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Entry version 70 (29 Sep 2021)
Sequence version 1 (26 Jun 2013)
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Protein
Submitted name:

Liprin-alpha, isoform C

Gene

Liprin-alpha

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Liprin-alpha, isoform CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Liprin-alphaImported
Synonyms:DLiprinImported, DLiprin-alphaImported, Dliprin-alphaImported, Dmel\CG11199Imported, LIPImported, lip-alphaImported, LIP.1Imported, LIP1Imported, LiprinImported, liprin-alphaImported, LPRImported, lprImported, oosImported
ORF Names:CG11199Imported, Dmel_CG11199Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0046704, Liprin-alpha

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0046704

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
M9PC73

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0046704, Expressed in cleaving embryo and 43 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
M9PC73, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
M9PC73

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini902 – 968SAMInterPro annotationAdd BLAST67
Domaini995 – 1051SAMInterPro annotationAdd BLAST57
Domaini1075 – 1144SAMInterPro annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni499 – 531DisorderedSequence analysisAdd BLAST33
Regioni643 – 663DisorderedSequence analysisAdd BLAST21
Regioni682 – 703DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili35 – 76Sequence analysisAdd BLAST42
Coiled coili92 – 112Sequence analysisAdd BLAST21
Coiled coili177 – 204Sequence analysisAdd BLAST28
Coiled coili266 – 300Sequence analysisAdd BLAST35
Coiled coili308 – 404Sequence analysisAdd BLAST97
Coiled coili430 – 485Sequence analysisAdd BLAST56
Coiled coili595 – 636Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi499 – 521Polar residuesSequence analysisAdd BLAST23
Compositional biasi649 – 663Polar residuesSequence analysisAdd BLAST15
Compositional biasi685 – 703Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the liprin family. Liprin-alpha subfamily.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00990000203651

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006923_0_0_1

Database of Orthologous Groups

More...
OrthoDBi
440941at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09562, SAM_liprin-alpha1_2_3_4_repeat1, 1 hit
cd09565, SAM_liprin-alpha1_2_3_4_repeat2, 1 hit
cd09568, SAM_liprin-alpha1_2_3_4_repeat3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029515, Liprin
IPR037620, Liprin-alpha_SAM_rpt_1
IPR037621, Liprin-alpha_SAM_rpt_2
IPR037622, Liprin-alpha_SAM_rpt_3
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR030442, Syd-2

The PANTHER Classification System

More...
PANTHERi
PTHR12587, PTHR12587, 2 hits
PTHR12587:SF20, PTHR12587:SF20, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00536, SAM_1, 1 hit
PF07647, SAM_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00454, SAM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105, SAM_DOMAIN, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

M9PC73-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWNMMCDVMP TISEDSISQR SSQFSGEDAN FEQLMVSMLD ERDKLMDSLR
60 70 80 90 100
EAQERLNETE NKLRDVEKER DSLQRQINAN LPQEFATLTK ELTQARETLL
110 120 130 140 150
ERDEEIGELK AERNNTRLLL EHLECLVSRH ERSLRMTVVK RQAAAQSGVS
160 170 180 190 200
SEVEVLKALK SLFEHHKALD EKVRERLRLS IEKNNMMEEE LSSAKEELAQ
210 220 230 240 250
YKAGVVPAGV GSGSGAGSAA TTAGGGGAEN GLKEKMAGVG GSGGVNGEAN
260 270 280 290 300
ELNDYAAKTH ELQTIIEKQT SELSQWQRRV SDLNNKISEL EENMSRVQKE
310 320 330 340 350
HCKAQDQCAK LQRDLRENVA QKEDQEERIT TLEKRYLNAQ RESTSLHDLN
360 370 380 390 400
EKLEQELRHK EAQLKAQERH GSAEDRIRGL ETNLDEKTNE VVRLNQRLKM
410 420 430 440 450
NEEHNLRLSS TVDKLLSESN ERLQVHLKER MHALDEKNAL TQELEKARKV
460 470 480 490 500
AEELHHEKSE IMKELSKTRL EIENFKRQLL QQEIAYNIQQ TEALTRSLSP
510 520 530 540 550
SSVVDPSGAF SRSNSHASFE THSLRRQSKQ RLSEENALVR SMAEQEWEKL
560 570 580 590 600
QQAAHAQQQA YELASAADCD DSDVLYAAAT DMMSPSGHTD AQTLAMMLQE
610 620 630 640 650
QLDAINNEIR LIQEEKQSTE ARAEELESRV GSLEHVNLLA RGRSMDRQSP
660 670 680 690 700
PMSGRSTPNS PQRDFMQKYH TLNLPVLSSD ASREELHGGM STTGDSSSGG
710 720 730 740 750
AASPLTARSM RLERVAQALA HSQEELRRRS IGLNPNASVA PNHTGGHMPL
760 770 780 790 800
SSHSYGLSPL SSRYGSQESL RHYNTMGSMS MLQTPTSGVS REAAAAAVQK
810 820 830 840 850
KKGIKSSLGR FFSKKEKVKG VKDTLPDGSP SMMSIGNLSI GLSEVDSNYD
860 870 880 890 900
AMSMTGGMMP RIASSQGSKI SSVDYGRQKK EHDYRNDLLG EAMKAGTPFA
910 920 930 940 950
LWNGPTIVAW LELWVGMPAW YVAACRANVK SGAIMSALSD TEIQREIGIS
960 970 980 990 1000
NPLHRLKLRL AIQEMVSLTS PSAPQTSRTT LAFGDMNHEW IGNYWLPGLG
1010 1020 1030 1040 1050
LPQYRTTFME CLVDARMLDH LTKKDLRGQL KMVDSFHRTS LQYGISMLKR
1060 1070 1080 1090 1100
LNYDRTELEH RRKMSENGLC DVLVWSNERV IRWVGSIGLK EYANNLLESG
1110 1120 1130 1140 1150
VHGGLMALDE GFDANAMGLA LQIPTQNAQA RQILDTEFNN LLQIATDRRP

