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Entry version 57 (17 Jun 2020)
Sequence version 1 (26 Jun 2013)
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Protein

Protein bark beetle

Gene

bark

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the maturation but not the establishment of septate junctions in developing epithelial cells and is involved in epithelial cell adhesion during septate junction maturation (PubMed:25704509). Plays a role in the proper localization of the septate junction core components pck/mega, kune, Nrx-IV and Nrg during late embryogenesis (PubMed:25704509). Involved in the formation of tricellular junctions which mediate cell contact where three epithelial cells meet but not of bicellular junctions (PubMed:25982676). Required for the accumulation of Gli at tricellular junctions.2 Publications

Miscellaneous

The name 'bark beetle' derives from the convoluted tracheal branches seen in mutant embryos which resemble the tracks of bark beetle larvae (PubMed:25704509). The name 'anakonda' is also based on the convoluted tracheal tube phenotype of mutant embryos (PubMed:25982676).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein bark beetle1 Publication
Alternative name(s):
Protein anakonda1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:barkImported
Synonyms:aka1 Publication
ORF Names:CG3921Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0031571 bark

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini35 – 2714ExtracellularCuratedAdd BLAST2680
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2715 – 2735HelicalSequence analysisAdd BLAST21
Topological domaini2736 – 3123CytoplasmicCuratedAdd BLAST388

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethality. Mutant embryos establish functional septate junctions but, due to rudimentary septae formation during subsequent embryonic development, these become non-functional (PubMed:25704509). Abnormal liquid clearance of tracheal tubes (PubMed:25704509). Convoluted and elongated tracheal branches (PubMed:25704509, PubMed:25982676). During late embryogenesis, mislocalization of septate junction core components pck/mega, kune, Nrx-IV and Nrg and impaired cell adhesion at the lateral cell membrane (PubMed:25704509). Mislocalization of Fas3 in the epithelia of mutant embryos and loss of accumulation of Gli at tricellular junctions (PubMed:25982676).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi503V → E in L224; embryonic lethality with excessively elongated tracheal tubes. 1 Publication1
Mutagenesisi567V → E in J55; embryonic lethality with excessively elongated tracheal tubes. 1 Publication1
Mutagenesisi678E → K in K93; embryonic lethality with excessively elongated tracheal tubes. 1 Publication1
Mutagenesisi680S → L in K104; embryonic lethality with excessively elongated tracheal tubes. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Sequence analysisAdd BLAST34
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500410129435 – 3123Protein bark beetleAdd BLAST3089

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi216 ↔ 284PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi221N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi231 ↔ 294PROSITE-ProRule annotation
Disulfide bondi262 ↔ 272PROSITE-ProRule annotation
Glycosylationi377N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi389N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi403N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi446 ↔ 474PROSITE-ProRule annotation
Glycosylationi498N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi523N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi615N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi620N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi630N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi639N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi658N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi672N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi702N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi709N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi834N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi900N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1040N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1096 ↔ 1164PROSITE-ProRule annotation
Disulfide bondi1109 ↔ 1174PROSITE-ProRule annotation
Disulfide bondi1144 ↔ 1154PROSITE-ProRule annotation
Glycosylationi1375N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1489N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1520N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1529N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1584N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1593N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1614N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1883N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1920N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1940N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1950 ↔ 2025PROSITE-ProRule annotation
Disulfide bondi1963 ↔ 2036PROSITE-ProRule annotation
Disulfide bondi2000 ↔ 2010PROSITE-ProRule annotation
Glycosylationi2139N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2231N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2251N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2314N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2357N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2459N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2536N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2546N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2566N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2596N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2636N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication
May be proteolytically cleaved in the extracellular domain.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
M9NDE3

PRoteomics IDEntifications database

More...
PRIDEi
M9NDE3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression detected in embryonic epithelia and central nervous system (at protein level) (PubMed:25982676). First detected during stage 13 in the tracheal system, the foregut, the hindgut, the salivary glands and the epidermis (PubMed:25704509, PubMed:25982676). Expression persists in these tissues until the end of embryogenesis (PubMed:25704509). Expression in epithelia declines from late stage 15 and expression appears in the central nervous system during stage 16 (PubMed:25982676).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0031571 Expressed in imaginal disc and 31 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VQV1 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
M9NDE3, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0297894

