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Entry version 53 (02 Dec 2020)
Sequence version 1 (01 May 2013)
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Protein
Submitted name:

IQ motif containing GTPase activating protein 1

Gene

IQGAP1

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
IQ motif containing GTPase activating protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IQGAP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9669 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000715 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9668.ENSMPUP00000015520

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 129Calponin-homology (CH)InterPro annotationAdd BLAST116
Domaini649 – 682WWInterPro annotationAdd BLAST34
Domaini974 – 1207Ras-GAPInterPro annotationAdd BLAST234

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili138 – 165Sequence analysisAdd BLAST28
Coiled coili233 – 267Sequence analysisAdd BLAST35
Coiled coili338 – 358Sequence analysisAdd BLAST21
Coiled coili546 – 566Sequence analysisAdd BLAST21
Coiled coili859 – 879Sequence analysisAdd BLAST21
Coiled coili1466 – 1486Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2128, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183076

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000972_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M3YW10

Identification of Orthologs from Complete Genome Data

More...
OMAi
PPMGVVR

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 1 hit
cd00201, WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR000048, IQ_motif_EF-hand-BS
IPR027417, P-loop_NTPase
IPR000593, RasGAP_C
IPR023152, RasGAP_CS
IPR001936, RasGAP_dom
IPR008936, Rho_GTPase_activation_prot
IPR001202, WW_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 1 hit
PF00612, IQ, 4 hits
PF00616, RasGAP, 1 hit
PF03836, RasGAP_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 1 hit
SM00015, IQ, 4 hits
SM00323, RasGAP, 1 hit
SM00456, WW, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit
SSF48350, SSF48350, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021, CH, 1 hit
PS50096, IQ, 4 hits
PS00509, RAS_GTPASE_ACTIV_1, 1 hit
PS50018, RAS_GTPASE_ACTIV_2, 1 hit
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

M3YW10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDERRRQNVA YEYLCHLEEA KRWMEACLGE DLPPTTELEE GLRNGVYLAK
60 70 80 90 100
LGNFFSPKVV SLKKIYDREQ TRYKATGLHF RHTDNVIQWL NAMHEIGLPK
110 120 130 140 150
IFYPETTDIY DRKNMPRCIY CIHALSLYLF KLGLAPQIQD LYGKVDFTEE
160 170 180 190 200
EINNMKIELE KYGIQMPAFS KIGGILANEL SVDEAALHAA VIAINEAVDR
210 220 230 240 250
RIAADTFVAL RNPNAMLVNL EEPLASTYQD VLYRAKQEKM TNAKNRTENS
260 270 280 290 300
ERERDVYEEL LTQAEIQGNI NKVNTSSALA NVDLALEQGV ALALFKALQS
310 320 330 340 350
PALGLRGLQQ QNGDWYLKQL LSDREQKRQG GQADPLQKEE LQCGVDAANG
360 370 380 390 400
AAQQYQRRLA AVAAINAAIQ KGVAEKTVLE LTNPEAQLPQ VYPFAADLYQ
410 420 430 440 450
KELATLQQQS PEHSLTHPEL SVAVEMLSSV ALINRALESG DMNTVWKQLS
460 470 480 490 500
SSVTGLTNIE EENCQRYLDE LMKLKTQAHA ENTAFITWND IQACVDHVNL
510 520 530 540 550
VVQEEHERIL AIGLINEALD EGDAQKTLQA LQIPAAKLEG VLAEVAQHYQ
560 570 580 590 600
DTLIRAKREK AQETRDESAV LWLDEIQGGI WQSNKDTQEA QRFALGIYAI
610 620 630 640 650
NEAVDSGDVG KTLSALRSPD VGLYGVIPEC GETYQSDLAE AKKKKLAAGD
660 670 680 690 700
NNSKWVKHWV KGGYYYYHNL ETQEGGWEEP PDFVQNSMQL SREEIQSSIS
710 720 730 740 750
GVTAAYNREQ LWLANEGLIT RLQARCRGYL VRKEFRSRMN FLKKQIPAIT
760 770 780 790 800
CIQSQWRGYK QKKAYQDRLA YLRAHKDEVV KIQSLARMHQ ARKRYRDRLQ
810 820 830 840 850
YFRDHINDII KIQAFIRANK ARDDYKTLIN AEDPPMIVVR KFVHLLDQSD
860 870 880 890 900
QDFQEELDLM KMREEVITLI RSNQQLENDL NLMDIKIGLL VKNKITLQDV
910 920 930 940 950
VSHSKKLTKK NKEQLSDMMM LNKQKGGLKA LSKEKREKLE AYQHLFYLLQ
960 970 980 990 1000
TNPTYLAKLI FQMPQNKSTK FMDSVIFTLY NYASNQREEY LLLRLFKTAL
1010 1020 1030 1040 1050
QEEIKSKVDQ IQEIVTGNPT VIKMVVSFNR GARGQNALRQ ILAPVVKEIM
1060 1070 1080 1090 1100
DDKSLNIKTD PVDIYKSWVN QMESQTGEAS KLPYDVTPEQ ALAHEEVKTR
1110 1120 1130 1140 1150
LDNSIRNMRA VTDKFLSAII SSVDKIPYGM RFIAKVLKDS LHEKFPDAGE
1160 1170 1180 1190 1200
DELLKIIGNL LYYRYMNPAI VAPDAFDIID LSAGGQLTTD QRRNLGSIAK
1210 1220 1230 1240 1250
MLQHAASNKM FLGDNAHLGI INEYLSQSYQ KFRRFFQTAC DVPELQDKFN
1260 1270 1280 1290 1300
VDEYSDLVTL TKPVIYISIG EIINTHTLLL DHQDAIAPEH NDPIHELLDD
1310 1320 1330 1340 1350
LGEVPTIESL IGESAGNLND PNKEALAKTE VSLTLTNKFD VPGDENAEMD
1360 1370 1380 1390 1400
ARTILLNTKR LIVDVIRFQP GETLTEILET PATSEQEAEH QRAMQRRAIR
1410 1420 1430 1440 1450
DAKTPDKMKK SKFVKEDSNL TLQEKKEKIQ SGLKKLTELG TVDPKNRYQE
1460 1470 1480 1490 1500
LINDIAKDIR NQRRYRQRRK AELVKLQQTY AALNSKATFY GEQVDYYKSY
1510 1520 1530 1540 1550
IKTCLDNLAS KGKVSKKPRE MKGKKSKKIS LKYTAARLHE KGVLLEIEDL
1560 1570 1580 1590 1600
QVNQFKNVIF EISPTEEVGD FEVKAKFMGV QMETFMLHYQ DLLQLQYEGV
1610 1620
AVMKLFNRAK VNVNLLIFLL NKKFYGK
Length:1,627
Mass (Da):185,878
Last modified:May 1, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB93E0F287D7EF457
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEYP01058892 Genomic DNA No translation available.
AEYP01058893 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMPUT00000015761; ENSMPUP00000015520; ENSMPUG00000015630

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01058892 Genomic DNA No translation available.
AEYP01058893 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9668.ENSMPUP00000015520

Genome annotation databases

EnsembliENSMPUT00000015761; ENSMPUP00000015520; ENSMPUG00000015630

Phylogenomic databases

eggNOGiKOG2128, Eukaryota
GeneTreeiENSGT00950000183076
HOGENOMiCLU_000972_2_1_1
InParanoidiM3YW10
OMAiPPMGVVR

Family and domain databases

CDDicd00014, CH, 1 hit
cd00201, WW, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR000048, IQ_motif_EF-hand-BS
IPR027417, P-loop_NTPase
IPR000593, RasGAP_C
IPR023152, RasGAP_CS
IPR001936, RasGAP_dom
IPR008936, Rho_GTPase_activation_prot
IPR001202, WW_dom
PfamiView protein in Pfam
PF00307, CH, 1 hit
PF00612, IQ, 4 hits
PF00616, RasGAP, 1 hit
PF03836, RasGAP_C, 1 hit
SMARTiView protein in SMART
SM00033, CH, 1 hit
SM00015, IQ, 4 hits
SM00323, RasGAP, 1 hit
SM00456, WW, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
SSF48350, SSF48350, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50021, CH, 1 hit
PS50096, IQ, 4 hits
PS00509, RAS_GTPASE_ACTIV_1, 1 hit
PS50018, RAS_GTPASE_ACTIV_2, 1 hit
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3YW10_MUSPF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3YW10
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: December 2, 2020
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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