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Protein
Submitted name:

Hyperkinetic, isoform I

Gene

Hk

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

  • potassium channel regulator activity Source: FlyBase
  • voltage-gated potassium channel activity Source: FlyBase

GO - Biological processi

  • circadian sleep/wake cycle, sleep Source: FlyBase
  • positive regulation of circadian sleep/wake cycle, sleep Source: FlyBase
  • potassium ion transport Source: FlyBase
  • protein complex oligomerization Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-1296072 Voltage gated Potassium channels
R-DME-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Submitted name:
Hyperkinetic, isoform IImported
Gene namesi
Name:HkImported
Synonyms:CG17779Imported, CG2287Imported, CG32688Imported, CG34319Imported, CG43388Imported, Dm_X:51771Imported, Dmel\CG43388Imported, hkImported, lincRNA.975Imported
ORF Names:CG43388Imported, Dmel_CG43388Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0263220 Hk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiM9NGY7

Expressioni

Gene expression databases

BgeeiFBgn0263220 Expressed in 16 organ(s), highest expression level in head
ExpressionAtlasiM9NGY7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliM9NGY7
SMRiM9NGY7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 377Aldo_ket_redInterPro annotationAdd BLAST316

Phylogenomic databases

eggNOGiKOG1575 Eukaryota
COG0667 LUCA
GeneTreeiENSGT00550000074567
OMAiQMALAWT
OrthoDBiEOG091G0KDN

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR005983 K_chnl_volt-dep_bsu_KCNAB
IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PRINTSiPR01577 KCNABCHANNEL
SUPFAMiSSF51430 SSF51430, 1 hit
TIGRFAMsiTIGR01293 Kv_beta, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.iShow all

M9NGY7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCRAPIASLD CMEEFSGTGG HLDFGRSISL GSNPALPLRH GSTPTPGLRY
60 70 80 90 100
KNLGKSGLRI SNVGLGTWPV FSPGVSDDQA EAILKLAIES GINLFDISEA
110 120 130 140 150
HSETEIGKIL QRAGWKRTAY VITTKVYWST KSEERGLSRK HIIECVRASL
160 170 180 190 200
QRLQLQYIDI VIIHKADPMC PMEEVVRAMS YVIQQGWAMY WGTARWSQVE
210 220 230 240 250
IMEAYTNCRQ FNCITPIVEQ SEYHMFCREK CELYLPEMYN KIGVGLMAWG
260 270 280 290 300
PLSMALSDTQ NGDKLFLPKG SFKTKSFSWT EDEINRNAAL SPQGSWGKDR
310 320 330 340 350
IDEGRRHCDR LRDLAALAEK LGCSPTQLSI AWSLKHEPVQ CLLLGATSAE
360 370 380 390
QLHQSLQSLQ LLPRLSSSVM LELERILENK PVRPPMISTL ALR
Length:393
Mass (Da):44,089
Last modified:June 26, 2013 - v1
Checksum:iB44C08D6BD9C1A7F
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9NEC7M9NEC7_DROME
Hyperkinetic, isoform F
Hk CG17779, CG2287, CG32688, CG34319, CG43388 Hk CG17779, CG2287, CG32688, CG34319, CG43388, Dm_X:51771, Dmel\CG43388, hk, lincRNA.975, CG43388, Dmel_CG43388
698Annotation score:
Q9W2X0Q9W2X0_DROME
Hyperkinetic, isoform E
Hk CG17779, CG2287, CG32688, CG34319, CG43388 Hk CG17779, CG2287, CG32688, CG34319, CG43388, Dm_X:51771, Dmel\CG43388, hk, lincRNA.975, CG43388, Dmel_CG43388
547Annotation score:
M9PHI0M9PHI0_DROME
Hyperkinetic, isoform M
Hk CG17779, CG2287, CG32688, CG34319, CG43388 Hk CG17779, CG2287, CG32688, CG34319, CG43388, Dm_X:51771, Dmel\CG43388, hk, lincRNA.975, CG43388, Dmel_CG43388
887Annotation score:
M9PGS8M9PGS8_DROME
Hyperkinetic, isoform L
Hk CG17779, CG2287, CG32688, CG34319, CG43388 Hk CG17779, CG2287, CG32688, CG34319, CG43388, Dm_X:51771, Dmel\CG43388, hk, lincRNA.975, CG43388, Dmel_CG43388
596Annotation score:
M9NF11M9NF11_DROME
Hyperkinetic, isoform H
Hk CG17779, CG2287, CG32688, CG34319, CG43388 Hk CG17779, CG2287, CG32688, CG34319, CG43388, Dm_X:51771, Dmel\CG43388, hk, lincRNA.975, CG43388, Dmel_CG43388
374Annotation score:
M9PE66M9PE66_DROME
Hyperkinetic, isoform K
Hk CG17779, CG2287, CG32688, CG34319, CG43388 Hk CG17779, CG2287, CG32688, CG34319, CG43388, Dm_X:51771, Dmel\CG43388, hk, lincRNA.975, CG43388, Dmel_CG43388
548Annotation score:
Q9W2W9Q9W2W9_DROME
HL08167p
Hk CG17779, CG2287, CG32688, CG34319, Dm_X:51771 Hk CG17779, CG2287, CG32688, CG34319, Dm_X:51771, Dmel\CG43388, hk, lincRNA.975, CG43388, Dmel_CG43388
392Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AFH07326.1
RefSeqiNP_001245612.1, NM_001258683.2
UniGeneiDm.4020

Genome annotation databases

EnsemblMetazoaiFBtr0307881; FBpp0300315; FBgn0263220
GeneIDi31955

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AFH07326.1
RefSeqiNP_001245612.1, NM_001258683.2
UniGeneiDm.4020

3D structure databases

ProteinModelPortaliM9NGY7
SMRiM9NGY7
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiM9NGY7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0307881; FBpp0300315; FBgn0263220
GeneIDi31955

Organism-specific databases

CTDi109541
FlyBaseiFBgn0263220 Hk

Phylogenomic databases

eggNOGiKOG1575 Eukaryota
COG0667 LUCA
GeneTreeiENSGT00550000074567
OMAiQMALAWT
OrthoDBiEOG091G0KDN

Enzyme and pathway databases

ReactomeiR-DME-1296072 Voltage gated Potassium channels
R-DME-6798695 Neutrophil degranulation

Miscellaneous databases

GenomeRNAii31955

Gene expression databases

BgeeiFBgn0263220 Expressed in 16 organ(s), highest expression level in head
ExpressionAtlasiM9NGY7 baseline and differential

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR005983 K_chnl_volt-dep_bsu_KCNAB
IPR005399 K_chnl_volt-dep_bsu_KCNAB-rel
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PRINTSiPR01577 KCNABCHANNEL
SUPFAMiSSF51430 SSF51430, 1 hit
TIGRFAMsiTIGR01293 Kv_beta, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM9NGY7_DROME
AccessioniPrimary (citable) accession number: M9NGY7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: September 12, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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