STAT3

Functionⁱ

GO - Molecular functionⁱ

chromatin DNA binding Source: Ensembl
DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
nuclear receptor activity Source: Ensembl
primary miRNA binding Source: Ensembl
protein homodimerization activity Source: Ensembl
protein kinase binding Source: Ensembl
protein phosphatase binding Source: Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
RNA polymerase II repressing transcription factor binding Source: Ensembl

GO - Biological processⁱ

astrocyte differentiation Source: Ensembl
cell population proliferation Source: Ensembl
eating behavior Source: Ensembl
energy homeostasis Source: Ensembl
eye photoreceptor cell differentiation Source: Ensembl
glucose homeostasis Source: Ensembl
growth hormone receptor signaling pathway via JAK-STAT Source: Ensembl
inflammatory response Source: Ensembl
interleukin-6-mediated signaling pathway Source: Ensembl
leptin-mediated signaling pathway Source: Ensembl
mRNA transcription by RNA polymerase II Source: Ensembl
negative regulation of autophagy Source: Ensembl
negative regulation of cell population proliferation Source: Ensembl
negative regulation of glycolytic process Source: Ensembl
negative regulation of neuron migration Source: Ensembl
negative regulation of primary miRNA processing Source: Ensembl
negative regulation of stem cell differentiation Source: Ensembl
phosphorylation Source: Ensembl
positive regulation of angiogenesis Source: Ensembl
positive regulation of cell migration Source: Ensembl
positive regulation of cytokine production involved in inflammatory response Source: Ensembl
positive regulation of erythrocyte differentiation Source: Ensembl
positive regulation of interleukin-10 production Source: Ensembl
positive regulation of interleukin-1 beta production Source: Ensembl
positive regulation of interleukin-8 production Source: Ensembl
positive regulation of metalloendopeptidase activity Source: Ensembl
positive regulation of miRNA mediated inhibition of translation Source: Ensembl
positive regulation of Notch signaling pathway Source: Ensembl
positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
positive regulation of tumor necrosis factor biosynthetic process Source: Ensembl
positive regulation of tumor necrosis factor secretion Source: Ensembl
positive regulation of vascular endothelial cell proliferation Source: Ensembl
protein import into nucleus Source: Ensembl
radial glial cell differentiation Source: Ensembl
regulation of cell cycle Source: Ensembl
regulation of feeding behavior Source: Ensembl
regulation of multicellular organism growth Source: Ensembl
response to estradiol Source: Ensembl
sexual reproduction Source: Ensembl
stem cell population maintenance Source: Ensembl
temperature homeostasis Source: Ensembl
T-helper 17 cell lineage commitment Source: Ensembl

Keywordsⁱ

Molecular function	ActivatorUniRule annotationARBA annotation, DNA-bindingUniRule annotationARBA annotation
Biological process	Transcription, Transcription regulationUniRule annotationARBA annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Signal transducer and activator of transcriptionUniRule annotation
Gene namesⁱ	Name:STAT3Imported
Organismⁱ	Mustela putorius furo (European domestic ferret) (Mustela furo)Imported
Taxonomic identifierⁱ	9669 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Carnivora › Caniformia › Mustelidae › Mustelinae › Mustela › Mustela putorius
Proteomesⁱ	UP000000715 Componentⁱ: Unassembled WGS sequence

Keywords - Cellular componentⁱ

CytoplasmUniRule annotationARBA annotation, NucleusUniRule annotationARBA annotation

PTM / Processingⁱ

Keywords - PTMⁱ

PhosphoproteinUniRule annotationARBA annotation

Interactionⁱ

GO - Molecular functionⁱ

protein homodimerization activity Source: Ensembl
protein kinase binding Source: Ensembl
protein phosphatase binding Source: Ensembl
RNA polymerase II repressing transcription factor binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9668.ENSMPUP00000010432

STRINGⁱ

9668.ENSMPUP00000010432

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	580 – 670	SH2InterPro annotationAdd BLAST		91

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	141 – 168	Sequence analysisAdd BLAST	28
Coiled coilⁱ	200 – 220	Sequence analysisAdd BLAST	21
Coiled coilⁱ	270 – 290	Sequence analysisAdd BLAST	21

Sequence similaritiesⁱ

Belongs to the transcription factor STAT family.UniRule annotationARBA annotation

Keywords - Domainⁱ

Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

eggNOGⁱ	KOG3667, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00990000203570
HOGENOMⁱ	CLU_014189_3_0_1
InParanoidⁱ	M3YGH5
OMAⁱ	GKYCRSE

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10374, SH2_STAT3, 1 hit
Gene3Dⁱ	1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR035855, STAT3_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction
PANTHERⁱ	PTHR11801, PTHR11801, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00017, SH2, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit
SMARTⁱ	View protein in SMART SM00964, STAT_int, 1 hit
SUPFAMⁱ	SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001, SH2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

M3YGH5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAAWIES QDWAYAASKE 
        60         70         80         90        100
SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME 
       110        120        130        140        150
IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD 
       160        170        180        190        200
VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM 
       210        220        230        240        250
QQLEQMLTAL DQMRRNIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA 
       260        270        280        290        300
CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ 
       310        320        330        340        350
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR 
       360        370        380        390        400
LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN 
       410        420        430        440        450
NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL 
       460        470        480        490        500
KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT 
       510        520        530        540        550
WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC 
       560        570        580        590        600
KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST 
       610        620        630        640        650
KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF 
       660        670        680        690        700
AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG 
       710        720        730        740        750
SAAPYLKTKF ICVTPTTCSN TIDLPMSPRT LDSLMQFGNN GEGAEPSAGG 
       760        770
QFESLTFDME LTSECATSPM

