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UniProtKB - M9PCD4 (M9PCD4_DROME)
Protein
Submitted name:
Liprin-alpha, isoform E
Gene
Liprin-alpha
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Biological processi
- anterograde synaptic vesicle transport Source: FlyBase
- axon extension Source: FlyBase
- axon guidance Source: FlyBase
- axon target recognition Source: FlyBase
- photoreceptor cell morphogenesis Source: FlyBase
- presynapse assembly Source: SynGO
- presynaptic active zone organization Source: FlyBase
- R7 cell development Source: FlyBase
- regulation of axon extension involved in axon guidance Source: FlyBase
- retinal ganglion cell axon guidance Source: FlyBase
- synapse assembly Source: FlyBase
- synapse organization Source: GO_Central
- synaptic assembly at neuromuscular junction Source: FlyBase
- synaptic vesicle localization Source: FlyBase
Enzyme and pathway databases
Reactomei | R-DME-181429, Serotonin Neurotransmitter Release Cycle R-DME-181430, Norepinephrine Neurotransmitter Release Cycle R-DME-210500, Glutamate Neurotransmitter Release Cycle R-DME-212676, Dopamine Neurotransmitter Release Cycle R-DME-264642, Acetylcholine Neurotransmitter Release Cycle R-DME-388844, Receptor-type tyrosine-protein phosphatases |
Names & Taxonomyi
Protein namesi | Submitted name: Liprin-alpha, isoform EImported |
Gene namesi | Name:Liprin-alphaImported Synonyms:DLiprinImported, DLiprin-alphaImported, Dliprin-alphaImported, Dmel\CG11199Imported, LIPImported, lip-alphaImported, LIP.1Imported, LIP1Imported, LiprinImported, liprin-alphaImported, LPRImported, lprImported, oosImported ORF Names:CG11199Imported, Dmel_CG11199Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0046704, Liprin-alpha |
VEuPathDBi | VectorBase:FBgn0046704 |
Subcellular locationi
Other locations
- axon cytoplasm Source: GOC
- focal adhesion Source: FlyBase
- neuromuscular junction Source: SynGO
- presynaptic active zone Source: FlyBase
- protein-containing complex Source: FlyBase
- synapse Source: FlyBase
Expressioni
Gene expression databases
Bgeei | FBgn0046704, Expressed in cleaving embryo and 43 other tissues |
ExpressionAtlasi | M9PCD4, baseline and differential |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 945 – 1011 | SAMInterPro annotationAdd BLAST | 67 | |
Domaini | 1038 – 1094 | SAMInterPro annotationAdd BLAST | 57 | |
Domaini | 1118 – 1187 | SAMInterPro annotationAdd BLAST | 70 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 542 – 575 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 686 – 706 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 720 – 758 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 777 – 797 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1189 – 1214 | DisorderedSequence analysisAdd BLAST | 26 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 35 – 76 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 92 – 112 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 177 – 204 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 266 – 300 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 308 – 384 | Sequence analysisAdd BLAST | 77 | |
