UniProtKB - M9PCT8 (M9PCT8_DROME)
Protein
Non-specific protein-tyrosine kinase
Gene
Abl
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalytic activityi
- EC:2.7.10.2ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 410 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
- transmembrane receptor protein tyrosine kinase activity Source: RHEA
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinaseARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:AblImported Synonyms:4674Imported, ABLImported, ablImported, Abl1Imported, abl1Imported, AblesonImported, AblKImported, Am ABLImported, C-ablImported, c-ablImported, cAblImported, D-AblImported, D-ablImported, D-ashImported, DAblImported, DablImported, dAblImported, DashImported, DdashImported, Dmel\CG4032Imported, DROTKABL3Imported, Dsrc7Imported, l(3)04674Imported, l(3)73BaImported, l(3)c-ablImported ORF Names:CG4032Imported, Dmel_CG4032Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0000017, Abl |
Expressioni
Gene expression databases
Bgeei | FBgn0000017, Expressed in head and 31 other tissues |
ExpressionAtlasi | M9PCT8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 187 – 248 | SH3InterPro annotationAdd BLAST | 62 | |
Domaini | 254 – 346 | SH2InterPro annotationAdd BLAST | 93 | |
Domaini | 371 – 627 | Protein kinaseInterPro annotationAdd BLAST | 257 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 97 | DisorderedSequence analysisAdd BLAST | 97 | |
Regioni | 139 – 168 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 642 – 672 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 687 – 772 | DisorderedSequence analysisAdd BLAST | 86 | |
Regioni | 885 – 904 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 921 – 991 | DisorderedSequence analysisAdd BLAST | 71 | |
Regioni | 1036 – 1083 | DisorderedSequence analysisAdd BLAST | 48 | |
Regioni | 1097 – 1239 | DisorderedSequence analysisAdd BLAST | 143 | |
Regioni | 1284 – 1307 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 1447 – 1555 | DisorderedSequence analysisAdd BLAST | 109 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 23 – 89 | PolarSequence analysisAdd BLAST | 67 | |
Compositional biasi | 702 – 764 | PolarSequence analysisAdd BLAST | 63 | |
Compositional biasi | 933 – 974 | PolarSequence analysisAdd BLAST | 42 | |
Compositional biasi | 1068 – 1083 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1097 – 1126 | PolarSequence analysisAdd BLAST | 30 | |
Compositional biasi | 1137 – 1167 | Pro-richSequence analysisAdd BLAST | 31 | |
Compositional biasi | 1172 – 1210 | PolarSequence analysisAdd BLAST | 39 | |
Compositional biasi | 1287 – 1307 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1447 – 1462 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1484 – 1498 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1499 – 1530 | PolarSequence analysisAdd BLAST | 32 |
Keywords - Domaini
SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000173757 |
Family and domain databases
CDDi | cd09935, SH2_ABL, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR033221, ABL1 IPR035837, ABL_SH2 IPR015015, F-actin-binding IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
PANTHERi | PTHR24418:SF162, PTHR24418:SF162, 1 hit |
Pfami | View protein in Pfam PF08919, F_actin_bind, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00808, FABD, 1 hit SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
M9PCT8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGAQQGKDRG AHSGGGGSGA PVSCIGLSSS PVASVSPHCI SSSSGVSSAP
60 70 80 90 100
LGGGSTLRGS RIKSSSSGVA SGSGSGGGGG GSGSGLSQRS GGHKDARCNP
110 120 130 140 150
TVGLNIFTEH NEALLQSRPL PHIPAGSTAA SLLADAAELQ QHQQDSGGLG
160 170 180 190 200
LQGSSLGGGH SSTTSVFESA HRWTSKENLL APGPEEDDPQ LFVALYDFQA
210 220 230 240 250
GGENQLSLKK GEQVRILSYN KSGEWCEAHS DSGNVGWVPS NYVTPLNSLE
260 270 280 290 300
KHSWYHGPIS RNAAEYLLSS GINGSFLVRE SESSPGQRSI SLRYEGRVYH
310 320 330 340 350
YRISEDPDGK VFVTQEAKFN TLAELVHHHS VPHEGHGLIT PLLYPAPKQN
360 370 380 390 400
KPTVFPLSPE PDEWEICRTD IMMKHKLGGG QYGEVYEAVW KRYGNTVAVK
410 420 430 440 450
TLKEDTMALK DFLEEAAIMK EMKHPNLVQL IGVCTREPPF YIITEFMSHG
460 470 480 490 500
NLLDFLRSAG RETLDAVALL YMATQIASGM SYLESRNYIH RDLAARNCLV
510 520 530 540 550
GDNKLVKVAD FGLARLMRDD TYTAHAGAKF PIKWTAPEGL AYNKFSTKSD
560 570 580 590 600
VWAFGVLLWE IATYGMSPYP AIDLTDVYHK LDKGYRMERP PGCPPEVYDL
610 620 630 640 650
MRQCWQWDAT DRPTFKSIHH ALEHMFQESS ITEAVEKQLN ANATSASSSA
660 670 680 690 700
PSTSGVATGG GATTTTAASG CASSSSATAS LSLTPQMVKK GLPGGQALTP
710 720 730 740 750
NAHHNDPHQQ QASTPMSETG STSTKLSTFS SQGKGNVQMR RTTNKQGKQA
760 770 780 790 800
PAPPKRTSLL SSSRDSTYRE EDPANARCNF IDDLSTNGIH KLKTANYFSQ
810 820 830 840 850
TLSRNFKTQI PTHHTHQIRT QQQQQQQSVQ QQQQIVPLSV QQQAHQQQQK
860 870 880 890 900
QQQYSIKKSS SCSSFLYDIL FRGLARDINS LTQRYDSETD PAADPDTDAT
910 920 930 940 950
GDSLEQSLSQ VIAAPVTNKM QHSLHSGGGG GGIGPRSSQQ HSSFKRPTGT
960 970 980 990 1000
PVMGNRGLET RQSKRSQLHS QAPGPGPPST QPHHGNNGVV TSAHPITVGA
1010 1020 1030 1040 1050
LDVMNVKQVV NRYGTLPKGA RIGAYLDSLE DSSEAAPALP ATAPSLPPAN
1060 1070 1080 1090 1100
GHATPPAARL NPKASPIPPQ QMIRSNSSGG VTMQNNAAAS LNKLQRHRTT
1110 1120 1130 1140 1150
TEGTMMTFSS FRAGGSSSSP KRSASGVASG VQPALANLEF PPPPLDLPPP
1160 1170 1180 1190 1200
PEEFEGGPPP PPPAPESAVQ AIQQHLHAQL PNNGNISNGN GTNNNDSSHN
1210 1220 1230 1240 1250
DVSNIAPSVE EASSRFGVSL RKREPSTDSC SSLGSPPEDL KEKLITEIKA
1260 1270 1280 1290 1300
AGKDTAPASH LANGSGIAVV DPVSLLVTEL AESMNLPKPP PQQQQKLTNG
1310 1320 1330 1340 1350
NSTGSGFKAQ LKKVEPKKMS APMPKAEPAN TIIDFKAHLR RVDKEKEPAT
1360 1370 1380 1390 1400
PAPAPATVAV ANNANCNTTG TLNRKEDGSK KFSQAMQKTE IKIDVTNSNV
1410 1420 1430 1440 1450
EADAGAAGEG DLGKRRSTGS INSLKKLWEQ QPPAPDYATS TILQQQPSVV
1460 1470 1480 1490 1500
NGGGTPNAQL SPKYGMKSGA INTVGTLPAK LGNKQPPAAP PPPPPNCTTS
1510 1520 1530 1540 1550
NSSTTSISTS SRDCTSRQQA SSTIKTSHST QLFTDDEEQS HTEGLGSGGQ
1560 1570 1580 1590 1600
GSADMTQSLY EQKPQIQQKP AVPHKPTKLT IYATPIAKLT EPASSASSTQ
1610 1620 1630 1640 1650
ISRESILELV GLLEGSLKHP VNAIAGSQWL QLSDKLNILH NSCVIFAENG
1660 1670 1680 1690 1700
AMPPHSKFQF RELVTRVEAQ SQHLRSAGSK NVQDNERLVA EVGQSLRQIS
NALNR
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP00522 | ABL_DROME | Tyrosine-protein kinase Abl | Abl ABL-1, Dash, CG4032 | 1,620 | Annotation score: | ||
A8JNU2 | A8JNU2_DROME | Non-specific protein-tyrosine kinas... | Abl 4674, ABL, abl, Abl1, abl1 | 1,638 | Annotation score: | ||
X2JGR4 | X2JGR4_DROME | Non-specific protein-tyrosine kinas... | Abl 4674, ABL, abl, Abl1, abl1 | 1,620 | Annotation score: | ||
M9PFX0 | M9PFX0_DROME | Non-specific protein-tyrosine kinas... | Abl 4674, ABL, abl, Abl1, abl1 | 1,589 | Annotation score: | ||
M9PCU1 | M9PCU1_DROME | Non-specific protein-tyrosine kinas... | Abl 4674, ABL, abl, Abl1, abl1 | 1,504 | Annotation score: | ||
M9PFI5 | M9PFI5_DROME | Non-specific protein-tyrosine kinas... | Abl 4674, ABL, abl, Abl1, abl1 | 1,607 | Annotation score: | ||
M9PFS1 | M9PFS1_DROME | Non-specific protein-tyrosine kinas... | Abl 4674, ABL, abl, Abl1, abl1 | 1,723 | Annotation score: | ||
M9PI83 | M9PI83_DROME | Non-specific protein-tyrosine kinas... | Abl 4674, ABL, abl, Abl1, abl1 | 1,522 | Annotation score: | ||
M9PFI8 | M9PFI8_DROME | Non-specific protein-tyrosine kinas... | Abl 4674, ABL, abl, Abl1, abl1 | 1,666 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AGB94652.1 |
RefSeqi | NP_001261959.1, NM_001275030.1 |
Genome annotation databases
EnsemblMetazoai | FBtr0330130; FBpp0303163; FBgn0000017 |
GeneIDi | 45821 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AGB94652.1 |
RefSeqi | NP_001261959.1, NM_001275030.1 |
3D structure databases
SMRi | M9PCT8 |
ModBasei | Search... |
Genome annotation databases
EnsemblMetazoai | FBtr0330130; FBpp0303163; FBgn0000017 |
GeneIDi | 45821 |
Organism-specific databases
CTDi | 45821 |
FlyBasei | FBgn0000017, Abl |
Phylogenomic databases
GeneTreei | ENSGT00940000173757 |
Miscellaneous databases
BioGRID-ORCSi | 45821, 0 hits in 3 CRISPR screens |
GenomeRNAii | 45821 |
Gene expression databases
Bgeei | FBgn0000017, Expressed in head and 31 other tissues |
ExpressionAtlasi | M9PCT8, baseline and differential |
Family and domain databases
CDDi | cd09935, SH2_ABL, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR033221, ABL1 IPR035837, ABL_SH2 IPR015015, F-actin-binding IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
PANTHERi | PTHR24418:SF162, PTHR24418:SF162, 1 hit |
Pfami | View protein in Pfam PF08919, F_actin_bind, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00808, FABD, 1 hit SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | M9PCT8_DROME | |
Accessioni | M9PCT8Primary (citable) accession number: M9PCT8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 26, 2013 |
Last sequence update: | June 26, 2013 | |
Last modified: | April 7, 2021 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |