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UniProtKB - M3YPK3 (M3YPK3_MUSPF)

Entry version 49 (07 Oct 2020)
Sequence version 1 (01 May 2013)
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Protein
Submitted name:

Transcriptional regulating factor 1

Gene

TRERF1

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transcriptional regulating factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRERF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9669 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Mustelidae › Mustelinae › Mustela ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000715 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9668.ENSMPUP00000013261

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini510 – 537C2H2-typeInterPro annotationAdd BLAST28
Domaini779 – 870ELM2InterPro annotationAdd BLAST92
Domaini885 – 936SANTInterPro annotationAdd BLAST52
Domaini1011 – 1040C2H2-typeInterPro annotationAdd BLAST30
Domaini1084 – 1111C2H2-typeInterPro annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni189 – 223DisorderedSequence analysisAdd BLAST35
Regioni245 – 314DisorderedSequence analysisAdd BLAST70
Regioni329 – 354DisorderedSequence analysisAdd BLAST26
Regioni384 – 448DisorderedSequence analysisAdd BLAST65
Regioni460 – 499DisorderedSequence analysisAdd BLAST40
Regioni525 – 575DisorderedSequence analysisAdd BLAST51
Regioni948 – 1008DisorderedSequence analysisAdd BLAST61
Regioni1034 – 1081DisorderedSequence analysisAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1100 – 1120Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi252 – 314PolarSequence analysisAdd BLAST63
Compositional biasi384 – 414PolarSequence analysisAdd BLAST31
Compositional biasi460 – 474PolarSequence analysisAdd BLAST15
Compositional biasi551 – 574Pro-richSequence analysisAdd BLAST24
Compositional biasi951 – 971AcidicSequence analysisAdd BLAST21
Compositional biasi1053 – 1081PolarSequence analysisAdd BLAST29

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4167, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160303

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009800_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		M3YPK3

Identification of Orthologs from Complete Genome Data

More...OMAi		VSDDEMP

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01448, ELM2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit
SM00355, ZnF_C2H2, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit
SSF57667, SSF57667, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 3 hits
PS50157, ZINC_FINGER_C2H2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

M3YPK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDQQLYKTN HVAHGGENLF YQQPPLGIHG GLNHNYGNTV TGAGLEAPQA 
        60         70         80         90        100
SPLSPHFPQD TRDGLGLPVG SKNLGQVDTS RQGGWGGHTG PGNHVQLRSN 
       110        120        130        140        150
LTNSNMMWGT PAQPEPADGY QYTYSQASEI RTQKLTSGVL HKLDSFTQVF 
       160        170        180        190        200
ANQNLRIQVN NMAQVLHTQS AVMDGAPDSA LRQLLSQKPM EPPAPALPAR 
       210        220        230        240        250
YQQVPQQAHP AFPGGLSKPA LQVGPHAGQG HLYYDYQQPL AQMPVQGGQP 
       260        270        280        290        300
LQAPPMLSQH MQQMQQQQYY PPQPQQAGQQ PLSLQEMQQP QQQSRPQQPQ 
       310        320        330        340        350
QQQQQQLQLQ QRQGPMQIPQ YYQPQPVMQH LQEQPQQQPP QMHLQPPSYH 
       360        370        380        390        400
RDAHQYGPEQ AHAVQLIQLG SVPQYYYQEP QQPYGHHVCQ QSHLPQHQQR 
       410        420        430        440        450
EDSQPKTYPG DRQAQAVLSS HGDLGPPDAG MGDPASSDLN RLGGALPHRP 
       460        470        480        490        500
LLSPSGIHLN NMGSQHQQLS PSALWPQMHL PDGRAQPGSP ESSGQSKGVF 
       510        520        530        540        550
GEQFDAKNKL TCSICLKEFK SLPALNGHMR SHGGMRASPS LKQEEGEKAL 
       560        570        580        590        600
PPQPQPQPPL PPPPPPPPQL PPEAESLTPM VMPVSVPVKL LPPKPGSQGF 
       610        620        630        640        650
ANSIVAAPST RDKPASSMSD DEMPVLELPK KHQPAVAKAE EPLKSLPDKK 
       660        670        680        690        700
KFRHRPEPLF IPPPPSYTAN SAAASSYSGA TLYQSQLRSP RILGDHLLLD 
       710        720        730        740        750
PAHELPPYTP PPMLSPVRQG SGLFSNVLIA GHGPGAHPQL PLTPLTPTPR 
       760        770        780        790        800
VLLCRSNSID GSNVTVTPGP GEQTIDVEPR INIGLRFQAE IPELQDVSAL 
       810        820        830        840        850
AQDTHKATLV WKPWPELENH DLQQRVENLL NLCCSSALPG GGTNSEFALH 
       860        870        880        890        900
SLFEAKGDVM VALEMLLLRK PVRLKCHPLA NYHYAGSDKW TSLERKLFNK 
       910        920        930        940        950
ALATYSKDFI FVQKMVKSKT VAQCVEYYYT WKKIMRLGRK HRTRLAEIDD 
       960        970        980        990       1000
SVTSEEEEEL EEEEEDPEED RKSTREEESE VPKSPEPPPG PALAPTEGPP 
      1010       1020       1030       1040       1050
LQALGQPSGS FICEMPNCGA VFSSRQALNG HARIHGGTNQ VTKARGAIPS 
      1060       1070       1080       1090       1100
GKQKPGSAQS GYCSVKSSPS HSTTSGETDP TTIFPCKECG KVFFKIKSRN 
      1110       1120       1130       1140       1150
AHMKTHRQQE EQQRQKAQKA AFAAEMAATI ERTTGPAGAP GLLPLDQLSL 
      1160       1170       1180       1190 
IKPIKDVDIL DGDMVQQLGG VMEEAEVVDT DLLLDDQDSV LLQGDAEL
Length:1,198
Mass (Da):131,090
Last modified:May 1, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87F21CE3234226E3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AEYP01006152 Genomic DNA No translation available.
AEYP01006153 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_004739961.1, XM_004739904.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMPUT00000013473; ENSMPUP00000013261; ENSMPUG00000013360

Database of genes from NCBI RefSeq genomes

More...GeneIDi		101684370

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01006152 Genomic DNA No translation available.
AEYP01006153 Genomic DNA No translation available.
RefSeqiXP_004739961.1, XM_004739904.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9668.ENSMPUP00000013261

Genome annotation databases

EnsembliENSMPUT00000013473; ENSMPUP00000013261; ENSMPUG00000013360
GeneIDi101684370

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55809

Phylogenomic databases

eggNOGiKOG4167, Eukaryota
GeneTreeiENSGT00940000160303
HOGENOMiCLU_009800_0_0_1
InParanoidiM3YPK3
OMAiVSDDEMP

Family and domain databases

InterProiView protein in InterPro
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01448, ELM2, 1 hit
SMARTiView protein in SMART
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit
SM00355, ZnF_C2H2, 3 hits
SUPFAMiSSF46689, SSF46689, 1 hit
SSF57667, SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 3 hits
PS50157, ZINC_FINGER_C2H2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3YPK3_MUSPF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3YPK3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: October 7, 2020
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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