Interferon regulatory factor 8

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl

GO - Biological processⁱ

• cellular response to interferon-gamma Source: Ensembl
• cellular response to lipopolysaccharide Source: Ensembl
• defense response to bacterium Source: Ensembl
• defense response to protozoan Source: Ensembl
• myeloid cell differentiation Source: Ensembl
• phagocytosis Source: Ensembl
• plasmacytoid dendritic cell differentiation Source: Ensembl
• positive regulation of interferon-gamma production Source: Ensembl
• positive regulation of interleukin-12 production Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• regulation of type I interferon production Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MCDRNGGRRL RQWLIEQIDS GMYPGLIWES EEKSMFRIPW KHAGKQDYNQ 
        60         70         80         90        100
EVDASIFKAW AVFKGKFKEG DKAEPATWKT RLRCALNKSP DFEEVTDRSQ 
       110        120        130        140        150
LDISEPYKVY RIVPEEEQKC RLGVATPGCV SEMTEMECGR PEMDELVKEP 
       160        170        180        190        200
SVDDYMGIVK RSPSPPDACR SQLLPECWMQ QQPSAGLPLV TGYTAYDTHH 
       210        220        230        240        250
SAFSQMVISF YYGGKLVGQT ATTCPEGCRL SLGQPALPGA KLYGPEGLEL 
       260        270        280        290        300
VRFPPADAIP SERQRQVTRK LFGHLERGVL LHSSRQGVLV KRLCQGRVFC 
       310        320        330        340        350
SGNAVLCKDR PNKLERDEVV KVFDTSQFFR ELQHFYNNQG RLPDSRVVLC 
       360        370        380        390        400
FGEEFPDLTP LRSKLILVQI EQLYVRQLVE EASKSCGGGS LAQTPEAPPL 
       410        420 
DQFFRMFPDV CTSHQRPFFR ENQQITV                          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