Coiled coili | 406 – 447 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 473 – 528 | Sequence analysisAdd BLAST | 56 | |
Coiled coili | 638 – 679 | Sequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 542 – 564 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 692 – 706 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 728 – 747 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 778 – 797 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1198 – 1214 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00990000203651 |
PhylomeDBi | M9PCD4 |
Family and domain databases
CDDi | cd09562, SAM_liprin-alpha1_2_3_4_repeat1, 1 hit cd09565, SAM_liprin-alpha1_2_3_4_repeat2, 1 hit cd09568, SAM_liprin-alpha1_2_3_4_repeat3, 1 hit |
Gene3Di | 1.10.150.50, 3 hits |
InterProi | View protein in InterPro IPR029515, Liprin IPR037620, Liprin-alpha_SAM_rpt_1 IPR037621, Liprin-alpha_SAM_rpt_2 IPR037622, Liprin-alpha_SAM_rpt_3 IPR001660, SAM IPR013761, SAM/pointed_sf IPR030442, Syd-2 |
PANTHERi | PTHR12587, PTHR12587, 1 hit PTHR12587:SF20, PTHR12587:SF20, 1 hit |
Pfami | View protein in Pfam PF00536, SAM_1, 1 hit PF07647, SAM_2, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 3 hits |
SUPFAMi | SSF47769, SSF47769, 3 hits |
PROSITEi | View protein in PROSITE PS50105, SAM_DOMAIN, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
M9PCD4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWNMMCDVMP TISEDSISQR SSQFSGEDAN FEQLMVSMLD ERDKLMDSLR
60 70 80 90 100
EAQERLNETE NKLRDVEKER DSLQRQINAN LPQEFATLTK ELTQARETLL
110 120 130 140 150
ERDEEIGELK AERNNTRLLL EHLECLVSRH ERSLRMTVVK RQAAAQSGVS
160 170 180 190 200
SEVEVLKALK SLFEHHKALD EKVRERLRLS IEKNNMMEEE LSSAKEELAQ
210 220 230 240 250
YKAGVVPAGV GSGSGAGSAA TTAGGGGAEN GLKEKMAGVG GSGGVNGEAN
260 270 280 290 300
ELNDYAAKTH ELQTIIEKQT SELSQWQRRV SDLNNKISEL EENMSRVQKE
310 320 330 340 350
HCKAQDQCAK LQRDLRENVA QKEDQEERIT TLEKRYLNAQ RESTSLHDLN
360 370 380 390 400
EKLEQELRHK EAQLKLHEEK IGAIEEKLEL SEQKLAQHAK LQPDMEEQLK
410 420 430 440 450
ARMEALTKAQ ERHGSAEDRI RGLETNLDEK TNEVVRLNQR LKMNEEHNLR
460 470 480 490 500
LSSTVDKLLS ESNERLQVHL KERMHALDEK NALTQELEKA RKVAEELHHE
510 520 530 540 550
KSEIMKELSK TRLEIENFKR QLLQQEIAYN IQQTEALTRS LSPSSVVDPS
560 570 580 590 600
GAFSRSNSHA SFETHSLRRQ SKQRLSEENA LVRSMAEQEW EKLQQAAHAQ
610 620 630 640 650
QQAYELASAA DCDDSDVLYA AATDMMSPSG HTDAQTLAMM LQEQLDAINN
660 670 680 690 700
EIRLIQEEKQ STEARAEELE SRVGSLEHVN LLARGRSMDR QSPPMSGRST
710 720 730 740 750
PNSPQRDFMQ KYHTLNLPVL SSDASREELH GGMSTTGDSS SGGAASPLTA
760 770 780 790 800
RSMRLERVAQ ALAHSQEELR RRSIGLNPNA SVAPNHTGGH MPLSSHSYGL
810 820 830 840 850
SPLSSRYGSQ ESLRHYNTMG SMSMLQTPTS GVSREAAAAA VQKKKGIKSS
860 870 880 890 900
LGRFFSKKEK VKGVKDTLPD GSPSMMSIGN LSIGLSEVDS NYDAMSMTGG
910 920 930 940 950
MMPRIASSQG SKISSVDYGR QKKEHDYRND LLGEAMKAGT PFALWNGPTI
960 970 980 990 1000
VAWLELWVGM PAWYVAACRA NVKSGAIMSA LSDTEIQREI GISNPLHRLK
1010 1020 1030 1040 1050
LRLAIQEMVS LTSPSAPQTS RTTLAFGDMN HEWIGNYWLP GLGLPQYRTT
1060 1070 1080 1090 1100
FMECLVDARM LDHLTKKDLR GQLKMVDSFH RTSLQYGISM LKRLNYDRTE
1110 1120 1130 1140 1150
LEHRRKMSEN GLCDVLVWSN ERVIRWVGSI GLKEYANNLL ESGVHGGLMA
1160 1170 1180 1190 1200
LDEGFDANAM GLALQIPTQN AQARQILDTE FNNLLQIATD RRPENEQRSA
1210
SXCSYSPPTS SVDE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9VM93 | Q9VM93_DROME | LD33094p | Liprin-alpha DLiprin, DLiprin-alpha, Dliprin-alpha, Dmel\CG11199, LIP | 1,201 | Annotation score: | ||
M9PC73 | M9PC73_DROME | Liprin-alpha, isoform C | Liprin-alpha DLiprin, DLiprin-alpha, Dliprin-alpha, Dmel\CG11199, LIP | 1,158 | Annotation score: | ||
M9PCR7 | M9PCR7_DROME | Liprin-alpha, isoform D | Liprin-alpha DLiprin, DLiprin-alpha, Dliprin-alpha, Dmel\CG11199, LIP | 1,205 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AGB92691.1 |
RefSeqi | NP_001260155.1, NM_001273226.1 |
Genome annotation databases
EnsemblMetazoai | FBtr0329943; FBpp0302975; FBgn0046704 |
GeneIDi | 249072 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AGB92691.1 |
RefSeqi | NP_001260155.1, NM_001273226.1 |
3D structure databases
ModBasei | Search... |
Proteomic databases
PaxDbi | M9PCD4 |
PRIDEi | M9PCD4 |
Protocols and materials databases
DNASUi | 249072 |
Genome annotation databases
EnsemblMetazoai | FBtr0329943; FBpp0302975; FBgn0046704 |
GeneIDi | 249072 |
Organism-specific databases
CTDi | 249072 |
FlyBasei | FBgn0046704, Liprin-alpha |
VEuPathDBi | VectorBase:FBgn0046704 |
Phylogenomic databases
GeneTreei | ENSGT00990000203651 |
PhylomeDBi | M9PCD4 |
Enzyme and pathway databases
Reactomei | R-DME-181429, Serotonin Neurotransmitter Release Cycle R-DME-181430, Norepinephrine Neurotransmitter Release Cycle R-DME-210500, Glutamate Neurotransmitter Release Cycle R-DME-212676, Dopamine Neurotransmitter Release Cycle R-DME-264642, Acetylcholine Neurotransmitter Release Cycle R-DME-388844, Receptor-type tyrosine-protein phosphatases |
Miscellaneous databases
BioGRID-ORCSi | 249072, 0 hits in 3 CRISPR screens |
GenomeRNAii | 249072 |
Gene expression databases
Bgeei | FBgn0046704, Expressed in cleaving embryo and 43 other tissues |
ExpressionAtlasi | M9PCD4, baseline and differential |
Family and domain databases
CDDi | cd09562, SAM_liprin-alpha1_2_3_4_repeat1, 1 hit cd09565, SAM_liprin-alpha1_2_3_4_repeat2, 1 hit cd09568, SAM_liprin-alpha1_2_3_4_repeat3, 1 hit |
Gene3Di | 1.10.150.50, 3 hits |
InterProi | View protein in InterPro IPR029515, Liprin IPR037620, Liprin-alpha_SAM_rpt_1 IPR037621, Liprin-alpha_SAM_rpt_2 IPR037622, Liprin-alpha_SAM_rpt_3 IPR001660, SAM IPR013761, SAM/pointed_sf IPR030442, Syd-2 |
PANTHERi | PTHR12587, PTHR12587, 1 hit PTHR12587:SF20, PTHR12587:SF20, 1 hit |
Pfami | View protein in Pfam PF00536, SAM_1, 1 hit PF07647, SAM_2, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 3 hits |
SUPFAMi | SSF47769, SSF47769, 3 hits |
PROSITEi | View protein in PROSITE PS50105, SAM_DOMAIN, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | M9PCD4_DROME | |
Accessioni | M9PCD4Primary (citable) accession number: M9PCD4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 26, 2013 |
Last sequence update: | June 26, 2013 | |
Last modified: | September 29, 2021 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |