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UniProtKB - M9PBH0 (M9PBH0_DROME)
Protein
Submitted name:
Klarsicht, isoform F
Gene
klar
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- kinesin binding Source: FlyBase
GO - Biological processi
- compound eye morphogenesis Source: FlyBase
- compound eye photoreceptor development Source: FlyBase
- flight Source: FlyBase
- larval visceral muscle development Source: FlyBase
- lipid droplet transport along microtubule Source: FlyBase
- lipid transport Source: FlyBase
- locomotion Source: FlyBase
- lumen formation, open tracheal system Source: FlyBase
- membrane organization Source: FlyBase
- microtubule anchoring Source: FlyBase
- negative regulation of pole plasm oskar mRNA localization Source: FlyBase
- nuclear migration Source: FlyBase
- nucleus localization Source: FlyBase
- nucleus organization Source: FlyBase
- regulation of intracellular transport Source: FlyBase
- tube morphogenesis Source: FlyBase
Names & Taxonomyi
Protein namesi | Submitted name: Klarsicht, isoform FImported |
Gene namesi | ORF Names:CG17046Imported, Dmel_CG17046Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0001316, klar |
VEuPathDBi | VectorBase:FBgn0001316 |
Subcellular locationi
Nucleus
- nuclear envelope Source: FlyBase
- nuclear outer membrane Source: FlyBase
Other locations
- cytoplasm Source: FlyBase
- integral component of membrane Source: UniProtKB-UniRule
- perinuclear region of cytoplasm Source: FlyBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 1589 | CytoplasmicPROSITE-ProRule annotationAdd BLAST | 1589 | |
Topological domaini | 1611 – 1636 | Perinuclear spacePROSITE-ProRule annotationAdd BLAST | 26 |
Keywords - Cellular componenti
Membrane, NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | FBgn0001316, Expressed in wing disc (Drosophila) and 40 other tissues |
ExpressionAtlasi | M9PBH0, baseline and differential |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1581 – 1636 | KASHInterPro annotationAdd BLAST | 56 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 46 – 67 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 174 – 205 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 234 – 272 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 374 – 405 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 490 – 531 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 620 – 690 | DisorderedSequence analysisAdd BLAST | 71 | |
Regioni | 909 – 936 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 968 – 1044 | DisorderedSequence analysisAdd BLAST | 77 | |
Regioni | 1466 – 1579 | DisorderedSequence analysisAdd BLAST | 114 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1119 – 1139 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1183 – 1216 | Sequence analysisAdd BLAST | 34 | |
Coiled coili | 1434 – 1461 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 174 – 196 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 382 – 405 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 640 – 656 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 660 – 675 | Basic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 917 – 936 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 987 – 1011 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 1030 – 1044 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1466 – 1485 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1526 – 1541 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the nesprin family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixARBA annotationFamily and domain databases
InterProi | View protein in InterPro IPR039906, Anc-1-like IPR012315, KASH |
PANTHERi | PTHR21524, PTHR21524, 2 hits |
Pfami | View protein in Pfam PF10541, KASH, 1 hit |
SMARTi | View protein in SMART SM01249, KASH, 1 hit |
PROSITEi | View protein in PROSITE PS51049, KASH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
M9PBH0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPQSSNSNIS SSNSLLQQRN HNIGNKMLPN KAHGKNIAVA VITPNSHGNT
60 70 80 90 100
SHGHGLGHGL GHELNKSPLG LRKTRHHHND TSKFNRSNRK SKNCAIFYFK
110 120 130 140 150
HLDTDNEQGN AAGSDLQSED DPSLIHRRRA GGDILKSADA STDDDDEGWL
160 170 180 190 200
YTATAAATLE VATAATAAPT AAAATSSVDG LQSTAVSSTT ATGGPLPPSD
210 220 230 240 250
DSDKENKVAL VSATTITAAA TATATSIATL HSSNYDSSSA CSSSNSNSNS
260 270 280 290 300
NSNSNGRLTE TSATSRVTQL QMQIHSQSQS QSQMELQING NAIDGRHIIS
310 320 330 340 350
NNNCYSSMQH QPQNNNEGEA AEDLAKIKMG DDEAAADMAN GNATKSQQMS
360 370 380 390 400
