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Entry version 61 (12 Aug 2020)
Sequence version 1 (26 Jun 2013)
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Protein
Submitted name:

Dynein heavy chain 64C, isoform D

Gene

Dhc64C

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported, Motor proteinARBA annotation
LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dynein heavy chain 64C, isoform DImported (EC:3.6.1.3Imported, EC:3.6.4.5Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dhc64CImported
Synonyms:CDImported, CdhcImported, cDhcImported, cDhc64CImported, DHCImported, DhcImported, dhcImported, DHC1Imported, Dhc46CImported, Dhc64Imported, DHC64CImported, Dhc64cImported, dhc64CImported, dhc64cImported, Dmel\CG7507Imported, DYHCImported, DyneinImported, FCP-AImported, Fs(3)LabImported, Fs(3)LaborcImported, Fs(3)Sz18Imported, HMW MAPImported, l(3)64CaImported, LabImported, Su(Gl)77Imported
ORF Names:CG7507Imported, Dmel_CG7507Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0261797, Dhc64C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation, DyneinARBA annotation, MicrotubuleARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
M9PBQ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261797, Expressed in oocyte and 37 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
M9PBQ0, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
M9PBQ0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1903 – 2052AAAInterPro annotationAdd BLAST150
Domaini2215 – 2366AAAInterPro annotationAdd BLAST152
Domaini2585 – 2735AAAInterPro annotationAdd BLAST151
Domaini2927 – 3093AAAInterPro annotationAdd BLAST167

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili537 – 564Sequence analysisAdd BLAST28
Coiled coili772 – 792Sequence analysisAdd BLAST21
Coiled coili1283 – 1313Sequence analysisAdd BLAST31
Coiled coili3206 – 3251Sequence analysisAdd BLAST46
Coiled coili3400 – 3420Sequence analysisAdd BLAST21
Coiled coili3428 – 3483Sequence analysisAdd BLAST56

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156103

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013594, Dynein_heavy_dom-1
IPR013602, Dynein_heavy_dom-2
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08385, DHC_N1, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

