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Entry version 57 (26 Feb 2020)
Sequence version 1 (26 Jun 2013)
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Protein
Submitted name:

Cacophony, isoform N

Gene

cac

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cacophony, isoform NImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cacImported
Synonyms:13Imported, alpha1AImported, Ca-alpha1AImported, Ca[[V]]2.1Imported, CACImported, CacImported, Cac1Imported, cac1Imported, CG1522Imported, CG15928Imported, dCac1Imported, DMCA1AImported, Dmca1AImported, Dmcalpha1AImported, Dmel\CG43368Imported, EE171Imported, H18Imported, H47Imported, l(1)11AaImported, l(1)13Imported, l(1)L13Imported, L13Imported, ldgImported, nbAImported, nonBImported, opm18Imported, opm47Imported, P18Imported
ORF Names:CG43368Imported, Dmel_CG43368Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0263111 cac

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei145 – 164HelicalSequence analysisAdd BLAST20
Transmembranei184 – 205HelicalSequence analysisAdd BLAST22
Transmembranei217 – 234HelicalSequence analysisAdd BLAST18
Transmembranei275 – 297HelicalSequence analysisAdd BLAST23
Transmembranei363 – 384HelicalSequence analysisAdd BLAST22
Transmembranei396 – 418HelicalSequence analysisAdd BLAST23
Transmembranei548 – 566HelicalSequence analysisAdd BLAST19
Transmembranei578 – 596HelicalSequence analysisAdd BLAST19
Transmembranei673 – 695HelicalSequence analysisAdd BLAST23
Transmembranei749 – 773HelicalSequence analysisAdd BLAST25
Transmembranei874 – 893HelicalSequence analysisAdd BLAST20
Transmembranei913 – 934HelicalSequence analysisAdd BLAST22
Transmembranei943 – 961HelicalSequence analysisAdd BLAST19
Transmembranei1010 – 1032HelicalSequence analysisAdd BLAST23
Transmembranei1124 – 1149HelicalSequence analysisAdd BLAST26
Transmembranei1205 – 1223HelicalSequence analysisAdd BLAST19
Transmembranei1235 – 1253HelicalSequence analysisAdd BLAST19
Transmembranei1326 – 1344HelicalSequence analysisAdd BLAST19
Transmembranei1415 – 1440HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0263111 Expressed in head and 15 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
M9NGZ9 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1456 – 1491EF-handInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni86 – 124DisorderedSequence analysisAdd BLAST39
Regioni487 – 523DisorderedSequence analysisAdd BLAST37
Regioni816 – 847DisorderedSequence analysisAdd BLAST32
Regioni1616 – 1675DisorderedSequence analysisAdd BLAST60
Regioni1691 – 1756DisorderedSequence analysisAdd BLAST66
Regioni1788 – 1867DisorderedSequence analysisAdd BLAST80
Regioni1929 – 1954DisorderedSequence analysisAdd BLAST26

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1884 – 1904Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi98 – 112PolyampholyteSequence analysisAdd BLAST15
Compositional biasi825 – 845PolyampholyteSequence analysisAdd BLAST21
Compositional biasi1704 – 1754PolarSequence analysisAdd BLAST51
Compositional biasi1799 – 1829PolarSequence analysisAdd BLAST31
Compositional biasi1833 – 1867PolyampholyteSequence analysisAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INF8 Eukaryota
COG1226 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170242

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000540_0_2_1

Database for complete collections of gene phylogenies

More...
PhylomeDBi
M9NGZ9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002048 EF_hand_dom
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167 CACHANNEL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01062 Ca_chan_IQ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

M9NGZ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGGVGARRR RGSSPMARLT ISNINGLDDN IAIIGDGVIR RSTHYGSQGS
60 70 80 90 100
NKRRRAPESF ALVQTRPNLG DLMLEAAQEV VQAEHQQDSL GGGHLGRKGA
110 120 130 140 150
HRLADRMGGP KKEENPPGGG PTSLFILTED NPIRKYTRFI IEWPPFEYAV
160 170 180 190 200
LLTIIANCVV LALEEHLPGG DKTVLAQKLE KTEAYFLCIF CVEASLKILA
210 220 230 240 250
LGLVLHKHSY LRNIWNIMDF FVVVTGFMTQ YPQIGPEVDL RTLRAIRVLR
260 270 280 290 300
PLKLVSGIPS LQVVLKSIIK AMAPLLQIGL LVLFAIVIFA IIGLEFYSGA
310 320 330 340 350
LHKTCYSLED PNKLVKEGES ETPCNTDNIL EKATGSFVCN NTTSMCLEKW
360 370 380 390 400
EGPNSGITSF DNIGFAMLTV FQCITMEGWT AILYWTNDAL GSAFNWIYFV
410 420 430 440 450
PLIVIGSFFM LNLVLGVLSG EFSNERNRVE RRMEFQKCRF RAMFQTAMVS
460 470 480 490 500
YLDWITQAEE VILAEERTTE EEKMHIMEAR RRNAAKRKKL KSLGKSKSTD
510 520 530 540 550
TEEEEAEEDY GDDGYLKTRS KPQGSCTGFW RAEKRFRFWI RHTVKTQWFY
560 570 580 590 600
WFVIVLVFLN TVCVAVEHYG QPSFLTEFLY YAEFIFLGLF MSEMFIKMYA
610 620 630 640 650
LGPRIYFESS FNRFDCVVIS GSIFEVIWSE VKGGSFGLSV LRALRLLRIF
660 670 680 690 700
KVTKYWSSLR NLVISLLNSM RSIISLLFLL FLFILIFALL GMQLFGGQFN
710 720 730 740 750
LPGGTPETNF NTFPIALLTV FQILTGEDWN EVMYQGIISQ GGAQKGMIYS
760 770 780 790 800
IYFIVLVLFG NYTLLNVFLA IAVDNLANAQ ELTAAEEEQV EEDKEKQLQE
810 820 830 840 850
LEKEMEALQA DGVHVENGDG AVAPSKSKGK KKEEEKKEEE EVTEGPKPML
860 870 880 890 900
PYSSMFILSP TNPIRRGAHW VVNLPYFDFF IMVVISMSSI ALAAEDPVRE
910 920 930 940 950
NSRRNKILNY FDYAFTGVFT IEMLLKIVDL GVILHPGSYL REFWNIMDAV
960 970 980 990 1000
VVICAAVSFG FDMSGSSAGQ NLSTIKSLRV LRVLRPLKTI KRVPKLKAVF
1010 1020 1030 1040 1050
DCVVNSLKNV VNILIVYILF QFIFSVIGVQ LFNGKFFYCT DESKHTSAEC
1060 1070 1080 1090 1100
QGSYFKYEED ELLPKQELRV WKPRAFHYDN VAAAMLTLFA VQTGEGWPQV
1110 1120 1130 1140 1150
LQHSMAATYE DRGPIQNFRI EMSIFYIVYF IVFPFFFVNI FVALIIITFQ
1160 1170 1180 1190 1200
EQGEAELQDG EIDKNQKSCI DFTIGARPLE RYMPKNRNTF KYKVWRIVVS
1210 1220 1230 1240 1250
TPFEYFIMML IVFNTLLLMM KYHNQGDMYE KSLKYINMGF TGMFSVETVL
1260 1270 1280 1290 1300
KIIGFGVKNF FKDPWNIFDL ITVLGSIVDA LWMEFGSNSI NVGFLRLFRA
1310 1320 1330 1340 1350
ARLIKLLRQG YTIRILLWTF VQSFKALPYV CLLIAMLFFI YAIIGMQVFG
1360 1370 1380 1390 1400
NIKLGTVENS ITRHNNFQSF IQGVMLLFRC ATGEAWPNIM LACLKGKACD
1410 1420 1430 1440 1450
DDAEKAPGEY CGSTLAYAYF VSFIFFCSFL MLNLFVAVIM DNFDYLTRDS
1460 1470 1480 1490 1500
SILGAHHLDE FVRIWAEYDP NATGKIHYTE MYDMLKNMDP PLGFGNKCPN
1510 1520 1530 1540 1550
RLAYKKLIRM NMPLDDELRV QFTTTLFALI RENLSIKMRA PEEMDQADME
1560 1570 1580 1590 1600
LRETITNIWP LQAKKMLNLL VPPSDQLNKG KLSVGKIYAG FLILESWRST
1610 1620 1630 1640 1650
RFGQLDSGMP MLELQDASRH PSQESLTGAD AGHLHPGHSY MNGHRRSPSL
1660 1670 1680 1690 1700
RHNGSPLARS PSPRRRGHQY IHHDIGFSDT VSNVVEMVKE TRHPRHGNSH
1710 1720 1730 1740 1750
PRYPRGSWSA STSPARSPSP SRYGGHLSRS KRTQLPYPTY GTTSLCQRSR
1760 1770 1780 1790 1800
SPSPARLQEM RERDRLGYGI DMGVTHVQHS YPTLASRRAG IGRRLPPTPS
1810 1820 1830 1840 1850
KPSTLQLKPT NINFPKLNAS PTHTHHSTPH SVHSLPHHRD LLRDPRDMYY
1860 1870 1880 1890 1900
SSRERERDRE RLRDRDRDRD RDRLHEYDLR YEYRDREREL YERERDRERE
1910 1920 1930 1940 1950
VERERLEYIA PLSFEQALAM GRTGRVLPSP VLNGFKPKSG LNPRHSDSDE

EDWC
Length:1,954
Mass (Da):223,509
Last modified:June 26, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCEA2FBB47A065F4F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P91645CAC1A_DROME
Voltage-dependent calcium channel t...
cac nbA, nonB, CG43368
1,851Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q59E50Q59E50_DROME
Voltage-dependent L-type calcium ch...
cac 13, alpha1A, Ca-alpha1A, Ca[[V]]2.1, CAC
1,850Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q59E51Q59E51_DROME
Voltage-dependent L-type calcium ch...
cac 13, alpha1A, Ca-alpha1A, Ca[[V]]2.1, CAC
1,849Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q59E52Q59E52_DROME
Cacophony, isoform I
cac 13, alpha1A, Ca-alpha1A, Ca[[V]]2.1, CAC
1,850Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NDV1M9NDV1_DROME
Cacophony, isoform O
cac 13, alpha1A, Ca-alpha1A, Ca[[V]]2.1, CAC
1,851Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q59E53Q59E53_DROME
Cacophony, isoform H
cac 13, alpha1A, Ca-alpha1A, Ca[[V]]2.1, CAC
1,849Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NF25M9NF25_DROME
Cacophony, isoform M
cac 13, alpha1A, Ca-alpha1A, Ca[[V]]2.1, CAC
1,783Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PHD4M9PHD4_DROME
Cacophony, isoform P
cac 13, alpha1A, Ca-alpha1A, Ca[[V]]2.1, CAC
1,869Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NEE2M9NEE2_DROME
Cacophony, isoform L
cac 13, alpha1A, Ca-alpha1A, Ca[[V]]2.1, CAC
1,926Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A4D6K1U1A0A4D6K1U1_DROME
Cacophony, isoform S
cac 13, alpha1A, Ca-alpha1A, Ca[[V]]2.1, CAC
1,852Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AFH07352.1

NCBI Reference Sequences

More...
RefSeqi
NP_001245638.1, NM_001258709.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0307325; FBpp0298326; FBgn0263111

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32158

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AFH07352.1
RefSeqiNP_001245638.1, NM_001258709.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiFBtr0307325; FBpp0298326; FBgn0263111
GeneIDi32158

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
12285
FlyBaseiFBgn0263111 cac

Phylogenomic databases

eggNOGiENOG410INF8 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00940000170242
HOGENOMiCLU_000540_0_2_1
PhylomeDBiM9NGZ9

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
32158

Gene expression databases

BgeeiFBgn0263111 Expressed in head and 15 other tissues
ExpressionAtlasiM9NGZ9 baseline and differential

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR002048 EF_hand_dom
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM9NGZ9_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M9NGZ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: February 26, 2020
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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