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Entry version 59 (26 Feb 2020)
Sequence version 1 (26 Jun 2013)
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Protein

Sodium channel protein

Gene

para

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:paraImported
Synonyms:basImported, bssImported, Dmel\CG9907Imported, DmNa[[V]]Imported, DmNa[[v]]Imported, DmNa[[v]]1Imported, DmNavImported, DmNav1Imported, l(1)14DaImported, l(1)ESHS48Imported, lincRNA.S9469Imported, Nav1Imported, OcdImported, olfDImported, parImported, ParaImported, sblImported, sbl-1Imported, ShuImported, ShuddererImported
ORF Names:CG9907Imported, Dmel_CG9907Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0285944 para

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei145 – 172HelicalUniRule annotationAdd BLAST28
Transmembranei216 – 238HelicalUniRule annotationAdd BLAST23
Transmembranei250 – 268HelicalUniRule annotationAdd BLAST19
Transmembranei274 – 296HelicalUniRule annotationAdd BLAST23
Transmembranei406 – 428HelicalUniRule annotationAdd BLAST23
Transmembranei790 – 813HelicalUniRule annotationAdd BLAST24
Transmembranei834 – 851HelicalUniRule annotationAdd BLAST18
Transmembranei863 – 887HelicalUniRule annotationAdd BLAST25
Transmembranei918 – 940HelicalUniRule annotationAdd BLAST23
Transmembranei998 – 1019HelicalUniRule annotationAdd BLAST22
Transmembranei1297 – 1319HelicalUniRule annotationAdd BLAST23
Transmembranei1325 – 1351HelicalUniRule annotationAdd BLAST27
Transmembranei1372 – 1403HelicalUniRule annotationAdd BLAST32
Transmembranei1490 – 1516HelicalUniRule annotationAdd BLAST27
Transmembranei1579 – 1597HelicalUniRule annotationAdd BLAST19
Transmembranei1609 – 1628HelicalUniRule annotationAdd BLAST20
Transmembranei1640 – 1659HelicalUniRule annotationAdd BLAST20
Transmembranei1703 – 1726HelicalUniRule annotationAdd BLAST24
Transmembranei1789 – 1812HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0264255 Expressed in head and 8 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
M9MSB8 differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1833 – 1868EF-handInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni35 – 84DisorderedSequence analysisAdd BLAST50
Regioni650 – 670DisorderedSequence analysisAdd BLAST21
Regioni1122 – 1196DisorderedSequence analysisAdd BLAST75
Regioni1957 – 2052DisorderedSequence analysisAdd BLAST96

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili432 – 482Sequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi35 – 65PolyampholyteSequence analysisAdd BLAST31
Compositional biasi1122 – 1136PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1137 – 1151PolarSequence analysisAdd BLAST15
Compositional biasi1152 – 1181PolyampholyteSequence analysisAdd BLAST30
Compositional biasi1182 – 1196AcidicSequence analysisAdd BLAST15
Compositional biasi1957 – 1980PolyampholyteSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2301 Eukaryota
ENOG410XNP6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167131

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002048 EF_hand_dom
IPR005821 Ion_trans_dom
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00170 NACHANNEL

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 55 potential isoforms that are computationally mapped.Show allAlign All

M9MSB8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEV
60 70 80 90 100
PQYGRKKKQK EIRYDDEDED EGPQPDPTLE QGVPIPVRLQ GSFPPELAST
110 120 130 140 150
PLEDIDPYYS NVLTFVVVSK GKDIFRFSAS KAMWMLDPFN PIRRVAIYIL
160 170 180 190 200
VHPLFSLFII TTILVNCILM IMPTTPTVES TEVIFTGIYT FESAVKVMAR
210 220 230 240 250
GFILCPFTYL RDAWNWLDFV VIALAYVTMG IDLGNLAALR TFRVLRALKT
260 270 280 290 300
VAIVPGLKTI VGAVIESVKN LRDVIILTMF SLSVFALMGL QIYMGVLTQK
310 320 330 340 350
CIKKFPLDGS WGNLTDENWD YHNRNSSNWY SEDEGISFPL CGNISGAGQC
360 370 380 390 400
DDDYVCLQGF GPNPNYGYTS FDSFGWAFLS AFRLMTQDFW EDLYQLVLRA
410 420 430 440 450
AGPWHMLFFI VIIFLGSFYL VNLILAIVAM SYDELQKKAE EEEAAEEEAI
460 470 480 490 500
REAEEAAAAK AAKLEERANA QAQAAADAAA AEEAALHPEM AKSPTYSCIS
510 520 530 540 550
YELFVGGEKG NDDNNKEKMS IRSVEVESES VSVIQRQPAP TTAHQATKVR
560 570 580 590 600
KVSTYTIRNG RGRFGIPGSD RKPLVLSTYQ DAQQHLPYAD DSNAVTPMSE
610 620 630 640 650
ENGAIIVPVY YGNLGSRHSS YTSHQSRISY TSHGDLLGGM AVMGVSTMTK
660 670 680 690 700
ESKLRNRNTR NQSVGATNGG TTCLDTNHKL DHRDYEIGLE CTDEAGKIKH
710 720 730 740 750
HDNPFIEPVQ TQTVVDMKDV MVLNDIIEQA AGRHSRASDR GVSVYYFPTE
760 770 780 790 800
DDDEDGPTFK DKALEVILKG IDVFCVWDCC WVWLKFQEWV SLIVFDPFVE
810 820 830 840 850
LFITLCIVVN TMFMAMDHHD MNKEMERVLK SGNYFFTATF AIEATMKLMA
860 870 880 890 900
MSPKYYFQEG WNIFDFIIVA LSLLELGLEG VQGLSVLRSF RLLRVFKLAK
910 920 930 940 950
SWPTLNLLIS IMGRTVGALG NLTFVLCIII FIFAVMGMQL FGKNYTDHKD
960 970 980 990 1000
RFPDGDLPRW NFTDFMHSFM IVFRVLCGEW IESMWDCMYV GDVSCIPFFL
1010 1020 1030 1040 1050
ATVVIGNLVV LNLFLALLLS NFGSSSLSAP TADNDTNKIA EAFNRIGRFK
1060 1070 1080 1090 1100
SWVKRNIADC FKLIRNKLTN QISDQPSEHG DNELELGHDE ILADGLIKKG
1110 1120 1130 1140 1150
IKEQTQLEVA IGDGMEFTIH GDMKNNKPKK SKYLNNATDD DTASINSYGS
1160 1170 1180 1190 1200
HKNRPFKDES HKGSAETMEG EEKRDASKED LGLDEELDEE GECEEGPLDG
1210 1220 1230 1240 1250
DIIIHAHDED ILDEYPADCC PDSYYKKFPI LAGDDDSPFW QGWGNLRLKT
1260 1270 1280 1290 1300
FQLIENKYFE TAVITMILMS SLALALEDVH LPQRPILQDI LYYMDRIFTV
1310 1320 1330 1340 1350
IFFLEMLIKW LALGFKVYFT NAWCWLDFVI VMVSLINFVA SLVGAGGIQA
1360 1370 1380 1390 1400
FKTMRTLRAL RPLRAMSRMQ GMRVVVNALV QAIPSIFNVL LVCLIFWLIF
1410 1420 1430 1440 1450
AIMGVQLFAG KYFKCEDMNG TKLSHEIIPN RNACESENYT WVNSAMNFDH
1460 1470 1480 1490 1500
VGNAYLCLFQ VATFKGWIQI MNDAIDSREV DKQPIRETNI YMYLYFVFFI
1510 1520 1530 1540 1550
IFGSFFTLNL FIGVIIDNFN EQKKKAGGSL EMFMTEDQKK YYNAMKKMGS
1560 1570 1580 1590 1600
KKPLKAIPRP RWRPQAIVFE IVTDKKFDII IMLFIGLNMF TMTLDRYDAS
1610 1620 1630 1640 1650
DTYNAVLDYL NAIFVVIFSS ECLLKIFALR YHYFIEPWNL FDVVVVILSI
1660 1670 1680 1690 1700
LGLVLSDIIE KYFVSPTLLR VVRVAKVGRV LRLVKGAKGI RTLLFALAMS
1710 1720 1730 1740 1750
LPALFNICLL LFLVMFIFAI FGMSFFMHVK EKSGINDVYN FKTFGQSMIL
1760 1770 1780 1790 1800
LFQMSTSAGW DGVLDAIINE EACDPPDNDK GYPGNCGSAT VGITFLLSYL
1810 1820 1830 1840 1850
VISFLIVINM YIAVILENYS QATEDVQEGL TDDDYDMYYE IWQQFDPEGT
1860 1870 1880 1890 1900
QYIRYDQLSE FLDVLEPPLQ IHKPNKYKII SMDIPICRGD LMYCVDILDA
1910 1920 1930 1940 1950
LTKDFFARKG NPIEETGEIG EIAARPDTEG YEPVSSTLWR QREEYCARLI
1960 1970 1980 1990 2000
QHAWRKHKAR GEGGGSFEPD TDHGDGGDPD AGDPAPDEAT DGDAPAGGDG
2010 2020 2030 2040 2050
SVNGTAEGAA DADESNVNSP GEDAAAAAAA AAAAAAAGTT TAGSPGAGSA
2060 2070 2080
GRQTAVLVES DGFVTKNGHK VVIHSRSPSI TSRTADV
Length:2,087
Mass (Da):234,465
Last modified:June 26, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E3566FDE6A6B15A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 55 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P35500SCNA_DROME
Sodium channel protein para
para CG9907
2,131Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JKQ0X2JKQ0_DROME
Sodium channel protein
para bas, bss, Dmel\CG9907, DmNa[[V]], DmNa[[v]]
2,131Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z0Z2B7Z0Z2_DROME
Sodium channel protein
para bas, bss, Dmel\CG9907, DmNa[[V]], DmNa[[v]]
2,114Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9MS71M9MS71_DROME
Sodium channel protein
para bas, bss, Dmel\CG9907, DmNa[[V]], DmNa[[v]]
2,092Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9MS73M9MS73_DROME
Sodium channel protein
para bas, bss, Dmel\CG9907, DmNa[[V]], DmNa[[v]]
2,079Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9MS92M9MS92_DROME
Sodium channel protein
para bas, bss, Dmel\CG9907, DmNa[[V]], DmNa[[v]]
2,143Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9MSP9M9MSP9_DROME
Sodium channel protein
para bas, bss, Dmel\CG9907, DmNa[[V]], DmNa[[v]]
2,062Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JFE8X2JFE8_DROME
Sodium channel protein
para bas, bss, Dmel\CG9907, DmNa[[V]], DmNa[[v]]
2,055Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9MS61M9MS61_DROME
Sodium channel protein
para bas, bss, Dmel\CG9907, DmNa[[V]], DmNa[[v]]
2,108Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9MS65M9MS65_DROME
Sodium channel protein
para bas, bss, Dmel\CG9907, DmNa[[V]], DmNa[[v]]
2,100Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: ADV37689.1

NCBI Reference Sequences

More...
RefSeqi
NP_001188607.1, NM_001201678.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0303662; FBpp0292679; FBgn0285944

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32619

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: ADV37689.1
RefSeqiNP_001188607.1, NM_001201678.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiFBtr0303662; FBpp0292679; FBgn0285944
GeneIDi32619

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
32619
FlyBaseiFBgn0285944 para

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
GeneTreeiENSGT00940000167131

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
para fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
32619

Gene expression databases

BgeeiFBgn0264255 Expressed in head and 8 other tissues
ExpressionAtlasiM9MSB8 differential

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR002048 EF_hand_dom
IPR005821 Ion_trans_dom
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM9MSB8_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M9MSB8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: February 26, 2020
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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