UniProtKB - M9PCF6 (M9PCF6_DROME)
AF4/FMR2 family member lilli
lilli
Functioni
Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation.
ARBA annotationGO - Biological processi
- periodic partitioning by pair rule gene Source: UniProtKB-KW
- regulation of gene expression Source: InterPro
Keywordsi
Molecular function | Developmental protein, Pair-rule proteinARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: AF4/FMR2 family member lilliARBA annotationAlternative name(s): Protein lilliputianARBA annotation |
Gene namesi | Name:lilliImported Synonyms:154454_atImported, 189YImported, AFF4Imported, BcDNA:GM02019Imported, BEST:GH09955Imported, dAFFImported, dAFF4Imported, Dmel\CG8817Imported, l(2)00632Imported, l(2)23CcImported, l(2)K00632Imported, l(2)K07920Imported, l(2)k07920Imported, l(2)k16124Imported, LilliImported, S(ls)4Imported, SS2-1Imported, Su(Raf)2AImported, Su(Raf)2aImported, SY2-1Imported ORF Names:CG8817Imported, Dmel_CG8817Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0041111, lilli |
VEuPathDBi | VectorBase:FBgn0041111 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-KW
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | FBgn0041111, Expressed in imaginal disc and 31 other tissues |
ExpressionAtlasi | M9PCF6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1369 – 1606 | AF-4_CInterPro annotationAdd BLAST | 238 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 37 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 65 – 245 | DisorderedSequence analysisAdd BLAST | 181 | |
Regioni | 348 – 475 | DisorderedSequence analysisAdd BLAST | 128 | |
Regioni | 516 – 545 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 663 – 1027 | DisorderedSequence analysisAdd BLAST | 365 | |
Regioni | 1055 – 1074 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1082 – 1101 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1128 – 1256 | DisorderedSequence analysisAdd BLAST | 129 | |
Regioni | 1505 – 1530 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 80 – 127 | Polar residuesSequence analysisAdd BLAST | 48 | |
Compositional biasi | 160 – 203 | Polar residuesSequence analysisAdd BLAST | 44 | |
Compositional biasi | 371 – 403 | Basic and acidic residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 404 – 427 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 439 – 475 | Polar residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 663 – 686 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 712 – 739 | Polar residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 800 – 826 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 850 – 864 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 871 – 921 | Polar residuesSequence analysisAdd BLAST | 51 | |
Compositional biasi | 931 – 1001 | Polar residuesSequence analysisAdd BLAST | 71 | |
Compositional biasi | 1002 – 1023 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1132 – 1146 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1161 – 1180 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1192 – 1252 | Basic and acidic residuesSequence analysisAdd BLAST | 61 | |
Compositional biasi | 1505 – 1526 | Polar residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_241798_0_0_1 |
OMAi | NMEATWT |
Family and domain databases
InterProi | View protein in InterPro IPR007797, AF4/FMR2 IPR043640, AF4/FMR2_CHD |
PANTHERi | PTHR10528, PTHR10528, 1 hit |
Pfami | View protein in Pfam PF18876, AF-4_C, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MEEYERRKRR EREKIERQQG IQIDDRETSL FGEPRRLTEG DAEITAALGE
60 70 80 90 100
FFEAREYINN QTVGISRSAP GAGNPRLQPN LAPQAKSLGH SPSSASSAAG
110 120 130 140 150
PTAASATTSL PGQQQHYQQQ QRPPTYVKQA DNKPPYNGRG GYPGQPMKND
160 170 180 190 200
IPSSSGMAPP RGPPRTSSSN SNSSSVTNNA SSGGVPASTP LGPPLSTQMP
210 220 230 240 250
NGREKSFLGP PAPALHNGTG GRFVPPAASK RPGVGQQPPP PEKDVNKIIS
260 270 280 290 300
DIANIFTVQP LTLIAATPHA PTRENYNLLA PNRQKYAMDI PSSPPSAEPS
310 320 330 340 350
SLMTPLFAPI TSPIAPLVTT PPQASQMPLG GATSGTILAG EALAPLHQLP
360 370 380 390 400
PTMPKAASGV TSPGPVKPLK TEKNHSLEKQ DSCLENDLEL SESEDEQRKK
