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Entry version 39 (16 Oct 2019)
Sequence version 2 (05 Dec 2018)
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Protein

Bromo domain-containing protein

Gene
N/A
Organism
Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bromo domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8083 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesPoeciliidaePoeciliinaeXiphophorus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002852 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8083.ENSXMAP00000005409

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini421 – 491BromoInterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni169 – 229DisorderedSequence analysisAdd BLAST61
Regioni297 – 327DisorderedSequence analysisAdd BLAST31
Regioni512 – 624DisorderedSequence analysisAdd BLAST113
Regioni702 – 786DisorderedSequence analysisAdd BLAST85
Regioni807 – 1240DisorderedSequence analysisAdd BLAST434

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi169 – 186PolyampholyteSequence analysisAdd BLAST18
Compositional biasi194 – 215PolyampholyteSequence analysisAdd BLAST22
Compositional biasi301 – 327PolyampholyteSequence analysisAdd BLAST27
Compositional biasi512 – 541PolyampholyteSequence analysisAdd BLAST30
Compositional biasi738 – 752Pro-richSequence analysisAdd BLAST15
Compositional biasi818 – 832Pro-richSequence analysisAdd BLAST15
Compositional biasi856 – 886PolarSequence analysisAdd BLAST31
Compositional biasi925 – 946PolarSequence analysisAdd BLAST22
Compositional biasi966 – 984PolarSequence analysisAdd BLAST19
Compositional biasi992 – 1006Pro-richSequence analysisAdd BLAST15
Compositional biasi1052 – 1078PolarSequence analysisAdd BLAST27
Compositional biasi1107 – 1129PolarSequence analysisAdd BLAST23
Compositional biasi1191 – 1205PolarSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

BromodomainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1472 Eukaryota
COG5076 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166757

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M3ZT66

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR029614 CECR2

The PANTHER Classification System

More...
PANTHERi
PTHR47092 PTHR47092, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439 Bromodomain, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

M3ZT66-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQGCPVSVE EVQSWWEVPA IAHFCSLFRT AFRLPDFEIE ELEKALSEQD
60 70 80 90 100
LDFLGDLVAC LLQGCYQRTD ITPQTFSSYL DDIISYRWEL EEGKPNPLRD
110 120 130 140 150
GPFDSLHPRT QVELLHRLCD YRLDAADVFD LLKGLDADSL RVEPLGQDGD
160 170 180 190 200
GALYWYFYGT RMYKEEPLDR KAESLSEFDP TLPERKRRGR PPKKRKLEDN
210 220 230 240 250
NLSEDESEGA DVKSDNGLDD FPPSAGRQRG AWSLVCDTEE QWISLAESIK
260 270 280 290 300
DRTSPQDRHL YRVISQNFLP EISSMIEHKE REQKQKLLDP APVRTSQWFS
310 320 330 340 350
ENHIKPEKED NLKARSEEER RKDEELDRQV LLAEQRREEE RLLQEEQQRE
360 370 380 390 400
KLEKMKAVEE RAKRRKMREE KAWLLSQGKD LPPELLNLEP SSPVRRTRKS
410 420 430 440 450
KEFYDIDDDC TALYKVLEAL KAHKDAWPFL EPVDDSYAPN YHDIIQTPMD
460 470 480 490 500
LSTIEKKLGD GEYVAKEEFI ADVKLMFENC VEYNGEDSEY TVMAESLERC
510 520 530 540 550
FNRALLKHFP SEDGDTDEEF HVSREDRERK DKKRNRTSKH LGPESLIRAT
560 570 580 590 600
EQVQRKRTPQ GKGSAPAEAE DSRMPLLQLP PHWASGPAQG PAHGSAHGLP
610 620 630 640 650
PNQQHMFHPR QQLRPPAGPP GPQMFAQRMA MDPRFSYPVH IPRPGDPNFS
660 670 680 690 700
RYPHSFNMQW IEHQNGFQPR DPHPCKSGPG CTKRLTGSTA TLWCNSTHLA
710 720 730 740 750
DGHHMGPRYP MGPNPNGGPT QQRPYIGPTH GPSLGPRPTA LQPGPPPEAS
760 770 780 790 800
MYPSHQRPEG RSLHPMGSRF PGPEGPAQLP YPGLRPPGLG SSSCIWPGVN
810 820 830 840 850
GPNAANQRSF SYGGMPPPMG HKPWPEAAGY PQHPPNAPHQ MSGSLGPPAS
860 870 880 890 900
RAPVLQSDPA SRTQSSSMLE SPEMLALQQL SASSGPPAGG FHQPGAPSGF
910 920 930 940 950
GSIPSKQLQL LGPTGDRGTD GQADTEPRGP TSNSKNDVNI RNEATPQRSV
960 970 980 990 1000
PAMRLELAAA LSPSGRPTGS ERTPSSQICQ QGADGPPEGS SRPHAASPPP
1010 1020 1030 1040 1050
SPQRVTLSSL PPSHPSTLLP PQPSAAEPGN QRPCEAVGRP DPEALMSAPP
1060 1070 1080 1090 1100
GMYKQFSSQT PPMGGSMGDN TGSNAAQRGP GGYSPAAPPP SQYGLGGALH
1110 1120 1130 1140 1150
AHYNKAPFPS QSLNAPPHPA YQQGGSNAFP YQQPPPPLRN MFPPHQYQQP
1160 1170 1180 1190 1200
AYYGPPLSRE GYQPPYRPQQ PDAPSAYLPV GAARSNGHFK DSAASPPSSS
1210 1220 1230 1240 1250
RAALLSPAGS EEGGCAEAPT GPISNQTAES SEPPESPKEI LDLDSHNAAA
1260 1270 1280 1290 1300
RHRGAPPLPL RHTHPAGFMY DPRALHPGMQ QGGAPPPHMM PQAAGGGTPY
1310 1320 1330 1340 1350
PGQPYPDPCY AAQRPHPHLM EALQRPQLPY PPGQMRMALY RHPRAAGHVQ
1360 1370 1380
GMMVQQRGPE RFLHPGQQMM ATPGGAGAKQ GL
Length:1,382
Mass (Da):152,217
Last modified:December 5, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E7F0FA86089937A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B5QUG6A0A3B5QUG6_XIPMA
Bromo domain-containing protein
1,345Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSXMAT00000005415; ENSXMAP00000005409; ENSXMAG00000005401

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi8083.ENSXMAP00000005409

Genome annotation databases

EnsembliENSXMAT00000005415; ENSXMAP00000005409; ENSXMAG00000005401

Phylogenomic databases

eggNOGiKOG1472 Eukaryota
COG5076 LUCA
GeneTreeiENSGT00940000166757
InParanoidiM3ZT66

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR029614 CECR2
PANTHERiPTHR47092 PTHR47092, 1 hit
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3ZT66_XIPMA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3ZT66
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: December 5, 2018
Last modified: October 16, 2019
This is version 39 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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