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Entry version 59 (26 Feb 2020)
Sequence version 1 (26 Jun 2013)
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Protein
Submitted name:

Lethal (2) giant larvae, isoform G

Gene

l(2)gl

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Lethal (2) giant larvae, isoform GImported
Submitted name:
Lethal (2) giant larvae, isoform HImported
Submitted name:
Lethal (2) giant larvae, isoform IImported
Submitted name:
Lethal (2) giant larvae, isoform JImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:l(2)glImported
Synonyms:D-LGLImported, dlglImported, Dmel\CG2671Imported, glImported, l(2)Imported, l(2) giant larvaImported, l(2)giant larvaeImported, L(2)GLImported, L(2)glImported, l-glImported, l[[2]]glImported, LGLImported, LglImported, lglImported, MENE (2L)-BImported, p127Imported, p127[l(2)gl]Imported, p127l(2)glImported
ORF Names:CG2671Imported, Dmel_CG2671Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0002121 l(2)gl

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0002121 Expressed in wing disc (Drosophila) and 31 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
M9NCX1 differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
M9NCX1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini268 – 362LLGLInterPro annotationAdd BLAST95
Domaini869 – 966Lgl_CInterPro annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1141 – 1161DisorderedSequence analysisAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1983 Eukaryota
ENOG410XS6Z LUCA

KEGG Orthology (KO)

More...
KOi
K06094

Database of Orthologous Groups

More...
OrthoDBi
122541at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000664 Lethal2_giant
IPR013905 Lgl_C_dom
IPR013577 LLGL2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08596 Lgl_C, 1 hit
PF08366 LLGL, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00962 LETHAL2GIANT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

M9NCX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKFIRGKGQ QPSADRHRLQ KDLFAYRKTA QHGFPHKPSA LAYDPVLKLM
60 70 80 90 100
AIGTQTGALK VFGQPGVELY GQHTLLNNSA SELNVQLLEW VYGTGRILSL
110 120 130 140 150
TAANQLILWE PVGATLLPIK TLPFDGKLKK VSSLCCSLSK DLLWIGTEGG
160 170 180 190 200
NIYQLDLHTF TIKEPVIYHD VVLEQVPPAY KLNPGAIESI RQLPNSPSKL
210 220 230 240 250
LVAYNRGLCV LWDFESASVQ RAYIAPGHGQ SVGLTVNFEG SEFTWYHADG
260 270 280 290 300
SYATWSIDNP EPPSNVNYVP YGPDPCKSIN RLYKGKRRSN DVIVFSGGMP
310 320 330 340 350
RSAYGDHNCV SVHASDGHKV CLDFTSKVID FFVTFENNRD VAEVLVVLLE
360 370 380 390 400
EELCAYDLTD PNICAIKAPY LHSVHASAVT CNYLASEVVQ SVYESILRAG
410 420 430 440 450
DEQDIDYSNI SWPITGGTLP DNLEESVEED ATKLYEILLT GHEDGSVKFW
460 470 480 490 500
DCTGVLLKPI YNFKTSSIFG SESDFRDDAA ADMSAEQVDE GEPPFRKSGL
510 520 530 540 550
FDPYSDDPRL AVKKIAFCPK TGQLIVGGTA GQIVIADFID LPEKVSLKYI
560 570 580 590 600
SMNLVSDRDG FVWKGHDQLN VRSNLLDGEA IPTTERGVNI SGVLQVLPPA
610 620 630 640 650
SITCMALEAS WGLVSGGTAH GLVLFDFKNF VPVFHRCTLN PNDLTGAGEQ
660 670 680 690 700
LSRRKSFKKS LRESFRKLRK GRSTRTNQSN QVPTTLEARP VERQIEARCA
710 720 730 740 750
DDGLGSMVRC LLFAKTYVTN VNITSPTLWS ATNASTVSVF LLHLPPAQTA
760 770 780 790 800
ATAVPSASGN APPHMPRRIS AQLAKEIQLK HRAPVVGISI FDQAGSPVDQ
810 820 830 840 850
LNAGENGSPP HRVLIASEEQ FKVFSLPQLK PINKYKLTAN EGARIRRIHF
860 870 880 890 900
GSFSCRISPE TLQSMHGCSP TKSTRSHGDG EADPNISGSL AVSRGDVYNE
910 920 930 940 950
TALICLTNMG DIMVLSVPEL KRQLNAAAVR REDINGVSSL CFTNSGEALY
960 970 980 990 1000
MMSSSELQRI ALATSRVVQP TGVVPVEPLE NEESVLEEND AENNKETYAC
1010 1020 1030 1040 1050
DEVVNTYEIK NPSGISICTR PAEENVGRNS VQQVNGVNIS NSPNQANETI
1060 1070 1080 1090 1100
SSSIGDITVD SVRDHLNMTT TTLCSINTEE TIGRLSVLST QTNKASTTVN
1110 1120 1130 1140 1150
MSEIPNINIS NLEDLESKRN TTETSTSSVV IKSIITNISH EKTNGDNKIG
1160
TPKTAPEESQ F
Length:1,161
Mass (Da):126,892
Last modified:June 26, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i979F73A01DA62A1A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P08111L2GL_DROME
Lethal(2) giant larvae protein
l(2)gl CG2671
1,161Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PBJ2M9PBJ2_DROME
Lethal (2) giant larvae, isoform K
l(2)gl D-LGL, dlgl, Dmel\CG2671, gl, l(2)
1,093Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AFH03478.1
AE014134 Genomic DNA Translation: AFH03479.1
AE014134 Genomic DNA Translation: AFH03480.1
AE014134 Genomic DNA Translation: AFH03481.1

NCBI Reference Sequences

More...
RefSeqi
NP_001245801.1, NM_001258872.2
NP_001245802.1, NM_001258873.2
NP_001245803.1, NM_001258874.2
NP_001245804.1, NM_001258875.2
NP_523439.2, NM_078715.4
NP_722584.1, NM_164349.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0078170; FBpp0077828; FBgn0002121
FBtr0078171; FBpp0077829; FBgn0002121
FBtr0306589; FBpp0297544; FBgn0002121
FBtr0306590; FBpp0297545; FBgn0002121
FBtr0306591; FBpp0297546; FBgn0002121
FBtr0306592; FBpp0297547; FBgn0002121

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33156

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG2671

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AFH03478.1
AE014134 Genomic DNA Translation: AFH03479.1
AE014134 Genomic DNA Translation: AFH03480.1
AE014134 Genomic DNA Translation: AFH03481.1
RefSeqiNP_001245801.1, NM_001258872.2
NP_001245802.1, NM_001258873.2
NP_001245803.1, NM_001258874.2
NP_001245804.1, NM_001258875.2
NP_523439.2, NM_078715.4
NP_722584.1, NM_164349.3

3D structure databases

SMRiM9NCX1
ModBaseiSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078170; FBpp0077828; FBgn0002121
FBtr0078171; FBpp0077829; FBgn0002121
FBtr0306589; FBpp0297544; FBgn0002121
FBtr0306590; FBpp0297545; FBgn0002121
FBtr0306591; FBpp0297546; FBgn0002121
FBtr0306592; FBpp0297547; FBgn0002121
GeneIDi33156
KEGGidme:Dmel_CG2671

Organism-specific databases

FlyBaseiFBgn0002121 l(2)gl

Phylogenomic databases

eggNOGiKOG1983 Eukaryota
ENOG410XS6Z LUCA
KOiK06094
OrthoDBi122541at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
l(2)gl fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
33156

Gene expression databases

BgeeiFBgn0002121 Expressed in wing disc (Drosophila) and 31 other tissues
ExpressionAtlasiM9NCX1 differential

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR000664 Lethal2_giant
IPR013905 Lgl_C_dom
IPR013577 LLGL2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08596 Lgl_C, 1 hit
PF08366 LLGL, 1 hit
PRINTSiPR00962 LETHAL2GIANT
SUPFAMiSSF50978 SSF50978, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM9NCX1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M9NCX1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: February 26, 2020
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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