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Protein

DNA polymerase

Gene
N/A
Organism
Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
OrganismiXiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)Imported
Taxonomic identifieri8083 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesPoeciliidaePoeciliinaeXiphophorus
Proteomesi
  • UP000002852 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi8083.ENSXMAP00000019121

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 105DNA_pol_alpha_NInterPro annotationAdd BLAST62
Domaini392 – 730DNA_pol_B_exo1InterPro annotationAdd BLAST339
Domaini788 – 1244DNA_pol_BInterPro annotationAdd BLAST457
Domaini1284 – 1470zf-DNA_PolInterPro annotationAdd BLAST187

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotation

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

eggNOGiKOG0970 Eukaryota
COG0417 LUCA
GeneTreeiENSGT00550000074891
InParanoidiM4AXC6
KOiK02320
OMAiPKDCIFP
OrthoDBiEOG091G00RR

Family and domain databases

Gene3Di1.10.3200.20, 1 hit
3.30.420.10, 1 hit
3.90.1600.10, 2 hits
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR024647 DNA_pol_a_cat_su_N
IPR023211 DNA_pol_palm_dom_sf
IPR038256 Pol_alpha_znc_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR015088 Znf_DNA-dir_DNA_pol_B_alpha
PfamiView protein in Pfam
PF12254 DNA_pol_alpha_N, 1 hit
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 1 hit
PF08996 zf-DNA_Pol, 1 hit
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

Sequencei

Sequence statusi: Complete.

M4AXC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVADPDKD MEVPDGDEKG DACGLAKSRS RREKREKVGR KSALEQLKKA
60 70 80 90 100
KKGEKIKYEV EEITSVYEEV DEQQYSKMVR ERQEDDWIID DDGTGYVEDG
110 120 130 140 150
REIFDDDLDD DVVESKGKGG AKGGESKKTL KKSSVAKPNT IKSLFMNSNV
160 170 180 190 200
KRPAEKDVDL SKDDLLGDIL QDLHNEKSSA LTPPPLVTLK KKKPVGSSLN
210 220 230 240 250
LFSIKPHVPK QEKPSSSGLK AKVIRPPPLD PSPQPSARPP PTTTEVLPEK
260 270 280 290 300
HEAELEEPNE EREDNSLAFE GVDFDEPMEV EHEEEKAVAK DEAKLEPEGG
310 320 330 340 350
LTATEVKVEH KAERQDPVLL PNRVGSSWGQ EAAGGVSEAP VEVQVDSSKL
360 370 380 390 400
PLVEGPDGEQ VFRFYWLDAF EDPYNQPGVV YLFGKVWIES AQSHVSCCVT
410 420 430 440 450
VKNIDRTMYL LPREFKTNPK TGAVSDQPVG MMDVYQEFNE LSEKFKIMKF
460 470 480 490 500
KSKKVEKSYA FEIPDVPSQC DYLEVRYSAD FPALPSDLKG TTFSHVFGTN
510 520 530 540 550
TSSLEHFLLS RKIKGPCWLD IKAPQLMNQP VSWCKVEALA VRSDLVSVIK
560 570 580 590 600
DLQPPPITIM SISLKTVQNP KTHHNEIVSL VALIHYSFHM DKAPPQPPYQ
610 620 630 640 650
THFCVISKPS DCIFPYDFKD AVKKKKVKVE MATSERTLLG CFLAKMHKID
660 670 680 690 700
PDVLVGHDIF GFDLEVLLQR INVCKVPHWS KIGRLRRANM PKLGGRGAFA
710 720 730 740 750
EKSATCGRLV CDVEISAKEL IRCKSYHLTE LAAQVLKVER VTVPQESIRN
760 770 780 790 800
LYSDSPHLLY LLELTWNDAK LILQIMCELN VLPLALQITS IAGNVLSRTL
810 820 830 840 850
MGGRSERNEF LLLHAFHDKN FIVPDKPSFK KAHLDTVEGE DDVDTGKGKR
860 870 880 890 900
KKKAAYAGGL VLDPKVGFYD KFVLLLDFNS LYPSIIQEFN ICFTTVQRQA
910 920 930 940 950
QNSHKKTDDD EPEEIPEIPD SNLEMGILPK EIRKLVERRK HVKQLMKQQD
960 970 980 990 1000
INPDLYMQYD IRQKALKLTA NSMYGCLGFS YSRFYAKPLA ALVTHKGREI
1010 1020 1030 1040 1050
LMHTKDMVQK MNLEVIYGDT DSIMINTNSK SLEEVFKLGH KIKAEVNKLY
1060 1070 1080 1090 1100
KLLEIDIDGV FKSLLLLKKK KYAALVVEQH GEGRYSVKQE LKGLDIVRRD
1110 1120 1130 1140 1150
WCDLAKECGN YVIGQILSDQ SRDVIVENIQ KHLVEVGEKV ANGNIPLNQY
1160 1170 1180 1190 1200
EIHKALTKDP QDYPDKKSLP HVHVALWINS QGGRRVKAGD TISYLICKDG
1210 1220 1230 1240 1250
STLAASQRAY ALEQLQKQEG LSVDTQYYLA QQVHPVVSRI CDPIDGIDAV
1260 1270 1280 1290 1300
LIASWLGLDP GQFRSQQQHQ REEEADGTLG AAAQLNDEER YKDCERFTFT
1310 1320 1330 1340 1350
CPQCGTDNIY DSVFEGAGDR AEPSLMRCCH IPCTNSPINN VVNISNKLQL
1360 1370 1380 1390 1400
DIRRHIKKYY SGWLVCEDQA CQNRTRRLPI AFSRHGPICP ACTRATLRAE
1410 1420 1430 1440 1450
YSEKALYNQL CFFSYIFDWD YAMAKLPNTV QKTCLKRSGS TRQVYLKLKE
1460 1470
VPDRALATSG YSEVNLAKLF QAFSSFK
Length:1,477
Mass (Da):166,658
Last modified:May 1, 2013 - v1
Checksum:iBF9D1DCF46206FA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGAJ01027547 Genomic DNA No translation available.
AGAJ01027548 Genomic DNA No translation available.
AGAJ01027549 Genomic DNA No translation available.
RefSeqiXP_005809925.1, XM_005809868.1

Genome annotation databases

EnsembliENSXMAT00000019149; ENSXMAP00000019121; ENSXMAG00000019037
GeneIDi102231967
KEGGixma:102231967

Similar proteinsi

Entry informationi

Entry nameiM4AXC6_XIPMA
AccessioniPrimary (citable) accession number: M4AXC6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: April 25, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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