UniProtKB - M9NGX0 (M9NGX0_DROME)
Protein
Palmitoyltransferase
Gene
Zdhhc8
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalytic activityi
- hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]UniRule annotationEC:2.3.1.225UniRule annotation
GO - Molecular functioni
- palmitoyltransferase activity Source: GO_Central
- protein-cysteine S-palmitoyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- protein palmitoylation Source: GO_Central
Keywordsi
Molecular function | AcyltransferaseUniRule annotation, Transferase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Zdhhc8Imported Synonyms:anon-Pen16Imported, CG12136Imported, CG15372Imported, CG17251Imported, CG32705Imported, Dm_X:47283Imported, Dmel\CG34449Imported, dZDHHC8Imported, p16Imported, Pen16Imported, pen16Imported ORF Names:CG34449Imported, Dmel_CG34449Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0085478, Zdhhc8 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 30 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 42 – 62 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 143 – 167 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 179 – 201 | HelicalUniRule annotationAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | FBgn0085478, Expressed in digestive system element and 33 other tissues |
ExpressionAtlasi | M9NGX0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 97 – 217 | DHHCInterPro annotationAdd BLAST | 121 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 336 – 440 | DisorderedSequence analysisAdd BLAST | 105 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 336 – 353 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 363 – 406 | PolarSequence analysisAdd BLAST | 44 |
Domaini
The DHHC domain is required for palmitoyltransferase activity.UniRule annotation
Sequence similaritiesi
Belongs to the DHHC palmitoyltransferase family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000175425 |
HOGENOMi | CLU_652591_0_0_1 |
OrthoDBi | 1264614at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001594, Palmitoyltrfase_DHHC |
Pfami | View protein in Pfam PF01529, DHHC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
M9NGX0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKCDVKTRY IPATFAWIVL LLTTFLFFFY PCQFYVKSHP WVLAYQGVIT
60 70 80 90 100
FFVLANFTLA TFMDPGIIPK ASPDEDCEEE LRAPLYKNAE INGITVKMKW
110 120 130 140 150
CVTCKFYRPP RCSHCSVCNH CIETFDHHCP WVNNCIGRRN YRFFFFFLVS
160 170 180 190 200
LSIHMLSIFS LCLVYVLKIM PNIKDTAPIV AIILMGLVTI LAIPIFGLTG
210 220 230 240 250
FHMVLVSRGR TTNEQVTGKF KGGYNPFSRG CWHNCCYTQF GPQYPSLLNP
260 270 280 290 300
KKYASRRSQV QNQAISTICN DRSGQQTGAG SGAGGNGTAA VSGGGGGVGS
310 320 330 340 350
GGGMRGTAVQ YSPRSFYDAS REKRGIQVKT YMAEGNGYNQ RSGSTTLYSK
360 370 380 390 400
LSPGRECSDT DLEPPPASQS QDCEPTPPLQ RHNSSSFYLP QVSDSGGLNG
410 420 430 440 450
SVSTGGGGGG DSPRHMRLYH PRHSPHARPR GLDPQRGYTS DALSPDHPVG
460 470 480 490 500
YGVGVNGSQQ QQQQALAAAA AAAAVAAQNQ RSATTTATPT MQQRIKPLGV
510 520
ATPLVMASPV RSQYSNSENS TNS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketX2JJ56 | X2JJ56_DROME | Palmitoyltransferase | Zdhhc8 anon-Pen16, CG12136, CG15372, CG17251, CG32705 | 852 | Annotation score: | ||
A8JUM5 | A8JUM5_DROME | Palmitoyltransferase | Zdhhc8 anon-Pen16, CG12136, CG15372, CG17251, CG32705 | 500 | Annotation score: | ||
Q9W345 | Q9W345_DROME | Zinc finger DHHC-type containing 8,... | Zdhhc8 anon-Pen16, CG12136, CG15372, CG17251, CG32705 | 934 | Annotation score: | ||
A8JUM2 | A8JUM2_DROME | Zinc finger DHHC-type containing 8,... | Zdhhc8 anon-Pen16, CG12136, CG15372, CG17251, CG32705 | 911 | Annotation score: | ||
M9PH36 | M9PH36_DROME | Zinc finger DHHC-type containing 8,... | Zdhhc8 anon-Pen16, CG12136, CG15372, CG17251, CG32705 | 1,052 | Annotation score: | ||
X2JE99 | X2JE99_DROME | Zinc finger DHHC-type containing 8,... | Zdhhc8 anon-Pen16, CG12136, CG15372, CG17251, CG32705 | 906 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AFH07306.1 |
RefSeqi | NP_001245592.1, NM_001258663.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0308591; FBpp0300815; FBgn0085478 |
GeneIDi | 31887 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AFH07306.1 |
RefSeqi | NP_001245592.1, NM_001258663.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
EnsemblMetazoai | FBtr0308591; FBpp0300815; FBgn0085478 |
GeneIDi | 31887 |
Organism-specific databases
CTDi | 29801 |
FlyBasei | FBgn0085478, Zdhhc8 |
Phylogenomic databases
GeneTreei | ENSGT00940000175425 |
HOGENOMi | CLU_652591_0_0_1 |
OrthoDBi | 1264614at2759 |
Miscellaneous databases
BioGRID-ORCSi | 31887, 0 hits in 3 CRISPR screens |
GenomeRNAii | 31887 |
Gene expression databases
Bgeei | FBgn0085478, Expressed in digestive system element and 33 other tissues |
ExpressionAtlasi | M9NGX0, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR001594, Palmitoyltrfase_DHHC |
Pfami | View protein in Pfam PF01529, DHHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | M9NGX0_DROME | |
Accessioni | M9NGX0Primary (citable) accession number: M9NGX0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 26, 2013 |
Last sequence update: | June 26, 2013 | |
Last modified: | February 10, 2021 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |