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Entry version 43 (11 Dec 2019)
Sequence version 1 (29 May 2013)
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Protein

Pectinesterase

Gene

PRUPE_ppa021446mg

Organism
Prunus persica (Peach) (Amygdalus persica)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts in the modification of cell walls via demethylesterification of cell wall pectin.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pectin degradation

This protein is involved in step 1 of the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pectinesterase (PRUPE_2G216300), Pectinesterase (PRUPE_ppa024139mg), Pectinesterase (PRUPE_6G318500), Pectinesterase (PRUPE_ppa003307mg), Pectinesterase (PRUPE_7G190300), Pectinesterase (PRUPE_2G210700), Pectinesterase (PRUPE_2G058300), Pectinesterase (PRUPE_7G218400), Pectinesterase (PRUPE_4G239700), Pectinesterase (PRUPE_1G529500), Pectinesterase (PRUPE_ppa003285mg), Pectinesterase (PRUPE_ppa022308mg), Pectinesterase (PRUPE_7G190500), Pectinesterase (PRUPE_7G190400), Pectinesterase (PRUPE_2G099900), Pectinesterase (PRUPE_7G192400), Pectinesterase (PRUPE_ppa003915mg), Pectinesterase (PRUPE_1G123800), Pectinesterase (PRUPE_ppa023319mg), Pectinesterase (PRUPE_3G263600), Pectinesterase (PRUPE_7G190700), Pectinesterase (PRUPE_2G141200), Pectinesterase (PRUPE_2G278200), Pectinesterase (PRUPE_2G141000), Pectinesterase (PRUPE_ppa020079mg), Pectinesterase (PRUPE_1G132000), Pectinesterase (PRUPE_ppa019869mg), Pectinesterase (PRUPE_8G264000), Pectinesterase (PRUPE_8G263900), Pectinesterase (PRUPE_I005000), Pectinesterase (PRUPE_ppa005208mg), Pectinesterase (PRUPE_1G178400), Pectinesterase (PRUPE_8G264100), Pectinesterase (PRUPE_2G100200), Pectinesterase (PRUPE_7G123900), Pectinesterase (PRUPE_2G100500), Pectinesterase (PRUPE_1G377100), Pectinesterase (PRUPE_2G003200), Uncharacterized protein (PRUPE_3G031000), Pectinesterase (PRUPE_1G006800), Pectinesterase (PRUPE_ppa015184mg), Pectinesterase (PRUPE_ppb020245mg), Pectinesterase (PRUPE_6G128200), Pectinesterase (PRUPE_2G058200), Pectinesterase (PRUPE_ppa021446mg), Pectinesterase (PRUPE_ppa017319mg), Pectinesterase (PRUPE_1G132300), Pectinesterase (PRUPE_I005200), Pectinesterase (PRUPE_6G128000), Pectinesterase (PRUPE_1G377600), Pectinesterase (PRUPE_1G529400), Pectinesterase (PRUPE_3G185700), Pectinesterase (PRUPE_1G105400), PMEI domain-containing protein (PRUPE_3G003700), Pectinesterase (PRUPE_6G312200), Pectinesterase (PRUPE_1G131900), Pectinesterase (PRUPE_5G069600), Pectinesterase (PRUPE_ppa019698mg), Pectinesterase (PRUPE_3G185700), Pectinesterase (PRUPE_ppa019857mg), Pectinesterase (PRUPE_ppa005976mg), Pectinesterase (PRUPE_1G330800), Pectinesterase (PRUPE_ppa020682mg), Pectinesterase (PRUPE_ppa024812mg), Pectinesterase (PRUPE_2G310600), Pectinesterase (PRUPE_ppa003400mg), Pectinesterase (PRUPE_1G116600), Pectinesterase (PRUPE_6G128300), Pectinesterase (PRUPE_6G344600), Pectinesterase (PRUPE_ppa024011mg), Pectinesterase (PRUPE_1G123500), Pectinesterase (PRUPE_3G149100), Pectinesterase (PRUPE_4G025200), Pectinesterase (PRUPE_6G318600), Pectinesterase (PRUPE_7G123900), Pectinesterase (PRUPE_ppa004437mg), Pectinesterase (PRUPE_7G192800), Pectinesterase/pectinesterase inhibitor PPE8B, Pectinesterase (PpPME1), Pectinesterase (PRUPE_1G123700), Pectinesterase (PRUPE_ppa003433mg), Pectinesterase (PRUPE_ppa023424mg), Pectinesterase (PRUPE_3G263600), Pectinesterase (PRUPE_2G278300), Pectinesterase (PRUPE_7G123900), Pectinesterase (PRUPE_7G011200), Pectinesterase (PRUPE_2G268200)
  2. Pectate lyase (PRUPE_1G239900), Pectate lyase (PRUPE_1G268500), Pectate lyase (PRUPE_5G161300), Pectate lyase (PRUPE_3G296600), Pectate lyase (PRUPE_ppa006229mg), Pectate lyase (PRUPE_5G186900), Pectate lyase (PRUPE_1G565000), Pectate lyase (PRUPE_1G565800), Pectate lyase (PRUPE_2G226100), Pectate lyase (PRUPE_ppa016145mg), Pectate lyase (PRUPE_1G060900), Pectate lyase (PRUPE_2G206100), Pectate lyase (PRUPE_4G017400), Pectate lyase (PRUPE_1G060900), Pectate lyase (PRUPE_4G020600), Pectate lyase (PRUPE_1G565500), Pectate lyase (PRUPE_8G206800), Pectate lyase (PRUPE_1G239900), Pectate lyase (PRUPE_1G268700), Pectate lyase (PL4), Pectate lyase (PL3), Pectate lyase (PRUPE_1G565700), Pectate lyase (PRUPE_5G161300), Pectate lyase (PRUPE_3G271600), Pectate lyase (PRUPE_5G245600), Pectate lyase (PRUPE_5G161300), Pectate lyase (PRUPE_1G060900), Pectate lyase (PRUPE_5G161300), Pectate lyase (PRUPE_2G206100), Pectate lyase (PRUPE_5G161300), Pectate lyase (PpPL2), Pectate lyase (PpPL1), Pectate lyase (PRUPE_ppa016012mg), Pectate lyase (PRUPE_7G126700)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway pectin degradation, which is itself part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-dehydro-3-deoxy-D-gluconate from pectin, the pathway pectin degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei320PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAspartyl esteraseUniRule annotationSAAS annotation, Hydrolase
Biological processCell wall biogenesis/degradationUniRule annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00545;UER00823

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PectinesteraseUniRule annotation (EC:3.1.1.11UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PRUPE_ppa021446mgImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPrunus persica (Peach) (Amygdalus persica)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3760 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeAmygdaloideaeAmygdaleaePrunus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell wallUniRule annotation, Secreted

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 136PMEIInterPro annotationAdd BLAST135

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the pectinesterase family.SAAS annotation
In the N-terminal section; belongs to the PMEI family.SAAS annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K01051

Identification of Orthologs from Complete Genome Data

More...
OMAi
NHRTIKE

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.140.40, 1 hit
2.160.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035513 Invertase/methylesterase_inhib
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR033131 Pectinesterase_Asp_AS
IPR000070 Pectinesterase_cat
IPR006501 Pectinesterase_inhib_dom
IPR018040 Pectinesterase_Tyr_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01095 Pectinesterase, 1 hit
PF04043 PMEI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00856 PMEI, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101148 SSF101148, 1 hit
SSF51126 SSF51126, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01614 PME_inhib, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00800 PECTINESTERASE_1, 1 hit
PS00503 PECTINESTERASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

M5XII4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
KTPYPETCKY TLTHAQKYSV PTRMSDFKKL AVQVTMQQAL KAQSHNKWLG
60 70 80 90 100
PKCRNKIEKA AWADCLSLYQ DTIMLLNQTI DPATKCTDYD AQTWLSTALT
110 120 130 140 150
NLDTCRAGFV ELGVSDFVLP LMSNNVSKLI SNTLSIGNGS NVPAVTNRYK
160 170 180 190 200
EGFPTWVSPG DRKLLQSSPA ADVVVAQDGS GNYKTIKEGL AAAEKRSGSN
210 220 230 240 250
RFVIHVKRGV YKENLEIKLK NIMLLGDGLR YTIITGSRSV VGGSTTFNSA
260 270 280 290 300
TVAVTGDGFI ARGITFRNTA GPENHQAVAL RSGADLSVFY RCGFEGYQDT
310 320 330 340 350
LYVHSQRQFY KECYVYGTVD FIFGNAAVVL QNCMIYARRP MNGQKNTITA
360 370 380 390 400
QGRTDPNQNT GISIHDSRVM AGSDLKPVLS SVKTYLGRPW KEYSRTVFLQ
410 420 430 440 450
SYLDTLVDPA GWLEWDGNFA LKTLYYGEYK NTGPGSSTSG RVNWGGYHVI
460 470 480
TSSSEASKFT VGNFIAGSSW LPATNVPFTA GL
Length:482
Mass (Da):52,957
Last modified:May 29, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B79A16E88AEAAF7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KB638974 Genomic DNA Translation: EMJ21308.1

NCBI Reference Sequences

More...
RefSeqi
XP_007220109.1, XM_007220047.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
ONI25066; ONI25066; PRUPE_2G278200

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18786681

Gramene; a comparative resource for plants

More...
Gramenei
ONI25066; ONI25066; PRUPE_2G278200

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pper:18786681

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KB638974 Genomic DNA Translation: EMJ21308.1
RefSeqiXP_007220109.1, XM_007220047.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblPlantsiONI25066; ONI25066; PRUPE_2G278200
GeneIDi18786681
GrameneiONI25066; ONI25066; PRUPE_2G278200
KEGGipper:18786681

Phylogenomic databases

KOiK01051
OMAiNHRTIKE

Enzyme and pathway databases

UniPathwayiUPA00545;UER00823

Family and domain databases

Gene3Di1.20.140.40, 1 hit
2.160.20.10, 1 hit
InterProiView protein in InterPro
IPR035513 Invertase/methylesterase_inhib
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR033131 Pectinesterase_Asp_AS
IPR000070 Pectinesterase_cat
IPR006501 Pectinesterase_inhib_dom
IPR018040 Pectinesterase_Tyr_AS
PfamiView protein in Pfam
PF01095 Pectinesterase, 1 hit
PF04043 PMEI, 1 hit
SMARTiView protein in SMART
SM00856 PMEI, 1 hit
SUPFAMiSSF101148 SSF101148, 1 hit
SSF51126 SSF51126, 1 hit
TIGRFAMsiTIGR01614 PME_inhib, 1 hit
PROSITEiView protein in PROSITE
PS00800 PECTINESTERASE_1, 1 hit
PS00503 PECTINESTERASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM5XII4_PRUPE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M5XII4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 29, 2013
Last sequence update: May 29, 2013
Last modified: December 11, 2019
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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