Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA replication licensing factor MCM7

Gene

MCM7

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, HelicaseUniRule annotationSAAS annotation, Hydrolase
Biological processCell cycleUniRule annotation, DNA replicationUniRule annotationSAAS annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication licensing factor MCM7UniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:MCM7UniRule annotationImported
OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
Taxonomic identifieri9669 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
Proteomesi
  • UP000000715 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9669.ENSMPUP00000010794

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 490MCMInterPro annotationAdd BLAST206

Sequence similaritiesi

Belongs to the MCM family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0482 Eukaryota
COG1241 LUCA
GeneTreeiENSGT00920000149094
InParanoidiM3YHI7
OMAiVKIQEMA
OrthoDBiEOG091G02LB

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR031327 MCM
IPR008050 MCM7
IPR018525 MCM_CS
IPR001208 MCM_dom
IPR027925 MCM_N
IPR033762 MCM_OB
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
PANTHERiPTHR11630 PTHR11630, 1 hit
PTHR11630:SF26 PTHR11630:SF26, 1 hit
PfamiView protein in Pfam
PF00493 MCM, 1 hit
PF14551 MCM_N, 1 hit
PF17207 MCM_OB, 1 hit
PRINTSiPR01657 MCMFAMILY
PR01663 MCMPROTEIN7
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00350 MCM, 1 hit
SUPFAMiSSF50249 SSF50249, 2 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00847 MCM_1, 1 hit
PS50051 MCM_2, 1 hit

Sequencei

Sequence statusi: Complete.

M3YHI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVDLDDVAE DDPELVDSIC ENTRRYVRLF ADAVQELLPQ YKEREVVNKD
60 70 80 90 100
VLDVYIEHRL MMEQRSRDPG AARSPQNQYP PELMRRFELY FQGPSSNKPR
110 120 130 140 150
VIREVRADSV GKLVTVRGIV TRVSEVKPRM VVATYTCDQC GAETYQPIQS
160 170 180 190 200
PTFMPLIMCP SQECQTNRSG GRLYLQTRGS KFIKFQEMKM QEHSDQVPVG
210 220 230 240 250
NIPRSITVLV EGENTRLAQP GDHVSVTGIF LPILRTGFRQ VVQGLLSETY
260 270 280 290 300
LEAHRVVKMN KSDDDEAVAG ELSAEELRHI AEEDFYEKLA ASIAPEIYGH
310 320 330 340 350
EDVKKALLLL LVGGVDQSPR GMKIRGNINI CLMGDPGVAK SQLLSYIDRL
360 370 380 390 400
APRSQYTTGR GSSGVGLTAA VLRDSVTGEL TLEGGALVLA DQGVCCIDEF
410 420 430 440 450
DKMAEADRTA IHEVMEQQTI SIAKAGILTT LNARCSILAA ANPAYGRYNP
460 470 480 490 500
RRSLEQNIQL PAALLSRFDL LWLIQDRPDR DNDLRLAQHI TYVHQHSRQP
510 520 530 540 550
PAQFEPLDMK LMRRYIAMCR EKQPTVPESL ADYITAAYVE MRREAWASKD
560 570 580 590 600
ATYTSARTLL AVLRLSTALA RLRMVDTVEK EDVNEAIRLM EMSKDSLLGD
610 620 630 640 650
KGQAARTQRP ADVIFATVRE LVSDGRSVRF AEAEQRCISR GFTPAQFQAA
660 670
LDEYEELNVW QVNTARTRIT FV
Length:672
Mass (Da):75,596
Last modified:May 1, 2013 - v1
Checksum:i99F0EB662320EADD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01103964 Genomic DNA No translation available.
RefSeqiXP_004781867.1, XM_004781810.2
XP_004781868.1, XM_004781811.2
XP_012906106.1, XM_013050652.1

Genome annotation databases

EnsembliENSMPUT00000010973; ENSMPUP00000010794; ENSMPUG00000010881
GeneIDi101672914

Similar proteinsi

Entry informationi

Entry nameiM3YHI7_MUSPF
AccessioniPrimary (citable) accession number: M3YHI7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: July 18, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health