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Entry version 58 (26 Feb 2020)
Sequence version 1 (26 Jun 2013)
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Protein
Submitted name:

Ankyrin 2, isoform R

Gene

Ank2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin 2, isoform RImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ank2Imported
Synonyms:ank2Imported, ank2-LImported, CG18025Imported, CG18227Imported, CG18768Imported, CG32373Imported, CG32375Imported, CG32377Imported, CG34121Imported, CG34158Imported, CG34416Imported, CG7462Imported, CG7493Imported, DAnk2Imported, Dank2Imported, dank2Imported, Dmel\CG42734Imported, ESTS:149B10SImported, SP2523Imported, sp2523Imported
ORF Names:CG42734Imported, Dmel_CG42734Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0261788 Ank2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261788 Expressed in head and 25 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
M9MRS5 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
M9MRS5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini160 – 935ANK_REP_REGIONInterPro annotationAdd BLAST776
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati193 – 225ANKPROSITE-ProRule annotationAdd BLAST33
Repeati226 – 258ANKPROSITE-ProRule annotationAdd BLAST33
Repeati259 – 291ANKPROSITE-ProRule annotationAdd BLAST33
Repeati292 – 314ANKPROSITE-ProRule annotationAdd BLAST23
Repeati354 – 386ANKPROSITE-ProRule annotationAdd BLAST33
Repeati387 – 419ANKPROSITE-ProRule annotationAdd BLAST33
Repeati420 – 452ANKPROSITE-ProRule annotationAdd BLAST33
Repeati453 – 485ANKPROSITE-ProRule annotationAdd BLAST33
Repeati486 – 518ANKPROSITE-ProRule annotationAdd BLAST33
Repeati519 – 551ANKPROSITE-ProRule annotationAdd BLAST33
Repeati552 – 584ANKPROSITE-ProRule annotationAdd BLAST33
Repeati585 – 617ANKPROSITE-ProRule annotationAdd BLAST33
Repeati618 – 650ANKPROSITE-ProRule annotationAdd BLAST33
Repeati651 – 683ANKPROSITE-ProRule annotationAdd BLAST33
Repeati684 – 716ANKPROSITE-ProRule annotationAdd BLAST33
Repeati717 – 749ANKPROSITE-ProRule annotationAdd BLAST33
Repeati750 – 782ANKPROSITE-ProRule annotationAdd BLAST33
Repeati783 – 815ANKPROSITE-ProRule annotationAdd BLAST33
Repeati816 – 848ANKPROSITE-ProRule annotationAdd BLAST33
Repeati849 – 881ANKPROSITE-ProRule annotationAdd BLAST33
Repeati882 – 914ANKPROSITE-ProRule annotationAdd BLAST33
Domaini1109 – 1266ZU5InterPro annotationAdd BLAST158
Domaini1268 – 1415ZU5InterPro annotationAdd BLAST148
Domaini1600 – 1682DeathInterPro annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni17 – 112DisorderedSequence analysisAdd BLAST96
Regioni131 – 163DisorderedSequence analysisAdd BLAST33
Regioni1043 – 1062DisorderedSequence analysisAdd BLAST20
Regioni1722 – 1743DisorderedSequence analysisAdd BLAST22
Regioni1837 – 1859DisorderedSequence analysisAdd BLAST23
Regioni2033 – 2073DisorderedSequence analysisAdd BLAST41
Regioni2108 – 2137DisorderedSequence analysisAdd BLAST30
Regioni2263 – 2307DisorderedSequence analysisAdd BLAST45
Regioni2323 – 2342DisorderedSequence analysisAdd BLAST20
Regioni2521 – 2543DisorderedSequence analysisAdd BLAST23
Regioni2729 – 2764DisorderedSequence analysisAdd BLAST36
Regioni2832 – 2931DisorderedSequence analysisAdd BLAST100
Regioni2984 – 3014DisorderedSequence analysisAdd BLAST31
Regioni3089 – 3251DisorderedSequence analysisAdd BLAST163
Regioni3420 – 3481DisorderedSequence analysisAdd BLAST62
Regioni3540 – 3563DisorderedSequence analysisAdd BLAST24
Regioni3685 – 3814DisorderedSequence analysisAdd BLAST130
Regioni3886 – 3912DisorderedSequence analysisAdd BLAST27
Regioni3926 – 3950DisorderedSequence analysisAdd BLAST25
Regioni4005 – 4049DisorderedSequence analysisAdd BLAST45
Regioni4268 – 4301DisorderedSequence analysisAdd BLAST34
Regioni4458 – 4496DisorderedSequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi32 – 46PolarSequence analysisAdd BLAST15
Compositional biasi48 – 62BasicSequence analysisAdd BLAST15
Compositional biasi76 – 91PolarSequence analysisAdd BLAST16
Compositional biasi1837 – 1856PolyampholyteSequence analysisAdd BLAST20
Compositional biasi2263 – 2298PolarSequence analysisAdd BLAST36
Compositional biasi2729 – 2747PolarSequence analysisAdd BLAST19
Compositional biasi2748 – 2764PolyampholyteSequence analysisAdd BLAST17
Compositional biasi2837 – 2856PolarSequence analysisAdd BLAST20
Compositional biasi2863 – 2881PolarSequence analysisAdd BLAST19
Compositional biasi2991 – 3012PolyampholyteSequence analysisAdd BLAST22
Compositional biasi3094 – 3119PolyampholyteSequence analysisAdd BLAST26
Compositional biasi3120 – 3140PolarSequence analysisAdd BLAST21
Compositional biasi3176 – 3194PolyampholyteSequence analysisAdd BLAST19
Compositional biasi3212 – 3242PolyampholyteSequence analysisAdd BLAST31
Compositional biasi3734 – 3786PolyampholyteSequence analysisAdd BLAST53
Compositional biasi3794 – 3810PolyampholyteSequence analysisAdd BLAST17
Compositional biasi3926 – 3944PolyampholyteSequence analysisAdd BLAST19
Compositional biasi4023 – 4047PolarSequence analysisAdd BLAST25
Compositional biasi4271 – 4294PolyampholyteSequence analysisAdd BLAST24
Compositional biasi4460 – 4476PolarSequence analysisAdd BLAST17
Compositional biasi4477 – 4496PolyampholyteSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4177 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167243

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000120_0_0_1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR040745 Ankyrin_UPA
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR000906 ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 7 hits
PF00531 Death, 1 hit
PF17809 UPA_2, 1 hit
PF00791 ZU5, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 24 hits
SM00218 ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 21 hits
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 19 potential isoforms that are computationally mapped.Show allAlign All

M9MRS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQFVTHIQP TLMEASQGHV PHHHGHQVGV QHSSHLPHSG HNMPSPPTHN
60 70 80 90 100
HHHAHGHGHH TSSGGHHGGA GGHSQKQAAH HSTTSGHAAK GQHHSPPSRI
110 120 130 140 150
HSPPTEHHPD HVGHYEYFQH QHEQIFHHEG ANGGASHKQQ THHHPNKHEH
160 170 180 190 200
CPTGHQSAGD GNTSFLRAAR AGNLERVLEH LKNNIDINTS NANGLNALHL
210 220 230 240 250
ASKDGHIHVV SELLRRGAIV DSATKKGNTA LHIASLAGQE EVVKLLLEHN
260 270 280 290 300
ASVNVQSQNG FTPLYMAAQE NHDAVVRLLL SNGANQSLAT EDGFTPLAVA
310 320 330 340 350
MQQGHDKVVA VLLESDTRGK VRLPALHIAA KKDDVKAATL LLDNDHNPDV
360 370 380 390 400
TSKSGFTPLH IASHYGNQNI ANLLIQKGAD VNYSAKHNIS PLHVAAKWGK
410 420 430 440 450
TNMVSLLLEK GGNIEAKTRD GLTPLHCAAR SGHEQVVDML LERGAPISAK
460 470 480 490 500
TKNGLAPLHM AAQGEHVDAA RILLYHRAPV DEVTVDYLTA LHVAAHCGHV
510 520 530 540 550
RVAKLLLDRN ADANARALNG FTPLHIACKK NRLKVVELLL RHGASISATT
560 570 580 590 600
ESGLTPLHVA AFMGCMNIVI YLLQHDASPD VPTVRGETPL HLAARANQTD
610 620 630 640 650
IIRILLRNGA QVDARAREQQ TPLHIASRLG NVDIVMLLLQ HGAQVDATTK
660 670 680 690 700
DMYTALHIAA KEGQDEVAAV LIENGAALDA ATKKGFTPLH LTAKYGHIKV
710 720 730 740 750
AQLLLQKEAD VDAQGKNGVT PLHVACHYNN QQVALLLLEK GASPHATAKN
760 770 780 790 800
GHTPLHIAAR KNQMDIATTL LEYGALANAE SKAGFTPLHL SSQEGHAEIS
810 820 830 840 850
NLLIEHKAAV NHPAKNGLTP MHLCAQEDNV NVAEILEKNG ANIDMATKAG
860 870 880 890 900
YTPLHVASHF GQANMVRFLL QNGANVDAAT SIGYTPLHQT AQQGHCHIVN
910 920 930 940 950
LLLEHKANAN AQTVNGQTPL HIARKLGYIS VLDSLKTITK EDETAAAPSQ
960 970 980 990 1000
AEEKYRVVAP EAMHESFMSD SEEEGGDTNW QLDAGYEYGF GPIYLPYYQG
1010 1020 1030 1040 1050
DKHYVSSEDN MLSDQPYRYL TVDEMKSLGD DSLPIDVTRD ERMDSNRMTQ
1060 1070 1080 1090 1100
SAEYASGVPP TIGEEVISPH KTQVYGSSPK ATVDGVYIAN GSGHDEPPHV
1110 1120 1130 1140 1150
GRKLSWKSFL VSFLVDARGG AMRGCRHSGV RMIIPSRSTC QPTRVTCRYV
1160 1170 1180 1190 1200
KPQRTMHPPQ LMEGEALASR VLELGPCSTK FIGPVVMEVP HFASLRGKER
1210 1220 1230 1240 1250
EIIILRSDNG ETWREHTIDN SEEIIHDVLQ QCFEPEEIAQ LEEQAGNHVC
1260 1270 1280 1290 1300
RFVTYDFPQY FAVVSRIRQE VHAIGPEGGM VSSTVVPQVQ AVFPQGALTK
1310 1320 1330 1340 1350
KIKVGLQAQP VDPDLTAKLL GRGVAVSPIV TVEPRRRKFH KAITLSMPAP
1360 1370 1380 1390 1400
KAHSQGMINQ YSGNTPTLRL LCSITGGPSR AQWEDVTGST PLTFVNDCVS
1410 1420 1430 1440 1450
FTTTVSARFW LMDCRNISDA TKMATELYKE VIHVPFIAKF VVFAKKVEPF
1460 1470 1480 1490 1500
EAKLRVFCMT DDREDKTLEK HELYTEVAKS RDVEVLEGKP QYIEMAGNLV
1510 1520 1530 1540 1550
PVTKSGDQLQ VQFKAFRENR LPFTVRVKDQ HADIVGRTLF MKEPKVAKGE
1560 1570 1580 1590 1600
PPQQPICILN IVLPEAVIPD STTAFSDRVT SAYRTSMFSL SKHQNDHYIG
1610 1620 1630 1640 1650
DIRIVDLSNL LGKDWIQLAP EIGINGEEID EIINQNTDSI ARQAQSMIRL
1660 1670 1680 1690 1700
YKDKPNYDIL SLETALKNIG RDDIMKKCKS GRLSHSREFD EADLMKNSES
1710 1720 1730 1740 1750
VEELVRRESK RIQQINEREE VKYSAEEKEV EESESDEEAA KRTVAERREK
1760 1770 1780 1790 1800
IVKRLSIERS IPASTQKKEI TREITEIKRK SLIEDKKAHH ESEILMQLPA
1810 1820 1830 1840 1850
DNVIIKTTTV PDQVIKMKMG KMDSTEVSKS EFDKELTHKF KTSGRSSEEE
1860 1870 1880 1890 1900
DQPSYPDQTD KIVQDISAAE KKEKDGVTFS RVTTITRQEA RDITEDFLEI
1910 1920 1930 1940 1950
EKRSQLPATS TTATVHEKFV EEIKEKTSPL ASVPQETVKE VQQVISEVTE
1960 1970 1980 1990 2000
IASKKVENII SSFESSKSVD ATTVLPTQPS VESTKVSETI KNLEDAKAVS
2010 2020 2030 2040 2050
AEQVKTVHVV ESSSIEETIA EFEAKKVKYD FHGGEPKTQI PKFTRKPSDD
2060 2070 2080 2090 2100
SMKPTAAPRA TVESETESVL ETKAEKPISK IPVKTIPTEA QKVSEVDARK
2110 2120 2130 2140 2150
ITQDFLQGEK LAAEPKPSPA ASKIPKVEPR KSVDKQVDRE SKILDDVVAS
2160 2170 2180 2190 2200
TATIMTAGLG DEQLKDQLVD HSEIIAKSET VAEKVTELLD TFHKIEEKVT
2210 2220 2230 2240 2250
KSEKTSEISS KVEELVKIEE KPLSQVQPKE DKVAEKVAEV IETFHKIEEK
2260 2270 2280 2290 2300
ITTADARELT RDFLSMEQQN QLPSMPQAAE KPLESSLTST SASEPESIVT
2310 2320 2330 2340 2350
VKPSPPASKI PVVEPRKIVF DESTKPLIEP EPVKTTEKKP LNERQLTADF
2360 2370 2380 2390 2400
LSMEQQTQLV SEPAKSLVEE VMKSAEQMVE QPKQQKSLNE RQLTEDFLLM
2410 2420 2430 2440 2450
EQQTQLPSDI VKPTDKLIDG IESAAPVGDE ASPFHTPKLT TSVVTQEPQQ
2460 2470 2480 2490 2500
LASEYDSDTF GKQATIPLGD SKIDQGLIAP VSMEPRKSLT DAEFCKSVGE
2510 2520 2530 2540 2550
TITKKMSVGV IEISDELKKI ESEIPHSQTP PPTPSDNKTD KQNEEPELIS
2560 2570 2580 2590 2600
LERDYLADTV TTLHTTTEST LERVSAITKI ETLHERKVEL SNLDTEKISH
2610 2620 2630 2640 2650
EIGDVKVGGG DDDSDGDSGD FVARIREEAN ILVDRVLEES VEIIESQGHQ
2660 2670 2680 2690 2700
ANGHEIAKLD YNSESENYAI TCDDIGGVDV IKSPTIESMS GKSFDDNMSF
2710 2720 2730 2740 2750
TDEHIHLPLH AQNTSTTMTT TITTQFQQQQ SQSAVSSTSA AKVASSRNQT
2760 2770 2780 2790 2800
EDESETRARR IDHKIEKLST DMDDVSARFD EAFEMSVPED EISALQGDFS
2810 2820 2830 2840 2850
KLSWDESVSP TTNTMADMAQ NQITPDNDIQ DLIAETGGDL PNSSETDTTP
2860 2870 2880 2890 2900
VPPSKESESK TETEPTVVTN AFTTTSHDTP TPKPRVLKAS SPVSEGTDST
2910 2920 2930 2940 2950
TIPGPVPKPE IPIDISFDAN APVPKPRAPI KHTEPFENLA ALAEQSDSIS
2960 2970 2980 2990 3000
LRSFELTEDI SKTDEPSTEL SIRSQLRDIV TTTTVSEDHT ESFEPTSEIS
3010 3020 3030 3040 3050
VDDADTEKSE GAEKTTSFYI GESSRNVIIK TSTRSASVTP QEEEAQGEIG
3060 3070 3080 3090 3100
IDAKDISLMK EVSVDSDEAN DVFKEFITMK PEDPIAMDSK ITRQGSETRN
3110 3120 3130 3140 3150
DILEFENADK DKTAEQKLSK VTTEESLTTS TGSSGRAIIE IAPSSSEDPD
3160 3170 3180 3190 3200
ESSKEIPEIV NTISEKAAAS DNFELPLEKS EWETSEKEIP TEGKPKVVHS
3210 3220 3230 3240 3250
PQQPQEASMK STLDRFHVDE ILAEEQVTDE HSSSDHKSFK DQTPSELGSS
3260 3270 3280 3290 3300
TVPQEYTFAV ESEDISSFIG IPEASMQTST LDSTQPPEGL FDTTIKETLN
3310 3320 3330 3340 3350
KQAAMAHYAQ DVFGRGERRD DHGSLGFIST GTAEELSSME EHMAKEEQAS
3360 3370 3380 3390 3400
LGFISTETAE DFSSMEDYYS EKLAIASVVA DEVATEKSLT TSTFEELSSD
3410 3420 3430 3440 3450
QSMKPIDVVV HRLKTETSPD SINRWSIPDV DTSSSSESFH RSFDKTQSRP
3460 3470 3480 3490 3500
LSSDLDNLVT TTGTGTSSDY QTAREFTTTG RTEGTEYISA VSTLGSSSLD
3510 3520 3530 3540 3550
SQSETSANLA SIDVSELSET LVASSAEVDA FEAEEMSRLR DLRADDEDSD
3560 3570 3580 3590 3600
ESVELPGTAG YPSIEQQSLM KRSQEMIFKP KTLDDEPLAV QVAQIEEYPK
3610 3620 3630 3640 3650
PKEAERTWGL AYPLEDSKVD SPRESEKGED ILLYHGDPRR SIDESKLASS
3660 3670 3680 3690 3700
LDEGSILSVS MSSTSNIDTV VENFDDIIGS AGSSSLTGIE GFQYGHDESI
3710 3720 3730 3740 3750
PSASVPEDAT FMLEMESKEH SPQDSNASTP PGGESKRRGH KRNESISGDA
3760 3770 3780 3790 3800
LKNLDKEVAL LGEGKESESE SDTDPYESEY ARQFRSPKER KSKKKKQAAA
3810 3820 3830 3840 3850
EMDHSGELEK RPFTPSQLVA EVIVEDSITE ELEAEAAMIE ERRPSQNMQD
3860 3870 3880 3890 3900
YSNIPDIMVT EDIKSPILEE ETDEFPEKML YKVRTEEELH KASDTSVYQK
3910 3920 3930 3940 3950
AKAEEKEQDF QRRVQEQYRQ KLEELKRAEV GAEYDDRKAP DSPDSFEMVE
3960 3970 3980 3990 4000
QPDISDEFVI IEEVAKEANE VDLGGQSIKI KPVKYEQKHD EDVEKIIIKS
4010 4020 4030 4040 4050
APADPKLGSQ LYKDDLNFEF EESPPTGASS SSEQQEESDS SETAAANKRW
4060 4070 4080 4090 4100
VEMQLTDNQL RYPYDLAGAV LEDIKEEDGE FEVGSSRISS FKDSFSSTPE
4110 4120 4130 4140 4150
YDVAARRYHS RGEHDDVSMS SLQEFESLEQ AISLENRNRT HQGSTDSSNG
4160 4170 4180 4190 4200
SFTRRYVVRH SGSGTAPGDD VSVSSLKDFE GLENACIEAH LIEIKAREEA
4210 4220 4230 4240 4250
ALLSRSDESN KSNGSDKGAT GNVVVTKVTR TVTRTEVVPS SQVESIEALL
4260 4270 4280 4290 4300
KQKLEREEGS VQGRVTDIGT TELDTKSKID SQDSEKDSID SMEISKSHDM
4310 4320 4330 4340 4350
MTSSIESFDI SKDATTRSDV DSLEIDKRHS RQESIESFGD EQLDLMTKFV
4360 4370 4380 4390 4400
SGGGVTLGDG LTTTTTTTTT STDADGHEHT VTRVITTITN VGGGIQELPM
4410 4420 4430 4440 4450
DESGMSKDVS VDSLNMCVEQ TTSSAGTTAT YQTSAGNSQM SGSVTSCASS
4460 4470 4480 4490
TLMEDSFPGV GGMSSSQMSA SFWSHDESTV VEDEGRDLAK KPQQGH
Length:4,496
Mass (Da):494,310
Last modified:June 26, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2765804C0A63F4DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9MRX4M9MRX4_DROME
Ankyrin 2, isoform U
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
13,559Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8JNM5A8JNM5_DROME
Ankyrin 2, isoform K
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
4,264Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7KU92Q7KU92_DROME
Ankyrin 2, isoform L
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
4,083Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8JNM4A8JNM4_DROME
Ankyrin 2, isoform G
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
2,532Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8JNM6A8JNM6_DROME
Ankyrin 2, isoform J
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
4,189Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8JNM7A8JNM7_DROME
Ankyrin 2, isoform F
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
4,114Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7KU95Q7KU95_DROME
Ankyrin 2, isoform M
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
2,404Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JGD3X2JGD3_DROME
Ankyrin 2, isoform Y
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
2,566Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9MRR4M9MRR4_DROME
Ankyrin 2, isoform T
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
4,223Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9MS19M9MS19_DROME
Ankyrin 2, isoform P
Ank2 ank2, ank2-L, CG18025, CG18227, CG18768
4,230Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE014296 Genomic DNA Translation: ADV37502.1

NCBI Reference Sequences

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RefSeqi
NP_001189065.1, NM_001202136.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0303115; FBpp0292234; FBgn0261788

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
38863

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: ADV37502.1
RefSeqiNP_001189065.1, NM_001202136.2

3D structure databases

SMRiM9MRS5
ModBaseiSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0303115; FBpp0292234; FBgn0261788
GeneIDi38863

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
287
FlyBaseiFBgn0261788 Ank2

Phylogenomic databases

eggNOGiKOG4177 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000167243
HOGENOMiCLU_000120_0_0_1

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
38863

Gene expression databases

BgeeiFBgn0261788 Expressed in head and 25 other tissues
ExpressionAtlasiM9MRS5 baseline and differential

Family and domain databases

Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR040745 Ankyrin_UPA
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR000906 ZU5_dom
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 7 hits
PF00531 Death, 1 hit
PF17809 UPA_2, 1 hit
PF00791 ZU5, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 24 hits
SM00218 ZU5, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 21 hits
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM9MRS5_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M9MRS5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: February 26, 2020
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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