M9PBQ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDSLENPDT SVDPIVNLSI ANYDAFANYL RKAVTILLPE DDVVPASLND
60 70 80 90 100
ALDDPVNQDT IRKFLSDPQV QALYVQRNCI KEDDSEQPAE GEDEKEQVTY
110 120 130 140 150
QISNDVHFTN SRMASLACIK RGLVVEADKS IHSQLRLINF SDGSPYETLH
160 170 180 190 200
AFISKSLAPY FKSYVKESGR ADRDGDKMAP SVEKKLAELE MGLLHLQQNI
210 220 230 240 250
DIPEITLTAH QTVNNVIRKC AEENRKAKVA DFGDKVEDSS FLNLLQNGVN
260 270 280 290 300
RWIAEIKKVT KLNRDPGSGT ALQEISFWLN LERALYRIQE KRESPEVALT
310 320 330 340 350
LDILKHGKRF HATVSFDTDT GLKQALATVA DYNPLMKDFP INDLLSATEL
360 370 380 390 400
EKIRPAVQQI FAHLRKVRNT KYPIQRCLKL IEAISRDLSQ QLLKVLGTRR
410 420 430 440 450
LMHIPFDEFE RVMNQCFEIF SCWDDEYDKL QGLLRDIVKK KRDEHLKMVW
460 470 480 490 500
RVSPAHKKLQ TRMEHMRKFR RQHEQLRTVI LRVLRPTKPA VGDDGNVVET
510 520 530 540 550
KQPYSLDAAD ANAIEEVNLA YENVKEVDCL DITKEGSEAW EAAVKRYEEK
560 570 580 590 600
IDRVETRITA HLRDQLGTAK NANEMFRIFS RFNALFVRPH IRGAIREYQT
610 620 630 640 650
QLIQRVKDDI EALHEKFKVQ YPQSKSCRLS SVRDLPPVAG SIIWARQIDN
660 670 680 690 700
QLTMYLKRVE DVLGKGWETH IEGQKLKADG DSFRAKLSIS DVFHEWARKV
710 720 730 740 750
QERNFGSTGR IFTIESTRSR IGRGNVLRLR VNFLPEIITL AKEVRNIKNL
760 770 780 790 800
GFRVPLTIVN KAHQANQIYP YAISLIESVR TYERTLEKLN NRSLAQNSVF
810 820 830 840 850
KIEDRASIVP LVAGLRKDVL NLVSEGIGLI WESYKLDPYV IRLSECVTQF
860 870 880 890 900
QEKVDDLLVV EEQLDVDVRS LETCPYSAAT FVEILSKIQH AVDDLSLRQY
910 920 930 940 950
SNLSVWVTRL DEEVEKKLAL RLQAGIQAWT EALTGNKKEV DTSMDTDAPA
960 970 980 990 1000
QPTHKLGGDP QIQNAVHEIR ITNQQMYLYP SIEEARFQIM QQFFAWQAIV
1010 1020 1030 1040 1050
TSQVRLQSTR YQVGLEKHVS QTYRNLLTKL PEGKILENAY GAIEQKVSEV
1060 1070 1080 1090 1100
RNYVDEWLRY QSLWDLQADM LYGRLGEDVN LWIKCLNDIK QSRTTFDTSD
1110 1120 1130 1140 1150
TRRAYGPIII DYAKVQAKVT LKYDSWHKEA LGKFGTLLGT EMTSFHSKVS
1160 1170 1180 1190 1200
KSRTDLEMQS IEAASTSDAV SFITYVQSLK KDMIAWDKQV EVFREAQRIL
1210 1220 1230 1240 1250
ERQRFQFPNT WLHVDNIEGE WSAFNEIIKR KDTAIQTQVA SLQAKIVAED
1260 1270 1280 1290 1300
KAVETRTVDF LNDWEKTKPT GGKIRPDDAL QQLQIFESKY SRLKEERDNV
1310 1320 1330 1340 1350
VKAKEALELQ ESAVPNNSAE RMNVALEELQ DLRGVWSELS KVWTQIDETR
1360 1370 1380 1390 1400
EKPWLSVQPR KLRQQLEAMM AQLKELPARL RMYESYEYVK KLIQSYIKVN
1410 1420 1430 1440 1450
MLIVELKSDA LKERHWKQLT KQLRVNWVLS DLSLGQVWDV NLQKNEGIVK
1460 1470 1480 1490 1500
DIILVAQGEM ALEEFLKQVR ESWQNYELDL INYQNKCRII RGWDDLFNKV
1510 1520 1530 1540 1550
KEHINSVAAM KLSPYYKVFE EEALTWEEKL NRINALFDVW IDVQRRWVYL
1560 1570 1580 1590 1600
EGIFSGSADI KTLLPVETSR FQSISSEFLG LMKKVTKSPK VMDVLNIPAV
1610 1620 1630 1640 1650
QRSLERLADL LGKIQKALGE YLERERTSFP RFYFVGDEDL LEIIGNSKNI
1660 1670 1680 1690 1700
ARLQKHFKKM FAGVAAILLN EENNVILGIS SREGEEVHFM NPVSTVEHPK
1710 1720 1730 1740 1750
INEWLSLVEK QMRFTLASLL AQAVQDIKQF RDGKIDPQAY MEWCDKYQAQ
1760 1770 1780 1790 1800
IVVLAAQILW SEDVESALQQ ASENNQSKPM QRVLGNVEST LNVLADSVLQ
1810 1820 1830 1840 1850
EQPPLRRRKL EHLINEFVHK RTVTRRLLNN GVTSPKSFQW LCEMRFYFDP
1860 1870 1880 1890 1900
RQTEVLQQLT IHMANARFFY GFEYLGVQDR LVQTPLTDRC YLTMTQALES
1910 1920 1930 1940 1950
RLGGSPFGPA GTGKTESVKA LGNQLGRFVL VFNCDETFDF QAMGRIFVGL
1960 1970 1980 1990 2000
CQVGAWGCFD EFNRLEERML SACSQQIQTI QEALKYEMDS NKESITVELV
2010 2020 2030 2040 2050
GKQVRVSPDM AIFITMNPGY AGRSNLPDNL KKLFRSLAMT TPDRQLIAEV
2060 2070 2080 2090 2100
MLFSQGFRSA EKLACKIVPF FKLCDEQLSN QSHYDFGLRA LKSVLISAGN
2110 2120 2130 2140 2150
VKRDRIMKIK EQMKQRGDEN IDEASVAENL PEQEILIQSV CETMVPKLVA
2160 2170 2180 2190 2200
EDIPLLFSLL SDVFPNVGYT RAEMKGLKEE IRKVCQEDYL VCGEGDEQGA
2210 2220 2230 2240 2250
AWMEKVLQLY QISNLNHGLM MVGPSGSGKS TAWKTLLKAL ERFEGVEGVA
2260 2270 2280 2290 2300
HVIDPKAISK EALYGVLDPN TREWTDGLFT HILRKIIDNV RGEINKRQWI
2310 2320 2330 2340 2350
IFDGDVDPEW VENLNSVLDD NKLLTLPNGE RLSLPPNVRV MFEVQDLKFA
2360 2370 2380 2390 2400
TLATVSRCGM VWFSEDVLST EMIFENYLSR LRSIPLEDGD EDFVGVIKPA
2410 2420 2430 2440 2450
KDKEEEVSPS LQVQRDIALL LLPFFSADGI VVRTLEYAMD QEHIMDFTRL
2460 2470 2480 2490 2500
RALSSLFSML NQAARNVLTF NAQHPDFPCS ADQLEHYIPK ALVYSVLWSF
2510 2520 2530 2540 2550
AGDAKLKVRI DLGDFVRSVT TVPLPGAAGA PIIDYEVNMS GDWVPWSNKV
2560 2570 2580 2590 2600
PVIEVETHKV ASPDIVVPTL DTVRHESLLY TWLAEHKPLV LCGPPGSGKT
2610 2620 2630 2640 2650
MTLFSALRAL PDMEVVGLNF SSATTPELLL KTFDHYCEYR KTPNGVVLSP
2660 2670 2680 2690 2700
VQIGKWLVLF CDEINLPDMD SYGTQRVISF LRQLVEHKGF YRASDQAWVS
2710 2720 2730 2740 2750
LERIQFVGAC NPPTDPGRKP LSHRFLRHVP IIYVDYPGET SLKQIYGTFS
2760 2770 2780 2790 2800
RAMLRLMPAL RGYAEPLTNA MVEFYLASQD RFTQDMQPHY VYSPREMTRW
2810 2820 2830 2840 2850
VRGICEAIRP LDSLPVEGLV RLWAHEALRL FQDRLVDDSE RRWTNENIDL
2860 2870 2880 2890 2900
VGQKHFPGIN QEEALQRPIL YSNWLSKDYM PVNREELREY VHARLKVFYE
2910 2920 2930 2940 2950
EELDVPLVLF DEVLDHVLRI DRIFRQPQGH LLLIGVSGAG KTTLSRFVAW
2960 2970 2980 2990 3000
MNGLSIFQIK VHNKYTSEDF DEDLRCVLRR SGCKDEKIAF ILDESNVLDS
3010 3020 3030 3040 3050
GFLERMNTLL ANGEVPGLFE GDEYTTLMTQ CKEGAQREGL MLDSSDELYK
3060 3070 3080 3090 3100
WFTQQVMRNL HVVFTMNPST DGLKDRAATS PALFNRCVLN WFGDWSDSAL
3110 3120 3130 3140 3150
FQVGKEFTTR VDLEKPNWHA PDFFPSVCPL VPANPTHRDA VINSCVYVHQ
3160 3170 3180 3190 3200
TLHQANARLA KRGGRTMAVT PRHYLDFIHH FVKLYNEKRS DLEEQQLHLN
3210 3220 3230 3240 3250
VGLNKIAETV EQVEEMQKSL AVKKQELQAK NEAANAKLKQ MFQDQQEAEK
3260 3270 3280 3290 3300
KKIQSQEIQI RLADQTVKIE EKRKYVMADL AQVEPAVIDA QAAVSSIKKK
3310 3320 3330 3340 3350
HLAEVRSMAN PPAVVKLALE SVCELLNESA TDWKAIRGIL VKDSFISSIV
3360 3370 3380 3390 3400
NLETDKITDD VREKMKSKYL SNPDYNFEKV NRASMACGPM VKWAIAQIEY
3410 3420 3430 3440 3450
ADMLKRVEPL REELRSLEEQ ADVNLASAKE TKDLVEQLER SIAAYKEEYA
3460 3470 3480 3490 3500
QLISQAQAIK TDLENVQAKV DRSIALLKSL NIERERWEST SETFKSQMST
3510 3520 3530 3540 3550
IIGDVLLSAA FIAYGGYFDQ HYRLNLFTTW SQHLQAASIQ YRADIARTEY
3560 3570 3580 3590 3600
LSNPDERLRW QANALPTDDL CTENAIMLKR FNRYPLIIDP SGQATTFLLN
3610 3620 3630 3640 3650
EYAGKKITKT SFLDDSFRKN LESALRFGNP LLVQDVENYD PILNPVLNRE
3660 3670 3680 3690 3700
LRRTGGRVLI TLGDQDIDLS PSFVIFLSTR DPTVEFPPDI CSRVTFVNFT
3710 3720 3730 3740 3750
VTRSSLQSQC LNQVLKAERP DIDEKRSDLL KLQGEFRLRL RQLEKSLLQA
3760 3770 3780 3790 3800
LNDAKGKILD DDSVITTLET LKKEAYDINQ KVDETDKVIA EIETVSQQYL
3810 3820 3830 3840 3850
PLSVACSNIY FTMDSLNQVH FLYQYSLKMF LDIFSTVLYN NPKLEGRTDH
3860 3870 3880 3890 3900
SERLGIVTRD LFQVCYERVA RGMIHIDRLT FALLMCKIHL KGTSESNLDA
3910 3920 3930 3940 3950
EFNFFLRSRE GLLANPTPVE GLSAEQIESV NRLALRLPIF RKLLEKVRSI
3960 3970 3980 3990 4000
PELGAWLQQS SPEQVVPQLW DESKALSPIA SSVHQLLLIQ AFRPDRVIAA
4010 4020 4030 4040 4050
AHNVVNTVLG EDFMPNAEQE LDFTSVVDKQ LNCNTPALLC SVPGFDASGR
4060 4070 4080 4090 4100
VDDLAAEQNK QISSIAIGSA EGFNQAERAI NMACKTGRWV LLKNVHLAPQ
4110 4120 4130 4140 4150
WLVQLEKKMH SLQPHSGFRL FLTMEINPKV PVNLLRAGRI FVFEPPPGIR
4160 4170 4180 4190 4200
ANLLRTFSTV PAARMMKTPS ERARLYFLLA WFHAIVQERL RYVPLGWAKK
4210 4220 4230 4240 4250
YEFNESDLRV ACDTLDTWID TTAMGRTNLP PEKVPWDALV TLLSQSIYGG
4260 4270 4280 4290 4300
KIDNDFDQRL LTSFLKKLFT ARSFEADFAL VANVDGASGG LRHITMPDGT
4310 4320 4330 4340 4350
RRDHFLKWIE NLTDRQTPSW LGLPNNAEKV LLTTRGTDLV SKLLKMQQLE
4360 4370 4380 4390 4400
DDDELAYSVE DQSEQSAVGR GEDGRPSWMK TLHNSATAWL ELLPKNLQVL
4410 4420 4430 4440 4450
KRTVENIKDP LYRYFEREVT SGSRLLQTVI LDLQDVVLIC QGEKKQTNHH
4460 4470 4480 4490 4500
RSMLSELVRG IIPKGWKRYT VPAGCTVIQW ITDFSNRVQQ LQKVSQLVSQ
4510 4520 4530 4540 4550
AGAKELQGFP VWLGGLLNPE AYITATRQCV AQANSWSLEE LALDVTITDA
4560 4570 4580 4590 4600
GLKNDQKDCC FGVTGLKLQG AQCKNNELLL ASTIMMDLPV TILKWIKISS
4610 4620 4630 4640 4650
EPRISKLTLP VYLNSTRTEL LFTVDLAVAA GQESHSFYER GVAVLTSTAL

N
Length:4,651
Mass (Da):531,378
Last modified:June 26, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA984D1A7A755178B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P37276DYHC_DROME
Dynein heavy chain, cytoplasmic
Dhc64C cDhc, CG7507
4,639Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PBQ3M9PBQ3_DROME
Dynein heavy chain 64C, isoform I
Dhc64C CD, Cdhc, cDhc, cDhc64C, DHC
4,661Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PE73M9PE73_DROME
Dynein heavy chain 64C, isoform E
Dhc64C CD, Cdhc, cDhc, cDhc64C, DHC
4,647Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PEC8M9PEC8_DROME
Dynein heavy chain 64C, isoform G
Dhc64C CD, Cdhc, cDhc, cDhc64C, DHC
4,648Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PHG8M9PHG8_DROME
Dynein heavy chain 64C, isoform H
Dhc64C CD, Cdhc, cDhc, cDhc64C, DHC
4,660Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PEN4M9PEN4_DROME
Dynein heavy chain 64C, isoform F
Dhc64C CD, Cdhc, cDhc, cDhc64C, DHC
4,652Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AGB94122.1

NCBI Reference Sequences

More...
RefSeqi
NP_001261427.1, NM_001274498.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0332745; FBpp0304986; FBgn0261797

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
38580

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AGB94122.1
RefSeqiNP_001261427.1, NM_001274498.1

3D structure databases

SMRiM9PBQ0
ModBaseiSearch...

Proteomic databases

PRIDEiM9PBQ0

Genome annotation databases

EnsemblMetazoaiFBtr0332745; FBpp0304986; FBgn0261797
GeneIDi38580

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
38580
FlyBaseiFBgn0261797, Dhc64C

Phylogenomic databases

GeneTreeiENSGT00940000156103

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
38580, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
38580

Gene expression databases

BgeeiFBgn0261797, Expressed in oocyte and 37 other tissues
ExpressionAtlasiM9PBQ0, baseline and differential

Family and domain databases

Gene3Di1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013594, Dynein_heavy_dom-1
IPR013602, Dynein_heavy_dom-2
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08385, DHC_N1, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 4 hits
SUPFAMiSSF52540, SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM9PBQ0_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M9PBQ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: August 12, 2020
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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