410 420 430 440 450
EGRSGGNSSN SSESDSSESG SESSSKNDLQ HHPNHQQHHH QLQQQQQQQQ
460 470 480 490 500
ATMQQQQVLQ QQHRSQPLTS NGAQNKKFRH EIIARGSNTI TGLLSSSGFG
510 520 530 540 550
SGGNVGPAGV NSNAVVGTGS GSGGTLSSGG SSSNKTPSPT ESNKWNLSRF
560 570 580 590 600
FHKPANQTNS ESVSPGNVSM KVPGILPGGA QIIPESIDVT TAIVKNEKND
610 620 630 640 650
MAMEEGEEED DDEEQQLRYG GGLSVTPVAV KKEAIDAVSE MALGAIPKTQ
660 670 680 690 700
IKRESAETLL SARLSDSGTS ASGSSSSSSS SSDSAMGGEV VPMPGPGETL
710 720 730 740 750
QLPGVPAAIT TVMRVQPTQS QKAPPSNSVT LTPILPLPTS PKQRQKKPRK
760 770 780 790 800
KKAITSAPIL DSSDDDEPPP KHPGLDHTAV SVQTQPATDT VKKGRGRPRK
810 820 830 840 850
QQQSGGSGNL SSASAGSSSQ TKGPTLTAAK KPLAKTPLAM SRARKREHSS
860 870 880 890 900
QSSSNGNTPT KKVATPQLVA APLKPTSNTA GSSSSDEDSS SSAESSSKSS
910 920 930 940 950
SSSSSSDDTE TQNTNCRIVK LNKTGAVQKK ALLGSGSSSP SSSGSEAEDQ
960 970 980 990 1000
TTRSQVGSGQ ALAQQLPPYK QLPISQHSQH LSSSDCSSSS GGCTAVCSSS
1010 1020 1030 1040 1050
SGEEDEGRRE KERERKPKSD KNKINTLTRI FNPKEGGAKK QGQVVIVDLQ
1060 1070 1080 1090 1100
EEQQQGKLDA AAQPSAPQAP PAAPAAIMAK PRMTPTQQQQ LGAGLASPAR
1110 1120 1130 1140 1150
TTTPHLTSLI CKIDLSKLSR ERIMRLKKLT PAQQNGHLTP KDQATNAVHV
1160 1170 1180 1190 1200
PNGYAGDTNP AAKVKHEHPV KPEPELDAGY EAKFKPGNVK QEFQLKQERD
1210 1220 1230 1240 1250
RDRERERERE RERERDRERE QPPGRRRKRS SSSSSSPYKE KKRKKEKADQ
1260 1270 1280 1290 1300
LQMGKELLPV PVLLPSNNHE RMPNHDRLSY DKLQLLHEDA AAVIGDVSAP
1310 1320 1330 1340 1350
NGSPTKKLLA MSPLPPPPTV TVAPATCNEA VQTTPPSATA TSAIAPPVPA
1360 1370 1380 1390 1400
TRLIYRSYFD RDVEHPSDDP RKNNQFLQEA INRKHAADLE RDSFNQVTLY
1410 1420 1430 1440 1450
LEAVVYFLLT ADAMERCSSE QATNTMYKDT LSLIKFISTK FRPYQQQSTT
1460 1470 1480 1490 1500
NIQHETHNKV AILSLRCQSL ISLKLYKLRR KDCRAIINSL TDFFRVGRGD
1510 1520 1530 1540 1550
IANGNTPSSI SPSNSVGSQG SGSNTPPGRI VPPDIHNMLC KQNEFLSYLN
1560 1570 1580 1590 1600
SAHELWDQAD RLVRTGNHID FIRELDHENG PLTLHSTMHE VFRYVQAGLK
1610
TLRDAVSHPT HQSQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9VQI9 | AFFL_DROME | AF4/FMR2 family member lilli | lilli l(2)00632, SS2-1, Su(Raf)2A, CG8817 | 1,673 | Annotation score: | ||
A0A1W5PXG3 | A0A1W5PXG3_DROME | AF4/FMR2 family member lilli | lilli 154454_at, 189Y, AFF4, BcDNA:GM02019, BEST:GH09955 | 1,626 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AGB92510.1 |
RefSeqi | NP_001137772.1, NM_001144300.2 NP_001137773.1, NM_001144301.1 NP_001137774.1, NM_001144302.2 NP_001259973.1, NM_001273044.1 |
Genome annotation databases
EnsemblMetazoai | FBtr0290038; FBpp0288477; FBgn0041111 FBtr0290039; FBpp0288478; FBgn0041111 FBtr0290040; FBpp0288479; FBgn0041111 FBtr0332458; FBpp0304731; FBgn0041111 |
GeneIDi | 33496 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AGB92510.1 |
RefSeqi | NP_001137772.1, NM_001144300.2 NP_001137773.1, NM_001144301.1 NP_001137774.1, NM_001144302.2 NP_001259973.1, NM_001273044.1 |
3D structure databases
SMRi | M9PCF6 |
ModBasei | Search... |
Proteomic databases
PRIDEi | M9PCF6 |
Genome annotation databases
EnsemblMetazoai | FBtr0290038; FBpp0288477; FBgn0041111 FBtr0290039; FBpp0288478; FBgn0041111 FBtr0290040; FBpp0288479; FBgn0041111 FBtr0332458; FBpp0304731; FBgn0041111 |
GeneIDi | 33496 |
Organism-specific databases
CTDi | 33496 |
FlyBasei | FBgn0041111, lilli |
VEuPathDBi | VectorBase:FBgn0041111 |
Phylogenomic databases
HOGENOMi | CLU_241798_0_0_1 |
OMAi | NMEATWT |
Miscellaneous databases
BioGRID-ORCSi | 33496, 0 hits in 3 CRISPR screens |
ChiTaRSi | lilli, fly |
GenomeRNAii | 33496 |
Gene expression databases
Bgeei | FBgn0041111, Expressed in imaginal disc and 31 other tissues |
ExpressionAtlasi | M9PCF6, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR007797, AF4/FMR2 IPR043640, AF4/FMR2_CHD |
PANTHERi | PTHR10528, PTHR10528, 1 hit |
Pfami | View protein in Pfam PF18876, AF-4_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | M9PCF6_DROME | |
Accessioni | M9PCF6Primary (citable) accession number: M9PCF6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 26, 2013 |
Last sequence update: | June 26, 2013 | |
Last modified: | January 19, 2022 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |