UniProtKB - M3YYY7 (M3YYY7_MUSPF)
Protein
Submitted name:
Nuclear factor of activated T cells 1
Gene
NFATC1
Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- sequence-specific double-stranded DNA binding Source: Ensembl
GO - Biological processi
- calcineurin-NFAT signaling cascade Source: Ensembl
- negative regulation of vascular associated smooth muscle cell differentiation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Nuclear factor of activated T cells 1Imported |
Gene namesi | Name:NFATC1Imported |
Organismi | Mustela putorius furo (European domestic ferret) (Mustela furo)Imported |
Taxonomic identifieri | 9669 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Mustelidae › Mustelinae › Mustela › |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nuclear body Source: Ensembl
- nuclear chromatin Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 395 – 577 | RHDInterPro annotationAdd BLAST | 183 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 45 – 83 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 188 – 287 | DisorderedSequence analysisAdd BLAST | 100 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 222 – 242 | PolarSequence analysisAdd BLAST | 21 |
Phylogenomic databases
eggNOGi | ENOG502QTX8, Eukaryota |
GeneTreei | ENSGT00940000157616 |
HOGENOMi | CLU_010185_1_1_1 |
InParanoidi | M3YYY7 |
OMAi | RGLGACN |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR008366, NFAT IPR015647, NFAT1 IPR008967, p53-like_TF_DNA-bd IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR12533, PTHR12533, 1 hit PTHR12533:SF5, PTHR12533:SF5, 1 hit |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR01789, NUCFACTORATC |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50254, REL_2, 1 hit |
i Sequence
Sequence statusi: Complete.
M3YYY7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTGLEEDQEF DFDFLFEFNQ SDEGPAAAPE HYSYASPGVS SALLPGSAQP
60 70 80 90 100
SLPAPGHDLQ ISAPGVPATA AGQPPGYGGA VDSGPSSYFL SSGHVRPNGA
110 120 130 140 150
PALESPRIEI TSYMGLHHGN NQCFHDVEVE DILPGSRRPP STATLSLPNL
160 170 180 190 200
EAYRDPSCLS PASSLSSRSC NSEASSYESN FSYPYASPQT SPWQSPCVSP
210 220 230 240 250
KTTDPEEGFP RGLGACGLLG SPRHSPSTSP RTSVTEESWL GARTSRPPSP
260 270 280 290 300
CNKRKYGLNG RQPSCSPHRS PTPSPRSSPR VSVTDDTWLG NSTQYTSSAI
310 320 330 340 350
VAAINALSTD GSLELDGVPV KARKTTPDHC PSVALKVEPA GEDLGTTPPT
360 370 380 390 400
AEFLPEEYPS FQHVRKGAFC DQYLSVPQHP YQWARPRSPT AYGSPSLPAL
410 420 430 440 450
DWQLPSRSGP YELRIEVQPK PHHRAHYETE GSRGAVKASA GGHPSVQLHG
460 470 480 490 500
YLENEPLTLQ LFIGTADDRL LRPHAFYQVH RITGKTVSTT SHEAILSNTK
510 520 530 540 550
VLEIPLLPEN NMRAIVDCAG ILKLRNSDIE LRKGETDIGR KNTRVRLVFR
560 570 580 590 600
VHIPQPSGRT LSLQVASNPI ECSQRSAQEL PLVEKQSAAS CPVLGGKKMV
610 620 630 640 650
LSGHNFLQDS KVIFVEKAPD GHHIWEMEAK MDRELCKPNS LVVEIPPFRN
660 670 680 690 700
QRITSPVQVS FYVCNGKRKR SQCQRFTYLP ANGNALLLAL STENEPRGPF
F
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AEYP01018556 Genomic DNA No translation available. AEYP01018557 Genomic DNA No translation available. AEYP01018558 Genomic DNA No translation available. AEYP01018559 Genomic DNA No translation available. AEYP01018560 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMPUT00000016793; ENSMPUP00000016547; ENSMPUG00000016650 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AEYP01018556 Genomic DNA No translation available. AEYP01018557 Genomic DNA No translation available. AEYP01018558 Genomic DNA No translation available. AEYP01018559 Genomic DNA No translation available. AEYP01018560 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9668.ENSMPUP00000016547 |
Genome annotation databases
Ensembli | ENSMPUT00000016793; ENSMPUP00000016547; ENSMPUG00000016650 |
Phylogenomic databases
eggNOGi | ENOG502QTX8, Eukaryota |
GeneTreei | ENSGT00940000157616 |
HOGENOMi | CLU_010185_1_1_1 |
InParanoidi | M3YYY7 |
OMAi | RGLGACN |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR008366, NFAT IPR015647, NFAT1 IPR008967, p53-like_TF_DNA-bd IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR12533, PTHR12533, 1 hit PTHR12533:SF5, PTHR12533:SF5, 1 hit |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR01789, NUCFACTORATC |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50254, REL_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | M3YYY7_MUSPF | |
Accessioni | M3YYY7Primary (citable) accession number: M3YYY7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2013 |
Last sequence update: | May 1, 2013 | |
Last modified: | October 7, 2020 | |
This is version 46 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |