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Protein

Innexin

Gene

shakB

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Structural component of the gap junctions.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
InnexinUniRule annotation
Gene namesi
Name:shakBImported
Synonyms:2Imported, 3Imported, 6Imported, CG12678Imported, CG1321Imported, CG15451Imported, CG32508Imported, Dmel\CG34358Imported, E81Imported, FBpp0111481Imported, inxUniRule annotation, inx8Imported, l(1)19EbImported, l(1)LB21Imported, l(1)R-10-14Imported, l(1)R-10-3Imported, l(1)R-10-7Imported, l(1)R-9-29Imported, l(1)TH73Imported, l(1)W3Imported, l(1)W3bImported, lincRNA.1031Imported, nj-156Imported, nj156Imported, PasImported, pasImported, passImported, R-9-29Imported, R9-29Imported, Shak BImported, Shak-BImported, shak-BImported, ShakBImported, shBImported, shkBImported, W3Imported
ORF Names:CG34358Imported, Dmel_CG34358Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0085387 shakB

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei114 – 131HelicalPROSITE-ProRule annotationAdd BLAST18
Transmembranei184 – 203HelicalPROSITE-ProRule annotationAdd BLAST20
Transmembranei273 – 300HelicalPROSITE-ProRule annotationAdd BLAST28

Keywords - Cellular componenti

Cell junction, Gap junctionPROSITE-ProRule annotation, Membrane

Expressioni

Gene expression databases

BgeeiFBgn0085387 Expressed in 30 organ(s), highest expression level in head

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0111481

Family & Domainsi

Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IEZ5 Eukaryota
ENOG410XQIC LUCA
GeneTreeiENSGT00530000064205
OrthoDBiEOG091G0TES

Family and domain databases

InterProiView protein in InterPro
IPR000990 Innexin
PANTHERiPTHR11893 PTHR11893, 1 hit
PfamiView protein in Pfam
PF00876 Innexin, 1 hit
PRINTSiPR01262 INNEXIN
PROSITEiView protein in PROSITE
PS51013 PANNEXIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

M9NGR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFLRGVYAF MQVSRSSVSH VKIDSPVFRL HTNATVILLI TFSIAVTTRQ
60 70 80 90 100
YVGNPIDCVH TRDIPEDVLN TYCWIHSTYT VVDAFMKKQG SEVPFPGVHN
110 120 130 140 150
SQGRGPLTIK HTKYYQWVAF TLFFQAILFY TPRWLWKSWE GGKIHALIMD
160 170 180 190 200
LDIGICSEAE KKQKKKLLLD YLWENLRYHN WWAYRYYVCE LLALINVIGQ
210 220 230 240 250
MFLMNRFFDG EFITFGLKVI DYMETDQEDR MDPMIYIFPR MTKCTFFKYG
260 270 280 290 300
SSGEVEKHDA ICILPLNVVN EKIYIFLWFW FILLTFLTLL TLIYRVVIIF
310 320 330 340 350
SPRMRVYLFR MRFRLVRRDA IEIIVRRSKM GDWFLLYLLG ENIDTVIFRD
360 370
VVQDLANRLG HNQHHRVPGL KGEIQDA
Length:377
Mass (Da):44,763
Last modified:June 26, 2013 - v1
Checksum:i350AEF32A457844C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P33085SHAKB_DROME
Innexin shaking-B
shakB Pas, shak-B, CG34358
372Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AFH07499.1
AE014298 Genomic DNA Translation: AFH07500.1
AE014298 Genomic DNA Translation: AHN59973.1
RefSeqiNP_001245787.1, NM_001258858.2
NP_001245788.1, NM_001258859.2
NP_001285503.1, NM_001298574.1
UniGeneiDm.2607

Genome annotation databases

EnsemblMetazoaiFBtr0309369; FBpp0301271; FBgn0085387
FBtr0309370; FBpp0301272; FBgn0085387
FBtr0342859; FBpp0309671; FBgn0085387
GeneIDi33062

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AFH07499.1
AE014298 Genomic DNA Translation: AFH07500.1
AE014298 Genomic DNA Translation: AHN59973.1
RefSeqiNP_001245787.1, NM_001258858.2
NP_001245788.1, NM_001258859.2
NP_001285503.1, NM_001298574.1
UniGeneiDm.2607

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0111481

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0309369; FBpp0301271; FBgn0085387
FBtr0309370; FBpp0301272; FBgn0085387
FBtr0342859; FBpp0309671; FBgn0085387
GeneIDi33062

Organism-specific databases

CTDi33062
FlyBaseiFBgn0085387 shakB

Phylogenomic databases

eggNOGiENOG410IEZ5 Eukaryota
ENOG410XQIC LUCA
GeneTreeiENSGT00530000064205
OrthoDBiEOG091G0TES

Miscellaneous databases

GenomeRNAii33062

Gene expression databases

BgeeiFBgn0085387 Expressed in 30 organ(s), highest expression level in head

Family and domain databases

InterProiView protein in InterPro
IPR000990 Innexin
PANTHERiPTHR11893 PTHR11893, 1 hit
PfamiView protein in Pfam
PF00876 Innexin, 1 hit
PRINTSiPR01262 INNEXIN
PROSITEiView protein in PROSITE
PS51013 PANNEXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiM9NGR8_DROME
AccessioniPrimary (citable) accession number: M9NGR8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: November 7, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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