UniProtKB - M3YA22 (M3YA22_MUSPF)
Protein
Submitted name:
SIM bHLH transcription factor 2
Gene
SIM2
Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: Ensembl
- DNA-binding transcription factor activity Source: InterPro
- protein heterodimerization activity Source: Ensembl
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- embryonic pattern specification Source: Ensembl
- lung development Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- nervous system development Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental proteinARBA annotation |
Biological process | DifferentiationARBA annotation, NeurogenesisARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: SIM bHLH transcription factor 2Imported |
Gene namesi | Name:SIM2Imported |
Organismi | Mustela putorius furo (European domestic ferret) (Mustela furo)Imported |
Taxonomic identifieri | 9669 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Mustelidae › Mustelinae › Mustela › |
Proteomesi |
|
Subcellular locationi
Nucleus
- nuclear body Source: Ensembl
Interactioni
GO - Molecular functioni
- protein heterodimerization activity Source: Ensembl
Protein-protein interaction databases
STRINGi | 9668.ENSMPUP00000008179 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 53 | BHLHInterPro annotationAdd BLAST | 53 | |
Domaini | 77 – 149 | PASInterPro annotationAdd BLAST | 73 | |
Domaini | 233 – 288 | PASInterPro annotationAdd BLAST | 56 | |
Domaini | 336 – 551 | Single-minded C-terminalInterPro annotationAdd BLAST | 216 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 363 – 389 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 407 – 426 | DisorderedSequence analysisAdd BLAST | 20 |
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
eggNOGi | KOG3559, Eukaryota |
GeneTreei | ENSGT00940000159985 |
HOGENOMi | CLU_010044_4_1_1 |
InParanoidi | M3YA22 |
OMAi | SECQWHY |
Family and domain databases
CDDi | cd00083, HLH, 1 hit cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001610, PAC IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR013655, PAS_fold_3 IPR010578, SIM_C |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit PF08447, PAS_3, 1 hit PF06621, SIM_C, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00086, PAC, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits PS51302, SIM_C, 1 hit |
i Sequence
Sequence statusi: Complete.
M3YA22-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKEKSKNAAK TRREKENGEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL
60 70 80 90 100
KMRAVFPEGL GDAWGQPSRA GPLDSVAKEL GSHLLQTLDG FVFVVASDGK
110 120 130 140 150
IMYISETASV HLGLSQVELT GNSIYEYIHP SDHDEMTAVL AAHQPLHHHL
160 170 180 190 200
LQEYEIERSF FLRMKCVLAK RNAGLTCSGY KVIHCSGYLK IRQYMLDMSL
210 220 230 240 250
YDSCYQIVGL VAVGQSLPPS AVTEIKLHSN MFMFRASLDL KLIFLDSRVT
260 270 280 290 300
ELTGYEPQDL IEKTLYHHVH GCDVFHLRYA HHLLLVKGQV TTKYYRLLSK
310 320 330 340 350
LGGWVWVQSY ATVVHNSRSS RPHCIVSVNY VLTEIEYKEL QLSLDQVSTS
360 370 380 390 400
KCQDSWRTAL STSQETRKLA KPKNTKMKTK LRTNPYPPQQ YSSFQMDKLE
410 420 430 440 450
CSQLGNWRAS PPANAPAPPE QQLHSESSDL LYAPSYSLPF SYRYGHFPLD
460 470 480 490 500
SHVFSSKKPM LPAKFGQPQA SPCEVARFFL STLPASGECQ WHYANPLVPS
510 520 530 540 550
SPTPAKSLSE PPVNAARHSL VPNYEDYSPT APKNEYGTPL VCFPSQFSKC
G
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AEYP01055196 Genomic DNA No translation available. AEYP01055197 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMPUT00000008309; ENSMPUP00000008179; ENSMPUG00000008240 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AEYP01055196 Genomic DNA No translation available. AEYP01055197 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9668.ENSMPUP00000008179 |
Genome annotation databases
Ensembli | ENSMPUT00000008309; ENSMPUP00000008179; ENSMPUG00000008240 |
Phylogenomic databases
eggNOGi | KOG3559, Eukaryota |
GeneTreei | ENSGT00940000159985 |
HOGENOMi | CLU_010044_4_1_1 |
InParanoidi | M3YA22 |
OMAi | SECQWHY |
Family and domain databases
CDDi | cd00083, HLH, 1 hit cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001610, PAC IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR013655, PAS_fold_3 IPR010578, SIM_C |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit PF08447, PAS_3, 1 hit PF06621, SIM_C, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00086, PAC, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits PS51302, SIM_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | M3YA22_MUSPF | |
Accessioni | M3YA22Primary (citable) accession number: M3YA22 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2013 |
Last sequence update: | May 1, 2013 | |
Last modified: | October 7, 2020 | |
This is version 54 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |