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Protein

Protein disulfide-isomerase A4

Gene

PDIA4

Organism
Mustela putorius furo (European domestic ferret) (Mustela furo)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase A4UniRule annotation (EC:5.3.4.1UniRule annotation)
Alternative name(s):
Endoplasmic reticulum resident protein 72UniRule annotation
Gene namesi
Name:PDIA4Imported
OrganismiMustela putorius furo (European domestic ferret) (Mustela furo)Imported
Taxonomic identifieri9669 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaMustelidaeMustelinaeMustela
Proteomesi
  • UP000000715 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21UniRule annotationAdd BLAST21
ChainiPRO_500514043922 – 645Protein disulfide-isomerase A4UniRule annotationAdd BLAST624

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi206 ↔ 209Redox-activeUniRule annotation
Disulfide bondi555 ↔ 558Redox-activeUniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.UniRule annotation

Protein-protein interaction databases

STRINGi9669.ENSMPUP00000006471

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 169ThioredoxinInterPro annotationAdd BLAST123
Domaini171 – 301ThioredoxinInterPro annotationAdd BLAST131
Domaini505 – 636ThioredoxinInterPro annotationAdd BLAST132

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili31 – 62Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Redox-active centerUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG0190 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00860000133691
InParanoidiM3Y570
OMAiYRAATQF
OrthoDBiEOG091G05J9

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR005792 Prot_disulphide_isomerase
IPR017068 Protein_diS-isomerase_A4
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 3 hits
PIRSFiPIRSF036862 Disulphide_isom_A4, 1 hit
SUPFAMiSSF52833 SSF52833, 5 hits
TIGRFAMsiTIGR01130 ER_PDI_fam, 1 hit
TIGR01126 pdi_dom, 3 hits
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 3 hits
PS51352 THIOREDOXIN_2, 3 hits

Sequencei

Sequence statusi: Complete.

M3Y570-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLRKACLLV LLLALAQLLV AASAGGPDED SSNKEDAIED EEEEEEDDEE
60 70 80 90 100
EEDDDLEVKE ENGVLVLNDV NFDNFVADKD TVLLEFYAPW CGHCKQFAPE
110 120 130 140 150
YEKIASALKE HDPPIPVAKI DATSESALAG RFGVSGYPTI KILKKGQAVD
160 170 180 190 200
YEGSRTQEEI VAKVKEVSQP NWTPPPEVTL VLTKENFDEV VDGADIILVE
210 220 230 240 250
FYAPWCGHCK KLAPEYEKAA KELSKRSPPI PLAKVDATAE TDLAKRFEVS
260 270 280 290 300
GYPTLKIFRK GKPFDYNGPR EKYGIVDYMI EQSGPPSKEI MSLKQVQEFL
310 320 330 340 350
KDGDDVIIIG VFKAESDPAY QQYQDAANNL REDYKFHHTF STEIAKFLKV
360 370 380 390 400
SSGKLVIMQP EKFQSKYEPR SHVMDILSST EGSAIKDHVL KHTLPLVGHR
410 420 430 440 450
KTSNDAKRYT RRPLVVVYYS VDFSFDYRAA TQFWRNKVLE VAKDFPEYTF
460 470 480 490 500
AVADEDDFAT EVKDLGLSES GEDVNAAILD EGGRKFAMEP DDFDSDTLRE
510 520 530 540 550
FVRAFKKGKL KPVVKSQPVP KNNKGPVKVV VGKTFDSIVM DPKKDVLIEF
560 570 580 590 600
YAPWCGHCKQ LEPEYTALGK KYKNHKNLVI AKMDATANDI TNDRYKVEGF
610 620 630 640
PTIYFAPSGD KKNPIKFEDG NRDLEHLSKF VEEHATKLSR TREDL
Length:645
Mass (Da):72,806
Last modified:May 1, 2013 - v1
Checksum:i9947BA90B63B2B2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEYP01064716 Genomic DNA No translation available.
AEYP01064717 Genomic DNA No translation available.
AEYP01064718 Genomic DNA No translation available.
RefSeqiXP_004765952.1, XM_004765895.2

Genome annotation databases

EnsembliENSMPUT00000006582; ENSMPUP00000006471; ENSMPUG00000006526
GeneIDi101690040

Similar proteinsi

Entry informationi

Entry nameiM3Y570_MUSPF
AccessioniPrimary (citable) accession number: M3Y570
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2013
Last sequence update: May 1, 2013
Last modified: July 18, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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