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
M9NDE3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini191 – 295SRCR 1PROSITE-ProRule annotationAdd BLAST105
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati358 – 380PbH1 1Sequence analysisAdd BLAST23
Repeati382 – 404PbH1 2Sequence analysisAdd BLAST23
Repeati406 – 428PbH1 3Sequence analysisAdd BLAST23
Domaini446 – 559CUBPROSITE-ProRule annotationAdd BLAST114
Repeati562 – 584PbH1 4Sequence analysisAdd BLAST23
Repeati586 – 609PbH1 5Sequence analysisAdd BLAST24
Repeati611 – 633PbH1 6Sequence analysisAdd BLAST23
Repeati756 – 778PbH1 7Sequence analysisAdd BLAST23
Repeati789 – 809PbH1 8Sequence analysisAdd BLAST21
Domaini1071 – 1175SRCR 2PROSITE-ProRule annotationAdd BLAST105
Repeati1219 – 1241PbH1 9Sequence analysisAdd BLAST23
Repeati1248 – 1270PbH1 10Sequence analysisAdd BLAST23
Repeati1451 – 1475PbH1 11Sequence analysisAdd BLAST25
Repeati1489 – 1511PbH1 12Sequence analysisAdd BLAST23
Repeati1553 – 1575PbH1 13Sequence analysisAdd BLAST23
Repeati1722 – 1744PbH1 14Sequence analysisAdd BLAST23
Domaini1912 – 2037SRCR 3PROSITE-ProRule annotationAdd BLAST126
Repeati2104 – 2126PbH1 15Sequence analysisAdd BLAST23
Repeati2128 – 2150PbH1 16Sequence analysisAdd BLAST23
Repeati2337 – 2361PbH1 17Sequence analysisAdd BLAST25
Repeati2372 – 2393PbH1 18Sequence analysisAdd BLAST22
Repeati2401 – 2424PbH1 19Sequence analysisAdd BLAST24

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFUC Eukaryota
ENOG410XPY8 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000296_1_0_1

Identification of Orthologs from Complete Genome Data

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OMAi
NHIERCT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
M9NDE3

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041 CUB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 1 hit
3.10.100.10, 1 hit
3.10.250.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000859 CUB_dom
IPR006626 PbH1
IPR011050 Pectin_lyase_fold/virulence
IPR035914 Sperma_CUB_dom_sf
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00530 SRCR, 3 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00258 SPERACTRCPTR

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00710 PbH1, 19 hits
SM00202 SR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854 SSF49854, 1 hit
SSF51126 SSF51126, 1 hit
SSF56436 SSF56436, 1 hit
SSF56487 SSF56487, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00420 SRCR_1, 1 hit
PS50287 SRCR_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform BImported (identifier: M9NDE3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLQHHKTNR QRISKPHRDP KWASICLWLL VTLAFSTHLA RSQESRQTED
60 70 80 90 100
SKEVELLQDN DIEFASLDGA SQLLPATRHS GADVTVAPQG STPSMTSSSS
110 120 130 140 150
YTELQGGEIL SDRILRRSES PYLARDDIEV LRGARLTIEP GVTIEFAPTK
160 170 180 190 200
GLKINGVLQA VGTPTSRIVL KSQSNTANYK LELPDDQEKG IRLVDGPTPV
210 220 230 240 250
EGRLQLFHKG AWRSVCSNSR NWTLADYGVA CKQLGYRGGR FWNWVERTPG
260 270 280 290 300
YYPRLLYEQP KCKGGEGSLQ DCAWTSRQMG AGACDYHNDL GIQCLPVHSE
310 320 330 340 350
TLGHWRGIYF DNAPSTKALG RDNIVYAAQS ESRLKYVDII RAGSGAGFNA
360 370 380 390 400
KSAVEVQGLP PQMEHVVISH SAYTGFNSTR PWAGFQLQNV TVRKCNGIGV
410 420 430 440 450
FVNSSQGAVQ LDGCSIVDNA GDGIKYVGHD LRGTERKDRA SIYDFCTLPT
460 470 480 490 500
TSGQTYPISL SFTQKYYAGS GKECGKYFFT RPGYLLTLHF ENFVLMQNET
510 520 530 540 550
ATVEIYDGAS TNDRLLFEWK ARNFTRPQSV TSTREKMFVR IRADARQELN
560 570 580 590 600
GFFRMTSGDS VAYDLKVSQS TVEDNGGRGV AIDNIRSKLH VHSSSVSGNG
610 620 630 640 650
HVAGVHVTSG AGDVNITSSN ISFNNGAGVN ITYYGGNRNI SRSALTANKG
660 670 680 690 700
YGVATWLNQT SDVNRMEYIP FNQTSVVEYS QIGGNLETGV FHGNFCRPIW
710 720 730 740 750
VNITGNSFNG SQQNDIFIES CYQATANGRP NMQLQLGHNQ FKYSQANSIY
760 770 780 790 800
LSPALNLQGR IEYNMFRFGS YGCLFINNDY IYPEFNYFPV KLIIQSNYFM
810 820 830 840 850
RNSGVHVVSL GLSPYSRAEV QYILFTRNFV RGNNITEAFG PLIAGSEGSD
860 870 880 890 900
GAGRLNPRSR VAAPVVVGSS NVDIFRNILH NLDSMYEIGS QLTDQSKIIN
910 920 930 940 950
ATCNWLGHTD ENKIYARLFH RNDRYNLAKI NYLPYLLHSS NPGSTAMITV
960 970 980 990 1000
STVVPRFFHE GSDVIGGEVD GQDMVPAGTY TVTKDINIRP GGKLILQPGT
1010 1020 1030 1040 1050
TLKFEPSVGM MVAGKLEARG RRPDDILFTL KRETIMGESN DTETIDLDSE
1060 1070 1080 1090 1100
TEAIDMETEV IPADGVPRVP VRLVGGAGAN EGRLQVYLKG RWGTVCDYGW
1110 1120 1130 1140 1150
NVLNAALVCH QLGYSLNPQD WRLLRSQLPN AGTSEDILMA NVRCTLQDRD
1160 1170 1180 1190 1200
VTKCRAEYEF ENTCSHENDV GLRCYEGAWA GVRFSMLAER ADLQYVTVEK
1210 1220 1230 1240 1250
AGLFDYTTNA FKPAVQMDHA RHNLENVRIV NNLQDGLGII YADIYAGKSV
1260 1270 1280 1290 1300
NNIKNSEFSG NKGSGISLKQ LDFRVSGSII KDNKGSGVSH DAVISALDQK
1310 1320 1330 1340 1350
EIGGWFNMAT DFNSFDTDYD PYLLPREISN IDLGTFEHKY IRTEELLGQN
1360 1370 1380 1390 1400
INRKIVVQCP AGYVIGIQLL NPIHNLSTES INILNARTEN IRSDLWQVKR
1410 1420 1430 1440 1450
DLNVFPVTSS SYGIIIYYES GLQALGGAVL MLSTVTAPVQ NIRNRIVSGA
1460 1470 1480 1490 1500
VPTLTIRSTK IQKNLRGITG IYYNRYIGDN GEYYLRKANE SIKLINSELS
1510 1520 1530 1540 1550
YNEREAILIR SPFWDVISSN LSEVTLHVNG SLITQNGLGI RQMSKDLRSS
1560 1570 1580 1590 1600
NNLFHYVIQD TTFEQNTHGG FQVSLPYVWQ YNENFTHSIY FGNSTWQRNR
1610 1620 1630 1640 1650
DFRISVSGHY TVFNITSNVF RENNCPGALI SLDGMEKRLR FDNNRFESNN
1660 1670 1680 1690 1700
AKFVLLFKAD SLSEIIGQVP ASIEFNSFKG NNIVTMTANY RNHYMKVARR
1710 1720 1730 1740 1750
IRKQHKIPTA VIRLDGVQNV RLYRNLIAEN EMDYNLVAGV RSARLNNYFE
1760 1770 1780 1790 1800
ARENWWGTKD TAFIEAKIFD FDNWNDHADV IYQPFLIEDS YDASVSVVVP
1810 1820 1830 1840 1850
FNQDQEIDLT NYKGGRVYKD LLLTKQSTPY YISSDITVMP GKTLTINHGV
1860 1870 1880 1890 1900
TMEFEPNVGI LVLGTLVAIG YRESPIVMRP FRNATRESLI DVQPKKRALE
1910 1920 1930 1940 1950
DMSAPLTEFD SIRLCTSANN CTGDADGLFG LNEGFLEYFN HTTLQWVPIC
1960 1970 1980 1990 2000
DSRFTERNAQ VVCRELGYDP LNVYYGHDRR IEFHTNSLTR IWSWVQPLEC
2010 2020 2030 2040 2050
RGDEERMEDC AERLNGQLYG HRHECRWDDV FVFVSCNGIA DDEVYWGGIR
2060 2070 2080 2090 2100
FANSKFEEIQ YEHRLHNTRS HARLPLRESQ LEFVRIEQAG ILHNHKAAAI
2110 2120 2130 2140 2150
QAIHKNPSIT SVSIENSANH GINMIAPSGK LNLNHLNINN TLGTGISIVS
2160 2170 2180 2190 2200
LSGEGRDSDE SSFTPLKKLD LPYKLFSLVD ICDPQKVLTI EERMLIYYKY
2210 2220 2230 2240 2250
DNNPVNCVKI FTSAFRAKPI GFRLLQSNLF NHSKLYGRTD FIKLYDGDIY
2260 2270 2280 2290 2300
NVTATYLGKI ESDTDNQRSF FKTKGPTMSL QLVASGAPET HGFIAEVVTV
2310 2320 2330 2340 2350
PISTLGQYRD ALHNITDTHI SGAIKGAVTY SSAGEVTPTL TLIGNRIEKN
2360 2370 2380 2390 2400
CRQLYGNFST CTSALNLDVQ NMNSLYFMNN LITENQGGLR IRADSRGSAT
2410 2420 2430 2440 2450
SLRGFVHHNL FMRNRNRPAL YVEGRQSSPY QEVELYRNYF AQNMAGYEDV
2460 2470 2480 2490 2500
IRLCQVVSNF SYNYVHSNVG GRIMEVSGFE KVRLQIYQTT AHNGFYRNFA
2510 2520 2530 2540 2550
TNWMTRATIV AGTAGQQYVD NIFENHENDY ELLTVNNSIL SFDYENRTFE
2560 2570 2580 2590 2600
TWSSKIDARH NYWSYNNTIS VQSRIRDKSD DPMLLEVLAV PFQMNNETIL
2610 2620 2630 2640 2650
DGKCPPGWAL VHDTCFIYVG APMTFHEARD FCRSENSTMP FIRTDKTTLW
2660 2670 2680 2690 2700
KYLQSQMRHL KYPDKVWIQD YNHIDRCTSF VFGEIEIEDC NKERGFICES
2710 2720 2730 2740 2750
DPRVIIDPLS WRADIFAISI ISAFVLAIIL LILVAFCWFA KSKHRHTQRL
2760 2770 2780 2790 2800
QRRNSIRQSL RSLNSIDPQG SLRRRPNYNM SSNGTLSKGQ DYKQMVANGS
2810 2820 2830 2840 2850
IDSMDKSVLS SEAGSFEGYE QKPHYNEYVN QNALRPAHPA QDHQSHKVAT
2860 2870 2880 2890 2900
ISKASGHRAR AAAAAAAALE PDAFELSYRN EGFRDNSTYG DNTRANSIST
2910 2920 2930 2940 2950
SVAEDTPIIH HTDQEIDEGG SDYYGNASTL PLRTEGGTPA GRRGQPGLAF
2960 2970 2980 2990 3000
LSELKQNLPE YQRSSHSSFM PHRSSGDSLP FDQKLDQFNY STESSLYRPA
3010 3020 3030 3040 3050
PAVPSSQQAT PADMRRPDSY YTAVRSSKAP VSHYRTPRPL AQPPAAPNVA
3060 3070 3080 3090 3100
PAGGPAQRRP KTVYQTASEE SSPTTPSPLT NQYHRSKSEA LLETDFDGDG
3110 3120
GSVGLQPLQT NGRSHSQPLE TAM
Length:3,123
Mass (Da):350,461
Last modified:June 26, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3AB68B97DE35D73D
GO
Isoform AImported (identifier: M9NDE3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2539-2547: ILSFDYENR → M

Show »
Length:3,115
Mass (Da):349,454
Checksum:iA17EA222A4718112
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0579952539 – 2547ILSFDYENR → M in isoform A. 9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF51061.1
AE014134 Genomic DNA Translation: AFH03540.1
AE014134 Genomic DNA Translation: AFH03541.1

NCBI Reference Sequences

More...
RefSeqi
NP_001245864.1, NM_001258935.3 [M9NDE3-1]
NP_001245865.1, NM_001258936.2 [M9NDE3-1]
NP_608808.1, NM_134964.4 [M9NDE3-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0077496; FBpp0077185; FBgn0031571 [M9NDE3-2]
FBtr0307051; FBpp0297894; FBgn0031571 [M9NDE3-1]
FBtr0307052; FBpp0297895; FBgn0031571 [M9NDE3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33604

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3921

UCSC genome browser

More...
UCSCi
CG3921-RA d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF51061.1
AE014134 Genomic DNA Translation: AFH03540.1
AE014134 Genomic DNA Translation: AFH03541.1
RefSeqiNP_001245864.1, NM_001258935.3 [M9NDE3-1]
NP_001245865.1, NM_001258936.2 [M9NDE3-1]
NP_608808.1, NM_134964.4 [M9NDE3-2]

3D structure databases

SMRiM9NDE3
ModBaseiSearch...

Protein-protein interaction databases

IntActiM9NDE3, 3 interactors
STRINGi7227.FBpp0297894

Proteomic databases

PaxDbiM9NDE3
PRIDEiM9NDE3

Genome annotation databases

EnsemblMetazoaiFBtr0077496; FBpp0077185; FBgn0031571 [M9NDE3-2]
FBtr0307051; FBpp0297894; FBgn0031571 [M9NDE3-1]
FBtr0307052; FBpp0297895; FBgn0031571 [M9NDE3-1]
GeneIDi33604
KEGGidme:Dmel_CG3921
UCSCiCG3921-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
33604
FlyBaseiFBgn0031571 bark

Phylogenomic databases

eggNOGiENOG410IFUC Eukaryota
ENOG410XPY8 LUCA
HOGENOMiCLU_000296_1_0_1
OMAiNHIERCT
PhylomeDBiM9NDE3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
33604 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
33604

Protein Ontology

More...
PROi
PR:M9NDE3

Gene expression databases

BgeeiFBgn0031571 Expressed in imaginal disc and 31 other tissues
GenevisibleiQ9VQV1 DM

Family and domain databases

CDDicd00041 CUB, 1 hit
Gene3Di2.60.120.290, 1 hit
3.10.100.10, 1 hit
3.10.250.10, 3 hits
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000859 CUB_dom
IPR006626 PbH1
IPR011050 Pectin_lyase_fold/virulence
IPR035914 Sperma_CUB_dom_sf
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
PfamiView protein in Pfam
PF00530 SRCR, 3 hits
PRINTSiPR00258 SPERACTRCPTR
SMARTiView protein in SMART
SM00710 PbH1, 19 hits
SM00202 SR, 3 hits
SUPFAMiSSF49854 SSF49854, 1 hit
SSF51126 SSF51126, 1 hit
SSF56436 SSF56436, 1 hit
SSF56487 SSF56487, 3 hits
PROSITEiView protein in PROSITE
PS00420 SRCR_1, 1 hit
PS50287 SRCR_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBARK_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M9NDE3
Secondary accession number(s): Q9VQV1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 9, 2015
Last sequence update: June 26, 2013
Last modified: June 17, 2020
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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