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Entry version 27 (31 Jul 2019)
Sequence version 1 (29 May 2013)
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Protein

Piezo-type mechanosensitive ion channel component

Gene

PIEZO1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channelUniRule annotation
Biological processIon transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Piezo-type mechanosensitive ion channel componentUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIEZO1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 41HelicalUniRule annotationAdd BLAST30
Transmembranei62 – 84HelicalUniRule annotationAdd BLAST23
Transmembranei126 – 143HelicalUniRule annotationAdd BLAST18
Transmembranei190 – 211HelicalUniRule annotationAdd BLAST22
Transmembranei217 – 236HelicalUniRule annotationAdd BLAST20
Transmembranei248 – 269HelicalUniRule annotationAdd BLAST22
Transmembranei438 – 455HelicalUniRule annotationAdd BLAST18
Transmembranei462 – 484HelicalUniRule annotationAdd BLAST23
Transmembranei509 – 530HelicalUniRule annotationAdd BLAST22
Transmembranei579 – 596HelicalUniRule annotationAdd BLAST18
Transmembranei602 – 621HelicalUniRule annotationAdd BLAST20
Transmembranei628 – 647HelicalUniRule annotationAdd BLAST20
Transmembranei680 – 701HelicalUniRule annotationAdd BLAST22
Transmembranei830 – 847HelicalUniRule annotationAdd BLAST18
Transmembranei985 – 1007HelicalUniRule annotationAdd BLAST23
Transmembranei1041 – 1063HelicalUniRule annotationAdd BLAST23
Transmembranei1162 – 1180HelicalUniRule annotationAdd BLAST19
Transmembranei1187 – 1206HelicalUniRule annotationAdd BLAST20
Transmembranei1218 – 1240HelicalUniRule annotationAdd BLAST23
Transmembranei1247 – 1264HelicalUniRule annotationAdd BLAST18
Transmembranei1284 – 1302HelicalUniRule annotationAdd BLAST19
Transmembranei1703 – 1722HelicalUniRule annotationAdd BLAST20
Transmembranei1729 – 1747HelicalUniRule annotationAdd BLAST19
Transmembranei1959 – 1982HelicalUniRule annotationAdd BLAST24
Transmembranei2002 – 2021HelicalUniRule annotationAdd BLAST20
Transmembranei2030 – 2051HelicalUniRule annotationAdd BLAST22
Transmembranei2063 – 2080HelicalUniRule annotationAdd BLAST18
Transmembranei2100 – 2120HelicalUniRule annotationAdd BLAST21
Transmembranei2132 – 2151HelicalUniRule annotationAdd BLAST20
Transmembranei2172 – 2196HelicalUniRule annotationAdd BLAST25
Transmembranei2431 – 2454HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
M4QHP2

PRoteomics IDEntifications database

More...
PRIDEi
M4QHP2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1235 – 1465PIEZOInterPro annotationAdd BLAST231
Domaini2110 – 2518Piezo_RRas_bdgInterPro annotationAdd BLAST409

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni738 – 769DisorderedSequence analysisAdd BLAST32
Regioni1356 – 1397DisorderedSequence analysisAdd BLAST42
Regioni1462 – 1498DisorderedSequence analysisAdd BLAST37
Regioni1576 – 1630DisorderedSequence analysisAdd BLAST55
Regioni1812 – 1835DisorderedSequence analysisAdd BLAST24
Regioni1846 – 1865DisorderedSequence analysisAdd BLAST20
Regioni1870 – 1920DisorderedSequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi746 – 760AcidicSequence analysisAdd BLAST15
Compositional biasi1356 – 1377PolyampholyteSequence analysisAdd BLAST22
Compositional biasi1576 – 1598PolarSequence analysisAdd BLAST23
Compositional biasi1605 – 1620PolarSequence analysisAdd BLAST16
Compositional biasi1812 – 1826PolyampholyteSequence analysisAdd BLAST15

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PIEZO (TC 1.A.75) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1893 Eukaryota
ENOG410YVF6 LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027272 Piezo
IPR031805 Piezo_dom
IPR031334 Piezo_RRas-bd_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13167 PTHR13167, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15917 PIEZO, 1 hit
PF12166 Piezo_RRas_bdg, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

M4QHP2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPHVFGAVL YWLLLPCALL AACLLRFSGL SLVYLLFLLL LPWFPGPTRC
60 70 80 90 100
GLQGHTGRLL RALLGLSLLF LVAHLALQIC LHTVPRLDQL LGPSCSRWET
110 120 130 140 150
LSRHIGVTRL DLKDIPNAIR LVAPDLGILV VSSVCLGICG RLARNTRQSP
160 170 180 190 200
HPRELDDDER DVDASPTAGL QEAATLAPTR RSRLAARFRV TAHWLLVAAG
210 220 230 240 250
RVLAVTLLAL AGIAHPSALS SVYLLLFLAL CTWWACHFPI STRGFSRLCA
260 270 280 290 300
AVGCFGAGHL ICLYCYQMPL AQALLPPAGI WARVLGLKDF VGPTNCSSPH
310 320 330 340 350
ALVLNTGLDW PVYASPGVLL LLCYATASLR KLRAYRPSGQ RKEAAKGYEA
360 370 380 390 400
RELELAELDQ WPQERESDQH VVPTAPDTEA DNCIVHELTG QSSVLRRPVR
410 420 430 440 450
PKRAEPREAS PLHSLGHLIM DQSYVCALIA MMVWSITYHS WLTFVLLLWA
460 470 480 490 500
CLIWTVRSRH QLAMLCSPCI LLYGMTLCCL RYVWAMDLRP ELPTTLGPVS
510 520 530 540 550
LRQLGLEHTR YPCLDLGAML LYTLTFWLLL RQFVKEKLLK WAESPAALTE
560 570 580 590 600
VTVADTEPTR TQTLLQSLGE LVKGVYAKYW IYVCAGMFIV VSFAGRLVVY
610 620 630 640 650
KIVYMFLFLL CLTLFQVYYS LWRKLLKAFW WLVVAYTMLV LIAVYTFQFQ
660 670 680 690 700
DFPAYWRNLT GFTDEQLGDL GLEQFSVSEL FSSILVPGFF LLACILQLHY
710 720 730 740 750
FHRPFMQLTD MEHVSLPGTR LPRWAHRQDA VSGTPLLREE QQEHQQQQQE
760 770 780 790 800
EEEEEEDSRD EGLGVATPHQ ATQVPEGAAK WGLVAERLLE LAAGFSDVLS
810 820 830 840 850
RVQVFLRRLL ELHVFKLVAL YTVWVALKEV SVMNLLLVVL WAFALPYPRF
860 870 880 890 900
RPMASCLSTV WTCVIIVCKM LYQLKVVNPQ EYSSNCTEPF PNSTNLLPTE
910 920 930 940 950
ISQSLLYRGP VDPANWFGVR KGFPNLGYIQ NHLQVLLLLV FEAIVYRRQE
960 970 980 990 1000
HYRRQHQLAP LPAQAVFASG TRQQLDQDLL GCLKYFINFF FYKFGLEICF
1010 1020 1030 1040 1050
LMAVNVIGQR MNFLVTLHGC WLVAILTRRH RQAIARLWPN YCLFLALFLL
1060 1070 1080 1090 1100
YQYLLCLGMP PALCIDYPWR WSRAVPMNSA PIKWLYLPDF FRAPNSTNLI
1110 1120 1130 1140 1150
SDFLLLLCAS QQWQVFSAER TEEWQRMAGV NTDRLEPLRG EPNPVPNFIH
1160 1170 1180 1190 1200
CRSYLDMLKL AVFRYLFWLV LVVVFVTGAT RISIFGLGYL LACFYLLLFG
1210 1220 1230 1240 1250
TALLQRDTRA RLVLWDCLIL YNVTVIISKN MLSLLACVFV EQMQTGFCWV
1260 1270 1280 1290 1300
IQLFSLVCTV KGYYDPKEMM DRDQDCLLPV EEAGIIWDSV CFFFLLLQRR
1310 1320 1330 1340 1350
VFLSHYYLHV RADLQATALL ASRGFALYNA ANLKSIDFHR RIEEKSLAQL
1360 1370 1380 1390 1400
KRQMERIRAK QEKHRQGRVD RSRPQDTLGP KDPGLEPGPD SPGGSSPLRR
1410 1420 1430 1440 1450
QWWRPWLDHA TVIHSGDYFL FESDSEEEEE AVPEDPRPSA QSAFQLAYQA
1460 1470 1480 1490 1500
WVTNAQAVLR RRQQEQEQAR QEQAGQLPTG GGPSQEVEPA EGPEEAAAGR
1510 1520 1530 1540 1550
SHVVQRVLST AQFLWMLGQA LVDELTRWLQ EFTRHHGTMS DVLRAERYLL
1560 1570 1580 1590 1600
TQELLQGGEV HRGVLDQLYT SQAEATLPGP TEAPNAPSTV SSGLGAEEPL
1610 1620 1630 1640 1650
SSMTDDMGSP LSTGYHTRSG SEEAVTDPGE REAGASLYQG LMRTASELLL
1660 1670 1680 1690 1700
DRRLRIPELE EAELFAEGQG RALRLLRAVY QCVAAHSELL CYFIIILNHM
1710 1720 1730 1740 1750
VTASAGSLVL PVLVFLWAML SIPRPSKRFW MTAIVFTEIA VVVKYLFQFG
1760 1770 1780 1790 1800
FFPWNSHVVL RRYENKPYFP PRILGLEKTD GYIKYDLVQL MALFFHRSQL
1810 1820 1830 1840 1850
LCYGLWDHEE DSPSKEHDKS GEEEQGAEEG PGVPAATTED HIQVEARVGP
1860 1870 1880 1890 1900
TDGTPESQVE LRPRDTRRIS LRFRRRKEGP ARKGAAAIEA EDREEEEGEE
1910 1920 1930 1940 1950
EKEAPTGREK RPSRSGGRVR AAGRRLQGFC LSLAQGTYRP LRRFFHDILH
1960 1970 1980 1990 2000
TKYRAATDVY ALMFLADVVD FIIIIFGFWA FGKHSAATDI TSSLSDDQVP
2010 2020 2030 2040 2050
EAFLVMLLIQ FSTMVVDRAL YLRKTVLGKL AFQVALVLAI HLWMFFILPA
2060 2070 2080 2090 2100
VTERMFNQNV VAQLWYFVKC IYFALSAYQI RCGYPTRILG NFLTKKYNHL
2110 2120 2130 2140 2150
NLFLFQGFRL VPFLVELRAV MDWVWTDTTL SLSSWMCVED IYANIFIIKC
2160 2170 2180 2190 2200
SRETEKKYPQ PKGQKKKKIV KYGMGGLIIL FLIAIIWFPL LFMSLVRSVV
2210 2220 2230 2240 2250
GVVNQPIDVT VTLKLGGYEP LFTMSAQQPS IIPFTAQAYE ELSRQFDPQP
2260 2270 2280 2290 2300
LAMQFISQYS PEDVVTAQIE GSSGALWRIS PPSRAQMKRE LYNGTADITL
2310 2320 2330 2340 2350
RFTWNFQRDL AKGGTVEYAN EKHMLALAPN STARRQLASL LEGTSDQSVV
2360 2370 2380 2390 2400
IPNLFPKYIR APNGPEANPV KQLQPNEEAD YLGVRIQLRR EQGAGATGFL
2410 2420 2430 2440 2450
EWWVIELQEC RTDCNLLPMV IFSDKVSPPS LGFLAGYGIM GLYVSIVLVI
2460 2470 2480 2490 2500
GKFVRGFFSE ISHSIMFEEL PCVDRILKLC QDIFLVRETR ELELEEELYA
2510 2520
KLIFLYRSPE TMIKWTREKE
Length:2,520
Mass (Da):286,645
Last modified:May 29, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A98359B4C78FE47
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KC602455 mRNA Translation: AGH27891.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC602455 mRNA Translation: AGH27891.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiM4QHP2
PRIDEiM4QHP2

Phylogenomic databases

eggNOGiKOG1893 Eukaryota
ENOG410YVF6 LUCA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PIEZO1 human

Family and domain databases

InterProiView protein in InterPro
IPR027272 Piezo
IPR031805 Piezo_dom
IPR031334 Piezo_RRas-bd_dom
PANTHERiPTHR13167 PTHR13167, 1 hit
PfamiView protein in Pfam
PF15917 PIEZO, 1 hit
PF12166 Piezo_RRas_bdg, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM4QHP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M4QHP2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 29, 2013
Last sequence update: May 29, 2013
Last modified: July 31, 2019
This is version 27 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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