IGF-II mRNA-binding protein, isoform L

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• mRNA 3'-UTR binding Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Imp promotes axonal remodeling by regulating profilin mRNA during brain development."
    Medioni C., Ramialison M., Ephrussi A., Besse F.
    Curr Biol 24:793-800(2014) [PubMed] [Europe PMC] [Abstract]
• mRNA binding Source: FlyBaseInferred from direct assayⁱ
  • "The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche."
    Toledano H., D'Alterio C., Czech B., Levine E., Jones D.L.
    Nature 485:605-610(2012) [PubMed] [Europe PMC] [Abstract]
  • "Lin28 is a critical factor in the function and aging of Drosophila testis stem cell niche."
    Sreejith P., Jang W., To V., Hun Jo Y., Biteau B., Kim C.
    Aging (Albany NY) 11:855-873(2019) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• carbohydrate metabolic process Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Use of Drosophila as an evaluation method reveals imp as a candidate gene for type 2 diabetes in rat locus Niddm22."
    Kawasaki K., Yamada S., Ogata K., Saito Y., Takahama A., Yamada T., Matsumoto K., Kose H.
    J Diabetes Res 2015:758564-758564(2015) [PubMed] [Europe PMC] [Abstract]
• mRNA splicing, via spliceosome Source: FlyBase <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes."
    Herold N., Will C.L., Wolf E., Kastner B., Urlaub H., Luhrmann R.
    Mol. Cell. Biol. 29:281-301(2009) [PubMed] [Europe PMC] [Abstract]
• mRNA transport Source: UniProtKB-KW
• nervous system development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "RNA interference screen to identify genes required for Drosophila embryonic nervous system development."
    Koizumi K., Higashida H., Yoo S., Islam M.S., Ivanov A.I., Guo V., Pozzi P., Yu S.H., Rovescalli A.C., Tang D., Nirenberg M.
    Proc Natl Acad Sci U S A 104:5626-5631(2007) [PubMed] [Europe PMC] [Abstract]
• neuron remodeling Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Imp promotes axonal remodeling by regulating profilin mRNA during brain development."
    Medioni C., Ramialison M., Ephrussi A., Besse F.
    Curr Biol 24:793-800(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of axon regeneration Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Imp promotes axonal remodeling by regulating profilin mRNA during brain development."
    Medioni C., Ramialison M., Ephrussi A., Besse F.
    Curr Biol 24:793-800(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of receptor signaling pathway via JAK-STAT Source: FlyBaseInferred from direct assayⁱ
  • "The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche."
    Toledano H., D'Alterio C., Czech B., Levine E., Jones D.L.
    Nature 485:605-610(2012) [PubMed] [Europe PMC] [Abstract]
• regulation of gene expression Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of RNA metabolic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to starvation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Use of Drosophila as an evaluation method reveals imp as a candidate gene for type 2 diabetes in rat locus Niddm22."
    Kawasaki K., Yamada S., Ogata K., Saito Y., Takahama A., Yamada T., Matsumoto K., Kose H.
    J Diabetes Res 2015:758564-758564(2015) [PubMed] [Europe PMC] [Abstract]
• spermatogenesis Source: FlyBase <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Imp (IGF-II mRNA-binding protein) is expressed during spermatogenesis in Drosophila melanogaster."
    Fabrizio J.J., Hickey C.A., Stabrawa C., Meytes V., Hutter J.A., Talbert C., Regis N.
    Fly (Austin) 2:47-52(2008) [PubMed] [Europe PMC] [Abstract]
• synaptic assembly at neuromuscular junction Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Motility screen identifies Drosophila IGF-II mRNA-binding protein--zipcode-binding protein acting in oogenesis and synaptogenesis."
    Boylan K.L., Mische S., Li M., Marques G., Morin X., Chia W., Hays T.S.
    PLoS Genet 4:e36-e36(2008) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MASELDQFAD LELSKEDREQ IFDPPLDRQQ LEGAGTSSVT TSKILISGIP 
        60         70         80         90        100
MQTRFEDIEP LLKPYGIVKQ CEAISSKDQN TQTVHITFEN PEQAQRAAVG 
       110        120        130        140        150
LNGVEFEGSK LHAEQLDKNQ RRSQRNQRNP YPGMPGPGRQ ADFPLRILVQ 
       160        170        180        190        200
SEMVGAIIGR QGSTIRTITQ QSRARVDVHR KENVGSLEKS ITIYGNPENC 
       210        220        230        240        250
TNACKRILEV MQQEAISTNK GELSPECSEI CLKILAHNNL IGRIIGKSGN 
       260        270        280        290        300
TIKRIMQDTD TKITVSSIND INSFNLERII TVKGLIENMS RAENQISTKL 
       310        320        330        340        350
RQSYENDLQA MAPQSLMFPG LHPMAMMSTP GNGMVFNTSM PFPSCQSFAM 
       360        370        380        390        400
SKTPASVVPP VFPNDLQETT YLYIPNNAVG AIIGTRGSHI RSIMRFSNAS 
       410        420        430        440        450
LKIAPLDADK PLDQQTERKV TIVGTPEGQW KAQYMIFEKM REEGFMCGTD 
       460        470        480        490        500
DVRLTVELLV ASSQVGRIIG KGGQNVRELQ RVTGSVIKLP EHALAPPSGG 
       510        520        530        540        550
DEETPVHIIG LFYSVQSAQR RIRAMMLSTN PPPITKKQKA AKEQLQQQQQ 
       560        570        580        590        600
SLAGAASSGS QQQQPQSPSQ QQALPPQLHH QPVSSASSSS TPPAHHQQQA 
       610        620        630 
STAATSHQLQ QQQPSPPPPG NATAAAAQQQ QQLASSQQ              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