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Entry version 47 (07 Oct 2020)
Sequence version 1 (01 May 2013)
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Protein

RHD domain-containing protein

Gene
N/A
Organism
Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RHD domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8083 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesPoeciliidaePoeciliinaeXiphophorus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002852 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8083.ENSXMAP00000009224

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini291 – 460RHDInterPro annotationAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni33 – 199DisorderedSequence analysisAdd BLAST167
Regioni217 – 251DisorderedSequence analysisAdd BLAST35
Regioni590 – 628DisorderedSequence analysisAdd BLAST39
Regioni684 – 703DisorderedSequence analysisAdd BLAST20
Regioni1012 – 1045DisorderedSequence analysisAdd BLAST34
Regioni1061 – 1142DisorderedSequence analysisAdd BLAST82
Regioni1207 – 1226DisorderedSequence analysisAdd BLAST20
Regioni1333 – 1369DisorderedSequence analysisAdd BLAST37

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili824 – 905Sequence analysisAdd BLAST82
Coiled coili951 – 986Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi35 – 57PolarSequence analysisAdd BLAST23
Compositional biasi64 – 104PolarSequence analysisAdd BLAST41
Compositional biasi144 – 159PolarSequence analysisAdd BLAST16
Compositional biasi590 – 620PolarSequence analysisAdd BLAST31
Compositional biasi1027 – 1045PolarSequence analysisAdd BLAST19
Compositional biasi1333 – 1357PolarSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSVE, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155213

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004396_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M4A430

Identification of Orthologs from Complete Genome Data

More...
OMAi
QMMENIQ

Database of Orthologous Groups

More...
OrthoDBi
95502at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
2.60.40.340, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR008366, NFAT
IPR008967, p53-like_TF_DNA-bd
IPR032397, RHD_dimer
IPR011539, RHD_DNA_bind_dom
IPR037059, RHD_DNA_bind_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12533, PTHR12533, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16179, RHD_dimer, 1 hit
PF00554, RHD_DNA_bind, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01789, NUCFACTORATC

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429, IPT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49417, SSF49417, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50254, REL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

M4A430-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSDFISLLS SDIDLNSPKS LYSKESVYDL LPKELQLQPS STQTDIPTMS
60 70 80 90 100
QKSGGEAGPP PSATLASDAT SCTSSPSASS SLAMGLSTSS SDHLTVSQHL
110 120 130 140 150
HSTGADGPGA SEMQGMEAAG SAPSRGGGGA NPTGGDGGTG VLSGMGVQQL
160 170 180 190 200
QNTPSKRRPV LNISPPPEDL FDDSQMSCQE EPAVAAAACP DSEHSSSMWA
210 220 230 240 250
DDSVSNFSII SSVSYNDNTE VPRKSRKRTP RQRPGPKPTP PEDSMDVFDA
260 270 280 290 300
DSAKGPHFVL SQLSTDKTSS IASSLDSATA VKGGSLSAQF PQRSDGKELK
310 320 330 340 350
ILVQPETQHR ARYLTEGSRG SVKDRTQQGF PTVKLEGISE PVVLQVFVAN
360 370 380 390 400
DAGRVKPHGF YQACRVTGRN TTACKEVDID GTTVIEIPLE PSNDMTLAVD
410 420 430 440 450
CVGILKLRNA DVEARIGVAG SKKKSTRARL AFRVNIPQPD GSVLTLQVPS
460 470 480 490 500
SPILCTQPAG LPEILKKSLH SGSVKGGEEV FIIGKNFLKG TKVIFQENIA
510 520 530 540 550
DDNSWQAEAK IDTDLFHQNH LVVTVPPFHS QSITSPVSVG IFVMTNAGRS
560 570 580 590 600
HEAQAFTYTP ESDNSSGQTV KTEGTSLVNT CIFDGEIKSV SSEQSDCSGQ
610 620 630 640 650
PSKRQEDTPM EVSSNPQPTD VFKPSPDPLI SVQQTLELNS SPHPGGEAFE
660 670 680 690 700
SPMPLQPEDV ELPQAPPVFP SLESLSTIQK QEISSTTSFP VSGDTTIPPV
710 720 730 740 750
TPEVPQQFLR DPQESLSPES SDNGGTIVVV AMPQMAAPTQ PPPQQTQVAL
760 770 780 790 800
FPQEGVAQLE RAVRELQAGG TTTLEQVLEV AVAQQQLNSV LYNPTASAES
810 820 830 840 850
LQQHVQENMN SLRLGNSDSS LSARQQIQMQ QQQQQQQIQM QQQQQIQMQQ
860 870 880 890 900
QQQQIQMQQQ QQQQIQMQQH QQQIQQQFQQ QQQILENLQQ QQQQQQQQLQ
910 920 930 940 950
QQVLSNMQIQ QQLMLQPQDQ QQLQQQQMME NIQQQQLQQN QQQQVLNNIQ
960 970 980 990 1000
LQDQQQQNQI LSNLQQQQEQ QVLEKLQQQL QAELLQPQIH SSPQAQQPVS
1010 1020 1030 1040 1050
LLQQAGELLT IQTSFPTPPP SHTSPPQQLF QSPQPLAETQ SSQQQVQAAL
1060 1070 1080 1090 1100
LQNTLTVLSG GGLGSEQQPT GSTIFLSTNP QPQQPQQQPQ LAFISSMETS
1110 1120 1130 1140 1150
SSQPQPVSMF QNQPPTQLSQ PMEQQQSPQQ NQQPPQQLPL GQQGTLFQSI
1160 1170 1180 1190 1200
PNHSQANAVS QNQISQPQQT GLLLCTSDLL FTTPAQAAPP IPGISVGIPQ
1210 1220 1230 1240 1250
PDAAEPMSFQ VQSSSGSNAA PAANQQQSLF QEQQPMQVTP SPSQVPNSQP
1260 1270 1280 1290 1300
VKLFIPQTSL SGLQGTIGSQ DLNTEAAAPT ATIFVVQGGV GVVASPGQQP
1310 1320 1330 1340 1350
PEQLFQTAVG GTVAPQGQPN LFVFGIQNDS SQLLSSSGPN LPAQTQAQNS
1360 1370 1380 1390 1400
SHMQPLLDQP MPQAAPGMHS NLQNTLQAQM QTSLENALQS NTQTPMQTSL
1410 1420 1430
QTQIQSSLQN QMQATISATS GMDKIEDILE SLQKQ
Length:1,435
Mass (Da):154,825
Last modified:May 1, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0FD766163D279944
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B5R471A0A3B5R471_XIPMA
RHD domain-containing protein
1,398Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSXMAT00000009238; ENSXMAP00000009224; ENSXMAG00000009207

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi8083.ENSXMAP00000009224

Genome annotation databases

EnsembliENSXMAT00000009238; ENSXMAP00000009224; ENSXMAG00000009207

Phylogenomic databases

eggNOGiENOG502QSVE, Eukaryota
GeneTreeiENSGT00940000155213
HOGENOMiCLU_004396_0_0_1
InParanoidiM4A430
OMAiQMMENIQ
OrthoDBi95502at2759

Family and domain databases

Gene3Di2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR008366, NFAT
IPR008967, p53-like_TF_DNA-bd
IPR032397, RHD_dimer
IPR011539, RHD_DNA_bind_dom
IPR037059, RHD_DNA_bind_dom_sf
PANTHERiPTHR12533, PTHR12533, 4 hits
PfamiView protein in Pfam
PF16179, RHD_dimer, 1 hit
PF00554, RHD_DNA_bind, 1 hit
PRINTSiPR01789, NUCFACTORATC
SMARTiView protein in SMART
SM00429, IPT, 1 hit
SUPFAMiSSF49417, SSF49417, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50254, REL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM4A430_XIPMA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M4A430
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: October 7, 2020
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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