12187, CG14950, CG16976, CG43375
643Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PDV6M9PDV6_DROME
Fife, isoform B
Fife anon-EST:Posey171, CG12187, CG14950, CG16976, CG43375
969Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AGB94035.1

NCBI Reference Sequences

More...
RefSeqi
NP_001261340.1, NM_001274411.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0333632; FBpp0305807; FBgn0264606

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
38337

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AGB94035.1
RefSeqiNP_001261340.1, NM_001274411.1

3D structure databases

SMRiM9PE32
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0305807

Proteomic databases

PaxDbiM9PE32

Genome annotation databases

EnsemblMetazoaiFBtr0333632; FBpp0305807; FBgn0264606
GeneIDi38337

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
38337
FlyBaseiFBgn0264606 Fife

Phylogenomic databases

eggNOGiKOG2060 Eukaryota
KOG3528 Eukaryota
ENOG410XNTC LUCA
HOGENOMiCLU_009277_0_0_1
OMAiTEDISCT

Enzyme and pathway databases

ReactomeiR-DME-181429 Serotonin Neurotransmitter Release Cycle
R-DME-181430 Norepinephrine Neurotransmitter Release Cycle
R-DME-210500 Glutamate Neurotransmitter Release Cycle
R-DME-212676 Dopamine Neurotransmitter Release Cycle
R-DME-264642 Acetylcholine Neurotransmitter Release Cycle
R-DME-888590 GABA synthesis, release, reuptake and degradation

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
38337

Gene expression databases

BgeeiFBgn0264606 Expressed in head and 6 other tissues
ExpressionAtlasiM9PE32 baseline and differential

Family and domain databases

Gene3Di2.60.40.150, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR039032 Rim-like
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR12157 PTHR12157, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF17820 PDZ_6, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM9PE32_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M9PE32
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: February 26, 2020
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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