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UniProtKB - M9NE01 (M9NE01_DROME)
Protein
Serine/threonine-protein phosphatase
Gene
Pp2B-14D
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalytic activityi
- EC:3.1.3.16ARBA annotation
- H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphateUniRule annotationARBA annotationEC:3.1.3.16UniRule annotationARBA annotation
Cofactori
Protein has several cofactor binding sites:GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
- calmodulin-dependent protein phosphatase activity Source: InterPro
- protein serine phosphatase activity Source: UniProtKB-EC
- protein threonine phosphatase activity Source: UniProtKB-EC
GO - Biological processi
- calcineurin-mediated signaling Source: InterPro
Keywordsi
Molecular function | Calmodulin-bindingARBA annotation, Hydrolase, Protein phosphataseARBA annotation |
Ligand | IronARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation) |
Gene namesi | Name:Pp2B-14DImported Synonyms:calneurImported, CaNImported, CaNAImported, CanAImported, canAImported, CanA14DImported, CnAImported, CnnA14DImported, D33Imported, Dmel\CG9842Imported, DmPp2B-14DImported, Pp12-14DImported, PP2BImported, Pp2BImported, PP2B 14DImported, PP2B-14DImported, Pp2b-14DImported, Pp2B-14DFImported, PpD33Imported ORF Names:CG9842Imported, Dmel_CG9842Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0011826, Pp2B-14D |
VEuPathDBi | VectorBase:FBgn0011826 |
Expressioni
Gene expression databases
Bgeei | FBgn0011826, Expressed in female gonad and 39 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 213 – 218 | SER_THR_PHOSPHATASEInterPro annotation | 6 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 88 | DisorderedSequence analysisAdd BLAST | 88 | |
Regioni | 530 – 570 | DisorderedSequence analysisAdd BLAST | 41 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 67 | Polar residuesSequence analysisAdd BLAST | 67 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_004962_6_0_1 |
OMAi | MESFCCL |
OrthoDBi | 463522at2759 |
Family and domain databases
CDDi | cd07416, MPP_PP2B, 1 hit |
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR041751, MPP_PP2B IPR043360, PP2B IPR006186, Ser/Thr-sp_prot-phosphatase |
PANTHERi | PTHR45673, PTHR45673, 1 hit |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit |
PRINTSi | PR00114, STPHPHTASE |
SMARTi | View protein in SMART SM00156, PP2Ac, 1 hit |
SUPFAMi | SSF56300, SSF56300, 1 hit |
PROSITEi | View protein in PROSITE PS00125, SER_THR_PHOSPHATASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
M9NE01-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSNNQSSSV AQAATSARTV SAGSAEATDA NSTASNNNNN SSSTAAAGNN
60 70 80 90 100
SDNSSPTTGT GTGASTGKLH GGHTAVNTKE RVVDSVPFPP SHKLTLAEVF
110 120 130 140 150
DQRTGKPNHE LLKQHFILEG RIEEAPALKI IQDGAALLRQ EKTMIDIEAP
160 170 180 190 200
VTVCGDIHGQ FYDLMKLFEV GGSPASTKYL FLGDYVDRGY FSIECVLYLW
210 220 230 240 250
SLKITYPQTL FLLRGNHECR HLTEYFTFKQ ECKIKYSERV YDACMDAFDC
260 270 280 290 300
LPLAALMNQQ FLCVHGGLSP EIHELEDIRR LDRFKEPPAF GPMCDLLWSD
310 320 330 340 350
PLEDFGNEKN SDFYTHNSVR GCSYFYSYAA CCDFLQNNNL LSIIRAHEAQ
360 370 380 390 400
DAGYRMYRKS QTTGFPSLIT IFSAPNYLDV YNNKAAVLKY ENNVMNIRQF
410 420 430 440 450
NCSPHPYWLP NFMDVFTWSL PFVGEKVTEM LVNVLNICSD DELMTEESEE
460 470 480 490 500
PLSDDEAALR KEVIRNKIRA IGKMARVFSV LREESESVLQ LKGLTPTGAL
510 520 530 540 550
PLGALSGGKQ SLKNAMQGFS PNHKITSFAE AKGLDAVNER MPPRRDQPPT
560 570
PSEDPNQHSQ QGGKNGAGHG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ27889 | PP2B2_DROME | Serine/threonine-protein phosphatas... | Pp2B-14D CG9842 | 570 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AFH07428.1 AE014298 Genomic DNA Translation: AFH07429.1 |
RefSeqi | NP_001245715.1, NM_001258786.3 NP_001245716.1, NM_001258787.2 NP_523373.2, NM_078649.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0074294; FBpp0074069; FBgn0011826 FBtr0305593; FBpp0294044; FBgn0011826 FBtr0309793; FBpp0301546; FBgn0011826 |
GeneIDi | 32624 |
KEGGi | dme:Dmel_CG9842 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AFH07428.1 AE014298 Genomic DNA Translation: AFH07429.1 |
RefSeqi | NP_001245715.1, NM_001258786.3 NP_001245716.1, NM_001258787.2 NP_523373.2, NM_078649.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
DNASUi | 32624 |
Genome annotation databases
EnsemblMetazoai | FBtr0074294; FBpp0074069; FBgn0011826 FBtr0305593; FBpp0294044; FBgn0011826 FBtr0309793; FBpp0301546; FBgn0011826 |
GeneIDi | 32624 |
KEGGi | dme:Dmel_CG9842 |
Organism-specific databases
CTDi | 32624 |
FlyBasei | FBgn0011826, Pp2B-14D |
VEuPathDBi | VectorBase:FBgn0011826 |
Phylogenomic databases
HOGENOMi | CLU_004962_6_0_1 |
OMAi | MESFCCL |
OrthoDBi | 463522at2759 |
Miscellaneous databases
BioGRID-ORCSi | 32624, 0 hits in 1 CRISPR screen |
GenomeRNAii | 32624 |
Gene expression databases
Bgeei | FBgn0011826, Expressed in female gonad and 39 other tissues |
Family and domain databases
CDDi | cd07416, MPP_PP2B, 1 hit |
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR041751, MPP_PP2B IPR043360, PP2B IPR006186, Ser/Thr-sp_prot-phosphatase |
PANTHERi | PTHR45673, PTHR45673, 1 hit |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit |
PRINTSi | PR00114, STPHPHTASE |
SMARTi | View protein in SMART SM00156, PP2Ac, 1 hit |
SUPFAMi | SSF56300, SSF56300, 1 hit |
PROSITEi | View protein in PROSITE PS00125, SER_THR_PHOSPHATASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | M9NE01_DROME | |
Accessioni | M9NE01Primary (citable) accession number: M9NE01 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 26, 2013 |
Last sequence update: | June 26, 2013 | |
Last modified: | January 19, 2022 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |