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Entry version 58 (17 Jun 2020)
Sequence version 1 (26 Jun 2013)
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Protein
Submitted name:

Homeodomain interacting protein kinase, isoform C

Gene

Hipk

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingImported, KinaseImported, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Homeodomain interacting protein kinase, isoform CImported (EC:2.7.11.-Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HipkImported
Synonyms:DHIPK2Imported, dhipk2Imported, Dmel\CG17090Imported, HIPKImported, hipKImported, hipkImported, HIPK2Imported
ORF Names:CG17090Imported, Dmel_CG17090Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0035142 Hipk

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0035142 Expressed in adult organism and 33 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
M9PDR2 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
M9PDR2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini108 – 436Protein kinaseInterPro annotationAdd BLAST329

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 90DisorderedSequence analysisAdd BLAST66
Regioni665 – 715DisorderedSequence analysisAdd BLAST51
Regioni792 – 999DisorderedSequence analysisAdd BLAST208
Regioni1015 – 1040DisorderedSequence analysisAdd BLAST26
Regioni1095 – 1158DisorderedSequence analysisAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi25 – 39PolarSequence analysisAdd BLAST15
Compositional biasi64 – 90PolarSequence analysisAdd BLAST27
Compositional biasi665 – 696PolyampholyteSequence analysisAdd BLAST32
Compositional biasi794 – 833PolarSequence analysisAdd BLAST40
Compositional biasi853 – 898PolarSequence analysisAdd BLAST46
Compositional biasi922 – 936PolarSequence analysisAdd BLAST15
Compositional biasi937 – 954Pro-richSequence analysisAdd BLAST18
Compositional biasi980 – 998PolarSequence analysisAdd BLAST19
Compositional biasi1018 – 1036PolarSequence analysisAdd BLAST19
Compositional biasi1103 – 1133Pro-richSequence analysisAdd BLAST31

Keywords - Domaini

HomeoboxImported

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0667 Eukaryota
ENOG410XPET LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155960

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003045_0_1_1

KEGG Orthology (KO)

More...
KOi
K08826

Identification of Orthologs from Complete Genome Data

More...
OMAi
QRTAHVS

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

M9PDR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISLVIRRLF RKDCDCGCVD SYNSSHGPPV QQDSSAAAGA GSVGSKAGSG
60 70 80 90 100
PGPDGIGPIS SLKTAHTKVA TSGGHANTQP PSKRSSSGAD GDYQLVQHEV
110 120 130 140 150
LYSLSAEYEV LEFLGRGTFG QVVKCWKRGT SEIVAIKILK NHPSYARQGQ
160 170 180 190 200
IEVSILSRLS QENADEFNFV RAFECFQHKN HTCLVFEMLE QNLYDFLKQN
210 220 230 240 250
KFSPLPLKYI RPILEQVLTA LLKLKQLGLI HADLKPENIM LVDPVRQPYR
260 270 280 290 300
VKVIDFGSAS HVSKTVCNTY LQSRYYRAPE IILGLPFCEA IDMWSLGCVV
310 320 330 340 350
AELFLGWPLY PGSSEFDQIR YISQTQGLPT EHMLNSASKT SKFFYRDVDS
360 370 380 390 400
TYPFWRLKTT EEHEAETNTK SKEARKYIFN CLDDIGQVNV PTDLEGGQLL
410 420 430 440 450
AEKTDRREFI DLLKRMLTID QERRLTPAEA LNHSFTRLTH LVDYVYCNNV
460 470 480 490 500
KASVQMMEVC RRGDFHTVQP ASTLVTNFVP SSTENMTFTI NNQLTSQVQR
510 520 530 540 550
LVRDGRPLAY EGLYQIYNGR SVARQYPQTR TDSFQHQLVS NILCPPSYQT
560 570 580 590 600
MPSPTKHVVV GSATMQPPLQ VPPQQYVNVP VPVSMVEPTS GQRMLLTNRV
610 620 630 640 650
QASGVAWPQT GRQMALVPSW PQQAPAHSLI VDSTPLFNVE EIYPKHHLNL
660 670 680 690 700
PRNDLKKESP AHHIAKGNSY RVPRHEKKEH QQLSPVKKRV KESSPPHQQR
710 720 730 740 750
YQRAAHVSPQ YHAHHNCNYG NGSGYSASAG SVVASSAASS SNIVNGSSSS
760 770 780 790 800
SHHHHVPVAH AQPYSSSSGH HIVSNCNANG GAGGAVVYQQ PPAHAHQQHG
810 820 830 840 850
QQPHPQSSQH PQHVKQPTIT IHDTPSPTAV ITISDSEDEG GEAGGAQVPV
860 870 880 890 900
LKQRAHAQSQ TSGSLLQHAP SSSCSRSSAH QQPHPHPQQQ QQQQINYGDH
910 920 930 940 950
DPEDARRRHH AAAAAAVGSP KHHHHQQQQQ PAPPPQQQQQ QYQPQPPPQQ
960 970 980 990 1000
VLPQPQPSIK YEPGQSQKKR ILAMAQSECG YQPQVPSQPS SSASLPHIPT
1010 1020 1030 1040 1050
KQEPAEFYPE YAAAPPQQLD TKRSSWAPTS SGSGVSALPL AHPKREAPSV
1060 1070 1080 1090 1100
APISYVAPSV APPLAHSKSS SASSSSSISA ATAAAAAAAA AAAASVGPPS
1110 1120 1130 1140 1150
WGPPQVYRQP SQPPPGSVGL PGSTQPPPSS VAPHPHHHSH GHHHHQAGTP
1160 1170 1180 1190 1200
LGGSPSSTAA AALLQPDIYA QGDIYRRPTV FVSQAAPSYA YANRAVVAPP
1210 1220 1230 1240 1250
PAHNSSSRQV IPSHPLPAHI QIPTQYSQFG PLSPAQVAAS KHAAHFAPTN

IWYGAE
Length:1,256
Mass (Da):136,856
Last modified:June 26, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i66BEED1955CD319E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9W0Q1Q9W0Q1_DROME
Homeodomain interacting protein kin...
Hipk DHIPK2, dhipk2, Dmel\CG17090, HIPK, hipK
1,340Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AGB93910.1

NCBI Reference Sequences

More...
RefSeqi
NP_001261215.1, NM_001274286.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0331786; FBpp0304171; FBgn0035142

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
38070

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG17090

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AGB93910.1
RefSeqiNP_001261215.1, NM_001274286.1

3D structure databases

SMRiM9PDR2
ModBaseiSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0331786; FBpp0304171; FBgn0035142
GeneIDi38070
KEGGidme:Dmel_CG17090

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
38070
FlyBaseiFBgn0035142 Hipk

Phylogenomic databases

eggNOGiKOG0667 Eukaryota
ENOG410XPET LUCA
GeneTreeiENSGT00940000155960
HOGENOMiCLU_003045_0_1_1
KOiK08826
OMAiQRTAHVS

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
38070 0 hits in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Hipk fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
38070

Gene expression databases

BgeeiFBgn0035142 Expressed in adult organism and 33 other tissues
ExpressionAtlasiM9PDR2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM9PDR2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M9PDR2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: June 17, 2020
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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