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UniProtKB - M9PDX8 (M9PDX8_DROME)
Protein
Submitted name:
Nervana 3, isoform E
Gene
nrv3
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- ATPase activator activity Source: GO_Central
GO - Biological processi
- cellular potassium ion homeostasis Source: GO_Central
- cellular sodium ion homeostasis Source: GO_Central
- potassium ion import across plasma membrane Source: GO_Central
- response to auditory stimulus Source: FlyBase
- sensory perception of sound Source: FlyBase
- sodium ion export across plasma membrane Source: GO_Central
Enzyme and pathway databases
Reactomei | R-DME-210991, Basigin interactions R-DME-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-936837, Ion transport by P-type ATPases |
Names & Taxonomyi
Protein namesi | Submitted name: Nervana 3, isoform EImported |
Gene namesi | ORF Names:CG8663Imported, Dmel_CG8663Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0032946, nrv3 |
VEuPathDBi | VectorBase:FBgn0032946 |
Subcellular locationi
Plasma Membrane
- sodium:potassium-exchanging ATPase complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 46 – 68 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | FBgn0032946, Expressed in brain and 36 other tissues |
ExpressionAtlasi | M9PDX8, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Belongs to the X(+)/potassium ATPases subunit beta family.ARBA annotation
Keywords - Domaini
Signal-anchorARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG3927, Eukaryota |
GeneTreei | ENSGT01030000234579 |
OrthoDBi | 998086at2759 |
Family and domain databases
Gene3Di | 2.60.40.1660, 1 hit |
InterProi | View protein in InterPro IPR000402, Na/K_ATPase_sub_beta IPR038702, Na/K_ATPase_sub_beta_sf |
PANTHERi | PTHR11523, PTHR11523, 1 hit |
Pfami | View protein in Pfam PF00287, Na_K-ATPase, 1 hit |
PROSITEi | View protein in PROSITE PS00390, ATPASE_NA_K_BETA_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
M9PDX8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADKKIGEYY APPVKMGKWE GFKKFLWNSE TSQCLGRTGS SWAKILLFYI
60 70 80 90 100
IFYAALTGFF AAIFTVFYQT LDNEKPKWML DNGLIGSNPG LGFRPMPPEA
110 120 130 140 150
NVESTLVWYE SSKKDNYKYW VDETSRFLKY HTYQDLEKQN QVNCSFEHPP
160 170 180 190 200
QDDKVCGIDF SSFSPCTADN NFGYHVARPC IFLKLNKIYN WIPEIYNDSK
210 220 230 240 250
TLPDHMPEEL KQHIKEKQSL RPNETNVVWV SCEGENPADV ENIKARDYYP
260 270 280 290 300
RMGFPRYYFP FKNIQGYIPP IVAVQFTVET GVLINIECKA WARNINHDRS
310
DRRGSVHFEL MVD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ7JS69 | Q7JS69_DROME | FI04632p | nrv3 Dmel\CG8663, JYbeta1, nervana3, Nrv3, nrv3-RC | 311 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AGB93210.1 |
RefSeqi | NP_001260675.1, NM_001273746.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0333355; FBpp0305547; FBgn0032946 |
GeneIDi | 35408 |
KEGGi | dme:Dmel_CG8663 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AGB93210.1 |
RefSeqi | NP_001260675.1, NM_001273746.2 |
3D structure databases
AlphaFoldDBi | M9PDX8 |
SMRi | M9PDX8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7227.FBpp0305547 |
PTM databases
SwissPalmi | M9PDX8 |
Proteomic databases
PaxDbi | M9PDX8 |
PRIDEi | M9PDX8 |
Protocols and materials databases
DNASUi | 35408 |
Genome annotation databases
EnsemblMetazoai | FBtr0333355; FBpp0305547; FBgn0032946 |
GeneIDi | 35408 |
KEGGi | dme:Dmel_CG8663 |
Organism-specific databases
CTDi | 35408 |
FlyBasei | FBgn0032946, nrv3 |
VEuPathDBi | VectorBase:FBgn0032946 |
Phylogenomic databases
eggNOGi | KOG3927, Eukaryota |
GeneTreei | ENSGT01030000234579 |
OrthoDBi | 998086at2759 |
Enzyme and pathway databases
Reactomei | R-DME-210991, Basigin interactions R-DME-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-936837, Ion transport by P-type ATPases |
Miscellaneous databases
BioGRID-ORCSi | 35408, 0 hits in 3 CRISPR screens |
ChiTaRSi | nrv3, fly |
GenomeRNAii | 35408 |
Gene expression databases
Bgeei | FBgn0032946, Expressed in brain and 36 other tissues |
ExpressionAtlasi | M9PDX8, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.1660, 1 hit |
InterProi | View protein in InterPro IPR000402, Na/K_ATPase_sub_beta IPR038702, Na/K_ATPase_sub_beta_sf |
PANTHERi | PTHR11523, PTHR11523, 1 hit |
Pfami | View protein in Pfam PF00287, Na_K-ATPase, 1 hit |
PROSITEi | View protein in PROSITE PS00390, ATPASE_NA_K_BETA_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | M9PDX8_DROME | |
Accessioni | M9PDX8Primary (citable) accession number: M9PDX8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 26, 2013 |
Last sequence update: | June 26, 2013 | |
Last modified: | May 25, 2022 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |