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Protein
Submitted name:

Trio Rho guanine nucleotide exchange factor

Gene

TRIO

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Trio Rho guanine nucleotide exchange factorImported
Gene namesi
Name:TRIOImported
OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
Taxonomic identifieri9669 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
Proteomesi
  • UP000000715 Componenti: Unassembled WGS sequence

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9669.ENSMPUP00000011052

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 174CRAL-TRIOInterPro annotationAdd BLAST146
Domaini1256 – 1431DHInterPro annotationAdd BLAST176
Domaini1443 – 1555PHInterPro annotationAdd BLAST113
Domaini1620 – 1685SH3InterPro annotationAdd BLAST66
Domaini1933 – 2109DHInterPro annotationAdd BLAST177
Domaini2121 – 2235PHInterPro annotationAdd BLAST115
Domaini2524 – 2589SH3InterPro annotationAdd BLAST66
Domaini2658 – 2748Ig-likeInterPro annotationAdd BLAST91
Domaini2769 – 3023Protein kinaseInterPro annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili721 – 748Sequence analysisAdd BLAST28
Coiled coili849 – 869Sequence analysisAdd BLAST21
Coiled coili907 – 927Sequence analysisAdd BLAST21
Coiled coili1139 – 1159Sequence analysisAdd BLAST21
Coiled coili1870 – 1890Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
KOG4240 Eukaryota
ENOG410XPCA LUCA
GeneTreeiENSGT00920000148975
InParanoidiM3YI95
OMAiAEPIPKM
OrthoDBiEOG091G00JY

Family and domain databases

CDDicd00160 RhoGEF, 2 hits
cd00170 SEC14, 1 hit
Gene3Di1.20.900.10, 2 hits
2.30.29.30, 2 hits
2.60.40.10, 1 hit
3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR028570 TRIO
PANTHERiPTHR22826:SF104 PTHR22826:SF104, 6 hits
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF07679 I-set, 1 hit
PF00169 PH, 2 hits
PF00069 Pkinase, 1 hit
PF00621 RhoGEF, 2 hits
PF00018 SH3_1, 1 hit
PF00435 Spectrin, 4 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 2 hits
SM00220 S_TKc, 1 hit
SM00516 SEC14, 1 hit
SM00326 SH3, 2 hits
SM00150 SPEC, 6 hits
SUPFAMiSSF48065 SSF48065, 2 hits
SSF48726 SSF48726, 1 hit
SSF50044 SSF50044, 2 hits
SSF52087 SSF52087, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50010 DH_2, 2 hits
PS50835 IG_LIKE, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50002 SH3, 2 hits

Sequencei

Sequence statusi: Complete.

M3YI95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFKQPSNSN FSLCISGFRK NDEMKAMDVL PILKEKVAYL SGGRDKRGGP
60 70 80 90 100
ILTFPARSNH DRIRQEDLRR LISYLACIPS EEVCKRGFTV IVDMRGSKWD
110 120 130 140 150
SIKPLLKILQ ESFPCCIHVA LIIKPDNFWQ KQRTNFGSSK FEFETNMVSL
160 170 180 190 200
EGLTKVVDPS QLTPEFDGCL EYNHEEWIEI RVAFEDYISN ATHMLSRLEE
210 220 230 240 250
LQDILAKKEL PQDLEGARNM IEEHSQLKKK VIKAPIEDLD LEGQKLLQRI
260 270 280 290 300
QSSDSFPKKN SGSGNADLQS LLPKVSAMLD RLHSTRQHLH QMWHVRKLKL
310 320 330 340 350
DQCFQLRLFE QDAEKMFDWI THNKGLFLNS YTEIGTSHPH AMELQTQHNH
360 370 380 390 400
FAMNCMNVYV NINRIMSVAN RLVESGHYAS QQIKQIANQL EQEWKAFAAA
410 420 430 440 450
LDERSTLLDM SSIFHQKAEK YMSNVDSWCK ACGEVDLPSE LQDLEDAIHH
460 470 480 490 500
HQGIYEHITL AYSEVSQDGK SLLDKLQRPL TPGSSDSLTA SANYSKAVHH
510 520 530 540 550
VLDVIHEVLH HQRQLENIWQ HRKVRLHQRL QLCVFQQDVQ QVLDWIENHG
560 570 580 590 600
EAFLSKHTGV GKSLHRARAL QKRHEDFEEV AQNTYTNADK LLEAAEQLAQ
610 620 630 640 650
TGECDPEEIY QAAHQLEDRI QDFVRRVEQR KILLDMSVSF HSHVKELWTW
660 670 680 690 700
LEELQKELLD DVYAESVEAV QDLIKRFGQQ QQTTLQVTVN VIKEGEDLIQ
710 720 730 740 750
QLRDSAISSN KTPHNSSISH IETVLQQLDE AQAQMEELFQ ERKIKLELFL
760 770 780 790 800
QLRIFERDAI DIISDLESWN DELSQQMNDF DTEDLTIAEQ RLQHHADKAL
810 820 830 840 850
TMNNLTFDVI HQGQDLLQYV NEVQASGVEL LCDRDVDMAT RVQDLLEFLH
860 870 880 890 900
EKQQELDVAA EQHRKHLEQC VQLRHLQAEV KQVLGWIRNG ESMLNAGLIT
910 920 930 940 950
ASSLQEAEQL QREHEQFQHA IEKTHQSALQ VQQKAEAMLQ ANHYDMDMIR
960 970 980 990 1000
DCAEKVASHW QQLMLKMEDR LKLVNASVAF YKTSEQVCSV LESLEQEYKR
1010 1020 1030 1040 1050
EEDWCGGADK LGPNSETDHV TPMISKHLEQ KEAFLKACTL ARRNADVFLK
1060 1070 1080 1090 1100
YLHRNSVNMP GMVTHIKAPE QQVKNILNEL FQRENRVLHY WTMRKRRLDQ
1110 1120 1130 1140 1150
CQQYVVFERS AKQALEWIHD NGEFYLSTHT STGSSIQHTQ ELLKEHEEFQ
1160 1170 1180 1190 1200
ITAKQTKERV KLLIQLADGF CEKGHAHAAE IKKCVTAVDK RYRDFSLRME
1210 1220 1230 1240 1250
KYRTSLEKAL GISSDSNKSS KSLQLDIIPA SVPGSEVKLR DAAHELNEEK
1260 1270 1280 1290 1300
RKSARRKEFI MAELIQTEKA YVRDLRECMD TYLWEMTSGV EEIPAGIVNR
1310 1320 1330 1340 1350
ELVIFGNMQE IYEFHNNIFL KELEKYEQLP EDVGHCFVTW ADKFQMYVTY
1360 1370 1380 1390 1400
CKNKPDSTQL ILEHAGSYFD EIQQRHGLAN SISSYLIKPV QRITKYQLLL
1410 1420 1430 1440 1450
KELLTCCEEG KGEIKDGLEV MLSVPKRAND AMHLSMLEGF DENIESQGEL
1460 1470 1480 1490 1500
ILQESFQVWD PKTLIRKGRE RHLFLFEMSL VFSKEVKDSS GRSKYLYKSK
1510 1520 1530 1540 1550
LFTSELGVTE HVEGDPCKFA LWVGRTPTSD NKIVLKASSI ENKQDWIKHI
1560 1570 1580 1590 1600
REVIQERTIH LKGALKEPIH IPKTAPAARQ KGRRDGEDLD SQGDGSSQPD
1610 1620 1630 1640 1650
TISIASRTSQ NTLDSDKLSG GCELTVVIHD FTACNSTELT IRRGQTVEVL
1660 1670 1680 1690 1700
ERPHDKPDWC LVRTTDRSPA AEGLVPCGSL CIAHSRSSME MEGIFNHKDS
1710 1720 1730 1740 1750
LSVSSNDASP PASVASLQPH MMGAQSSPGP KRPGNTLRKW LTSPVRRLSS
1760 1770 1780 1790 1800
GKADGHVKKL AHKHKKSREV RKSADAGSQK DSDDSAATPQ DETVEERGRN
1810 1820 1830 1840 1850
EGLSSGTLSK SSSSGMQSCG EEEGEEGADA VPLPPPMAIQ QHSLLQPDSQ
1860 1870 1880 1890 1900
DDKASSRLLV RPTSSETPSA AELVSAIEEL VKSKMALEDR PSSLLVDQGD
1910 1920 1930 1940 1950
SSSPSFNPSD NSLLSSSSPI DEMEERKSSS LKRRHYVLQE LVETERDYVR
1960 1970 1980 1990 2000
DLGCVVEGYM ALMKEDGVPD DMKGKDKIVF GNIHQIYDWH RDFFLGELEK
2010 2020 2030 2040 2050
CLEDPEKLGS LFVKHERRLH MYIVYCQNKP KSEHIVSEYI DTFFEDLKQR
2060 2070 2080 2090 2100
LGHRLQLTDL LIKPVQRIMK YQLLLKDFLK YSKKASLDTS ELERAVEVMC
2110 2120 2130 2140 2150
IVPKRCNDMM NVGRLQGFDG KIVAQGKLLL QDTFLVTDQD SGLLPRCKER
2160 2170 2180 2190 2200
RVFLFEQIVI FSEPLDKKKG FSMPGFLFKN SIKVSCLCLE ENVENDPCKF
2210 2220 2230 2240 2250
ALTSRTGGVV ETFILHSSSP SVRQTWIHEI NQILENQRNF LNALTSPIEY
2260 2270 2280 2290 2300
QRNHSGSGGG GGGGSSGGSS GGGAPGAGGG NPSTGPGSCS GLPSSSRSRP
2310 2320 2330 2340 2350
SRIPQPVRHH SPVLVSSAAS SQAEADKMSG MSTPSPAPPL PGSSPAPEAG
2360 2370 2380 2390 2400
PGQPGRHTPG EPEGPQQDSE HIPKMKVIES PRKSSGSAAG AGRDADAKEA
2410 2420 2430 2440 2450
RANQEDSRSR SSLGSLPLGK PRPGAVSPLN SPVATAFPSP IGKEPFPPSS
2460 2470 2480 2490 2500
PLQKGGSFWS SIPASPASRP GSFTFPGDSD SLQRQAQRHT APGKDTDRMS
2510 2520 2530 2540 2550
TCSSASEQSV QSTQSNGSES SSSSNISTML VTHDYTAVKE DEISVCQGEV
2560 2570 2580 2590 2600
VQILASNQQN MFLVFRAATD QCPAAEGWIP GFVLGHTSAV IMENPDGTLK
2610 2620 2630 2640 2650
KSTSWHTALR LRKKSEKKDK DGKREGKLEN GYRKSREGLS NKVSVKLLNP
2660 2670 2680 2690 2700
NYIYDVPPEF VIPLSEVTCE TGETVVLRCR VCGRPKASIT WKGPEHNTLN
2710 2720 2730 2740 2750
NDGHYSISYS DLGEATLKII GVTTEDDGIY TCIAVNDMGS ASSSASLRVL
2760 2770 2780 2790 2800
GPGSDGIMVT WKDNFDSFYS EVAELGRGRF SVVKKCDQKG TKRAVATKFV
2810 2820 2830 2840 2850
NKKLMKRDQV THELGILQNL QHPLLIGLLD TFETPTSYVL VLEMADQGRL
2860 2870 2880 2890 2900
LDCVVRWGNL TEGKIRAYLG EVLEAVRYLH NCRIAHLDLK PENILVDQSL
2910 2920 2930 2940 2950
AKPTIKLADF GDAVQLNTTY YIHQLLGNPE FAAPEIILGN PISLTSDTWS
2960 2970 2980 2990 3000
VGVLTYVLLS GVSPFLDDSV EETCLNICRL DFSFPEDCFK GVSQKAKEFV
3010 3020 3030 3040 3050
CFLLQEDPAK RPSAALALQE QWLQAGHGGG KGVGVLDTSR LTSFIERRKH
3060 3070
QNDVRPIRSV KNFLQSRLLP RV
Length:3,072
Mass (Da):345,396
Last modified:May 1, 2013 - v1
Checksum:i19F4C5F301510462
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01051685 Genomic DNA No translation available.
AEYP01051686 Genomic DNA No translation available.
AEYP01051687 Genomic DNA No translation available.
RefSeqiXP_012916220.1, XM_013060766.1

Genome annotation databases

EnsembliENSMPUT00000011237; ENSMPUP00000011052; ENSMPUG00000011143
GeneIDi101682713

Similar proteinsi

Entry informationi

Entry nameiM3YI95_MUSPF
AccessioniPrimary (citable) accession number: M3YI95
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: July 18, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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