NGVYSRADSC NFTVWAAETV ASCHLPPRSP AKSAKSSKSQ ASNATVSGST
410 420 430 440 450
LVSPVKGKVS HDSIKQLVLE AEHLVRDAQE TALKTPTKQK HSIIKISSTV
460 470 480 490 500
KKREVTMPHP IKQRVEEWLE HQPSTPQLLT RSHTHELLPS CKPDDCEASG
510 520 530 540 550
EASETDSVPQ AGAGVNGGAP NGAGSDTSEG FTDSIATCMQ TSTNSYGNST
560 570 580 590 600
ERIGGSAEPI GQPVTPLGFG SSNQSLNVKI VKRSQTRRKS ERPWSVSCLS
610 620 630 640 650
QLTTDAAQLT TARIVENSPS GLASHSISES ALDSLSPGPR PRAASSSGTG
660 670 680 690 700
SNAAKKADSK GSLRRRKARK KRISAASAGR KSDSGSELGG DLTQTLMKSC
710 720 730 740 750
ESMSSQQLQE FTNALLSIQK GAVVAPLSPK GDVSGVPSLA DGEGGETQLM
760 770 780 790 800
LPKFRVGSFT TAGLLATDTR LGALAALSNY MNEDEQQAEL STEDHHSSIS
810 820 830 840 850
ETAWDNYQEK YNSENYSEGF DSDAARRLLE FGDDYRNFID SQSDCCSSLS
860 870 880 890 900
AANNLDSFSP PRMDSLQKHE LKTLHINQDT ITSTVDHARR QRALELQYER
910 920 930 940 950
RRKTLEVRRK SCQDMDESLM ASPQSDQQQQ QLQVTPSLSA SATALMTTPK
960 970 980 990 1000
IQSTSHQISH RAESVGRKLD FGGMSHSAQS LLRRTSESDT STRRRRTVTA
1010 1020 1030 1040 1050
DERRRSSRNL EKCIKLIPAT TSSSSGSDSE DGEQEMRSLL QQSRDRLDDT
1060 1070 1080 1090 1100
RALKIRCHLL RPEDYNEIIN TCRDNIRCLE AVLRGPPGTV LSNHCAGQTK
1110 1120 1130 1140 1150
DLLGAWEDLL SWSENASAAR KLQQEMSVLK SSLQRLGDKP TPELLDTEPA
1160 1170 1180 1190 1200
IQIAVEALKL EQTQLTSYRT NMLRLNASVH SWLTKQERRL QSALEEQEQQ
1210 1220 1230 1240 1250
QESEQLKQQK LVEEEKGADV QKELASTGAV AITVTDSNGN QVEALATGEA
1260 1270 1280 1290 1300
STSTPAWDVH TLMSSEQEFH KHLKNEVSDM YSSWDEADAR INTQLEMLTN
1310 1320 1330 1340 1350
SLIAWRQLES GLSEFQLALG QDRGTLKGLE GALDKGQATP VELAQNVKLV
1360 1370 1380 1390 1400
AKLLSEKVHV SQEQLLAVQQ HLDPNHIYHI TKFTASNGSL SDSGISDGGA
1410 1420 1430 1440 1450
TSDGGLSERE RRLGVLRRLA KQLELALAPG SEAMRSIAAR MESAEADLKH
1460 1470 1480 1490 1500
LQNTCRDLIV RTAASHQQKQ QIQQNQTQQV SPKANGHIKK QAAKGKAEPQ
1510 1520 1530 1540 1550
SPGRRGKGAR KARQAKKAGE DQQVEEPSLS PEQQKMVLKQ LKTLTSGDGG
1560 1570 1580 1590 1600
DDPSDDPSLL FNLESSEEDG EGADPAQTSK RGWAWRIARA AVPMQVALFT
1610 1620 1630
IFCAACLMQP NCCDNLNNLS MSFTPQLRYI RGPPPI
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9Y0E4 | KLAR_DROME | Klarsicht protein | klar CG17046 | 2,262 | Annotation score: | ||
A8JNH1 | A8JNH1_DROME | GM19713p | klar Dmel\CG17046, Klar, klar-RC, kls, marb | 567 | Annotation score: | ||
Q9W0Q4 | Q9W0Q4_DROME | Klarsicht, isoform A | klar Dmel\CG17046, Klar, kls, marb, CG17046 | 2,262 | Annotation score: | ||
M9PGK7 | M9PGK7_DROME | Klarsicht, isoform E | klar Dmel\CG17046, Klar, kls, marb, CG17046 | 2,272 | Annotation score: | ||
X2JAH4 | X2JAH4_DROME | Klarsicht, isoform I | klar Dmel\CG17046, Klar, kls, marb, CG17046 | 511 | Annotation score: | ||
Q7YU15 | Q7YU15_DROME | Klarsicht, isoform B | klar Dmel\CG17046, Klar, kls, marb, CG17046 | 2,045 | Annotation score: | ||
M9PDJ0 | M9PDJ0_DROME | Klarsicht, isoform G | klar Dmel\CG17046, Klar, kls, marb, CG17046 | 1,180 | Annotation score: | ||
A8JNH2 | A8JNH2_DROME | Klarsicht, isoform D | klar Dmel\CG17046, Klar, kls, marb, CG17046 | 1,823 | Annotation score: | ||
X2J8G9 | X2J8G9_DROME | Klarsicht, isoform H | klar Dmel\CG17046, Klar, kls, marb, CG17046 | 1,197 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AGB93907.1 |
RefSeqi | NP_001261212.1, NM_001274283.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0333851; FBpp0305984; FBgn0001316 |
GeneIDi | 38067 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AGB93907.1 |
RefSeqi | NP_001261212.1, NM_001274283.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
DNASUi | 38067 |
Genome annotation databases
EnsemblMetazoai | FBtr0333851; FBpp0305984; FBgn0001316 |
GeneIDi | 38067 |
Organism-specific databases
CTDi | 38067 |
FlyBasei | FBgn0001316, klar |
VEuPathDBi | VectorBase:FBgn0001316 |
Miscellaneous databases
BioGRID-ORCSi | 38067, 0 hits in 1 CRISPR screen |
ChiTaRSi | klar, fly |
GenomeRNAii | 38067 |
Gene expression databases
Bgeei | FBgn0001316, Expressed in wing disc (Drosophila) and 40 other tissues |
ExpressionAtlasi | M9PBH0, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR039906, Anc-1-like IPR012315, KASH |
PANTHERi | PTHR21524, PTHR21524, 2 hits |
Pfami | View protein in Pfam PF10541, KASH, 1 hit |
SMARTi | View protein in SMART SM01249, KASH, 1 hit |
PROSITEi | View protein in PROSITE PS51049, KASH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | M9PBH0_DROME | |
Accessioni | M9PBH0Primary (citable) accession number: M9PBH0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 26, 2013 |
Last sequence update: | June 26, 2013 | |
Last modified: | January 19, 2022 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |