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Entry version 47 (29 Sep 2021)
Sequence version 1 (01 May 2013)
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Protein
Submitted name:

SH3 and PX domains 2A

Gene

SH3PXD2A

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SH3 and PX domains 2AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SH3PXD2AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9669 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000715 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projectionARBA annotation, CytoplasmARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9668.ENSMPUP00000016715

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 128PXInterPro annotationAdd BLAST125
Domaini151 – 210SH3InterPro annotationAdd BLAST60
Domaini251 – 310SH3InterPro annotationAdd BLAST60
Domaini433 – 492SH3InterPro annotationAdd BLAST60
Domaini822 – 881SH3InterPro annotationAdd BLAST60
Domaini1054 – 1115SH3InterPro annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni399 – 429DisorderedSequence analysisAdd BLAST31
Regioni490 – 825DisorderedSequence analysisAdd BLAST336
Regioni879 – 944DisorderedSequence analysisAdd BLAST66
Regioni988 – 1041DisorderedSequence analysisAdd BLAST54

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi623 – 657Polar residuesSequence analysisAdd BLAST35
Compositional biasi665 – 701Polar residuesSequence analysisAdd BLAST37
Compositional biasi744 – 765Polar residuesSequence analysisAdd BLAST22
Compositional biasi892 – 913Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi991 – 1005Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SH3PXD2 family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0905, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157732

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013051_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M3YZF5

Identification of Orthologs from Complete Genome Data

More...
OMAi
THRRTSF

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06888, PX_FISH, 1 hit
cd12074, SH3_Tks5_1, 1 hit
cd12077, SH3_Tks5_2, 1 hit
cd12079, SH3_Tks5_3, 1 hit
cd12019, SH3_Tks5_4, 1 hit
cd12020, SH3_Tks5_5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001683, PX_dom
IPR036871, PX_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR037961, SH3PXD2_PX
IPR034917, SH3PXD2A
IPR035450, SH3PXD2A_SH3_1
IPR035452, SH3PXD2A_SH3_2
IPR035449, SH3PXD2A_SH3_3
IPR035453, SH3PXD2A_SH3_4
IPR035454, SH3PXD2A_SH3_5

The PANTHER Classification System

More...
PANTHERi
PTHR15706:SF22, PTHR15706:SF22, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00787, PX, 1 hit
PF00018, SH3_1, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00312, PX, 1 hit
SM00326, SH3, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 5 hits
SSF64268, SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50195, PX, 1 hit
PS50002, SH3, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

M3YZF5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAYCVQDAT VVDVEKRRNP SKHYVYIINV TWSDSTSQTI YRRYSKFFDL
60 70 80 90 100
QMQLLDKFPI EGGQKDPKQR IIPFLPGKIL FRRSHIRDVA VKRLKPIDEY
110 120 130 140 150
CRALVRLPPH ISQCDEVFRF FEARPEDVNP PKEDYGSSKR KSGADTNAEP
160 170 180 190 200
MILEQYVVVS NYKKQENSEL SLQAGEVVDV IEKNESGWWF VSTSEEQGWV
210 220 230 240 250
PATYLEAQNG TRDDSDINTS KTGEVSKRRK AHLRRLDRRW TLGGMVNRQH
260 270 280 290 300
SREEKYVTVQ PYTSQSKDEI GFEKGVTVEV IRKNLEGWWY IRYLGKEGWA
310 320 330 340 350
PASYLKKAKD DLPARKKNLA GPVEIIGNIM EISNLLNKKA SGDKETPPAE
360 370 380 390 400
SEGPEAPITK KEISLPILCN ASNGSALGVP ERSVSKLAQG SPAVARIAPQ
410 420 430 440 450
RAQISSPNLR TRPPPRRESS LGFQLPKPPE PPSVEVEYYT IAEFQSCISD
460 470 480 490 500
GISFRGGQKA EVIDKNSGGW WYVQIGEKEG WAPASYIDKR KKPNLSRRTS
510 520 530 540 550
TLTRPKVPPP APPSKPKEAE EGPAGSAESQ DSPLKLKYEE PEYDIPAFGF
560 570 580 590 600
DSEPELSEEP TEDSGSGDRR PSQAHRPSPA SSLQRARFRV GGSSEDVAPE
610 620 630 640 650
EETIYENEGF RPCAEDALSA RRSSRDSQSP GGSPLSLARK NSPRSGSPKS
660 670 680 690 700
SSLLKLKAEK NAQAELGKNH SSASSSSITI NTTCSSSSSS SSLSKNSGDL
710 720 730 740 750
KPRSASDAGI RGTPPVGPKR DADLKAGLTS CARAKPSVRP KPFLNRAESQ
760 770 780 790 800
SQEKMDISTL RRQLRPTGQL RGGLKGSKSE DSELPPQAAF EGSSEGSRRG
810 820 830 840 850
SADLITPPAA TPPCPTKKGP EGQATSYTTC SAYQKVQDSE ISFPAGVEVQ
860 870 880 890 900
VLEKLESGWW YVRFGELEGW APSHYLVLGE NEQPDPAGKE PDTVSPKNKQ
910 920 930 940 950
HEGKSDSLEK IEKRVQALNT VNQNKRATPP IPSKPPGGFS KTSAASAVKL
960 970 980 990 1000
RNGVRQVAVR PQSVFVSPPP KDNNLSCALR RNESLTATDG LRGVRRNSSF
1010 1020 1030 1040 1050
STARSAAAEA KGRLPERAAS QGSDTPLLPG QRNGIPVSPV RPKPIEKSQF
1060 1070 1080 1090 1100
IHNNLKDVYV SIADYEGDEE TAGFQEGVSM EVLERNPNGW WYCQILDGAK
1110
PFKGWVPSNY LEKKN
Length:1,115
Mass (Da):122,763
Last modified:May 1, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16A57D6FC091D3C6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEYP01025955 Genomic DNA No translation available.
AEYP01025956 Genomic DNA No translation available.
AEYP01025957 Genomic DNA No translation available.
AEYP01025958 Genomic DNA No translation available.
AEYP01025959 Genomic DNA No translation available.
AEYP01025960 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMPUT00000016964; ENSMPUP00000016715; ENSMPUG00000016820

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01025955 Genomic DNA No translation available.
AEYP01025956 Genomic DNA No translation available.
AEYP01025957 Genomic DNA No translation available.
AEYP01025958 Genomic DNA No translation available.
AEYP01025959 Genomic DNA No translation available.
AEYP01025960 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9668.ENSMPUP00000016715

Genome annotation databases

EnsembliENSMPUT00000016964; ENSMPUP00000016715; ENSMPUG00000016820

Phylogenomic databases

eggNOGiKOG0905, Eukaryota
GeneTreeiENSGT00940000157732
HOGENOMiCLU_013051_0_0_1
InParanoidiM3YZF5
OMAiTHRRTSF

Family and domain databases

CDDicd06888, PX_FISH, 1 hit
cd12074, SH3_Tks5_1, 1 hit
cd12077, SH3_Tks5_2, 1 hit
cd12079, SH3_Tks5_3, 1 hit
cd12019, SH3_Tks5_4, 1 hit
cd12020, SH3_Tks5_5, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683, PX_dom
IPR036871, PX_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR037961, SH3PXD2_PX
IPR034917, SH3PXD2A
IPR035450, SH3PXD2A_SH3_1
IPR035452, SH3PXD2A_SH3_2
IPR035449, SH3PXD2A_SH3_3
IPR035453, SH3PXD2A_SH3_4
IPR035454, SH3PXD2A_SH3_5
PANTHERiPTHR15706:SF22, PTHR15706:SF22, 1 hit
PfamiView protein in Pfam
PF00787, PX, 1 hit
PF00018, SH3_1, 4 hits
SMARTiView protein in SMART
SM00312, PX, 1 hit
SM00326, SH3, 5 hits
SUPFAMiSSF50044, SSF50044, 5 hits
SSF64268, SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195, PX, 1 hit
PS50002, SH3, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3YZF5_MUSPF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3YZF5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: September 29, 2021
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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