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Entry version 60 (02 Jun 2021)
Sequence version 1 (01 May 2013)
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Protein
Submitted name:

Leucine rich repeats and IQ motif containing 1

Gene

LRRIQ1

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1621 – 1680HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental proteinPROSITE-ProRule annotation, DNA-bindingPROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Leucine rich repeats and IQ motif containing 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRIQ1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9669 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000715 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmARBA annotation, NucleusPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9668.ENSMPUP00000007670

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1619 – 1679HomeoboxInterPro annotationAdd BLAST61
Domaini1795 – 1808OARInterPro annotationAdd BLAST14

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni75 – 98DisorderedSequence analysisAdd BLAST24
Regioni389 – 416DisorderedSequence analysisAdd BLAST28
Regioni1069 – 1089DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili215 – 257Sequence analysisAdd BLAST43
Coiled coili262 – 282Sequence analysisAdd BLAST21
Coiled coili305 – 325Sequence analysisAdd BLAST21
Coiled coili617 – 637Sequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1795 – 1808OARPROSITE-ProRule annotationAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi75 – 92Basic and acidic residuesSequence analysisAdd BLAST18

Keywords - Domaini

Coiled coilSequence analysis, HomeoboxPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0490, Eukaryota
KOG0531, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162858

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002837_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
M3Y8L3

Identification of Orthologs from Complete Genome Data

More...
OMAi
FVPEPIP

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR000048, IQ_motif_EF-hand-BS
IPR032675, LRR_dom_sf
IPR003654, OAR_dom
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046, Homeodomain, 1 hit
PF00612, IQ, 2 hits
PF03826, OAR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389, HOX, 1 hit
SM00015, IQ, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit
PS50096, IQ, 3 hits
PS50803, OAR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

