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Entry version 35 (26 Feb 2020)
Sequence version 1 (01 May 2013)
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Protein
Submitted name:

Zinc finger BED-type containing 4

Gene

ZBED4

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger BED-type containing 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZBED4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9669 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000715 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9668.ENSMPUP00000018648

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini114 – 171BED-typeInterPro annotationAdd BLAST58
Domaini281 – 338BED-typeInterPro annotationAdd BLAST58
Domaini452 – 501BED-typeInterPro annotationAdd BLAST50
Domaini554 – 611BED-typeInterPro annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni26 – 75DisorderedSequence analysisAdd BLAST50
Regioni167 – 283DisorderedSequence analysisAdd BLAST117
Regioni339 – 392DisorderedSequence analysisAdd BLAST54
Regioni407 – 443DisorderedSequence analysisAdd BLAST37
Regioni614 – 633DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi26 – 66PolyampholyteSequence analysisAdd BLAST41
Compositional biasi179 – 193Pro-richSequence analysisAdd BLAST15
Compositional biasi346 – 367Pro-richSequence analysisAdd BLAST22
Compositional biasi368 – 389PolarSequence analysisAdd BLAST22

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1121 Eukaryota
ENOG4111T8J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161365

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006260_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M3Z4Y6

Identification of Orthologs from Complete Genome Data

More...
OMAi
KSPAWKH

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037220 BED_dom
IPR008906 HATC_C_dom
IPR012337 RNaseH-like_sf
IPR003656 Znf_BED
IPR036236 Znf_C2H2_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05699 Dimer_Tnp_hAT, 1 hit
PF02892 zf-BED, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00614 ZnF_BED, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140996 SSF140996, 1 hit
SSF53098 SSF53098, 1 hit
SSF57667 SSF57667, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50808 ZF_BED, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

M3Z4Y6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENNQETHPK RDGELVSDKI NFKIEEEDGV RIPNHSLEGV AIKREQDRPG
60 70 80 90 100
AERGGEQTEA REAGGDREPP GQCLPADQEE EYGALFSQYS STLYDVAMEA
110 120 130 140 150
VTQSLLSGRG AGSRKKSPAW KHFFISPRDS TKAICTYCMK EFSRGKNEKD
160 170 180 190 200
LSTSCLMRHV RRAHPTVLGQ ETGGGGPALP SLSPPPLRLP PPPADAGDLG
210 220 230 240 250
AARSPLKLAP KLASKVQSPD DVTEEPVVPS EVPPDTSAPD RYGREEALGG
260 270 280 290 300
PPHLPPLPGE ESAENGLERN PPLPKGTSGS RRRSAVWKHF YLSPLDNSKA
310 320 330 340 350
VCVHCMNEFS RGKNGKDLGT SCLIRHMWRA HRSIVLQENG GGSGIPPPYA
360 370 380 390 400
APPTLLPALP PPDGDPSSVA SSPGQPARVS PSASSSPDRL PEELQVRLSV
410 420 430 440 450
GDALAEDTAP ASDDVGAASL ESSPEKLQAG GLSPGPLDCG AGSQQSKKVI
460 470 480 490 500
KRLKSEVWQH FSLAPTDSLK AVCRHCACVI SRGRRGDVGT SCLMRHLYRR
510 520 530 540 550
HADVVGAPKG APGASLANSP YATLASAEGA ASRSTDLPSL VPRNSPVLFP
560 570 580 590 600
VSSKKTSKLW NHFSICSADP TKVVCLHCGR TISRGKKPTN LGTSCLLRHL
610 620 630 640 650
QRFHSGVLKA EAPRVARASS SPGPRGPLSA QLPGAASFED PNEKFYDSHP
660 670 680 690 700
VAKKITSLIA EMIALDLQPY SFVDNVGFNR LLEYLKPQYS VPSPSYFSRT
710 720 730 740 750
AIPGMYNNVK QVVLSHLKEA ESGVVHFTSG IWMSTQTREY LTLTAHWVTF
760 770 780 790 800
ASSARPYRED HHGSALLDVS QVDCDYSGSS IRKQLEGWWE AWVTSSGLQV
810 820 830 840 850
GITVTDNPSI GKTLSEGERA GLQCFSHTVN LVVSEALKSQ RMVQSLLSTA
860 870 880 890 900
RKLCERVQRS PRAKEKLAEL QRAYGLPPHH LLQDVPSRWS TSLHMLERLV
910 920 930 940 950
EQKRAVNEVS VECGFRELIS CDQWEVMRSV CLALKPFDAA GREMSAHAST
960 970 980 990 1000
LSQVIPMIHI LNRKIEMLFE ETMGIDTMLK SLKEAMVSRL AATLRDPRYI
1010 1020 1030 1040 1050
LATLLDPRYK ASLFSEEEAE QYTRDLIREL EALNPTSDNT PIPNGCDAGA
1060 1070 1080 1090 1100
PSQGTVGEEN LWSLMAKMTK KGPREKTKVP EDMVLAYLEE EVLEHGCDPL
1110 1120 1130 1140 1150
TYWNLKKAAW PGLAALAVRF LGCPPSIVPS ERLFNTPTEN GSFGQSRLMT
1160 1170
EHFEKLIFLK VNLPLIYFQY
Length:1,170
Mass (Da):127,708
Last modified:May 1, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i92BA7239E1D0A1BE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AEYP01086365 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
XP_004775485.1, XM_004775428.2
XP_004775486.1, XM_004775429.2
XP_004775487.1, XM_004775430.2
XP_012902702.1, XM_013047248.1
XP_012902703.1, XM_013047249.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMPUT00000018920; ENSMPUP00000018648; ENSMPUG00000018768

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
101677858

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01086365 Genomic DNA No translation available.
RefSeqiXP_004775485.1, XM_004775428.2
XP_004775486.1, XM_004775429.2
XP_004775487.1, XM_004775430.2
XP_012902702.1, XM_013047248.1
XP_012902703.1, XM_013047249.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9668.ENSMPUP00000018648

Genome annotation databases

EnsembliENSMPUT00000018920; ENSMPUP00000018648; ENSMPUG00000018768
GeneIDi101677858

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9889

Phylogenomic databases

eggNOGiKOG1121 Eukaryota
ENOG4111T8J LUCA
GeneTreeiENSGT00940000161365
HOGENOMiCLU_006260_0_0_1
InParanoidiM3Z4Y6
OMAiKSPAWKH

Family and domain databases

InterProiView protein in InterPro
IPR037220 BED_dom
IPR008906 HATC_C_dom
IPR012337 RNaseH-like_sf
IPR003656 Znf_BED
IPR036236 Znf_C2H2_sf
PfamiView protein in Pfam
PF05699 Dimer_Tnp_hAT, 1 hit
PF02892 zf-BED, 4 hits
SMARTiView protein in SMART
SM00614 ZnF_BED, 4 hits
SUPFAMiSSF140996 SSF140996, 1 hit
SSF53098 SSF53098, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50808 ZF_BED, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3Z4Y6_MUSPF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3Z4Y6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: February 26, 2020
This is version 35 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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