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UniProtKB - M9NGD4 (M9NGD4_DROME)

Entry version 63 (19 Jan 2022)
Sequence version 1 (26 Jun 2013)
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Protein
Submitted name:

Nna1 carboxypeptidase, isoform E

Gene

Nna1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidaseImported, Hydrolase, Protease

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nna1 carboxypeptidase, isoform EImported (EC:3.4.17.-Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nna1Imported
Synonyms:CG11428Imported, CG32627Imported, CG32628Imported, Dmel\CG44533Imported, NnaDImported
ORF Names:CG44533Imported, Dmel_CG44533Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0265726, Nna1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0265726

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0265726, Expressed in adult organism and 26 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		M9NGD4, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		M9NGD4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini623 – 758Pepdidase_M14_NInterPro annotationAdd BLAST136
Domaini781 – 1000Peptidase_M14InterPro annotationAdd BLAST220

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 33DisorderedSequence analysisAdd BLAST33
Regioni143 – 197DisorderedSequence analysisAdd BLAST55
Regioni250 – 293DisorderedSequence analysisAdd BLAST44
Regioni362 – 414DisorderedSequence analysisAdd BLAST53
Regioni432 – 462DisorderedSequence analysisAdd BLAST31
Regioni511 – 539DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi143 – 163Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi271 – 288Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi390 – 406Acidic residuesSequence analysisAdd BLAST17
Compositional biasi523 – 539Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M14 family.ARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040626, Pepdidase_M14_N
IPR000834, Peptidase_M14

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18027, Pepdidase_M14_N, 1 hit
PF00246, Peptidase_M14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

M9NGD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKGVKDKEN RNSAMGPEIC EVQQHPSKQN DGFLGSFLSK GLKTNQLVVN 
        60         70         80         90        100
TDEKTLRPVA RLKEPRDLFA LPKDKDNDCS QQAPRWPVEC QVIEERIIHI 
       110        120        130        140        150
PYVPAVPEPL NAPTGNELKP RPVGEENGIV VFSYSPISAV NYEKPKAKKE 
       160        170        180        190        200
DDESSDESDY SSDSRQDSTP PSRSTPMRLA GGGECAPGKL NSVSKMINNV 
       210        220        230        240        250
DNRSTSASLD DNDDYYDDEY DTSGGYCGGS GEAKEKAIIK DLIEAKKKRY 
       260        270        280        290        300
QEEAEVTPVG GGTARNSRAA SRSEASKDAS DIDDIWKNNT SEYKPASPRY 
       310        320        330        340        350
VLSQFGKNVT KAVIDRIVDH EDLVPPSGSQ KVSNQFAVGP VKLPKTNIAR 
       360        370        380        390        400
LEVAFERSAC QDRSKSRLKK KMSSSRRRRE STSDEDSSSS SLGNEEDEEV 
       410        420        430        440        450
DDSDSDAENT GSGIGLRRIL GSYSARLAGG AEKCPCPGSG SVSDTETLVG 
       460        470        480        490        500
DESRSRLAGS NGLHQQDVVC SRNRQAQSRS PLRSVPHTHA ATVAAAAAAL 
       510        520        530        540        550
ARGRNRDKDG CLGGKDEKNM GMGVGTTGTS SMGTRTSSPV RNNVFRLSKD 
       560        570        580        590        600
QHILLNSMTS QETTGTLISS TSTNQTTTTT NSSQSFLCSD LPQAQFSRSA 
       610        620        630        640        650
VGGARFMTNC HPMNPEEYDG LEFESRFESG NLAKAVQITP TYYELYLRPD 
       660        670        680        690        700
LYTSRSKQWF YFRVRRTRRK MLYRFSIVNL VKSDSLYNDG MQPVMYSTLG 
       710        720        730        740        750
AKEKSEGWRR CGDNICYYRN DDESASSSAN EDDEDNSTYT LTFTIEFEHD 
       760        770        780        790        800
DDTVFFAHSY PYTYSDLQDY LMEIQRHPVK SKFCKLRLLC RTLAGNNVYY 
       810        820        830        840        850
LTVTAPSSNE ENMRRKKSIV VSARVHPSET PASWMMKGLM DFITGDTTVA 
       860        870        880        890        900
KRLRHKFIFK LVPMLNPDGV IVGNTRNSLT GKDLNRQYRT VIRETYPSIW 
       910        920        930        940        950
YTKAMIRRLI EECGVAMYCD MHAHSRKHNI FIYGCENKRN PEKKLTEQVF 
       960        970        980        990       1000
PLMLHKNSAD RFSFESCKFK IQRSKEGTGR IVVWMLGITN SYTIEASFGG 
      1010       1020       1030       1040       1050
SSLGSRKGTH FNTQDYEHMG RAFCETLLDY CDENPNKVKR HAKLFKQIKK 
      1060       1070       1080 
IRKREKREQK ALKLQKMADQ GCIMNDKLKV KRSVEKSVS
Length:1,089
Mass (Da):121,983
Last modified:June 26, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E96178D1A989BCB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9VY99NNAD_DROME
Cytosolic carboxypeptidase Nna1
Nna1 NnaD, CG44533
1,201Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NEF7M9NEF7_DROME
Nna1 carboxypeptidase, isoform F
Nna1 CG11428, CG32627, CG32628, Dmel\CG44533, NnaD
913Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NF40M9NF40_DROME
Nna1 carboxypeptidase, isoform G
Nna1 CG11428, CG32627, CG32628, Dmel\CG44533, NnaD
748Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JBR4X2JBR4_DROME
Nna1 carboxypeptidase, isoform H
Nna1 CG11428, CG32627, CG32628, Dmel\CG44533, NnaD
1,890Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JDN6X2JDN6_DROME
Nna1 carboxypeptidase, isoform I
Nna1 CG11428, CG32627, CG32628, Dmel\CG44533, NnaD
1,889Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JK43X2JK43_DROME
Nna1 carboxypeptidase, isoform J
Nna1 CG11428, CG32627, CG32628, Dmel\CG44533, NnaD
1,694Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014298 Genomic DNA Translation: AFH07369.1

NCBI Reference Sequences

More...RefSeqi		NP_001245655.1, NM_001258726.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0340675; FBpp0309517; FBgn0265726

Database of genes from NCBI RefSeq genomes

More...GeneIDi		32329

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AFH07369.1
RefSeqiNP_001245655.1, NM_001258726.1

3D structure databases

SMRiM9NGD4
ModBaseiSearch...

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		32329

Genome annotation databases

EnsemblMetazoaiFBtr0340675; FBpp0309517; FBgn0265726
GeneIDi32329

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		32329
FlyBaseiFBgn0265726, Nna1
VEuPathDBiVectorBase:FBgn0265726

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		32329, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		32329

Gene expression databases

BgeeiFBgn0265726, Expressed in adult organism and 26 other tissues
ExpressionAtlasiM9NGD4, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR040626, Pepdidase_M14_N
IPR000834, Peptidase_M14
PfamiView protein in Pfam
PF18027, Pepdidase_M14_N, 1 hit
PF00246, Peptidase_M14, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM9NGD4_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M9NGD4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: January 19, 2022
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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