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Entry version 68 (26 Feb 2020)
Sequence version 1 (26 Jun 2013)
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Protein
Submitted name:

Nejire, isoform C

Gene

nej

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei2120Acetyl-CoA; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei2125Acetyl-CoAPROSITE-ProRule annotation1
Binding sitei2129Acetyl-CoAPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri514 – 600TAZ-typePROSITE-ProRule annotationAdd BLAST87
Zinc fingeri2398 – 2479TAZ-typePROSITE-ProRule annotationAdd BLAST82

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferasePROSITE-ProRule annotationImported, Transferase
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1234158 Regulation of gene expression by Hypoxia-inducible Factor
R-DME-201722 Formation of the beta-catenin:TCF transactivating complex
R-DME-3214847 HATs acetylate histones
R-DME-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-DME-5621575 CD209 (DC-SIGN) signaling
R-DME-6781823 Formation of TC-NER Pre-Incision Complex
R-DME-6782135 Dual incision in TC-NER
R-DME-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-DME-6804758 Regulation of TP53 Activity through Acetylation
R-DME-6811555 PI5P Regulates TP53 Acetylation
R-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DME-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-DME-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-DME-8941858 Regulation of RUNX3 expression and activity
R-DME-8951936 RUNX3 regulates p14-ARF
R-DME-9018519 Estrogen-dependent gene expression
R-DME-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
R-DME-9617629 Regulation of FOXO transcriptional activity by acetylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nejire, isoform CImported (EC:2.3.1.48Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nejImported
Synonyms:anon-WO0147981.11Imported, anon-WO03040301.89Imported, CBPImported, CbpImported, cbpImported, CBP_Imported, CG15321Imported, CrbpImported, dCBPImported, dKAT3Imported, dmCBPImported, Dmel\CG15319Imported, l(1)G0112Imported, l(1)G0350Imported, l(1)G0470Imported, NejImported, nej CBPImported, NejireImported, p300Imported
ORF Names:CG15319Imported, Dmel_CG15319Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0261617 nej

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
M9MS40

PRoteomics IDEntifications database

More...
PRIDEi
M9MS40

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261617 Expressed in female gonad and 25 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
M9MS40 differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0291862

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
M9MS40

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini514 – 600TAZ-typeInterPro annotationAdd BLAST87
Domaini944 – 1023KIXInterPro annotationAdd BLAST80
Domaini1721 – 1793BromoInterPro annotationAdd BLAST73
Domaini1951 – 2334CBP/p300-type HATInterPro annotationAdd BLAST384
Domaini2335 – 2378ZZ-typeInterPro annotationAdd BLAST44
Domaini2398 – 2479TAZ-typeInterPro annotationAdd BLAST82

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni33 – 87DisorderedSequence analysisAdd BLAST55
Regioni111 – 156DisorderedSequence analysisAdd BLAST46
Regioni310 – 334DisorderedSequence analysisAdd BLAST25
Regioni349 – 471DisorderedSequence analysisAdd BLAST123
Regioni617 – 657DisorderedSequence analysisAdd BLAST41
Regioni688 – 713DisorderedSequence analysisAdd BLAST26
Regioni765 – 839DisorderedSequence analysisAdd BLAST75
Regioni874 – 949DisorderedSequence analysisAdd BLAST76
Regioni1070 – 1119DisorderedSequence analysisAdd BLAST50
Regioni1149 – 1190DisorderedSequence analysisAdd BLAST42
Regioni1230 – 1605DisorderedSequence analysisAdd BLAST376
Regioni1636 – 1701DisorderedSequence analysisAdd BLAST66
Regioni2061 – 2063Acetyl-CoA bindingPROSITE-ProRule annotation3
Regioni2073 – 2074Acetyl-CoA bindingPROSITE-ProRule annotation2
Regioni2211 – 2250DisorderedSequence analysisAdd BLAST40
Regioni2686 – 2741DisorderedSequence analysisAdd BLAST56
Regioni2861 – 2963DisorderedSequence analysisAdd BLAST103
Regioni3005 – 3034DisorderedSequence analysisAdd BLAST30
Regioni3096 – 3240DisorderedSequence analysisAdd BLAST145

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2176 – 2203Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi112 – 156PolarSequence analysisAdd BLAST45
Compositional biasi359 – 380PolarSequence analysisAdd BLAST22
Compositional biasi416 – 439PolarSequence analysisAdd BLAST24
Compositional biasi446 – 471PolarSequence analysisAdd BLAST26
Compositional biasi639 – 657PolarSequence analysisAdd BLAST19
Compositional biasi781 – 834PolarSequence analysisAdd BLAST54
Compositional biasi905 – 923PolarSequence analysisAdd BLAST19
Compositional biasi1070 – 1091PolarSequence analysisAdd BLAST22
Compositional biasi1149 – 1167PolarSequence analysisAdd BLAST19
Compositional biasi1230 – 1314PolarSequence analysisAdd BLAST85
Compositional biasi1326 – 1382PolarSequence analysisAdd BLAST57
Compositional biasi1398 – 1465PolarSequence analysisAdd BLAST68
Compositional biasi1473 – 1487PolarSequence analysisAdd BLAST15
Compositional biasi1495 – 1524PolarSequence analysisAdd BLAST30
Compositional biasi1539 – 1553PolarSequence analysisAdd BLAST15
Compositional biasi1563 – 1580PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1581 – 1605PolarSequence analysisAdd BLAST25
Compositional biasi2220 – 2236BasicSequence analysisAdd BLAST17
Compositional biasi2727 – 2741PolarSequence analysisAdd BLAST15
Compositional biasi2878 – 2948PolarSequence analysisAdd BLAST71
Compositional biasi3096 – 3145PolarSequence analysisAdd BLAST50
Compositional biasi3154 – 3173PolarSequence analysisAdd BLAST20
Compositional biasi3174 – 3196Pro-richSequence analysisAdd BLAST23

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri514 – 600TAZ-typePROSITE-ProRule annotationAdd BLAST87
Zinc fingeri2398 – 2479TAZ-typePROSITE-ProRule annotationAdd BLAST82

Keywords - Domaini

BromodomainPROSITE-ProRule annotationSAAS annotation, Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1778 Eukaryota
COG5076 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166210

KEGG Orthology (KO)

More...
KOi
K04498

Database of Orthologous Groups

More...
OrthoDBi
27346at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
M9MS40

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15802 RING_CBP-p300, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.246.20, 1 hit
1.20.1020.10, 2 hits
1.20.920.10, 1 hit
2.10.110.40, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR031162 CBP_P300_HAT
IPR013178 Histone_AcTrfase_Rtt109/CBP
IPR003101 KIX_dom
IPR036529 KIX_dom_sf
IPR010303 RING_CBP-p300
IPR038547 RING_CBP-p300_sf
IPR035898 TAZ_dom_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR013083 Znf_RING/FYVE/PHD
IPR000197 Znf_TAZ
IPR000433 Znf_ZZ

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439 Bromodomain, 1 hit
PF06001 DUF902, 1 hit
PF08214 HAT_KAT11, 1 hit
PF02172 KIX, 1 hit
PF02135 zf-TAZ, 2 hits
PF00569 ZZ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 1 hit
SM01250 KAT11, 1 hit
SM00551 ZnF_TAZ, 2 hits
SM00291 ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47040 SSF47040, 1 hit
SSF47370 SSF47370, 1 hit
SSF57933 SSF57933, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51727 CBP_P300_HAT, 1 hit
PS50952 KIX, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50134 ZF_TAZ, 2 hits
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

M9MS40-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMADHLDEPP QKRVKMDPTD ISYFLEENLP DELVSSNSGW SDQLTGGAGG
60 70 80 90 100
GNGGGGASGV TTNPTSGPNP GGGPNKPAAQ GPGSGTGGVG VGVNVGVGGV
110 120 130 140 150
VGVGVVPSQM NGAGGGNGSG TGGDDGSGNG SGAGNRISQM QHQQLQHLLQ
160 170 180 190 200
QQQQGQKGAM VVPGMQQLGS KSPNLQSPNQ GGMQQVVGTQ MGMVNSMPMS
210 220 230 240 250
ISNNGNNGMN AIPGMNTIAQ GNLGNMVLTN SVGGGMGGMV NHLKQQPGGG
260 270 280 290 300
GGGMINSVSV PGGPGAGAGG VGAGGGGAVA ANQGMHMQNG PMMGRMVGQQ
310 320 330 340 350
HMLRGPHLMG ASGGAGGPGN GPGGGGPRMQ NPNMQMNFRP FAAQLNSLPY
360 370 380 390 400
GVGQYGGPGG GNNPQQQQQQ QQQQLLAQQM AQRGGVVPGM PQGNRPVGTV
410 420 430 440 450
VPMSTLGGDG SGPAGQLVSG NPQQQQMLAQ QQTGAMGPRP PQPNQLLGHP
460 470 480 490 500
GQQQQQQQQP GTSQQQQQQQ GVGIGGAGVV ANAGTVAGVP AVAGGGAGGA
510 520 530 540 550
VQSSGPGGAN RDVPDDRKRQ IQQQLMLLLH AHKCNRRENL NPNREVCNVN
560 570 580 590 600
YCKAMKSVLA HMGTCKQSKD CTMQHCASSR QILLHYKTCQ NSGCVICYPF
610 620 630 640 650
RQNHSVFQNA NVPPGGGPAG IGGAPPGGGG AGGGAAGAGG NLQQQQQQQQ
660 670 680 690 700
QQQQNQQPNL TGLVVDGKQG QQVAPGGGQN TAIVLPQQQG AGGAPGAPKT
710 720 730 740 750
PADMVQQLTQ QQQQQQQQVH QQQVQQQELR RFDGMSQQVV AGGMQQQQQQ
760 770 780 790 800
GLPPVIRIQG AQPAVRVLGP GGPGGPSGPN VLPNDVNSLH QQQQQMLQQQ
810 820 830 840 850
QQQGQNRRRG GLATMVEQQQ QHQQQQQQPN PAQLGGNIPA PLSVNVGGFG
860 870 880 890 900
NTNFGGAAAG GAVGANDKQQ LKVAQVHPQS HGVGAGGASA GAGASGGQVA
910 920 930 940 950
AGSSVLMPAD TTGSGNAGNP NQNAGGVAGG AGGGNGGNTG PPGDNEKDWR
960 970 980 990 1000
ESVTADLRNH LVHKLVQAIF PTSDPTTMQD KRMHNLVSYA EKVEKDMYEM
1010 1020 1030 1040 1050
AKSRSEYYHL LAEKIYKIQK ELEEKRLKRK EQHQQMLMQQ QGVANPVAGG
1060 1070 1080 1090 1100
AAGGAGSAAG VAGGVVLPQQ QQQQQQQQQQ QGQQPLQSCI HPSISPMGGV
1110 1120 1130 1140 1150
MPPQQLRPQG PPGILGQQTA AGLGVGVGVT NNMVTMRSHS PGGNMLALQQ
1160 1170 1180 1190 1200
QQRMQFPQQQ QQQPPGSGAG KMLVGPPGPS PGGMVVNPAL SPYQTTNVLT
1210 1220 1230 1240 1250
SPVPGQQQQQ QFINANGGTG ANPQLSEIMK QRHIHQQQQQ QQQQQQQGML
1260 1270 1280 1290 1300
LPQSPFSNST PLQQQQQQQQ QQQQQQQATS NSFSSPMQQQ QQGQQQQQQK
1310 1320 1330 1340 1350
PGSVLNNMPP TPTSLEALNA GAGAPGTGGS ASNVTVSAPS PSPGFLSNGP
1360 1370 1380 1390 1400
SIGTPSNNNN NSSANNNPPS VSSLMQQPLS NRPGTPPYIP ASPVPATSAS
1410 1420 1430 1440 1450
GLAASSTPAS AAATCASSGS GSNSSSGATA AGASSTSSSS SAGSGTPLSS
1460 1470 1480 1490 1500
VSTPTSATMA TSSGGGGGGG GNAGGGSSTT PASNPLLLMS GGTAGGGTGA
1510 1520 1530 1540 1550
TTTTSTSSSS RMMSSSSSLS SQMAALEAAA RDNDDETPSP SGENTNGSGG
1560 1570 1580 1590 1600
SGNAGGMASK GKLDSIKQDD DIKKEFMDDS CGGNNDSSQM DCSTGGGKGK
1610 1620 1630 1640 1650
NVNNDGTSMI KMEIKTEDGL DGEVKIKTEA MDVDEAGGST AGEHHGEGGG
1660 1670 1680 1690 1700
GSGVGGGKDN INGAHDGGAT GGAVDIKPKT ETKPLVPEPL APNAGDKKKK
1710 1720 1730 1740 1750
CQFNPEELRT ALLPTLEKLY RQEPESVPFR YPVDPQALGI PDYFEIVKKP
1760 1770 1780 1790 1800
MDLGTIRTNI QNGKYSDPWE YVDDVWLMFD NAWLYNRKTS RVYRYCTKLS
1810 1820 1830 1840 1850
EVFEAEIDPV MQALGYCCGR KYTFNPQVLC CYGKQLCTIP RDAKYYSYQN
1860 1870 1880 1890 1900
SLKEYGVASN RYTYCQKCFN DIQGDTVTLG DDPLQSQTQI KKDQFKEMKN
1910 1920 1930 1940 1950
DHLELEPFVN CQECGRKQHQ ICVLWLDSIW PGGFVCDNCL KKKNSKRKEN
1960 1970 1980 1990 2000
KFNAKRLPTT KLGVYIETRV NNFLKKKEAG AGEVHIRVVS SSDKCVEVKP
2010 2020 2030 2040 2050
GMRRRFVEQG EMMNEFPYRA KALFAFEEVD GIDVCFFGMH VQEYGSECPA
2060 2070 2080 2090 2100
PNTRRVYIAY LDSVHFFRPR QYRTAVYHEI LLGYMDYVKQ LGYTMAHIWA
2110 2120 2130 2140 2150
CPPSEGDDYI FHCHPTDQKI PKPKRLQEWY KKMLDKGMIE RIIQDYKDIL
2160 2170 2180 2190 2200
KQAMEDKLGS AAELPYFEGD FWPNVLEESI KELDQEEEEK RKQAEAAEAA
2210 2220 2230 2240 2250
AAANLFSIEE NEVSGDGKKK GQKKAKKSNK SKAAQRKNSK KSNEHQSGND
2260 2270 2280 2290 2300
LSTKIYATME KHKEVFFVIR LHSAQSAASL APIQDPDPLL TCDLMDGRDA
2310 2320 2330 2340 2350
FLTLARDKHF EFSSLRRAQF STLSMLYELH NQGQDKFVYT CNHCKTAVET
2360 2370 2380 2390 2400
RYHCTVCDDF DLCIVCKEKV GHQHKMEKLG FDIDDGSALA DHKQANPQEA
2410 2420 2430 2440 2450
RKQSIQRCIQ SLAHACQCRD ANCRLPSCQK MKLVVQHTKN CKRKPNGGCP
2460 2470 2480 2490 2500
ICKQLIALCC YHAKNCEEQK CPVPFCPNIK HKLKQQQSQQ KFQQQQLLRR
2510 2520 2530 2540 2550
RVALMSRTAA PAALQGPAAV SGPTVVSGGV PVVGMSGVAV SQQVIPGQAG
2560 2570 2580 2590 2600
ILPPGAGGMS PSTVAVPSPV SGGAGAGGMG GMTSPHPHQP GIGMKPGGGH
2610 2620 2630 2640 2650
SPSPNVLQVV KQVQEEAARQ QVSHGGGFGK GVPMAPPVMN RPMGGAGPNQ
2660 2670 2680 2690 2700
NVVNQLGGMG VGVGGVGGVG VGGVGGVGVN QLNSGGGNTP GAPISGPGMN
2710 2720 2730 2740 2750
VNHLMSMDQW GGGGAGGGGA NPGGGNPQAR YANNTGGMRQ PTHVMQTNLI
2760 2770 2780 2790 2800
PPQQQQQMMG GLGGPNQLGG GQMPVGGQHG GMGMGMGAPP MAGTVGGVRP
2810 2820 2830 2840 2850
SPGAGGGGGS ATGGGLNTQQ LALIMQKIKN NPTNESNQHI LAILKQNPQI
2860 2870 2880 2890 2900
MAAIIKQRQQ SQNNAAAGGG APGPGGALQQ QQAGNGPQNP QQQQQQQQQQ
2910 2920 2930 2940 2950
QVMQQQQMQH MMNQQQGGGG PQQMNPNQQQ QQQQVNLMQQ QQQGGPGGPG
2960 2970 2980 2990 3000
SGLPTRMPNM PNALGMLQSL PPNMSPGVST QGGMVPNQNW NKMRYMQMSQ
3010 3020 3030 3040 3050
YPPPYPQRQR GPHMGGAGPG PGQQQFPGGG GGAGNFNAGG AGGAGGVVGV
3060 3070 3080 3090 3100
GGVPGGAGTV PGGDQYSMAN AAAASNMLQQ QQGQVGVGVG VGVKPGPGQQ
3110 3120 3130 3140 3150
QQQMGVGMPP GMQQQQQQQQ PLQQQQMMQV AMPNANAQNP SAVVGGPNAQ
3160 3170 3180 3190 3200
VMGPPTPHSL QQQLMQSARS SPPIRSPQPT PSPRSAPSPR AAPSASPRAQ
3210 3220 3230 3240 3250
PSPHHVMSSH SPAPQGPPHD GMHNHGMHHQ SPLPGVPQDV GVGVGVGVGV
3260 3270 3280
GVNVNVGNVG VGNAGGALPD ASDQLTKFVE RL
Length:3,282
Mass (Da):341,431
Last modified:June 26, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A5A472BB9EF3918
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9W321Q9W321_DROME
Nejire, isoform B
nej anon-WO0147981.11, anon-WO03040301.89, CBP, Cbp, cbp
3,276Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PH39M9PH39_DROME
Nejire, isoform E
nej anon-WO0147981.11, anon-WO03040301.89, CBP, Cbp, cbp
3,266Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE014298 Genomic DNA Translation: ADV37657.1

NCBI Reference Sequences

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RefSeqi
NP_001188575.1, NM_001201646.2

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0302722; FBpp0291862; FBgn0261617

Database of genes from NCBI RefSeq genomes

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GeneIDi
43856

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG15319

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: ADV37657.1
RefSeqiNP_001188575.1, NM_001201646.2

3D structure databases

SMRiM9MS40
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0291862

Proteomic databases

PaxDbiM9MS40
PRIDEiM9MS40

Genome annotation databases

EnsemblMetazoaiFBtr0302722; FBpp0291862; FBgn0261617
GeneIDi43856
KEGGidme:Dmel_CG15319

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43856
FlyBaseiFBgn0261617 nej

Phylogenomic databases

eggNOGiKOG1778 Eukaryota
COG5076 LUCA
GeneTreeiENSGT00940000166210
KOiK04498
OrthoDBi27346at2759
PhylomeDBiM9MS40

Enzyme and pathway databases

ReactomeiR-DME-1234158 Regulation of gene expression by Hypoxia-inducible Factor
R-DME-201722 Formation of the beta-catenin:TCF transactivating complex
R-DME-3214847 HATs acetylate histones
R-DME-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-DME-5621575 CD209 (DC-SIGN) signaling
R-DME-6781823 Formation of TC-NER Pre-Incision Complex
R-DME-6782135 Dual incision in TC-NER
R-DME-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-DME-6804758 Regulation of TP53 Activity through Acetylation
R-DME-6811555 PI5P Regulates TP53 Acetylation
R-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-DME-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-DME-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-DME-8941858 Regulation of RUNX3 expression and activity
R-DME-8951936 RUNX3 regulates p14-ARF
R-DME-9018519 Estrogen-dependent gene expression
R-DME-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
R-DME-9617629 Regulation of FOXO transcriptional activity by acetylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
nej fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
43856

Gene expression databases

BgeeiFBgn0261617 Expressed in female gonad and 25 other tissues
ExpressionAtlasiM9MS40 differential

Family and domain databases

CDDicd15802 RING_CBP-p300, 1 hit
Gene3Di1.10.246.20, 1 hit
1.20.1020.10, 2 hits
1.20.920.10, 1 hit
2.10.110.40, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR031162 CBP_P300_HAT
IPR013178 Histone_AcTrfase_Rtt109/CBP
IPR003101 KIX_dom
IPR036529 KIX_dom_sf
IPR010303 RING_CBP-p300
IPR038547 RING_CBP-p300_sf
IPR035898 TAZ_dom_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR013083 Znf_RING/FYVE/PHD
IPR000197 Znf_TAZ
IPR000433 Znf_ZZ
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF06001 DUF902, 1 hit
PF08214 HAT_KAT11, 1 hit
PF02172 KIX, 1 hit
PF02135 zf-TAZ, 2 hits
PF00569 ZZ, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM01250 KAT11, 1 hit
SM00551 ZnF_TAZ, 2 hits
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF47040 SSF47040, 1 hit
SSF47370 SSF47370, 1 hit
SSF57933 SSF57933, 2 hits
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51727 CBP_P300_HAT, 1 hit
PS50952 KIX, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50134 ZF_TAZ, 2 hits
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM9MS40_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M9MS40
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: February 26, 2020
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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