M3Y8L3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIVCPTGAP VRKDPSIFLG IGCCRGYALF GGSGRCLPTK PRDIAAWMME
60 70 80 90 100
NDGDDDDTKL KEEIEAELDK ISISSLEKDD VDSDSKSDIQ SDDSDTDLDE
110 120 130 140 150
LPESVLHCIN IIKNKSKTAE ELILQDLEDT DVLSYSYGVV PNHMHLRIEL
160 170 180 190 200
STEHKEHPEQ LIKMLSEIEK EEFLRNKIHC GGPDSIPEPD LHDLPVDKHV
210 220 230 240 250
LPDDADINFG YCEVEERCRQ SFEAWQEKQK ELEDQEKETL KAQRDREKKQ
260 270 280 290 300
FQEEEEKRHC WMKQFEVEKK KLENIQKQEQ DKMNDELHKE EKMWKEKFKK
310 320 330 340 350
HEEFIKSLHL QMEEERTRFK DLQEKEKMRL LKRQHNAAVT IQAKYKAFVA
360 370 380 390 400
YQKYNPIIKE QLESKKKKAQ EWKEKEAKIR QMEEEKLKRL EEEQKVEEER
410 420 430 440 450
KKQKQEERRK REKEYEEKKT IIRREKEQLL NKERLRLRED AHKQLIISRA
460 470 480 490 500
LKKDEYNIKN LTVEDTSKNK DDIAKKVGDE KSKKWEDVPL WLLEKSNRTE
510 520 530 540 550
NVDRQLVLKE SIQAQSKDPI IDQAILAEFK VKNENLAKQQ CSEKIVKEEG
560 570 580 590 600
KCKNTDKKTE LEKPGLKENV KEQFQMQELK LQIQNGEHMK TAINENMRQD
610 620 630 640 650
TQIILGHNEK INKVRNNEAW KIIQDNQQNK IQKVEKEELT EQNGTLYEEN
660 670 680 690 700
NISVSSMKQQ ALKLENSEVI GENITIQEKE IDLKSKETEE VPKDNTLNSD
710 720 730 740 750
VIFNSNDSMV TTEGKINEQD YIFGRNGLCE DLGSYNAKSS LIFKEINSLK
760 770 780 790 800
SQLKEIPEEC HENRAECEST VTCSLSKPTL LSSIEEKRLA WIKSHKPWFE
810 820 830 840 850
IFKQNQQKKF VQRKRPVKCP ASMMPPLNTL EILRCGPWKT LQQVTTVTFQ
860 870 880 890 900
DLPGCSLSTL AECPNLQFLS LRRCGLISLH SLSNCKKLKH IDAQENHIET
910 920 930 940 950
INCENLDNLC VVLLNKNQLT SFHGLDGCTN IQNLELSHNK ITRIDLTSAI
960 970 980 990 1000
RWFDACYSLH ELSITGNPLL QEINWRDFLL KVLPALRILN GEMLNSYSER
1010 1020 1030 1040 1050
HTEEHYEPEL GRFVILCQSQ IQEFNSLVES YINGKGNFVT LDAAENLCHY
1060 1070 1080 1090 1100
FNKLMTLSNE CRYSHEHGSI SVTQREDPET QQNHLTPTNS DSILQNRVLH
1110 1120 1130 1140 1150
SCADKYKLDS PDTSEKWMNS GSSHSTFTNS LCEDTEGRNQ EEIVYQKRED
1160 1170 1180 1190 1200
SKSNSISMER IPFMETVMTS SLLWNCQNTE HRKKVMAAMV IQAYWRGYIE
1210 1220 1230 1240 1250
RRRIHFSTKL QPPAIEPLMS KPNYCIKNKT ILKKEKRENT VNIQEQREKA
1260 1270 1280 1290 1300
AILIQAVWKG FLLRKKLTTA LEAIKNEESE EEYEEINLED FTFDEAALEE
1310 1320 1330 1340 1350
EWLTLDSTRF PSQTLLVPNQ LHWPKFSGTL KYDDTSLNLR SHPAQAWLCN
1360 1370 1380 1390 1400
EKEDLFSSEH AQFNSRSQYR TLSWTPESKT SRKSLLKTEK EEKISKEWGF
1410 1420 1430 1440 1450
KDIATAQQML KRAQKMKSKK LKKKLDPMVC LALLKNNENK VSVTKSPKMA
1460 1470 1480 1490 1500
QPRRDGYFEG KKEELIYEDA TPNEKLERRK EYTYQWLHTQ VGIHETTNSR
1510 1520 1530 1540 1550
NMKCNHFLPE LDPDVLNGGR VQLVARLVSR EDTDLDLFSM TSGSALSVKR
1560 1570 1580 1590 1600
EKKNQAHRHS AGSSMNYGIT KVEGQPLHTE LNRAMDNCNS LRMSPVKGMP
1610 1620 1630 1640 1650
EKGELDELGD KCDSNVSSSK KRRHRTTFTS LQLEELEKVF QKTHYPDVYV
1660 1670 1680 1690 1700
REQLALRTEL TEARVQVWFQ NRRAKWRKRE RYGQIQQAKS HFAATYDISV
1710 1720 1730 1740 1750
LPRTDSYPQI QNNLWAGNAS GGSVVTSCML PRDTSSCMTP YSHSPRTDSS
1760 1770 1780 1790 1800
YTGFSNHQNQ FSHVPLNNFF TDSLLTGATN GHAFETKPEF ERRSSSIAVL
1810
RMKAKEHTAN ISWAM
Length:1,815
Mass (Da):211,303
Last modified:May 1, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBEBBDE4BE5B53ED6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEYP01024913 Genomic DNA No translation available.
AEYP01024914 Genomic DNA No translation available.
AEYP01024915 Genomic DNA No translation available.
AEYP01024916 Genomic DNA No translation available.
AEYP01024917 Genomic DNA No translation available.
AEYP01024918 Genomic DNA No translation available.
AEYP01024919 Genomic DNA No translation available.
AEYP01024920 Genomic DNA No translation available.
AEYP01024921 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMPUT00000007793; ENSMPUP00000007670; ENSMPUG00000007727

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01024913 Genomic DNA No translation available.
AEYP01024914 Genomic DNA No translation available.
AEYP01024915 Genomic DNA No translation available.
AEYP01024916 Genomic DNA No translation available.
AEYP01024917 Genomic DNA No translation available.
AEYP01024918 Genomic DNA No translation available.
AEYP01024919 Genomic DNA No translation available.
AEYP01024920 Genomic DNA No translation available.
AEYP01024921 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9668.ENSMPUP00000007670

Genome annotation databases

EnsembliENSMPUT00000007793; ENSMPUP00000007670; ENSMPUG00000007727

Phylogenomic databases

eggNOGiKOG0490, Eukaryota
KOG0531, Eukaryota
GeneTreeiENSGT00940000162858
HOGENOMiCLU_002837_0_0_1
InParanoidiM3Y8L3
OMAiFVPEPIP

Family and domain databases

CDDicd00086, homeodomain, 1 hit
Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR000048, IQ_motif_EF-hand-BS
IPR032675, LRR_dom_sf
IPR003654, OAR_dom
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00046, Homeodomain, 1 hit
PF00612, IQ, 2 hits
PF03826, OAR, 1 hit
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SM00015, IQ, 3 hits
SUPFAMiSSF46689, SSF46689, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit
PS50096, IQ, 3 hits
PS50803, OAR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3Y8L3_MUSPF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M3Y8L3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: June 2, 2021
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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