ENEQRSAS
Length:1,158
Mass (Da):129,760
Last modified:June 26, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6A852FB15CDC268
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PCD4M9PCD4_DROME
Liprin-alpha, isoform E
Liprin-alpha DLiprin, DLiprin-alpha, Dliprin-alpha, Dmel\CG11199, LIP
1,214Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9VM93Q9VM93_DROME
LD33094p
Liprin-alpha DLiprin, DLiprin-alpha, Dliprin-alpha, Dmel\CG11199, LIP
1,201Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PCR7M9PCR7_DROME
Liprin-alpha, isoform D
Liprin-alpha DLiprin, DLiprin-alpha, Dliprin-alpha, Dmel\CG11199, LIP
1,205Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AGB92689.1

NCBI Reference Sequences

More...
RefSeqi
NP_001260153.1, NM_001273224.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0329941; FBpp0302973; FBgn0046704

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
249072

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG11199

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AGB92689.1
RefSeqiNP_001260153.1, NM_001273224.1

3D structure databases

SMRiM9PC73
ModBaseiSearch...

Proteomic databases

PRIDEiM9PC73

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
249072

Genome annotation databases

EnsemblMetazoaiFBtr0329941; FBpp0302973; FBgn0046704
GeneIDi249072
KEGGidme:Dmel_CG11199

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
249072
FlyBaseiFBgn0046704, Liprin-alpha
VEuPathDBiVectorBase:FBgn0046704

Phylogenomic databases

GeneTreeiENSGT00990000203651
HOGENOMiCLU_006923_0_0_1
OrthoDBi440941at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
249072, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
249072

Gene expression databases

BgeeiFBgn0046704, Expressed in cleaving embryo and 43 other tissues
ExpressionAtlasiM9PC73, baseline and differential

Family and domain databases

CDDicd09562, SAM_liprin-alpha1_2_3_4_repeat1, 1 hit
cd09565, SAM_liprin-alpha1_2_3_4_repeat2, 1 hit
cd09568, SAM_liprin-alpha1_2_3_4_repeat3, 1 hit
Gene3Di1.10.150.50, 3 hits
InterProiView protein in InterPro
IPR029515, Liprin
IPR037620, Liprin-alpha_SAM_rpt_1
IPR037621, Liprin-alpha_SAM_rpt_2
IPR037622, Liprin-alpha_SAM_rpt_3
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR030442, Syd-2
PANTHERiPTHR12587, PTHR12587, 2 hits
PTHR12587:SF20, PTHR12587:SF20, 2 hits
PfamiView protein in Pfam
PF00536, SAM_1, 1 hit
PF07647, SAM_2, 1 hit
SMARTiView protein in SMART
SM00454, SAM, 3 hits
SUPFAMiSSF47769, SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105, SAM_DOMAIN, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM9PC73_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M9PC73
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: September 29, 2021
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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