UniProtKB - M9MMA2 (M9MMA2_DANRE)
Protein
Submitted name:
Si:ch211-129c21.1
Gene
si:ch211-129c21.1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- chemorepellent activity Source: GO_Central
- semaphorin receptor binding Source: GO_Central
GO - Biological processi
- axon guidance Source: GO_Central
- negative chemotaxis Source: GO_Central
- negative regulation of alkaline phosphatase activity Source: GO_Central
- negative regulation of axon extension involved in axon guidance Source: GO_Central
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- neural crest cell migration Source: GO_Central
- ossification involved in bone maturation Source: GO_Central
- positive regulation of cell migration Source: GO_Central
- positive regulation of GTPase activity Source: GO_Central
- semaphorin-plexin signaling pathway Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: Si:ch211-129c21.1Imported |
Gene namesi | Name:si:ch211-129c21.1Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-030131-5796, si:ch211-129c21.1 |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: GO_Central
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 674 – 697 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSDARG00000024775, Expressed in early embryo and 22 other tissues |
ExpressionAtlasi | M9MMA2, baseline |
Interactioni
GO - Molecular functioni
- chemorepellent activity Source: GO_Central
- semaphorin receptor binding Source: GO_Central
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 481 | SemaInterPro annotationAdd BLAST | 481 | |
Domaini | 537 – 622 | Ig-likeInterPro annotationAdd BLAST | 86 |
Sequence similaritiesi
Belongs to the semaphorin family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000165728 |
HOGENOMi | CLU_009051_4_1_1 |
OMAi | NYSTMLM |
OrthoDBi | 450722at2759 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013151, Immunoglobulin IPR002165, Plexin_repeat IPR016201, PSI IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR027231, Semaphorin IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR11036, PTHR11036, 1 hit |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF01437, PSI, 1 hit PF01403, Sema, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00423, PSI, 1 hit SM00630, Sema, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51004, SEMA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
M9MMA2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRHADRKQFY ERHLLKCVSD NHAITFKEQG IWNYSTMLIR EDLGLLVLGA
60 70 80 90 100
REAVFALDIN DISVSRSKVL WKVTEEKQKE CTSKGKHPDI DCHNYIRMLH
110 120 130 140 150
QMNDSVMYIC GTNAFSPTCD YITYDNGQLQ LEGKQEDGRG KCPFDPFQRS
160 170 180 190 200
SSVMVDQDLY SATSLNFLGS EPVILRTSPI TLRTLLKSSW LNEPNFIYMD
210 220 230 240 250
AVPESEDSPE GDDDKIYMFF SENAIEYDFY NKLVVSRVAR VCKGDMGGLR
260 270 280 290 300
TLQRKWTSFL KARLDCSVPE PSLPYVIQDV FHVRHQKWRK SVFYAIFTSQ
310 320 330 340 350
SSSTDQSSAV CAYNVTDISN VFSRGKFKTE VAVEMSDVKW VTYSGDLPVP
360 370 380 390 400
RPGDCINNAA RTSGIKSSMN IPDKTLQFIR DRPLMDDAVH PITGKPLLLK
410 420 430 440 450
RGPLLTRLVV DMVTAADGQS YPMMFVGTAN GYVQKAVNYD GEMHIIEEVK
460 470 480 490 500
LFESEEAIDV LRLHQNQLYA GSASGVVQMP VSNCSRYSSC LDCVLARDPY
510 520 530 540 550
CAWDVPAQRC SRFPASTEHA KSNLIQSLKD GDATQCPITA PIEPKVRTLV
560 570 580 590 600
LGNNIRLLCR PDSNLAQVNW NLAGKPLPFS NRKYTIYNDA ILISNASSAD
610 620 630 640 650
AGRYTCVSVE QAKGKHYTKT LAIYDLHEEV AVVVTDKIKT TLGIPNEIYT
660 670 680 690 700
TSSGLIKPEE PPSFSKNQAS DSKWIAMQVA LAMLSIMMAC LLIWNLYMGH
710 720 730 740 750
ISPFMCCGRQ PIKSHGNLPR MEYKSAGNDV MDSKPQMVNL CVTTNSNLEV
760 770
TGFHRNGDPS TGIHLFKYIT DESEI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM9MMB2 | M9MMB2_DANRE | Si:ch211-129c21.1 | si:ch211-129c21.1 | 115 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX005201 Genomic DNA No translation available. |
RefSeqi | NP_001038473.1, NM_001045008.1 |
Genome annotation databases
Ensembli | ENSDART00000105597; ENSDARP00000096374; ENSDARG00000024775 |
GeneIDi | 563087 |
KEGGi | dre:563087 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX005201 Genomic DNA No translation available. |
RefSeqi | NP_001038473.1, NM_001045008.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSDART00000105597; ENSDARP00000096374; ENSDARG00000024775 |
GeneIDi | 563087 |
KEGGi | dre:563087 |
Organism-specific databases
ZFINi | ZDB-GENE-030131-5796, si:ch211-129c21.1 |
Phylogenomic databases
GeneTreei | ENSGT00940000165728 |
HOGENOMi | CLU_009051_4_1_1 |
OMAi | NYSTMLM |
OrthoDBi | 450722at2759 |
Gene expression databases
Bgeei | ENSDARG00000024775, Expressed in early embryo and 22 other tissues |
ExpressionAtlasi | M9MMA2, baseline |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013151, Immunoglobulin IPR002165, Plexin_repeat IPR016201, PSI IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR027231, Semaphorin IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR11036, PTHR11036, 1 hit |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF01437, PSI, 1 hit PF01403, Sema, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00423, PSI, 1 hit SM00630, Sema, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51004, SEMA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | M9MMA2_DANRE | |
Accessioni | M9MMA2Primary (citable) accession number: M9MMA2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 29, 2013 |
Last sequence update: | May 29, 2013 | |
Last modified: | December 2, 2020 | |
This is version 49 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |