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Entry version 40 (02 Jun 2021)
Sequence version 1 (01 May 2013)
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Protein
Submitted name:

SAM and SH3 domain containing 1

Gene

SASH1

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SAM and SH3 domain containing 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SASH1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9669 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000715 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9668.ENSMPUP00000017953

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini461 – 522SH3InterPro annotationAdd BLAST62
Domaini540 – 604SAMInterPro annotationAdd BLAST65
Domaini1075 – 1139SAMInterPro annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni128 – 164DisorderedSequence analysisAdd BLAST37
Regioni223 – 251DisorderedSequence analysisAdd BLAST29
Regioni356 – 467DisorderedSequence analysisAdd BLAST112
Regioni524 – 547DisorderedSequence analysisAdd BLAST24
Regioni621 – 641DisorderedSequence analysisAdd BLAST21
Regioni741 – 963DisorderedSequence analysisAdd BLAST223

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi237 – 251Polar residuesSequence analysisAdd BLAST15
Compositional biasi416 – 442Polar residuesSequence analysisAdd BLAST27
Compositional biasi443 – 460Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi621 – 635Polar residuesSequence analysisAdd BLAST15
Compositional biasi769 – 783Polar residuesSequence analysisAdd BLAST15
Compositional biasi932 – 946Polar residuesSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4384, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156778

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_281404_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M3Z2Z1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VESWPRS

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09559, SAM_SASH1_repeat1, 1 hit
cd09492, SAM_SASH1_repeat2, 1 hit
cd11967, SH3_SASH1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021090, rSAM/SH3_domain-containing
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR037627, SASH1_SAM_repeat1
IPR037630, SASH1_SAM_repeat2
IPR035720, SASH1_SH3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00536, SAM_1, 1 hit
PF07647, SAM_2, 1 hit
PF07653, SH3_2, 1 hit
PF12485, SLY, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00454, SAM, 2 hits
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 2 hits
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105, SAM_DOMAIN, 2 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

M3Z2Z1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTWHSSMQII TTPVSPMCVR GWRSSGSGGF PRTWKWNTLP KSNSEDSSVG
60 70 80 90 100
KGDWKKKNKY FWQNFRKNQK GIMRQTSKGE DVGYVASEIT MSDEERIQLM
110 120 130 140 150
MMVKEKMITI EEALARLKEY EAQHRQSAAL DPADWPDGSY PTFDGSSNCN
160 170 180 190 200
SREQSDEETE ESVKFKRLHK LVNSTRRVRK KLIRVEEMRK PSTEGGEEHV
210 220 230 240 250
FENSPGLDER SALYSGVHKK PFFFDGSPEK PPEDESDSLT TSPSSSSLDT
260 270 280 290 300
WGAGRKLVKT FSKGESRGLI KPPKKMGTFF SYPEEEKAQK VSRSLTEGEM
310 320 330 340 350
KKGLGSLSHG RTCSFGGFDL TNRSLHIGSN NSDPMSKEGD FVYKEVIKSP
360 370 380 390 400
TASRISLGKK VKSVKETMRK RMSKKYSSSV SEQDSGLDGM PGSPPPSQPD
410 420 430 440 450
GEHMDKPKLK AGGSVESLRS SLSGQSSMSG QTVSTTDSST SNRESVKSED
460 470 480 490 500
GDDEEPPYRG PFCGRARVHT DFTPSPYDTD SLKLKKGDII DIISKPPMGT
510 520 530 540 550
WMGLLNNKVG TFKFIYVDVL NEEEEKPKRP TRRRRKGRPP QPKSVEDLLD
560 570 580 590 600
RINLKEHMPT FLFNGYEDLD TFKLLEEEDL DELNIRDPEH RAVLLTAVEL
610 620 630 640 650
LQEYDSNSDQ SGSQEKLLVD SQGLSGCSPR DSGCYESSEN LEHGKSRKTG
660 670 680 690 700
LLSVKSSTES SLKSFNRNQL GHYPTLPLTK SADALKQGEE GRLGSGLSPR
710 720 730 740 750
ASKCCDQPCG AGPNKNRRSL PVSICRSCET LEGPQAVEAW PRSHSLDDLQ
760 770 780 790 800
GEPAAEKDVP GKVTDPCPQT VPQVPQKTTP FIAKVQSPKR DPAVDNALLL
810 820 830 840 850
TQSKRCSEPQ KPATRKLEGS TAPSPRGASP PPCLPKTYDA QHPGVKPSLT
860 870 880 890 900
RMPLEGHRKG LEFEGTYHPP GTKEGLAAEQ RGPETRAQAK HPAQPPPVPA
910 920 930 940 950
KKSRERLANG LHPSPPGPNA PSLPAKKGSP SDCHSPQASR PPSGQEPGSP
960 970 980 990 1000
LSARPPPWLS ELPESTSLQE HGVKLGPALT RKISCARGVD LEMLTENKLR
1010 1020 1030 1040 1050
AEGIDLTEEP YSDKHGRCGI PEALVQRYAE DLDQPERDVA THMDQIRVKL
1060 1070 1080 1090 1100
LQKQHRMAIP SGGLTEICRK PLSPGCISSV SDWLVSIGLP MYTSALTEAG
1110 1120 1130 1140
FSTLGQVPSL SHICLQEAGI TEERHISKLM SAARLFKLPP GPEAM
Length:1,145
Mass (Da):126,002
Last modified:May 1, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA10AA205F16ACAB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEYP01032431 Genomic DNA No translation available.
AEYP01032432 Genomic DNA No translation available.
AEYP01032433 Genomic DNA No translation available.
AEYP01032434 Genomic DNA No translation available.
AEYP01032435 Genomic DNA No translation available.
AEYP01032436 Genomic DNA No translation available.
AEYP01032437 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMPUT00000018215; ENSMPUP00000017953; ENSMPUG00000018064

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01032431 Genomic DNA No translation available.
AEYP01032432 Genomic DNA No translation available.
AEYP01032433 Genomic DNA No translation available.
AEYP01032434 Genomic DNA No translation available.
AEYP01032435 Genomic DNA No translation available.
AEYP01032436 Genomic DNA No translation available.
AEYP01032437 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9668.ENSMPUP00000017953

Genome annotation databases

EnsembliENSMPUT00000018215; ENSMPUP00000017953; ENSMPUG00000018064

Phylogenomic databases

eggNOGiKOG4384, Eukaryota
GeneTreeiENSGT00940000156778
HOGENOMiCLU_281404_0_0_1
InParanoidiM3Z2Z1
OMAiVESWPRS

Family and domain databases

CDDicd09559, SAM_SASH1_repeat1, 1 hit
cd09492, SAM_SASH1_repeat2, 1 hit
cd11967, SH3_SASH1, 1 hit
Gene3Di1.10.150.50, 2 hits
InterProiView protein in InterPro
IPR021090, rSAM/SH3_domain-containing
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR037627, SASH1_SAM_repeat1
IPR037630, SASH1_SAM_repeat2
IPR035720, SASH1_SH3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF00536, SAM_1, 1 hit
PF07647, SAM_2, 1 hit
PF07653, SH3_2, 1 hit
PF12485, SLY, 1 hit
SMARTiView protein in SMART
SM00454, SAM, 2 hits
SM00326, SH3, 1 hit
SUPFAMiSSF47769, SSF47769, 2 hits
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50105, SAM_DOMAIN, 2 hits
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3Z2Z1_MUSPF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3Z2Z1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: June 2, 2021
This is version 40 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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