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Protein
Submitted name:

Low affinity immunoglobulin gamma Fc region receptor III-A

Gene

FCGR3A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Names & Taxonomyi

Protein namesi
Submitted name:
Low affinity immunoglobulin gamma Fc region receptor III-AImported
Gene namesi
Name:FCGR3AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000203747.9
HGNCiHGNC:3619 FCGR3A

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei312 – 334HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000203747

PTM / Processingi

Proteomic databases

PRIDEiM9MML0

Expressioni

Gene expression databases

BgeeiENSG00000203747 Expressed in 91 organ(s), highest expression level in leukocyte
ExpressionAtlasiM9MML0 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiM9MML0, 1 interactor

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 210Ig-likeInterPro annotationAdd BLAST82
Domaini225 – 294Ig-likeInterPro annotationAdd BLAST70

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IKYD Eukaryota
ENOG41114N1 LUCA
GeneTreeiENSGT00760000119130
OrthoDBiEOG091G0JSA

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

M9MML0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEGTLWQIL CVSSDAQPQT FEGVKGADPP TLPPGSFLPG PVLWWGSLAR
60 70 80 90 100
LQTEKSDEVS RKGNWWVTEM GGGAGERLFT SSCLVGLVPL GLRISLVTCP
110 120 130 140 150
LQCGIMWQLL LPTALLLLVS AGMRTEDLPK AVVFLEPQWY RVLEKDSVTL
160 170 180 190 200
KCQGAYSPED NSTQWFHNES LISSQASSYF IDAATVDDSG EYRCQTNLST
210 220 230 240 250
LSDPVQLEVH IGWLLLQAPR WVFKEEDPIH LRCHSWKNTA LHKVTYLQNG
260 270 280 290 300
KGRKYFHHNS DFYIPKATLK DSGSYFCRGL FGSKNVSSET VNITITQGLA
310 320 330 340 350
VSTISSFFPP GYQVSFCLVM VLLFAVDTGL YFSVKTNIRS STRDWKDHKF

KWRKDPQDK
Length:359
Mass (Da):40,257
Last modified:June 7, 2017 - v2
Checksum:i180C2F892DA538D7
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P08637FCG3A_HUMAN
Low affinity immunoglobulin gamma F...
FCGR3A CD16A, FCG3, FCGR3, IGFR3
254Annotation score:
H0Y755H0Y755_HUMAN
Low affinity immunoglobulin gamma F...
FCGR3A
307Annotation score:
A0A1W2PQB1A0A1W2PQB1_HUMAN
Fc of IgG low affinity IIIa recepto...
FCGR3A
290Annotation score:
C9JC71C9JC71_HUMAN
Low affinity immunoglobulin gamma F...
FCGR3A
105Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590385 Genomic DNA No translation available.
RefSeqiNP_000560.6, NM_000569.7
UniGeneiHs.372679

Genome annotation databases

EnsembliENST00000367969; ENSP00000356946; ENSG00000203747
GeneIDi2214
UCSCiuc001gar.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590385 Genomic DNA No translation available.
RefSeqiNP_000560.6, NM_000569.7
UniGeneiHs.372679

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiM9MML0, 1 interactor

Proteomic databases

PRIDEiM9MML0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367969; ENSP00000356946; ENSG00000203747
GeneIDi2214
UCSCiuc001gar.4 human

Organism-specific databases

CTDi2214
EuPathDBiHostDB:ENSG00000203747.9
HGNCiHGNC:3619 FCGR3A
OpenTargetsiENSG00000203747
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKYD Eukaryota
ENOG41114N1 LUCA
GeneTreeiENSGT00760000119130
OrthoDBiEOG091G0JSA

Miscellaneous databases

ChiTaRSiFCGR3A human
GenomeRNAii2214

Gene expression databases

BgeeiENSG00000203747 Expressed in 91 organ(s), highest expression level in leukocyte
ExpressionAtlasiM9MML0 baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiM9MML0_HUMAN
AccessioniPrimary (citable) accession number: M9MML0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 29, 2013
Last sequence update: June 7, 2017
Last modified: September 12, 2018
This is version 44 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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