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Entry version 54 (12 Aug 2020)
Sequence version 1 (01 May 2013)
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Protein
Submitted name:

Rho GTPase activating protein 23

Gene

ARHGAP23

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rho GTPase activating protein 23Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP23Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9669 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000715 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9668.ENSMPUP00000015036

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 139PDZInterPro annotationAdd BLAST89
Domaini817 – 937PHInterPro annotationAdd BLAST121
Domaini1034 – 1226Rho-GAPInterPro annotationAdd BLAST193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni56 – 75DisorderedSequence analysisAdd BLAST20
Regioni195 – 244DisorderedSequence analysisAdd BLAST50
Regioni252 – 271DisorderedSequence analysisAdd BLAST20
Regioni313 – 334DisorderedSequence analysisAdd BLAST22
Regioni376 – 454DisorderedSequence analysisAdd BLAST79
Regioni960 – 979DisorderedSequence analysisAdd BLAST20
Regioni991 – 1018DisorderedSequence analysisAdd BLAST28
Regioni1258 – 1285DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi215 – 233PolarSequence analysisAdd BLAST19
Compositional biasi403 – 420PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1264 – 1278PolarSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4407, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157982

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001776_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M3YUM6

Identification of Orthologs from Complete Genome Data

More...
OMAi
SAWATMV

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR041681, PH_9
IPR001849, PH_domain
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17820, PDZ_6, 1 hit
PF15410, PH_9, 1 hit
PF00620, RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 1 hit
SM00233, PH, 1 hit
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350, SSF48350, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106, PDZ, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50238, RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

M3YUM6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPLGPRDGC SPGRPLPWQG PRTLLLHKSL QDGFGFTLRH FIVYPPESAV
60 70 80 90 100
HCSLKEEENG GRGGGGGGPS PRHHRLEPMD TIFVKNVKDD GPAHRAGLRT
110 120 130 140 150
GDRLVKVNGE SVIGKTYSQV IALIQNSDDT LELSIMPKDE DILQLAYSQD
160 170 180 190 200
AYLKGNEPYS GEARSIPEPP PICYHRKTYA PPARVSAWAT MVPEPLSAPP
210 220 230 240 250
SDPRSPAAWS DPGPRVPSTT RTHPDNPSLG MSQPRPSPGA FPRDRLEDVT
260 270 280 290 300
AHRPWPCSTS QGALSQLGQE GWHRARSDDY LSRATRSAEA LGPGALVSPR
310 320 330 340 350
FERCGWASQR PSARTSACSS RDLPAPQAQP PPGLQGLDDI GYIGYRSYSP
360 370 380 390 400
SFQRRTGLLH ALSFRDSPFG GLPTFSLAQS QASFPPEASE PPRVVRPEPS
410 420 430 440 450
TRALEPPTED RRDEVILRQK PPTGRKVQLP PARQMNLGFG EESPEPETSG
460 470 480 490 500
RVERLGKKVA PLATTEDSLA SIPFIGEPFF CSFVLQPPFL PPSHSFFSPL
510 520 530 540 550
LFSSLFLLPP VFPPLSPSLP FVCPPTHPFL SLLLSCSLSP PSLCLFVHFS
560 570 580 590 600
LPSLHPFFIL PFLCSFHSSF LPSTLHPTNT SVRHRARLCA LLECVVPRQG
610 620 630 640 650
QSRGDAEGVL PGEQMLDKGE ARVERPADSQ VSGLTRGLCL TSISGMKQGL
660 670 680 690 700
GGLEHWGCGL GLEVRLGMGW AGSALSHLYP PLPLLADEPT SPSIDLQAKH
710 720 730 740 750
VPASAVVSSA MNSAPVLGTS PSSPTFTFAL GRHYSQDCSS IKAGRRSSYL
760 770 780 790 800
LAITTERSKS CDDGLNTFRE ESRALSGHYL PSVVSLQSLD SWGTSEDADA
810 820 830 840 850
PSKRHSTSDL SDATFSDIRR EGWLYYKQVL TKKGKKAGGG LRQWKRVYAA
860 870 880 890 900
LRARSLSLSK ERREPGPAAA GAAAAVAGED EAAPVCIGSC LVDISYSETK
910 920 930 940 950
RRHVFRLTTA DFCEYLFQAE DRDDMLGWIR AIRENSRAEG EDPGCANQAL
960 970 980 990 1000
ISKKLNDYRK VSHSSGPKDD SSPKISRGLG GLKSEFLKQS TARGLRTQDQ
1010 1020 1030 1040 1050
PAGSKDDSAA PPKTPWGINI IKKNKKAAPR AFGVRLEECQ PAIENQRVPL
1060 1070 1080 1090 1100
IVAACCRIVE ARGLESTGIY RVPGNNAVVS SLQEQLNRGP GDINLQDERW
1110 1120 1130 1140 1150
QDLNVISSLL KSFFRKLPEP LFTDDKYNDF IEANRIEDSR ERLKRLRKLI
1160 1170 1180 1190 1200
RDLPGHYYET LKFLVGHLKT IADHSEKNKM EPRNLALVFG PTLVRTSEDN
1210 1220 1230 1240 1250
MADMVTHMPD RYKIVETLIQ HSDWFFSDDE DKGERTPVDD KEPQSVPNIE
1260 1270 1280 1290 1300
YLLPNIGRTV PPGDPGSDST TCSSAKSKGS WAPKKEPYAR EMLAISFISA
1310
VNRKRKKRRE
Length:1,310
Mass (Da):143,716
Last modified:May 1, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18F11DEE54BB4D87
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEYP01062061 Genomic DNA No translation available.
AEYP01062062 Genomic DNA No translation available.
AEYP01062063 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMPUT00000015273; ENSMPUP00000015036; ENSMPUG00000015145

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01062061 Genomic DNA No translation available.
AEYP01062062 Genomic DNA No translation available.
AEYP01062063 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9668.ENSMPUP00000015036

Genome annotation databases

EnsembliENSMPUT00000015273; ENSMPUP00000015036; ENSMPUG00000015145

Phylogenomic databases

eggNOGiKOG4407, Eukaryota
GeneTreeiENSGT00940000157982
HOGENOMiCLU_001776_1_0_1
InParanoidiM3YUM6
OMAiSAWATMV

Family and domain databases

Gene3Di1.10.555.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR041681, PH_9
IPR001849, PH_domain
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
PfamiView protein in Pfam
PF17820, PDZ_6, 1 hit
PF15410, PH_9, 1 hit
PF00620, RhoGAP, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SM00233, PH, 1 hit
SM00324, RhoGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106, PDZ, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50238, RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3YUM6_MUSPF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3YUM6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: August 12, 2020
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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