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Entry version 38 (11 Dec 2019)
Sequence version 1 (01 May 2013)
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Protein
Submitted name:

MON2 homolog, regulator of endosome-to-Golgi trafficking

Gene

MON2

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MON2 homolog, regulator of endosome-to-Golgi traffickingImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MON2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9669 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000715 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9668.ENSMPUP00000016610

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 184DCBInterPro annotationAdd BLAST176
Domaini212 – 385Sec7_NInterPro annotationAdd BLAST174
Domaini854 – 930DUF1981InterPro annotationAdd BLAST77
Domaini934 – 1380Mon2_CInterPro annotationAdd BLAST447
Domaini1381 – 1738Mon2_CInterPro annotationAdd BLAST358

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni512 – 540DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi512 – 535PolarSequence analysisAdd BLAST24

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0929 Eukaryota
KOG1848 Eukaryota
ENOG410XQA8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013286

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M3YZ50

Identification of Orthologs from Complete Genome Data

More...
OMAi
YIPSQAF

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR026829 Mon2-like
IPR032817 Mon2_C
IPR015403 Sec7_C
IPR032691 Sec7_N

The PANTHER Classification System

More...
PANTHERi
PTHR10663:SF333 PTHR10663:SF333, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF16206 Mon2_C, 2 hits
PF12783 Sec7_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

M3YZ50-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGTNSPEAV KKLLENMQSD LRALSLECKK KFPPVKEAAE SGIIKVKTIA
60 70 80 90 100
ARNTEILAAL KENSSEVVQP FLMGCGTKEP KITQLCLTAI QRLMSHEVVS
110 120 130 140 150
ETAAGNIINM LWQLMENSLE ELKLLQTVLV LLTTNTVVHD ESLSKAIVLC
160 170 180 190 200
FRLHFTKDNI TNNTAAATVR QVVTVVFERM VAEDERHRDI IEQPVLVQGN
210 220 230 240 250
SNRRSVSTLK PCAKDAYMLF QDLCQLVNAD APYWLVGMTE MTRTFGLELL
260 270 280 290 300
ESVLNDFPQV FLQHQEFSFL LKERVCPLVI KLFSPNIKFR QGSSSSSSPA
310 320 330 340 350
PVEKPYFPIC MRLLRVVSVL IKQFYSLLVT ECEIFLSLLV KFLDADKPQW
360 370 380 390 400
LRAVAVESIH RLCVQPQLLR SFCQSYDMKQ HSTKVFRDIV NALGSFIQSL
410 420 430 440 450
FLVPPTGNPA TTNQAGNNNS GGPVSAPANS GMLGIGGGVT LLPAFEYRGT
460 470 480 490 500
WIPILTITVQ GSAKATYLEM LDKVEPPTIP EGYAMSVAFH CLLDLVRGIT
510 520 530 540 550
SMIEGELGEV ETECQTTTEA ASSPTQSSEQ QELQSTSDQM DKEKVSRAVW
560 570 580 590 600
EEMVNACWCG LLAALSLLLD ASTDEAATEN ILKAELTMAA LCGRLGLVTS
610 620 630 640 650
RDAFITAICK GSLPPHYALT VLNTTTAATL SNKSYSIQGQ SVMMISPSSE
660 670 680 690 700
SHQQVVAVGQ PLAVQPQGTV MLTSKNIQCM RTLLNLAHCH GAVLGTSWQL
710 720 730 740 750
VLATLQHLVW ILGLKPSSGG ALKPGRAVEG PSTVLTTAVM TDLPVISNIL
760 770 780 790 800
SRLFESSQYL DDVSLHHLIN ALCSLSLEAM DMAYGNNKEP SLFAVAKLLE
810 820 830 840 850
TGLVNMHRIE ILWRPLTGHL LEVCQHPNSR MREWGAEALT SLIKAGLTFN
860 870 880 890 900
HDPPLSQNQR LQLLLLNPLK EMSSINHPDI RLKQLECVLQ ILQSQGDSLG
910 920 930 940 950
PGWPLVLGVM GAIRNDQGES LIRTAFQCLQ LVVTDFLPTM PCTCLQIVVD
960 970 980 990 1000
VAGSFGLHNQ ELNISLTSIG LLWNISDYFF QRGETIEKEL NKEEAAQQKQ
1010 1020 1030 1040 1050
AEEKGVVLNR PFHPAPPFDC LWLCLYAKLG ELCVDPRPAV RKSAGQTLFS
1060 1070 1080 1090 1100
TIGAHGTLLQ HSTWHTVIWK VLFHLLDRVR ESSTTADKEK IESGGGNILI
1110 1120 1130 1140 1150
HHSRDTAEKQ WAETWVLTLA GVARIFNTRR YLLQPLGDFS RAWDVLLDHI
1160 1170 1180 1190 1200
QSAALSKNNE VSLAALKSFQ EILQIVSPVR DSDKPETPPA VNVPVPVLLG
1210 1220 1230 1240 1250
SISGPGLSRP FVRTDSIGDR LGRYNSSEPP VVTDELEDLN LWWAAWSTWY
1260 1270 1280 1290 1300
RIGSESTKPP VTFDKLTFIP SQPFLTALIQ IFPALYQHIK TGFNMDDLQK
1310 1320 1330 1340 1350
LGVILHSAVS VPISSDASPF ILPSYTEAVL TSLQEAVLTA LDVLQKPLKI
1360 1370 1380 1390 1400
KVYNHSLHLV LRYFQRNCNT QFSKAICVGP ENMQIMYPAI FDQLLAFVEF
1410 1420 1430 1440 1450
SCKPPQYGQL ETKHIANAKY NQIQLFAPAE WVALNYVPFA ERSLEVVVDL
1460 1470 1480 1490 1500
YQKTACHKAV VNEKVLQNII KTLRVPLSLK YSCPSESTWK LAVSSLLKVL
1510 1520 1530 1540 1550
SIGLPVARQH ASSGKFDSMW PELANTFEDF LFTKSIPPDN LSIQEFQRNE
1560 1570 1580 1590 1600
SIDVEVVQLI STEILPYANF IPKEFVGQIM TMLNKGSIHS QSSSFTEAEI
1610 1620 1630 1640 1650
DIRLREEFSK MCFETLLQFS FSNKVTTPQE GYISRMALSV LLKRSQDVLH
1660 1670 1680 1690 1700
RYIEDERLSG KCPLPRQQVT EIIFVLKAVS TLIDSLKKTQ PENVDGNTWA
1710 1720 1730 1740
QVIALYPTLV ECITCSSAEV CSALKEALVP FKDFMQPPAS KVQNGES
Length:1,747
Mass (Da):193,728
Last modified:May 1, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA02A6F5A48F843C8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEYP01066302 Genomic DNA No translation available.
AEYP01066303 Genomic DNA No translation available.
AEYP01066304 Genomic DNA No translation available.
AEYP01066305 Genomic DNA No translation available.
AEYP01066306 Genomic DNA No translation available.
AEYP01066307 Genomic DNA No translation available.
AEYP01066308 Genomic DNA No translation available.
AEYP01066309 Genomic DNA No translation available.
AEYP01066310 Genomic DNA No translation available.
AEYP01066311 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMPUT00000016857; ENSMPUP00000016610; ENSMPUG00000016714

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01066302 Genomic DNA No translation available.
AEYP01066303 Genomic DNA No translation available.
AEYP01066304 Genomic DNA No translation available.
AEYP01066305 Genomic DNA No translation available.
AEYP01066306 Genomic DNA No translation available.
AEYP01066307 Genomic DNA No translation available.
AEYP01066308 Genomic DNA No translation available.
AEYP01066309 Genomic DNA No translation available.
AEYP01066310 Genomic DNA No translation available.
AEYP01066311 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9668.ENSMPUP00000016610

Genome annotation databases

EnsembliENSMPUT00000016857; ENSMPUP00000016610; ENSMPUG00000016714

Phylogenomic databases

eggNOGiKOG0929 Eukaryota
KOG1848 Eukaryota
ENOG410XQA8 LUCA
GeneTreeiENSGT00390000013286
InParanoidiM3YZ50
OMAiYIPSQAF

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR026829 Mon2-like
IPR032817 Mon2_C
IPR015403 Sec7_C
IPR032691 Sec7_N
PANTHERiPTHR10663:SF333 PTHR10663:SF333, 1 hit
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF16206 Mon2_C, 2 hits
PF12783 Sec7_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3YZ50_MUSPF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3YZ50
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: December 11, 2019
This is version 38 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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