Length:770

Mass (Da):88,069

Last modified:May 1, 2013 - v1

Checksum:ⁱ4776D23526C23E1D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AEYP01079452 Genomic DNA No translation available. AEYP01079453 Genomic DNA No translation available. AEYP01079454 Genomic DNA No translation available. AEYP01079455 Genomic DNA No translation available. AEYP01079456 Genomic DNA No translation available. AEYP01079457 Genomic DNA No translation available. AEYP01079458 Genomic DNA No translation available. AEYP01079459 Genomic DNA No translation available. AEYP01079460 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AEYP01079452 Genomic DNA No translation available.
AEYP01079453 Genomic DNA No translation available.
AEYP01079454 Genomic DNA No translation available.
AEYP01079455 Genomic DNA No translation available.
AEYP01079456 Genomic DNA No translation available.
AEYP01079457 Genomic DNA No translation available.
AEYP01079458 Genomic DNA No translation available.
AEYP01079459 Genomic DNA No translation available.
AEYP01079460 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENSMPUT00000010600; ENSMPUP00000010432; ENSMPUG00000010509

Ensemblⁱ

ENSMPUT00000010600; ENSMPUP00000010432; ENSMPUG00000010509

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
M3YGH5	Signal transducer and activator of transcription		Enhydra lutris kenyoni		770	UniRef100_M3YGH5

Protein	Similar proteins		Species	Score	Length	Source
M3YGH5	Signal transducer and activator of transcription 3	)	MOUSE		770	UniRef90_P42227
Signal transducer and activator of transcription 3		CHICK		771
Signal transducer and activator of transcription 3		PIG		770
Signal transducer and activator of transcription 3		RAT		770
Signal transducer and activator of transcription 3		BOVIN		770
+274

Protein	Similar proteins		Species	Score	Length	Source
M3YGH5	Signal transducer and activator of transcription 3	)	HUMAN		770	UniRef50_P40763
Signal transducer and activator of transcription 3		CHICK		771
Signal transducer and activator of transcription 3		PIG		770
Signal transducer and activator of transcription 3		BOVIN		770
Signal transducer and activator of transcription 3		RAT		770
+1168

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AEYP01079452 Genomic DNA No translation available. AEYP01079453 Genomic DNA No translation available. AEYP01079454 Genomic DNA No translation available. AEYP01079455 Genomic DNA No translation available. AEYP01079456 Genomic DNA No translation available. AEYP01079457 Genomic DNA No translation available. AEYP01079458 Genomic DNA No translation available. AEYP01079459 Genomic DNA No translation available. AEYP01079460 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AEYP01079452 Genomic DNA No translation available.
AEYP01079453 Genomic DNA No translation available.
AEYP01079454 Genomic DNA No translation available.
AEYP01079455 Genomic DNA No translation available.
AEYP01079456 Genomic DNA No translation available.
AEYP01079457 Genomic DNA No translation available.
AEYP01079458 Genomic DNA No translation available.
AEYP01079459 Genomic DNA No translation available.
AEYP01079460 Genomic DNA No translation available.

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Protein-protein interaction databases

STRINGⁱ	9668.ENSMPUP00000010432

STRINGⁱ

9668.ENSMPUP00000010432

Genome annotation databases

Ensemblⁱ	ENSMPUT00000010600; ENSMPUP00000010432; ENSMPUG00000010509

Ensemblⁱ

ENSMPUT00000010600; ENSMPUP00000010432; ENSMPUG00000010509

Phylogenomic databases

eggNOGⁱ	KOG3667, Eukaryota
GeneTreeⁱ	ENSGT00990000203570
HOGENOMⁱ	CLU_014189_3_0_1
InParanoidⁱ	M3YGH5
OMAⁱ	GKYCRSE

Family and domain databases

CDDⁱ	cd10374, SH2_STAT3, 1 hit
Gene3Dⁱ	1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR000980, SH2 IPR036860, SH2_dom_sf IPR001217, STAT IPR035855, STAT3_SH2 IPR036535, STAT_N_sf IPR013800, STAT_TF_alpha IPR015988, STAT_TF_coiled-coil IPR013801, STAT_TF_DNA-bd IPR012345, STAT_TF_DNA-bd_N IPR013799, STAT_TF_prot_interaction
PANTHERⁱ	PTHR11801, PTHR11801, 1 hit
Pfamⁱ	View protein in Pfam PF00017, SH2, 1 hit PF01017, STAT_alpha, 1 hit PF02864, STAT_bind, 1 hit PF02865, STAT_int, 1 hit
SMARTⁱ	View protein in SMART SM00964, STAT_int, 1 hit
SUPFAMⁱ	SSF47655, SSF47655, 1 hit SSF48092, SSF48092, 1 hit SSF49417, SSF49417, 1 hit SSF55550, SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001, SH2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	M3YGH5_MUSPF
Accessionⁱ	M3YGH5Primary (citable) accession number: M3YGH5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 1, 2013
	Last sequence update:	May 1, 2013
	Last modified:	December 2, 2020
	This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - M3YGH5 (M3YGH5_MUSPF)

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Signal transducer and activator of transcription

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